scholarly journals Prevention of recurrence of endometrial polyps in women of reproductive age

2021 ◽  
Vol 6 ◽  
pp. 66-70
Author(s):  
G.О. Tolstanova
Keyword(s):  
Ascorbic Acid ◽  
Reproductive Age ◽  
Control Group ◽  
Antioxidant Protection ◽  
Endometrial Polyps ◽  
Sh Groups ◽  
The Third ◽  
Prevention Of Recurrence ◽  
Complex Drug ◽  
Integral Indicator

The objective: the optimization of management of women in reproductive age after removal of endometrial polyps based on the study of the antioxidant status of the organism.Materials and methods. We examined 150 women in reproductive age with endometrial polyps, 65 (43.3%) patients of them were diagnosed with glandular polyp, 85 (56.7%) – with glandular fibrous polyps. 110 patients after polypectomy were divided into three clinical groups: the first group (32 (29.1%) women) did not receive anti-relapse therapy, the second group (36 (32.7%) persons) used dydrogesterone, the third group (42 (38.2%) women) – received complex drug anti-recurrence therapy (thioctic acid preparation, ascorbic acid, α-tocopherol acetate, indole-3-carbinol). In all women, the antioxidant indicators in blood and the presence of recurrent polyps were determined in 12 months after the treatment. Results. Before polypectomy in patients with endometrial polyps, a decrease of indicators of antiradical activity by 28.52%, restored forms of non-protein SH-groups – by 16.46%, protein SH-groups – by 25.31%, ascorbic acid – by 27.04%, α-tocopherol – by 21.62%, the value of the integral indicator of antioxidant protection – by 31.01% were found compared to the persons in the control group, as well as an increase in the concentration of malonic dealdehyde by 37.23%, non-protein SS groups – by 43.48%, protein SS-groups - by 29.43% and oxidized forms of ascorbic acid – by 29.68%.In 12 months after polypectomy, recurrence of the pathology was in 21.9% of patients of the first group, in 16.7% – of the second group, and no recurrence was detected in women in the third group.Conclusions. In patients with endometrial polyps there are a decrease in level of components of antioxidant protection in the organism and the expressed intensification of processes of free radical and peroxide oxidation of lipids. The use of a comprehensive approach that combines the polypectomy with the use of antioxidant drugs in the postoperative period, in such patients allows to prevent a recurrence of the pathology.

Features of the cervix uteri in women of reproductive age with endometrial polyps and micropolyps

2016 ◽  
pp. 108-111
Author(s):  
T.F. Tatarchuk ◽  
◽  
D.G. German ◽  
Keyword(s):  
Reproductive Age ◽  
Cervix Uteri ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Endometrial Polyps ◽  
Group Iii ◽  
Aggressive Form ◽  
Group I ◽  
Group Ii ◽  
Control Group Group

The article presents the comparative analysis of the state of the cervix in women with endometrial polyps and micropolyps. Patients and methods. The study involved 130 patients aged 18-35 years: 70 patients with endometrial polyps (group I), 30 patients with micropolyps (group II) and 30 patients of the control group (group III). Results. According to the anamnesis of women in the I group were significantly more frequent diseases of the cervix, which corrected physical surgery methods, in particular cryodestruction. In group II, the representatives of these indicators were similar to healthy. Normal colposcopic picture met significantly less frequently in patients and I, and II group. The differences in the incidence of HPV high oncogenic risk in all groups were not statistically significant. Conclusion. Destructive methods used in the detection of any changes in the cervix are often overly aggressive, form scars and contributing to inflamaciones process. In the chain of events leading to the formation of PE, cervical pathology and its correction can take the basic place. Key words: endometrial polyp, micropolyps, chronic endometritis, uterine cervix, colposcopy.

scholarly journals Characteristics of Uterine Hyperplastic Processes in Women with Obesity

2016 ◽  
Vol 23 (3) ◽  
Author(s):  
O. M. Makarchuk ◽  
Abdulrakhman Abdulbaset Moslem
Keyword(s):  
Uterine Leiomyoma ◽  
Metabolic Disorders ◽  
Significant Risk ◽  
Reproductive Age ◽  
Sexual Disorders ◽  
Control Group ◽  
Histological Structure ◽  
Obese Women ◽  
Women Of Reproductive Age ◽  
Endometrial Polyps

Introduction. Analysis of uterine leiomyoma incidence indicates not only its growth but also the increase in the number of women of early reproductive age. However, the problem of trigger mechanisms for its development is still uncertain and actual.The objective of the research was to assess the characteristic features of hyperplastic processes in uterus on the background of dishormonal and metabolic disorders.Materials and methods. 60 women of reproductive age with uterine leiomyoma participated in the clinical trial. They gave their informed written consent. The control group consisted of 20 healthy women of reproductive age. Statistical analysis was conducted using material package “STATISTICA for Windows®-6.0” and methods of odds ratio (OR) calculating and its 95% Confidential Interval (95% CI).Results and their discussion. According to the results of the research the main factors contributing to uterine fibroid development in women with obesity were determined. They included: the age of 30-45 years, instrumental intervention in the womb (abortion, diagnostic curettage, etc. (OR = 8.2; 95% CI: 5.1-13.5)); chronic inflammatory diseases of genitalia (OR = 7.9; 2.9-21.9); hormonal imbalances (fibro-cystic breast disease, thyroid disorders (OR = 8.61; 3.1-23.8), liver and gastrointestinal tract disorders (OR = 5.8; 2.1-15.9) sexual disorders and stress inductive factors (OR = 2.6; 1.4-7.1) (usually fibroids occur in 1-2 years after severe stress). There is a significant percentage of adenomyosis and endometrial hyperplastic processes. Growth of tumors in women with obesity increases to 35-40 years of age, and is associated not only with a progressive decrease in the functional activity of the ovaries, their sensitivity to gonadotrophic stimulation, but also with chronic functional exertion of regulation systems on the background of metabolic disorders of hemostasis and homeostasis in this category of women.Conclusions. One of the most significant risk factors for hyperplastic processes of the reproductive organs is obesity and associated metabolic disorders. In case of metabolic disorders activity and hepatocytes on the background of obesity the number of combined forms of hyperplastic processes in the uterus increases by 1.9 times. The main risk factor for fibroids in obese women is hepatocytes dysfunction on the background of a high percentage of hepatobiliary pathology, endocrine pathology – 68.3% (thyroid dysfunction, fibro-cystic breast changes). Morphological and histological structure of endometrium in obese women leads to the growth of endometrial polyps (36.66%).

scholarly journals Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

2019 ◽  
Vol 4 (1) ◽  
pp. 31-35
Author(s):  
Maria A. Rashidova ◽  
Leonid F. Sholokhov ◽  
Marina A. Darenskaya ◽  
Lyubov I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Viral Hepatitis ◽  
Functional State ◽  
Chronic Viral Hepatitis ◽  
Protection System ◽  
Reproductive Age ◽  
Control Group ◽  
Antioxidant Protection ◽  
Chronic Form ◽  
Antioxidant Protection System

Background.Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim.To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results.In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.

scholarly journals Research of indicators of pro- and antioxidant system in spermoplasm in violation of fertility in men

Urology ◽  
2021 ◽  
Vol 25 (2) ◽  
Author(s):  
O.D. Melenevsky ◽  
O.M. Chaika ◽  
O.V. Tretyakova
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Protection System ◽  
Reproductive Age ◽  
Antioxidant Systems ◽  
Control Group ◽  
Antioxidant Protection ◽  
Study Results ◽  
Mda Content ◽  
Antioxidant Protection System

The article presents the study results of marker indicators of pro- and antioxidant spermoplasm systems among men of reproductive age with various types of infertility. It is shown that patients who were diagnosed with “secretory male infertility”, had the level of MDA content that was exceeding control indicators in 1.2 times (aЈ0,05) with simultaneous activation of SOD (in 132.2%, aЈ0,05) against the background of slight CAT activity decreasing. The SOD/CAT ratio increased in 1.44 times compared to the control, and the activity of GAOS enzymes was not significantly different from the control group. The condition of  pro- and antioxidant protection system can be classified as “activated” due to “SOD + CAT” link with imbalance in the system, which can lead to progression of cytotoxic effects. The patients’ segmentation who were diagnosed with “excretory-toxic male infertility” into three subgroups by MDA content in spermoplasm made it possible to establish that the first subgroup was characterized by “compensatory activation” mainly of GAOS against the background of decreasing MDA content, in the second subgroup - indicators of the pro- and anti-radical protection system did not have reliable differences comparing with control results. The third subgroup showed increase of MDA content (66.1%, aЈ0,01) and activity decrease of all anti-radical protection systems. The state of pro- and antioxidant protection system in this subgroup can be classified as “oxidative stress.” The indicators study of pro-antioxidant systems in spermoplasm among patients with various types of male infertility will allow to carry out pathogenetically justified prevention and correction of conditions, which are accompanied by development of oxidative stress.

scholarly journals Clinical and diagnostic aspects of testosterone deficiency in women of fertile age

2021 ◽  
Vol 17 (1) ◽  
pp. 81-85
Author(s):  
Z.Yu. Khalimova ◽  
A.A. Almakhmatova
Keyword(s):  
Free Testosterone ◽  
Reproductive Age ◽  
Control Group ◽  
Androgen Deficiency ◽  
Testosterone Deficiency ◽  
Overweight Women ◽  
Diagnostic Aspects ◽  
The Third ◽  
Definition Of

Background. The role of androgens in a woman has not been fully appreciated. Currently, there is no clear and gene­rally accepted definition of the concept of androgen deficiency in women by analogy with that in men. The purpose of the study was to investigate the clinical and diagnostic aspects of testoste­rone deficiency in women of fertile age. Materials and methods. The study included 60 women with testosterone deficiency without other concomitant pathology. The average age of the patients was 28.3 years. The control group consisted of 20 healthy women. The patients were divided into three groups based on their body mass index (BMI). The first group consisted of 20 overweight women (BMI 25–29.9 kg/m2), the second group — 20 women with first-degree obesity, and the third group — 20 women with second-degree obesity. Results. On the 14th day of the ovarian-menstrual cycle, the patients from the first group showed a tendency towards a decrease in the basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone against the background of significant hypoandrogenaemia. Patients with obesity (II degree) showed a significant decrease in basal levels of LH, FSH, estradiol, progesterone against the background of significant hypoandrogenaemia. The correlation analysis revealed a direct relationship between testosterone deficiency and obesity. Thus, the lowest testosterone values were found in patients of the third group (< 0.05 nmol/l). At the same time, the testosterone level in the patients of the first and second groups was also significantly reduced — from 0.02 to 0.05 nmol/l, respectively. The levels of dehydroepiandrosterone and 17-hydroxycorticosteroids were significantly reduced, especially in the third group — 0.3 μg/ml and 0.1 nmol/l, respectively. Conclusions. Most women of reproductive age with testosterone deficiency have hypomenorrhea with low free testosterone. A direct correlation was established between testosterone deficiency and the degree of obesity in women with androgen deficiency.

Comparing the effects of Triptorelin and Calendula officinalis on size and pathology of induced endometriosis in rats

2019 ◽  
Vol 11 (3) ◽  
pp. 132-136
Author(s):  
Tahere Poordast ◽  
Fatemeh Sadat Najib ◽  
Nader Tanide ◽  
Afsoon Kanani ◽  
Maral Mokhtari ◽  
...  
Keyword(s):  
Reproductive Age ◽  
Female Rats ◽  
Control Group ◽  
Calendula Officinalis ◽  
Women Of Reproductive Age ◽  
The Third ◽  
Single Intramuscular Injection ◽  
Significant Difference ◽  
The Mean ◽  
Area And Volume

Background: Endometriosis is defined as the growth of endometrial glands and stoma extra-uterine sites. It is an estrogen-dependent inflammatory disease estimated to affect 10% of women of reproductive age. This study aimed at comparing the effects of Triptorelin and Calendula officinalis on the induced endometriosis in female rats. Materials and Methods: In this experimental study in an animal model, 52 rats with induced endometriosis were divided into four groups. The control group was treated with 0.5 mL/kg normal saline orally, the second group with single intramuscular injection of Triptorelin S.R.11.25 (3 mg/kg), the third group with Calendula 1000 mg/kg, and the fourth group with Calendula 2000 mg/kg for 6 weeks. The mean area and volume of endometriosis and pathological scores of endometriotic implants were compared between groups. Results: After 6 weeks of treatment, Triptorelin was able to reduce the mean area and volume of endometriotic implants (p < 0.05), but Calendula did not have a significant effect compared to the control group. Mean rank of pathologic score in Triptorelin group had a significant difference with the control group and Calendula 1000 mg/kg (adjusted α < 0.001, adjusted α = 0.004). There was no significant difference in score between the control group and Calendula 1000 mg/kg and 2000 mg/kg. Conclusion: Based on our findings in the used doses, Calendula was not effective for the treatment of experimental endometriosis in rats.

scholarly journals Induction a Rat Model of Premature Ovarian Insufficiency (POI) Using D Galactose Feeding During the Critical Periods of Development: an Experimental Protocol

2020 ◽  
Author(s):  
Marzieh Roatami Dovom ◽  
Mahsa Noroozzadeh ◽  
Nariman Mosaffa ◽  
Abbas Piryaei ◽  
Azita Zadevakili ◽  
...  
Keyword(s):  
Rat Model ◽  
Clinical Manifestations ◽  
Female Offspring ◽  
Reproductive Hormones ◽  
Reproductive Age ◽  
Premature Ovarian Insufficiency ◽  
Control Group ◽  
Critical Periods ◽  
Ovarian Insufficiency ◽  
The Third

Abstract Introduction: Premature ovarian insufficiency (POI) affects about 1% of women of reproductive age, with no curative treatment. Several efforts have been made to develop an animal model of POI that mimics all manifestations of this disease; however, these models are limited due to increased mortality or high toxicity. Overall, well-developed animal models may improve our knowledge of diseases and can be suitable for identifying the underlying mechanisms and detecting the optimal treatment methods. In the present study, we aimed to present a functional rat model of POI, mimicking the clinical manifestations of POI in women. Materials and Methods: This experimental study was performed in two steps. In the first step (induction of the rat POI model), a total of 40 pregnant Wistar rats were randomly divided into four groups. Three experimental groups were fed galactose-enriched diets at days 3-15 of pregnancy (group 1); on the third day of pregnancy until the end of pregnancy (group 2); and on the third day of pregnancy until the end of the weaning period (group 3). Also, group 4 (control group) was fed a standard pellet during pregnancy and breastfeeding period. In the second step of the study, the ovarian morphology (microscopic and macroscopic), reproductive hormones, and immunological and metabolic characteristics of the female offspring were examined in all experimental groups and compared with the controls at three time points, that is, postnatal days (PNDs) 45, 105, and 180 of age.Results: In this study, we presented an optimal model of POI that highly mimics the clinical manifestations of this disease in women. Conclusion: A functional rat model of POI may be suitable for increasing our understanding of this disease and filling the knowledge gaps.

The effects of Cyclosporin-A (CYA) on the Ultrastructure of Gingival Mast Cells (GMC) in Behcet's disease (BD)

1990 ◽  
Vol 48 (3) ◽  
pp. 358-359
Author(s):  
Oktay Arda ◽  
Ulkü Noyan ◽  
Selgçk Yilmaz ◽  
Mustafa Taşyürekli ◽  
İsmail Seçkin ◽  
...  
Keyword(s):  
Unknown Etiology ◽  
Control Group ◽  
Target Cells ◽  
Gingival Hyperplasia ◽  
Cellular Activity ◽  
Direct Relation ◽  
Immune Disease ◽  
Genital Ulceration ◽  
Functional Changes ◽  
The Third

Turkish dermatologist, H. Beheet described the disease as recurrent triad of iritis, oral aphthous lesions and genital ulceration. Auto immune disease is the recent focus on the unknown etiology which is still being discussed. Among the other immunosupressive drugs, CyA included in it's treatment newly. One of the important side effects of this drug is gingival hyperplasia which has a direct relation with the presence of teeth and periodontal tissue. We are interested in the ultrastructure of immunocompetent target cells that were affected by CyA in BD.Three groups arranged in each having 5 patients with BD. Control group was the first and didn’t have CyA treatment. Patients who had CyA, but didn’t show gingival hyperplasia assembled the second group. The ones displaying gingival hyperplasia following CyA therapy formed the third group. GMC of control group and their granules are shown in FIG. 1,2,3. GMC of the second group presented initiation of supplementary cellular activity and possible maturing functional changes with the signs of increased number of mitochondria and accumulation of numerous dense cored granules next to few normal ones, FIG. 4,5,6.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

The role of immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia of different severity

2016 ◽  
pp. 138-140
Author(s):  
S.I. Zhuk ◽  
◽  
O.A. Taran ◽  
A.N. Koshmienskaya ◽  
T.V. Lobastova ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cervical Intraepithelial Neoplasia ◽  
Precancerous Lesions ◽  
Molecular Genetic ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Moderate Degree ◽  
Ki 67 ◽  
The Third ◽  
Diagnosis And Prognosis

The objective: the finding of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia of different severity to optimize the diagnosis and prognosis of the disease. Patients and methods. The study involved 42 women of reproductive age with cervical intraepithelial the neoplasia of the cervix varying degrees applied to the doctor of cervical pathology Zhitomir regional oncologic dispensary. All women (n=42) were divided into groups. The first group included 15 patients (35.7%) with cervical intraepithelial neoplasia with mild. The second group included 13 women (31%) with cervical intraepithelial neoplasia a moderate degree. The third group was represented by patients with cervical intraepithelial neoplasia with severe – 14 respondents (33.3 per cent). Results. Marker BCL-2 in patients of the first group was positive in 7 patients (46.7%), Smooth Muscule Actin was positive in 9 patients (60%) and Ki-67 was diagnosed in 8 of the surveyed women (53.3%). In the second group of BCL-2 was positive in 8 patients (61.5%), Clone 124, Smooth Muscule Actin, Clone 1A4 was positive in 9 patients (69.2%), and Ki-67 was diagnosed in 12 of the surveyed women (92.3%). Marker BCL-2 in patients of the third group was positive in 12 patients (85.7%), Smooth Muscule Actin was positive in 10 patients (71.4%) and Ki-67 was diagnosed in 13 of the surveyed women (92.9% ). Conclusion. Carcinogenesis is associated with molecular genetic damage to the cervix. Some of the products of this process can be used as prognostic and diagnostic markers of tumor progression. Determination of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia makes it possible to accurately verify the diagnosis and to predict the course of pathological changes in the flat epithelium of the cervix. Key words: cervical intraepithelial neoplasia, cervical cancer, morphological diagnostics of precancerous lesions, BCL-2, Smooth Muscule Actin, Ki-67.

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