scholarly journals Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

2021 ◽  
Author(s):  
Mostafa A. Askar ◽  
Mona S. Guida ◽  
Seham. M. AbuNour ◽  
Essam A. Ragab ◽  
Eiman N. Ali ◽  
...  
Keyword(s):  
Body Weight ◽  
Gamma Rays ◽  
Hematological Parameters ◽  
The Body ◽  
Histopathological Study ◽  
Biological Processes ◽  
T Helper ◽  
Γ Rays ◽  
Cd4 Cell ◽  
Morphological State

Abstract Zinc Coumarate and zinc caffeiatenano-particles (ZCoNPs, ZCaNPs) have been shown to affectthe different biological processes. This work was undertaken to evaluate the mitigating action of ZCoNPs in combination with ZCaNPsagainst liver damage induced by gamma rays (γ-rays). Rats were exposed to 7Gy of γ-rays, and theninjected intraperitoneally (i.p.) with ZCoNPs [2U / rat / day (5 mg/kg)], and ZCaNPs [2U / rat / day (15 mg/kg)] for 7 consecutive days.The results showed that irradiated rats treated with ZCoNPs (5 mg/kg/body weight) in combination with ZCaNPs (15 mg/kg/body weight) for 7 days revealed a significant increase in the body weight, antioxidants levels, T Helper (CD4) Cell and T Cytotoxic (CD8), associated with amarked decrease in the level of lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. Moreover, positive alterations in the morphological state, hematological parameters, and thecell cycle phases were noticed. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment.Thus, ZCoNPs and ZCaNPscould be usedas a natural mitigating agent to reduce the hazards of ionizing radiation.

scholarly journals The Effects of Different Exercise Types on Hematological Parameters in Sedentary Women

2018 ◽  
Vol 6 (8) ◽  
pp. 96 ◽  
Author(s):  
Güner Çiçek
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Blood Cell ◽  
Aerobic Exercise ◽  
Hematological Parameters ◽  
Exercise Group ◽  
The Body ◽  
Strength Exercise ◽  
Strength Exercises ◽  
Sedentary Women

The purpose of this study is to investigate the effect of aerobic and strength exercises on hematological parameters in sedentary women. To achieve the purpose of this study, a total of 23 volunteers including aerobic exercise group (AE, n: 10), strength exercise group (SE, n:13) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent. The HR was measured using a heart rate monitor for each subject.The women's white blood cell (WBC), thrombocyte (PLT), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT) and mean corpuscular volume (MCV) were measured before and after exercise. For statistical analysis, the Wilcoxon signed-rank test was used for intra-group evaluations, and the Mann Whitney U test was used for inter-group evaluations. After the exercise program, there were a meaningful decrease in the body weight and body mass index (BMI) the women in both intervention groups. In addition, in the hematological results of strength exercise group, some meaningful decreases were determined in the values of RBC, HGB, HCT and MCV (p<0.01). As a results, it was observed that regular aerobic and strength exercises can positively influence the body weight and BMI parameters of sedentary women. Along with this, a meaningful decrease has been found in the values of RBC, HGB, HCT and MCV of strength exercise group compared to aerobic exercise.

scholarly journals Anti-arthritic Evaluation of Different Extracts of Boerhaavia diffusa Linn. in FCA Induced Arthritis In Rats

2018 ◽  
Vol 8 (5-s) ◽  
pp. 388-393 ◽  
Author(s):  
Deepika Parmar ◽  
Neetesh Kumar Jain ◽  
Vivek Tomar
Keyword(s):  
Body Weight ◽  
Phenolic Compounds ◽  
Methanolic Extract ◽  
Hematological Parameters ◽  
Extraction Methods ◽  
The Body ◽  
Haematological Parameters ◽  
Phytochemical Study ◽  
Methanolic Extracts ◽  
Boerhaavia Diffusa

The main aim of study is to evaluate the anti-arthritic effect of different extracts of Boerhaavia diffusa in arthritic rats. Different extracts were prepared by successive solvent extraction methods by using the various polar and non polar solvents and their % yields were calculated. Arthritis was induced by FCA induced arthritis model in rats and paw volume was measured on different days. Body weights of all animals were also measured simultaneously and at the end of experiment some haematological parameters were measured. On preliminary phytochemical studies extracts showed the presence of alkaloids, fatty acids, terpenoids, flavonoids and phenolic compounds. Among all extracts, methanolic extract significantly decreased the paw volume in all treated groups. Methanolic extracts also restored the body weight significantly. The results of our study revealed that all the extracts treated group’s causes significant alterations in the hematological parameters and maximal effects were observed at 400 mg/kg. Since methanolic extract showed best activity in arthritic model and its phytochemical study showed presence of flavonoids and phenolic compounds, so it may be possible that anti-arthritic activity of root extracts may be due to presence flavonoids.  Keywords: Arthritis, FCA induced arthritis, Boerhaavia diffusa, haematological parameters, and Body weight

Acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii (Miq.) Miq. stem bark in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 89-97
Author(s):  
EL Lappa ◽  
◽  
C Bogning Zangueu ◽  
EL Nguemfo ◽  
JJ Kojom Wanche ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Hematological Parameters ◽  
Lethal Dose ◽  
Relative Weight ◽  
Stem Bark ◽  
The Body ◽  
Female Rats ◽  
Male Rats

Ficus vogelii is a medicinal plant mainly found in tropical Africa and reported to treat inflammatory complaints. This study aims to evaluate the acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii stem bark in wistar rats. For acute study, aqueous extract at a single dose of 5000 mg/kg body weight was administered to female rats and observed for 14 days. In the sub-chronic study, the extract was administered daily to both sex rats at the doses of 100, 200, 400, and 600 mg/kg body weight for 28 consecutive days. Body weight was measured weekly, while hematological, biochemical, and histopathological parameters were analyzed after euthanize. Aqueous extract of Ficus vogelii at all tested doses didn’t produced any mortality or significant change on the body weight and relative weight of rats on acute and sub-chronic studies. The lethal dose 50 was estimated greater than 5000 mg/kg (DL50˃5000 mg/kg). Hematological parameters were recorded non-significant in all treated rats. Aqueous extract at 600 mg/kg significantly changed transaminases and alkaline phosphatase activities, these changes were reversible in satellites. The concentrations of bilirubin was increased at 200 and 600 mg/kg in male rats, at 100, 400 mg/kg in female rats. The levels of lipids markers didn’t changed, except the significant decrease of LDL-cholesterol. Histological examination didn’t showed any change in the architecture of the liver and kidney of rats treated compared to control. Thus aqueous extract of Ficus vogelii stem bark didn’t produced adverse effects in rats after oral acute and sub-chronic treatment.

scholarly journals The Clinical and Hematological changes in Rabbits exposed to Melia azedarach fruits under experimental conditions

2015 ◽  
Vol 1 (1) ◽  
pp. 12 ◽  
Author(s):  
AL- Zubaedi Raad Mahmood
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Bleeding Time ◽  
Hematological Parameters ◽  
The Body ◽  
Melia Azedarach ◽  
Control Group ◽  
Clotting Time ◽  
Experimental Conditions ◽  
Hb Concentration

The study was conducted on 10 local breed rabbits, of 1-2 years age, of 1- 1.5 kg body weight. They were feed concentrated and green food, and left ad libitum for water, and kept in room of 20- 25 oC. The animals divided into two groups of 5 each. First as treated group received the plant in powder form mixed with the food at a dose rate of 5 g/ animal / day for three weeks , while the second left without exposure as a control group .The main dependent parameters in the study were , clinical parameters ( body temperature , heartbeat , respiratory rate, body weight , in addition to monitor any abnormal signs appear on the animals . While the main hematological parameters were included , RBC count , WBC count , Hb concentration,PCV percentage , Red cell indices , Bleeding time and Clotting time. The body temperature, respiratory rates, heart rate were increased .The body weight decreased .The bleeding time and clotting time were prolonged. The erythrocyte count, Hb concentration, and MCV values were decreased; PCV and MCHC did not showed any significant changes. The MCH increased. The total leucocytes count and the basophiles percentage did not showed any significant changes. The Heterophils and monocytes percentage increased .The lymphocytic and Eosinophil percentage were decreased during the study.

scholarly journals Amelioration of complete Freund’s adjuvant-induced arthritis by Calotropis procera latex in rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Roshni Patel ◽  
Shahrukh Kadri ◽  
Priyanshee Gohil ◽  
Shrikalp Deshpande ◽  
Gaurang Shah
Keyword(s):  
Body Weight ◽  
Bone Erosion ◽  
Hematological Parameters ◽  
Adult Population ◽  
The Body ◽  
Complete Freund’S Adjuvant ◽  
Calotropis Procera ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Abstract Background Rheumatoid arthritis is the most common cause of disability, affecting 0.3–1% of the adult population worldwide. The latex of Calotropis procera possesses potent anti-inflammatory as well as analgesic properties. In light above facts, the present study was designed to evaluate anti-arthritic activity of Calotropis procera latex in complete Freund's adjuvant (CFA)-induced arthritis in Wistar albino rats. Complete Freund's adjuvant was injected into the left hind paw on day 0, and treatment of prednisolone and Calotropis procera latex was given from day 0 to 28. Various biochemical, hematological and functional parameters as well as radiological and histopathological changes of joint along with body weight and paw volume were measured. Results Calotropis procera treatment significantly lowered paw volume in CFA-induced arthritic rats. Significant improvement was observed in functional, biochemical and hematological parameters in Calotropis procera-treated rats. However, the body weight remained unaffected. Histological and radiographical examination of synovial joints in Calotropis procera-treated animals exhibited less synovial hyperplasia, infiltration and accumulation of inflammatory cell in synovial fluid, cartilage and bone erosion and joint space narrowing. Conclusion Calotropis procera latex possesses anti-arthritic activity, which is facilitated by modulation in the level of inflammatory mediators and oxidative stress. The improvement in hematological as well as biochemical parameters might be reflected on functional, histopathological, radiological changes and thereby disease progression.

scholarly journals Effects of neem, betel leaf, devil's tree, jute and turmeric against gastrointestinal nematodes in sheep

1970 ◽  
Vol 8 (2) ◽  
pp. 259-263 ◽  
Author(s):  
MR Amin ◽  
M Mostofa ◽  
MN Islam ◽  
MA Asgar
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Water Extract ◽  
Gastrointestinal Nematode ◽  
Experimental Period ◽  
Gastrointestinal Nematodes ◽  
The Body ◽  
Control Group ◽  
Betel Leaf ◽  
Group A

Effects of neem, betel leaf, devil’s tree, jute and turmeric against natural gastrointestinal nematodes in sheep and on some hematological parameters (TEC, Hb and PCV) and body weight were studied. Thirty (30) naturally parasitized sheep were randomly divided into six groups(A, B, C, D, E and F), each consisting of five sheep. Ten percent water extract of leaves of neem, betel leaf, devil’s tree and jute were administered orally to the sheep of group A, B, C and D, respectively. Sheep of group E was treated orally with 10% water extract of rhizome of turmeric. Sheep of group F was kept as infected control group. Fecal samples, hematological parameters and body weight were examined before treatment and on 7th, 14th, 21st and 28th day. A significant (p<0.01) reduction of EPG count was found following administration of neem (37.60-47.03%), betel leaf (6.43-14.00%), devil’s tree (3.04-11.04%), jute (0.50-5.26%) and turmeric (0.46-8.30) in sheep. The EPG count of the control group (F) were significantly (p<0.01) increased up to the last day of experimental period. After treatment with neem, betel leaf, devil’s tree, jute and turmeric total erythrocyte count (TEC), hemoglobin (Hb) content and packed cell volume (PCV) were increased significantly (p<0.01 and p<0.05) in sheep. The body weight was increased significantly (p<0.01 and p<0.05) in neem, betel leaf, devil’s tree, jute and turmeric treated sheep. On the other hand, body weight was decreased in untreated control group. The present study reveal that 10% water extract of neem was moderately effective and betel leaf, devil’s tree, jute and turmeric were relatively less effective against gastrointestinal nematodes in sheep. Keywords: Neem; Betel leaf; Devil’s tree; Jute; Turmeric; Gastrointestinal nematode DOI: 10.3329/jbau.v8i2.7935 J. Bangladesh Agril. Univ. 8(2): 259-263, 2010  

Evaluation of the effectiveness of ironcontaining drugs in the complex therapy of antenatal hypotrophy of piglets

2021 ◽  
Vol 1 (6) ◽  
pp. 13-17
Author(s):  
R. V. Rogov ◽  
◽  
Zh. Yu. Muradyan ◽  
I. G. Ryazanov ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Clinical Study ◽  
Body Weight Gain ◽  
Hematological Parameters ◽  
Live Weight ◽  
The Body ◽  
Treatment Regimens ◽  
Complex Therapy ◽  
Experimental Group

In the conditions of the pig breeding complex, the effectiveness of two treatment regimens for antenatal hypotrophy of piglets was studied. Two groups of piglets were formed, where the ironcontaining drug «Ursoferran – 200» was used in complex therapy in the 1st experimental group, and «Ferropen-200»in the 2nd experimental group. In a clinical study, hypotrophic piglets showed characteristic symptoms of the disease. In the experiment, the live weight of piglets was measured at the time of farrowing and on the 3rd, 7th, 14th and 21st days of life. The hematological parameters were studied. The most pronounced therapeutic effect was observed in the 1st experimental group, where the body weight gain was higher by 8,3% than in the 2nd experimental group.

DYNAMICS OF PROTEIN METABOLISM AND ACTIVITY OF AMINOTRANSFERASES OF DOGS BY ADDING DIHYDROQUERCETIN

2016 ◽  
Vol 1 (2) ◽  
pp. 60-63
Author(s):  
Полищук ◽  
Sergey Polishchuk ◽  
Молянова ◽  
Galina Molyanova
Keyword(s):  
Body Weight ◽  
Blood Cells ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
The Body ◽  
German Shepherd ◽  
Physiological Indicators ◽  
Formalin Edema ◽  
And Function ◽  
Experimental Group

The purpose of research is to increase protective and adaptive reactions, the service and the working potential of an organism of dogs through the use of DHQ. The article presents the results of an experiment to the effect of DHQ on the dynamics of hematological parameters of dogs blood. Dihydroquercetin – an active antioxidant, a natural scavenger of oxygen free radicals, hepatoprotective, has anti-inflammatory action due to limitations of the formalin edema and histamine, and inhibits the formation of serous fluid, pain killers, immunocorrectional properties. Due to the high complexing properties it displays the body of heavy metals, including radionuclides, it helps to restore the tone of blood vessels, normalization of the lipid spectrum of the blood and slows the development of atherosclerotic plaques. Investigations were carried out in Dogs State Service Ministry of I A of Russia zonal center in Samara Region by clinically healthy of dog breed German Shepherd, age 2-4 years with an average body weight of 30 kg on the background conditions and feeding, adopted by the enterprise. Dogs experimental group received Dihydroquercetin to 0.001 g/kg body weight dose once a day with food. When added to the basic diet Dihydroquercetin dog experimental group show an increase in indicators such as red blood cells – by 18.3% (p&#60;0.01), hemoglobin – by 11.7% (p &#60;0.01) hematocrit – 7.1% (p&#60;0.01), white blood cells – by 9.1% (p&#60;0.05) compared to control data. The research results give reason to believe that the use of dietary supplements in Dihydroquercetin in dogs diet dose 0.001 g/kg allows significantly increase the morphological and physiological indicators of animal organism. In this case a significant increase erythrocytes and hemoglobin and hematocrit indicates increased oxidative metabolism and function of the intensity of the blood in dogs treated with the drug, and increase in the blood indicates an increase in immune status.

scholarly journals Effects of oxyclozanide (Tremacid®) preparation against fascioliasis on clinical and haematological parameters in cattle of Bangladesh

2015 ◽  
Vol 3 (1) ◽  
pp. 46 ◽  
Author(s):  
Naim Alam ◽  
Md Islam ◽  
Matiar Howlader ◽  
Nasrin Lucky
Keyword(s):  
Body Weight ◽  
Untreated Control ◽  
Hematological Parameters ◽  
Experimental Period ◽  
The Body ◽  
Haematological Parameters ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Untreated Control Group ◽  
Group B

<p>The effects of Oxyclozanide (Tremacid®) on some clinical (body weight) and haematological parameters (TEC, Hb, PCV, ESR and TLC) were determined in this study. Among 55 cattle, 10 were selected, which were suffering from fascioliasis and divided randomly into two groups. Each group was consisting of five cattle. One was treated with Tremacid® @ (15 mg/kg body weight). Other was kept as an infected control group. Before trials with Tremacid® initial body weight, EPG of liver fluke and hematological parameters were examined. During the experimental period the faecal samples, clinical and hematological parameters were examined on 7th, 14th, 21st and 28th days for the determination of effects of Tremacid®. A significant reduction of EPG count was found on 7th, 14th, 21st and 28th day of Tremacid® (61.87%, 71.22%, 76.98% and 84.53%) in a treated cattle group. The EPG of an untreated control group was significantly (p&lt;0.01) increased about 3.97%, 7.64%, 11.04% and 64.89% respectively. Total TEC was increased after treatment with Tremacid® and decreased in an untreated control group significantly (p&lt;0.01), Likewise, after treatment with Tremacid® Hb content and PCV were increased, and ESR was decreased. Total leukocyte count (TLC) was decreased and the body weight was increased after Tremacid® treatment in the group A. On the other hand, Hb content PCV and body weight was decreased significantly (p&lt;0.01) in the group B.</p>

scholarly journals Evaluation of Sperm Impairing Factor from Serratia marcescens as Male Contraceptive in Mouse Model

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Aditi Chauhan ◽  
Vijay Prabha
Keyword(s):  
Body Weight ◽  
Serum Level ◽  
Serratia Marcescens ◽  
Hematological Parameters ◽  
The Body ◽  
Saline Control ◽  
Seminiferous Tubules ◽  
Hematological Indices ◽  
Seminal Parameters ◽  
The Right

The present study was carried out to assess the contraceptive efficacy of sperm agglutinating factor (SAF) isolated from Serratia marcescens, in male Balb/c mice. Mice were administered via an intratesticular route with different concentrations of SAF, viz., 10, 50, 100, 200, or 400 µg, in the right testis only which served as a test while the left side served as control except otherwise stated. Mice were sacrificed on day 3, 7, 14, 21, 30, 45, 60, and 90 after administration, and results in terms of change in body weight, seminal parameters, tissue somatic indices (TSI), hematological parameters, serum level of testosterone, lipid peroxidation, and histology were studied. The body weight and TSI remained unaffected in all the experimental groups. In case of seminal parameters, the right testis treated with 10 μg, 50 μg, 100 μg, 200 μg, or 400 μg of SAF showed azoospermia up to day 7, 14, 21, 45, and 90, respectively. The hematological indices, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were found to be unaltered when the group receiving SAF (test) was compared with the groups receiving phosphate buffer saline (control) in the right testis; however, the treatment had a negative effect on the serum level of testosterone. It also affected the oxidative status of the right testis. Furthermore, histological studies revealed hypospermatogenesis and alterations in the seminiferous tubules which included intraepithelial vacuolation and exfoliation in the right side as compared to the left side. Thus, the results suggest that SAF (400 µg) causes suppression of spermatogenesis, without causing apparent toxic effects.

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