scholarly journals Effects of cystic fibrosis on the oral cavity

2021 ◽  
Vol 3 (2) ◽  
pp. 061-072
Author(s):  
H. Goumghar ◽  
M. Sidqui

Cystic fibrosis is a complex, lethal, multi-system autosomal recessive disease resulting from mutations on chromosome 7 that cause dysfunction of an ion channel located on epithelial surfaces. Pulmonary disease is the leading cause of morbidity and mortality in CF. The specific dental manifestations of the disease may result from the condition itself or from complications of treatment. This study presents the dental problems observed in patients with cystic fibrosis and reported in the literature. Particular attention was paid to dental caries, disturbances in the mineralization of hard dental tissues, gingivitis and changes in the content and properties of saliva.

Pharmacia ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 151-154
Author(s):  
Maria Becheva ◽  
Petar Atanasov

Cystic fibrosis (CF) is a complex, systemic autosomal recessive disease that affects the functions of the respiratory system, the digestive tract and all exocrine glands. The frequency for Europe averages 1: 2500 to 1: 3500 live births. The total number of patients with cystic fibrosis in Bulgaria is about 180. About 10% of the patients are diagnosed at birth. About 60–70% of patients are diagnosed before they reach one year of age. Respiratory symptoms predominate in the clinical picture in patients with cystic fibrosis and determine the prognosis in more than 90% of the patients. The treatment of patients with cystic fibrosis is strictly individualized, pharmacological and non-pharmacological and requires a comprehensive therapeutic approach. The complex therapy also includes bronchodilators, NSAIDs, corticosteroids, respiratory rehabilitation in combination with general body massage. Continued courses of broad-spectrum antibiotics are required to suppress chronic infection. With the progression of the disease, complications such as atelectasis, pneumothorax and pulmonary hemorrhages are observed. The establishment of specialized centers with trained and experienced professionals is essential in order to provide optimal patient care. These include frequent clinical evaluations, follow-up of complications, and early interventions for the treatment of patients with cystic fibrosis. The aim of the article is to familiarize the audience with the therapeutic measures applied in the treatment of patients with cystic fibrosis.


2015 ◽  
Vol 64 (2) ◽  
pp. 118-121
Author(s):  
Marcela Daniela Ionescu ◽  
◽  
Ioana-Alina Anca ◽  
Mihaela Balgradean ◽  
◽  
...  

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians. Lung disease is characterized by impaired mucocilliary clearance with airway obstruction and chronic pulmonary infection and inflammation. Wheeze is a common symptom in CF, but in some cases the wheeze is due to the presence of concomitant asthma. There is no consensus on how to define CF asthma, but the diagnosis is predominantly based on the patient’s strong family and personal history of atopy.


Author(s):  
A. Efremova ◽  
T. Bukharova ◽  
N. Petrova ◽  
N.Kashirskaya Kashirskaya ◽  
Y. Melyanovskaya ◽  
...  

Cystic fibrosis (CF) is the most common life-threatening autosomal recessive disease. CF is caused by mutations in the CFTR gene that encodes an anionic channel, which is expressed in epithelial cells. The most common genetic variant is F508del, its allelic frequency in the Russian Federation 52.81% (2017). This variant belongs to class II, leads to incorrect folding of the CFTR protein and its premature degradation. Currently, the effectiveness of target therapy can be individually evaluated by forskolin-induced swelling (FIS) assay on intestinal organoids obtained from CF patients with different genotypes.


2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sara Zarei ◽  
Ali Mirtar ◽  
Forest Rohwer ◽  
Douglas J. Conrad ◽  
Rebecca J. Theilmann ◽  
...  

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians with a reported incidence of 1 in every 3200 live births. Most strikingly, CF is associated with early mortality. Host in flammatory responses result in airway mucus plugging, airway wall edema, and eventual destruction of airway wall support structure. Despite aggressive treatment, the median age of survival is approximately 38 years. This work is the first attempt to parameterize the distributions of mucus in a CF lung as a function of time. By default, the model makes arbitrary choices at each stage of the construction process, whereby the simplest choice is made. The model is sophisticated enough to fit the average CF patients' spirometric data over time and to identify several interesting parameters: probability of colonization, mucus volume growth rate, and scarring rate. Extensions of the model appropriate for describing the dynamics of single patient MRI data are also discussed.


2012 ◽  
Vol 93 (4) ◽  
pp. 634-637
Author(s):  
T Yu Shiryak ◽  
R A Saleev ◽  
R Z Urazova ◽  
O Yu Anisimova

Aim. To determine the role of complications of caries of deciduous teeth in the structure of pathology of hard dental tissues. Methods. Conducted was a dental examination and treatment of 1016 children aged 1 to 9 years who were treated at the children’s dental clinic. Results. The overall prevalence of caries was 78.64%, the need for treatment was - 73.82%. Complications of dental caries were found in 60.83% of cases. 55.21% of children had temporary tooth pulpitis, 41.24% - had a diagnosis of «periodontitis». Premature removal of deciduous teeth was performed in 12.11% of cases. At an early age (1-3 years) 47.35% of the children were registered as having affected deciduous teeth, almost half of them had teeth with complicated dental caries (20.0%). In children of preschool age (4-6 years) the prevalence of caries disease was 92.17%, and complications of caries were diagnosed in 78.80% of cases. In the group of primary school children (7-9 years) the proportion of children with affected temporary teeth was 98.34%. 86.77% of children had deciduous teeth with complications of caries. Every child who comes to children’s dentist at an early age, already has an average of 2.33 affected teeth, in the preschool age - 4.8 teeth, in the primary school years - 5.02 affected deciduous teeth. In evaluating the intensity of dental caries it was established that each child had on average 1.96 teeth with uncomplicated caries and 2.08 teeth with caries complications. Treatment or retreatment was necessary in 70.69% of cases of affected teeth, of them uncomplicated caries accounted for 35.96%. Conclusion. Revealed was a high prevalence and need for treatment of complicated caries of deciduous teeth starting from an early age.


2021 ◽  
Vol 3 (2) ◽  
pp. 073-079
Author(s):  
H. Goumghar ◽  
M. Sidqui

Cystic fibrosis (CF) is the most common severe autosomal recessive disease in the Caucasian population. Although it remains incurable, it is currently possible to extend the life expectancy of patients with modern therapeutic possibilities. Given the medical issues that a child with CF faces, oral health may be perceived as being of lesser importance. Thus, the establishment of good dietary and oral hygiene practices may not take place, leading to an increased risk of caries and gingivitis due to poor oral hygiene. A change in patient management may be necessary to ensure optimal care.


2018 ◽  
pp. 55-59
Author(s):  
I.V. Kovach ◽  
H.V. Shtompel ◽  
Ye.N. Dychko ◽  
A.V. Verbytska

Modern domestic preventive dentistry has success in the theory of the origin and development of major dental diseases, practice of treatment, including dental caries, and uses these results to prevent children’s diseases in the country. However, the desired effectiveness of preventive measures have not been achieved primarily among the population and individual level, taking into account some specific characteristics of residence region, etiology and pathogenesis of the demineralization phenomena of hard dental tissues in different periods of child’s development. Adverse environmental conditions and technogenic character are not taken into account, when air, soil and groundwater are oversaturated with environmental contaminants and toxicants. They cause fatal breakage in biochemical reactions and metabolic processes in childhood and at a young age, when defective dental health brings a lot of problems in the adult period of life, and, as a result, reduces the life. Investigation of dental health had been conducted in 251 preschool age children (first age group consisted of 3-4 years-old, II group consisted of 5-6 – years-old with 123 and 128 people respectively). In addition, all the observed children were divided into two groups depending on the use of prophylactic anti-caries interventions: the basic group was in compliance with the "Program- maximum" and control the "Program- minimum". Approximately 60 members were in the monitoring teams of different age groups. The "Program-minimum" included measures of general health, balanced diet with the significant restriction of carbohydrate and perform twice a day hygiene actions in the oral cavity. The “Program – maximum” also included the ingestion of calcium citrate and amino acids with SH-group of methionine. Such treatment and prophylactic complex has the adaptive, antioxidant, antidote and immune resolving action. It makes sense for neutralization of eco toxicants – heavy metals in the area of children’s residence. It was found that level of Fe and Zn was in the threatening degree of content, and Cd is moderate in the living environment of the examined children. It provokes and enhances the glycolytic processes in the oral cavity. Harmful effect of toxicants in the oral cavity, and also in a children's organism as a whole, was clearly fixed in the mineralization of the skeleton flat bones of children. It was revealed with densitometry of the calcaneus that 53 individuals had  indicators, particularly BUA. They indicated the weakening of the skeleton mineralization. It indirectly pointed to problems in the hard tissues of the teeth. However, the use of treatment and prophylactic complex improved the bone structures density. The level of calcium and phosphate in the oral fluid of the observed individuals had recovered to optimal after three years of use of treatment and prophylactic complex, contributed to effective secondary mineralization both in temporary and in permanent teeth. Thus, the use of treatment and prophylactic complex in people of the basic group allowed quite convincingly and positively to impact on the incidence of caries of deciduous and permanent teeth. The rate of growth of dental caries intensity after three years of preventive interventions in the basic group was three times less than in the control group. At the same time, the caries preventive efficacy was 59-62%, and this is a very positive indicator. These results are evidence of proven necessity of prophylactic of dental health correction in children years of those people who reside in areas with a very complex technogenic environment due to metallurgical plants located in the Prydniprovsk region.


2019 ◽  
Vol 72 (5) ◽  
pp. 1048-1052
Author(s):  
Lyudmila F. Кaskova ◽  
Тetyana B. Маndziuk ◽  
Larissa P. Ulasevych ◽  
Natallia B. Kuzniak

Introduction: Caries occurs most frequently among dental diseases of the hard dental tissues in children. Its occurrence and intensity do not decrease, although scientists and practitioners make much efforts directed to the reduction of these indices The aim: Therefore, the objective of our study was to investigate the indices of rate salivation and viscosity of the oral fluid in children at different age periods with caries and intact teeth. Materials and methods: 134 children, 7-9 years old, and 89 children,10-12 years old, studying at Poltava schools were examined. Dental examination was conducted according to the common methods. Caries intensity in all the children was determined by Caries Filling Extraction (CFE) Index, and CFE+cfe. To determine salivation rate the oral fluid was collected on empty stomach in the morning into sterile calibrated tubes during 5 minutes. Results and conclusions: Investigations of physical indices of the oral fluid in children of 7-9 and 10-12 years of age did not find their reliable difference considering the child’s age. Meanwhile the indices of salivation rate and oral fluid viscosity in children with caries and without it were found to differ much. That is, the course of carious process in children is associated with reduced salivation rate and increased index of the oral fluid viscosity, which in its turn deteriorates hygienic state of the oral cavity enabling to activate the activity of dental deposit microflora and its effect on enamel demineralization followed by occurrence of carious defect of temporary and especially permanent teeth recently erupted and poorly mineralized. The results obtained were calculated by variation statistics method. The indices were considered to be reliable with р≤0,05.


2021 ◽  
Vol 11 (6) ◽  
pp. 42-46
Author(s):  
Marcin Makuch ◽  
Marcelina Makuch

Cystic fibrosis (CF) is life-shortening autosomal recessive disease, caused by mutations in the cystic fibrosis transmembrane conductance regulator protein. The most common of CF complications is cystic fibrosis-related diabetes (CFRD). The pathophysiology of CFRD is complex. The best test for screening and diagnosis of CFRD is the oral glucose tolerance test (OGTT). Insulin therapy is a treatment of choice in CFDR pharmacotherapy. An inseparable element of CFRD therapy is also physical activity and diet.


Author(s):  
A. V. Goryainova ◽  
P. V. Shumilov ◽  
N. Yu. Kashirskaya ◽  
S. Yu. Semykin

The article considers the issue of cystic fibrosis – a monogenic autosomal recessive disease. It describes the history of the CFTR gene discovery, the further search for modifier genes to explain the variability of the clinical manifestations of cystic fibrosis. The review discusses problems of connective tissue dysplasia and somatic pathology, which is formed due to the connective tissue dysmorphogenesis in patients with cystic fibrosis; and also the article contains justification for the connection between the formation of severe fibrosis of the lungs and liver and the presence of clinical and genetic markers of connective tissue dysplasia. The author assumes that the clinical and genetic polymorphisms of connective tissue influence the course of cystic fibrosis, formation of bronchiectasis, interstitial pneumofibrosis, cystic fibrosis dysplasia, liver fibrosis and cirrhosis.


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