scholarly journals ION CHANGES IN BLOOD DURING OPISTHORCHIASIS IN EXPERIMENT

2019 ◽  
pp. 580-584
Author(s):  
Sidelnikova
Keyword(s):  
Ionic Composition ◽  
Venous Blood ◽  
Control Group ◽  
Observation Group ◽  
Arithmetic Average ◽  
Automated Hematology Analyzer ◽  
Ionic Imbalance ◽  
Quantitative Indicators ◽  
Sodium Plasma

Changes in the ionic composition of blood in opisthorchiasis, in the long-term inva-sion, is a current little-studied aspect. The experiment was conducted on rodents (rabbits), of puberty, male. Infection was carried out by oral administration of the metacercariae Opistorchis felineus at the rate of 50 larvae per individual (n = 10), defined in the observation group. The control group consisted of clinically healthy animals (n = 10). After 18 months, a biochemical blood test was performed to de-termine the quantitative indicators of potassium and sodium. Plasma isolation was performed by centrifuging venous blood, then incubated at room temperature for an hour, and the indicators were calculated using an automated hematology analyzer. Statistical data processing was performed using the software package Microsoft Of-fice Exel by calculating the arithmetic average with standard error of the mean. The analysis of intergroup data was carried out using the non-parametric Mann-Whitney U-test for unrelated aggregates with an abnormal distribution, with p ≤ 0.05.It is established that the content of potassium sharply exceeds the normal numerical criteria, the average amount of this ion is 6.932±0.772. When compared with the control, the differences are statistically significant (U = 0, p > 0.05). The amount of sodium in the observation group was 141.4±6.888, which falls within the range of normal values. When compared with the control, the differences are not statistically significant (U = 36, p > 0.05).Thus, when opisthorchiasis in the long-term invasion in rabbits in the experiment, an ionic imbalance is observed, with a predominance of potassium, with normal so-dium content. The established changes can be associated with impaired renal func-tion, angiopathy, general intoxication, provoked by the disease.

scholarly journals Neoadjuvant Chemotherapy plus Bevacizumab Combined with Total Mesorectal Excision in Treating Locally Advanced Rectal Cancer Patients with BRAF Mutation: Clinical Benefit and Safety

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jintian Song ◽  
Yi Wang ◽  
Hui Yu ◽  
Liang Zheng ◽  
Xiongchao Cai ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Clinical Benefit ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Control Group ◽  
Observation Group ◽  
Mesorectal Excision ◽  
Short Term

Objective. To investigate clinical benefit and safety of neoadjuvant chemotherapy (NAC) plus bevacizumab combined with total mesorectal excision (TME) in treating patients with BRAF-mutated locally advanced rectal cancer (LARC). Methods. This study included LARC patients with BRAF mutation admitted to the Oncology Department of Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, between June 2013 and December 2018. Patients in the control group received a standard treatment regimen of TME combined with NAC ( n = 45 ), and patients in the observation group received NAC plus bevacizumab combined with TME ( n = 55 ). The short-term clinical efficacy of the two groups after NAC treatment was observed and compared, including differences in the pathological downstaging rate. The incidence of perioperative complications and adverse reactions during neoadjuvant therapy was compared to evaluate the safety of the treatment. Besides, the relapse-free survival (RFS) and overall survival (OS) of patients were analyzed to evaluate the long-term clinical benefit of the treatment. Results. Compared with the control group, the ypT staging rate ( p = 0.014 ) in the observation group was markedly lower. In addition, patients in the observation group had a prominently lower overall incidence of complications ( p < 0.001 ) during the perioperative period and a remarkably lower incidence of leukopenia ( p = 0.037 ) during neoadjuvant therapy. In terms of long-term clinical benefit, the RFS of patients in the observation group was evidently longer ( p = 0.037 ) than that in the control group. Conclusion. Compared with TME plus NAC treatment, the short-term and long-term clinical benefits are higher and safety is more favorable of NAC plus bevacizumab combined with TME in treating LARC patients.

scholarly journals Resection of extrahepatic bile ducts with partial hepatectomy for treating intra- and extrahepatic hepatolithiasis

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
HongTian Xia ◽  
XiangFei Meng ◽  
XianLei Xin ◽  
Tao Yang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Bile Duct ◽  
Surgical Procedures ◽  
Bile Ducts ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Surgical Methods ◽  
Cox Analysis ◽  
Fair Poor

Abstract Background To evaluate the efficacy and safety of our new surgical procedures for primary intra- and extrahepatic hepatolithiasis. Hepatolithiasis is an intractable disease with frequent recurrences. Methods From 1996 to 2005, 142 patients with intrahepatic and/or extrahepatic hepatolithiasis treated with the conventional surgical methods were included as the control group, while 128 consecutive patients treated with new surgical methods from 2006 to 2015 were included as the observation group. The new surgical procedures included a comprehensive intraoperative exploration of the bile ducts, focusing on the structure and function of the hilar bile duct and duodenal papilla, exploration of the affected liver, and bile culture. Results The observation group had a significantly higher complete stone clearance rate than the control group (100% vs. 65.96%). The observation group had significantly lower incidences of cholangitis and bile duct stones, as well as a higher excellent and good long-term surgical efficacy rate (86.24% vs. 52.73%). Multivariate Cox analysis showed that the control group had a higher risk for fair + poor efficacy than the observation group (HR: 8.47). Conclusions Our new surgical procedures are safe and can provide a good long-term efficacy for treating primary hepatolithiasis intra- and extrahepatic hepatolithiasis.

scholarly journals Effect of Psychological Intervention Combined with Dietary Guidance on Quality of Life and Long-Term Efficacy of Bushen Quyu Decoction in Treatment of Patients with Advanced Ovarian Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Dan Liu ◽  
Guangwen Shi ◽  
Chao Yin ◽  
Zhendong Liu ◽  
Aixia Yang
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Psychological Intervention ◽  
Advanced Ovarian Cancer ◽  
Treatment Compliance ◽  
Control Group ◽  
Observation Group ◽  
Nursing Satisfaction

Objective. To study the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Decoction in the treatment of patients with advanced ovarian cancer. Methods. 220 patients with advanced (stages III to IV) ovarian cancer in our hospital from May 2015 to October 2018 were selected and randomly divided into a control group and an observation group, with 110 cases in each group. The patients in the control group received basic nursing care and treatment with Bushen Quyu Decoction, and the patients in the observation group were combined with psychological intervention and dietary guidance on the basis of the treatment of the patients in the control group. The clinical efficacy, nursing satisfaction, treatment compliance, quality of life, negative emotion comparison, and long-term efficacy of the two groups were compared. Moreover, the changes of immune function indexes and the content of tumor markers were compared between the two groups. Results. The total effective rate of treatment in the observation group (64.55%) was higher than that in the control group (31.82%). The nursing satisfaction of the observation group was 94.55%, the nursing satisfaction of the control group was 84.55%, and the difference was statistically significant p < 0.01 . The treatment compliance of the observation group was 98.18%, the treatment compliance of the control group was 82.73%, and the difference was statistically significant p < 0.0001 . After nursing, the Anxiety Self-Rating Scale (SAS) score and Self-Rating Depression Scale (SDS) score of the two groups of patients were decreased ∗ p < 0.05 , and the score of the observation group decreased more significantly p Δ < 0.05 . After nursing, the scores of the two groups of patients in social/family status, physical function, physiological function, and emotional status increased ∗ p < 0.05 , and the observation group was significantly higher than the control group p Δ < 0.05 . After nursing, the CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than the control group p < 0.05 . The CD8+ level of the observation group was significantly lower than the control group p < 0.05 . After nursing, the levels of tumor markers in the two groups were decreased ∗ p < 0.05 , and the observation group was downregulated more significantly than the control group p Δ < 0.05 . The two-year cumulative survival rate of the observation group was 78.18%, and the two-year cumulative survival rate of the control group was 54.55%. The observation group was significantly higher than the control group p < 0.05 . Conclusions. Psychological intervention combined with dietary guidance can significantly improve the quality of life and mental state of patients with advanced ovarian cancer, enhance the patient’s immune function, reduce the serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA199) levels, and improve survival rate and survival time, which has important clinical significance.

scholarly journals Long-Term Effect of Left Atrial Appendage Occlusion in Treating Patients with Previous Ischemic Stroke on the Disease Recurrence

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jia Yu ◽  
Yufeng Liu ◽  
Peng Sun ◽  
Xing Guo ◽  
Haiyang Jiang ◽  
...  
Keyword(s):  
Left Atrial Appendage ◽  
Disease Recurrence ◽  
Term Effect ◽  
Control Group ◽  
Observation Group ◽  
Systemic Embolism ◽  
Exact Test ◽  
Left Atrial Appendage Occlusion ◽  
Long Term Effect

Background and Objective. Thrombolytics and anticoagulants are conventional drugs for ischemic stroke (IS) treatment, whereas some patients have unfavorable responses to these drugs. The disease presents a relatively high recurrence rate. This investigation attempted to unveil the long-term effect of left atrial appendage occlusion (LAAO) in treating patients with previous IS on the disease recurrence. Methods. A total of 120 patients with IS admitted to Tangdu Hospital from July 2016 to September 2017 were grouped into the control group ( n = 60 ) and the observation group ( n = 60 ). Patients in the control group were only treated with thrombolytics and anticoagulants while those in the observation group were treated with both drugs and LAAO. Transesophageal echocardiography (TEE) was performed to observe the occlusion of LAA in patients in the observation group after 45 d and 6 months, respectively. Clinical outcomes in two groups were compared from the following aspects: recurrence of IS, incidence of systemic embolism, and the 3-year recurrence-free survival (RFS). The 3-year IS recurrence of patients was compared by Fisher’s exact test. Results. No significant differences were observed at baseline levels (age, sex, etc.) between the observation group and control group ( p > 0.05 ). During follow-up visit of 45 d and 6 months, all occluders met the efficacious occludsion criteria. The results of TEE at 45 d after LAAO showed that 50% of patients (30/60) in the observation group had complete occlusion of LAA. The results of TEE at 6 months after LAAO suggested that 58.3% of patients (35/60) had complete occlusion of LAA. IS recurrence in the observation group (3.33%, 2/60) was significantly lower than that in the control group (18.33%, 11/60), with the difference presenting statistical significance ( p = 0.008 ). Incidence of systemic embolism in the observation group (1.67%, 1/60) was markedly lower than that in the control group (13.33%, 11/60) ( p = 0.014 ). The average RFS in the observation group (31.97 months, 95% CI: 27.50~32.31 months) was notably longer than that in the control group (29.91 months, 95% CI: 29.85~32.92 months) ( p < 0.05 ). The 3-year IS recurrence of patients between two groups compared by Fisher’s exact test showed significant differences (1 year: p = 0.014 , 2 year: p = 0.008 , 3 year: p = 0.008 ). Conclusion. Regarding patients with previous IS who had poor response to thrombolytics and anticoagulants, LAAO could effectively decrease recurrence of IS and incidence of systemic embolism and prolong RFS of patients. LAAO was, therefore, an alternative for patients with high IS recurrence risk.

scholarly journals The Changes of Whole Blood Cells and Plasma Proteins in Donors After Plateletpheresis: 42 Donors With a Interval of 14-16 Days and More Than 20 Times

2021 ◽  
Author(s):  
Jun Li ◽  
Hongmei Liao ◽  
Danfeng Cheng
Keyword(s):  
Whole Blood ◽  
Blood Cells ◽  
Plasma Proteins ◽  
Venous Blood ◽  
Control Group ◽  
Observation Group ◽  
Research Subjects ◽  
Normal Range ◽  
Blood Samples ◽  
Whole Blood Cells

Abstract Background To study the changes of whole blood cells and plasma proteins in donors after plateletpheresis with multiple donations. Materials and Methods From October 2015 to September 2019, 42 donors with a plateletpheresis interval of 14-16 days and more than 20 times were selected as the research subjects. The venous blood samples were collected from the first and the last screening before plateletpheresis. The result of last screening before plateletpheresis as the observation group, and the first as the control group. Then, the venous blood samples was detected. Results The whole blood cells and plasma proteins in donors after plateletpheresis changes within a normal range in the two groups. The PLT counts in the the observation group was 220.1±40.4 x109/L, which was no statistically significant compared with the change of 216.6±44.5 x109/L in the control group(P>0.05). The HGB in the the observation group was 142.8±10.2 g/L, which was no statistically significant compared with the change of 142.1±8.3g/L in the control group(P>0.05). The HCT in the the observation group was 43.50±3.2%, which was no statistically significant compared with the change of 44.1±2.8% in the control group(P>0.05). The serum TP levels in the the observation group was 70.4±4.7g/L, which was no statistically significant compared with the change of 69.0±4.8g/L in the control group(P>0.05). The serum ALB levels in the observation group was 46.3±2.3g/L, which was no statistically significant compared with the change of 45.8±2.3g/L in the control group(P>0.05). Conclusion There have no effect on the whole blood cells and plasma proteins in donors after plateletpheresis with multiple donations.

Long Term and Low Dose Mifepristone in The Treatment of Uterine Leiomyoma

2021 ◽  
Vol 7 (5) ◽  
pp. 1681-1685
Author(s):  
Panpan Liu ◽  
Meifang Dou ◽  
Li’an Yi ◽  
Kemei Li ◽  
Fenghua Yan
Keyword(s):  
Uterine Leiomyoma ◽  
Adverse Reactions ◽  
Low Dose ◽  
Hot Flashes ◽  
Control Group ◽  
Observation Group ◽  
Conventional Dose ◽  
Long Term Effect ◽  
Significant Difference

To explore the long-term effect of low-dose mifepristone in the treatment of uterine leiomyoma. Methods: 90 cases of hysteromyoma treated in our hospital from December 2018 to May 2019 were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with conventional dose (25mg / D) of mifepristone, and the observation group with low dose (12.5mg / D) of mifepristone. The uterine volume, uterine fibroid volume, hormone level, therapeutic effect and adverse reactions were compared between the two groups. Results: After treatment, the volume of uterus and hysteromyoma in the two groups decreased significantly, but there was no significant difference between the observation group and the control group (P > 0.05); the level of E2, P, FSH in the two groups decreased, but there was no significant difference between the observation group and the control group (P > 0.05); the treatment effect of the observation group and the control group was no significant difference (P > 0.05); the adverse reactions of nausea, anorexia, hot flashes and fatigue in the observation group The birth rate was significantly lower than that of the control group (P < 0.05). Conclusion: Low dose mifepristone can also effectively reduce the level of estrogen and progesterone in patients with uterine leiomyoma, reduce the volume of leiomyoma, reduce the incidence of adverse reactions, with high safety, which is worthy of clinical application.

Effects of Long-term Creatine Supplementation on Liver and Kidney Functions in American College Football Players

2002 ◽  
Vol 12 (4) ◽  
pp. 453-460 ◽  
Author(s):  
David L. Mayhew ◽  
Jerry L. Mayhew ◽  
John S. Ware
Keyword(s):  
Venous Blood ◽  
Creatine Supplementation ◽  
Blood Parameters ◽  
Blood Analysis ◽  
American Football ◽  
Control Group ◽  
Daily Consumption ◽  
Training Experience ◽  
Liver And Kidney

The purpose of this study was to determine the effect of long-term Cr supplementation on blood parameters reflecting liver and kidney function. Twenty-three members of an NCAA Division II American football team (ages = 19–24 years) with at least 2 years of strength training experience were divided into a Cr monohydrate group (CrM, n = 10) in which they voluntarily and spontaneously ingested creatine, and a control group (n = 13) in which they took no supplements. Individuals in the CrM group averaged regular daily consumption of 5 to 20 g (mean ± SD = 13.9 ± 5.8 g) for 0.25 to 5.6 years (2.9 ± 1.8 years). Venous blood analysis for serum albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, urea, and creatinine produced no significant differences between groups. Creatinine clearance was estimated from serum creatinine and was not significantly different between groups. Within the CrM group, correlations between all blood parameters and either daily dosage or duration of supplementation were nonsignificant. Therefore, it appears that oral supplementation with CrM has no long-term detrimental effects on kidney or liver functions in highly trained college athletes in the absence of other nutritional supplements.

scholarly journals Preoperative neoadjuvant chemotherapy on surgical condition and oncogene expression in advanced gastric cancer

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Guangyu Sun Sun ◽  
Shuyan Wang ◽  
Guangsheng Liu
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Gastric Cancer ◽  
Adverse Reactions ◽  
Control Group ◽  
Observation Group ◽  
Oncogene Expression ◽  
Long Term Prognosis ◽  
Surgical Condition

Objective: To evaluate the effect of preoperative neoadjuvant chemotherapy regimen of XELOX (capecitabine combined with oxaliplatin) on surgical condition and oncogene expression in advanced gastric cancer. Methods: From January 2015 to July 2016, 124 patients with advanced gastric cancer who were admitted to our hospital were selected. Random number table method was used to divide them into an observation group and a control group, 62 each group. The observation group received two courses of neoadjuvant chemotherapy (XELOX) before operation, and the control group received surgery. The operation condition, expression of oncogenes in gastric cancer lesions, occurrence of adverse reactions and the long-term prognosis were compared between the two groups. Results: The R0 resection rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The operation time of the observation group was shorter than that of the control group, the amount of intraoperative bleeding and the amount of postoperative drainage of the observation group were less than that of the control group, and the differences were statistically significant (P<0.05). The mRNA expression of gastrokine 1, multiple tumor suppressor protein, Wilms tumor gene on the X chromosome (WTX gene) and gene of phosphate and tension homology deleted on chromosome ten (PTEN gene) in the observation group after treatment was significantly higher than that in the control group before treatment, and the increase amplitude of the observation group was more obvious than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). In terms of long-term prognosis, the disease-free survival time and average survival time of the observation group during the two-year follow-up period were significantly better than those of the control group, and the recurrence rate of the observation group was significantly lower than that of the control group; the differences were statistically significant (P<0.05). Conclusion: Preoperative XELOX for advanced gastric cancer patients can effectively increase the proportion of radical surgery, reduce the risk of surgery, and significantly regulate the expression of oncogene, thus improving the long-term prognosis of patients. doi: https://doi.org/10.12669/pjms.36.3.1608 How to cite this:Sun G, Wang S, Liu G. Preoperative neoadjuvant chemotherapy on surgical condition and oncogene expression in advanced gastric cancer. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1608 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Long-Term Assessment of Rehabilitation Treatment of Sports through Artificial Intelligence Research

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Chaofan Zeng ◽  
Ying Huang ◽  
Longer Yu ◽  
Qingmei Zeng ◽  
Bijun Wang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Blood Pressure ◽  
Blood Glucose ◽  
Health Management ◽  
Blood Lipid ◽  
Practical Significance ◽  
Control Group ◽  
Management Service ◽  
Observation Group

Background. Artificial intelligence (AI) technology has been incorporated into all walks of life, especially the integration of machine learning and health management has achieved very significant progress and results. It is very necessary to analyze personalized sports health management services and long-term assessment of health issues in the era of AI. Methods. This paper explores AI + personalized sports management service system design ideas, system operation process, management stage design, taking common chronic diseases, and diabetes as examples. 150 patients were divided into an observation group and a control group, and the blood glucose, blood pressure, blood lipid, and knowledge awareness rate were compared. Results. The blood glucose, blood pressure, and blood lipid levels of the observation group all reduced, and the awareness rate of diabetes knowledge increased, which proved that the AI research has great value in sports rehabilitation research coupled with long term health assessment and is worth further research. Conclusion. The AI research proposed in this paper is of far-reaching practical significance in helping the transformation and upgrading of the sports health management service industry, promoting the innovative development of sports health management service supply, and promoting national fitness and national health.

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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