scholarly journals Antimicrobial effect of Lagenaria siceraria (Mol.) Standley, against certain bacteria and fungal strains

2011 ◽  
Vol 3 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Y. P. Nagaraja ◽  
K. N. Geetha ◽  
M. S. Vinay
Keyword(s):  
Antimicrobial Effect ◽  
Salmonella Typhi ◽  
Klebsiella Pneumonia ◽  
Lagenaria Siceraria ◽  
Bacterial Strains ◽  
Absolute Alcohol ◽  
Soxhlet Apparatus ◽  
The Family ◽  
Antibacterial And Antifungal ◽  
Chloroform Methanol

This study was performed to evaluate the antibacterial and antifungal potency of Lagenaria siceraria (Mol.) Standley, commonly known as bottle gourd belonging to the family Cucurbitaceae. Petroleum Ether, Chloroform, Methanol, Absolute alcohol and Water showed a majority of the compound including Steroids, Alkaloids, Tannins, Flavonoids, Lactones and Carbohydrates. All the five extracts were prepared by using soxhlet apparatus and the extracts showed moderate to potent antimicrobial activity against the bacterial strains: Escherichia coli, Enterococcus faecalis, Klebsiella pneumonia, Salmonella typhi, Staphylococcus aureus and antifungal strains: such as Aspergillus flavus, Aspergillus oryzae and Trichoderma harzianum.

Bioactivity of Some Natural and Semisynthetic Coumarin Derived Compounds

2021 ◽  
Vol 19 (6) ◽  
pp. 129-138
Author(s):  
Yasser Fakri Mustafa ◽  
Moath Kahtan Bashir ◽  
Mahmood Khudhayer Oglah ◽  
Raghad Riyadh Khalil ◽  
Eman Tareq Mohammed
Keyword(s):  
Pathogenic Fungi ◽  
Salmonella Typhi ◽  
Positive Influence ◽  
Shigella Dysenteriae ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Cancerous Cell ◽  
Free Hydroxyl ◽  
Antibacterial And Antifungal ◽  
Diffusion Assay

A couple of natural coumarins was identified in the seeds of two apples’ cultivars commonly known as Granny Smith and Red Delicious. The effect of the phenolic hydroxyl moieties found in these products was evaluated on the bioactivity. This evaluation included the structural alteration of these moieties into less hydrophilic ones to explore the significance of the parent moieties on the biological activity. The investigated biopotentials were antioxidant, antiproliferative, antibacterial, and antifungal effects. The antioxidant potential was investigated by detecting the ability of the natural and semisynthetic coumarins to trap the free hydroxyl and DPPH radicals. The antiproliferative potential was assessed via an MTT-depended assay versus eight cancerous-cell lines, included HeLa, SK-OV-3, AR42J, MCF-7, AB12, KYSE-30, LC540, and AMN3. The antibacterial potential was tested versus six common pathogenic bacterial strains via a well-defined disc diffusion assay. These pathogens were Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Haemophilus influenzae, Shigella dysenteriae, and Pseudomonas aeruginosa. The antifungal potential was also screened by utilizing a similar microbiological technique versus three pathogenic fungi, involved Candida albicans, Aspergillus flavus, and Aspergillus niger. It is concluded that the investigated chemical moiety has a positive influence on the antioxidant and antiproliferative potentials of the natural derivatives, and a negative one on their antibacterial and antifungal potentials.

scholarly journals Antibacterial and Antifungal Activity of Heartwood of Acacia catechu of Nepal

2012 ◽  
Vol 27 ◽  
pp. 94-99 ◽  
Author(s):  
Susan Joshi ◽  
Yagya Prasad Subedi ◽  
Shobha Kumari Paudel
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Salmonella Typhi ◽  
Klebsiella Pneumonia ◽  
Zone Of Inhibition ◽  
Diethyl Ether Extract ◽  
Pseudomonas Species ◽  
Acacia Catechu ◽  
Antibacterial And Antifungal

Antibacterial activity of different extracts of heartwood of Acacia catechu were tested against 11 species of bacteria and antifungal activity were tested against four species of fungi. Among bacteria species highest zone of inhibition (ZOI) was measured against Pseudomonas species by diethyl ether extract, likewise among fungal organism highest zone of inhibition (ZOI) was measured against Fusarium oxysporim by ethyl acetate extract. No extracts showed activity against Salmonella typhi, Salmonella paratyphi, Escherichia coli and Proteus mirabilis. The minimum bactericidal concentration (MBC) of ethyl acetate extract was evaluated against Bacillus subtilis, Klebsiella pneumonia, Staphylococus aureus and Shigella species.DOI: http://dx.doi.org/10.3126/jncs.v27i1.6667 J. Nepal Chem. Soc., Vol. 27, 2011 94-99 

scholarly journals Synthesis and Antimicrobial Activity of New Derivatives of Angular Polycyclic Phenoxazine Ring System

2019 ◽  
Vol 35 (4) ◽  
pp. 1320-1326
Author(s):  
Mercy Amarachukwu Ezeokonkwo ◽  
Kingsley Chizoba Iloka ◽  
Uchechukwu Chris Okoro ◽  
Efeturi Abreham Onoabedje ◽  
Benjamin Ebere Ezema ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Antifungal Agents ◽  
Salmonella Typhi ◽  
Biological Evaluation ◽  
Ring System ◽  
Klebsiella Pneumonia ◽  
Streptococcus Pneumonia ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Synthesis of angular polycyclic phenoxazine derivatives incorporating different phenols is reported in 30-99% yields. O-arylation of 6-chlorodibenzo[a,j] phenoxazin-5-one with a variety of electron-deficient, electron-neutral and electron-rich phenols under the catalytic palladium (II) acetate/t-BuXphos system furnished the compounds of interest. The highest yields were obtained when the intermediate was coupled with electron-rich phenols. IR, 1H-NMR, 13C-NMR and Mass spectra data, confirmed the structures of all the synthesized compounds. Study on the in vitro biological evaluation of the compounds against microorganisms revealed that they are potent antibacterial and antifungal agents, as they showed significant biological activity against Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, Salmonella typhi, klebsiella pneumonia, Pseudomonas aeruginasa, Basillus substilis, Candida albicans and Aspergillus niger.

scholarly journals Antibacterial and Antifungal Activity of Essential Oil of Origanum Majorana Lon a Few Bacteria and Fungi

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Mouna Mehani
Keyword(s):  
Essential Oil ◽  
Inhibitory Effect ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
The Sustainable Development ◽  
Bacteria And Fungi ◽  
Origanum Majorana ◽  
Antibacterial And Antifungal ◽  
High Inhibitory Effect ◽  
Essential Oil Yield

The objective of this study is to assess the fungal and antimicrobial activity of the essential oil (ET) of marjoram (Origanum majorana L.). This strategy can contribute to the sustainable development of our country. Preliminary tests performed on the essential oil of Origanum majorana showed that this oil has antibacterial activity vis-à-vis the bacterial strains (Enterococcus feacalis, Enterobacter cloaceai, Proteus microsilis, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa) and antifungic (Fusarium sporotrichioide and Fusarium graminearum). The culture medium used was nutrient broth Muller Hinton. The interaction between the bacteria and the essential oil is expressed by a zone of inhibition with diameters of MIC indirectly expression of. And we used the PDA medium to determine the fungal activity. The extraction of the aromatic fraction (essentially oil hydrolat) of the fresh aerian part of the Origanum majorana was performed by hydrodistillation. The average essential oil yield is 0.99%. The antimicrobial and fungal study of the essential oil and hydrosol showed a high inhibitory effect on the growth of pathogens.

scholarly journals Phytochemical Screening and Antimicrobial Analysis of Fadogia andersonii Robyn Plant Extrac

2021 ◽  
Vol 25 (2) ◽  
pp. 209-213
Author(s):  
J. Nzeako ◽  
G.I. Ndukwe ◽  
J.D. Habila ◽  
E.A. Oluwabukola ◽  
I. Owoicho
Keyword(s):  
Escherichia Coli ◽  
Streptococcus Pyogenes ◽  
Cardiac Glycosides ◽  
Salmonella Typhi ◽  
Inhibitory Effect ◽  
Klebsiella Pneumonia ◽  
Phytochemical Screening ◽  
Whole Plant ◽  
The Family

Medicinal plants extracts are now generally considered as effective medicines that play a major role in modern pharmacy. The plant Fadogia andersonii belonging to the Family Rubiaceae, which is used in ethno-medicine was studied. Preliminary phytochemical analyses of the whole plant revealed the presence of the following metabolites: Saponins, terpenes, steroids, flavonoids, tannins, alkaloids, cardiac glycosides and carbohydrates. Anthraquinones was found to be absent. Antimicrobial screening of the methanol plant’s extract carried out (in vitro) on Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Bacillus cereus, Klebsiella pneumonia, Streptococcus pneumoniae, Streptococcus pyogenes, Candida albican and Aspergillus flavus showed that the extract has activity on the tested microorganisms. However, it showed no inhibitory effect against Escherichia coli. The extract was found to inhibit the growth of S. aureus, B. cereus, S. pyogenes and C. albican at 25mg/ml with a corresponding MBC at 50mg/ml. S.typhi and S. pneumonia were inhibited at 50mg/ml with a corresponding MBC at 100mg/ml. It also inhibited the growth of P. aeruginosa, K. pneumonia and A. flavus at 100mg/ml with a corresponding MBC at 200mg/ml. The observed antimicrobial effects were believed to be due to the presence of active principles which were detected in the phytochemical screening. Keywords: Phytochemicals, Antimicrobials, Fadogia andersonii Robyn

scholarly journals Bioactive potential of Pseudomonas alcaliphila isolated from a marine sponge against human pathogens

2019 ◽  
Vol 8 (3) ◽  
pp. 2494-22503
Author(s):  
Sathiyamurthy K. ◽  
Bavithra H.
Keyword(s):  
Inhibitory Activity ◽  
Antimicrobial Agents ◽  
Salmonella Typhi ◽  
Amide Bond ◽  
Biological Applications ◽  
Human Pathogens ◽  
Bacterial Strains ◽  
Bioactive Potential ◽  
Chloroform Methanol ◽  
Metabolite Extraction

Metabolite extraction is considered as one of the important steps in metabolomics, the marine metabolite are the new source of the most antimicrobial agents used in both pharmacological and biological applications. In the present study, sponge associated bacterial metabolites was investigated. A total of 20 bacterial strains were isolated from the sponge Haliclona sp., All the strains were screened primarily with cross streaking method against human bacterial pathogens. The potent isolate was chosen based on the good inhibitory activity and metabolite extraction was achieved using chloroform: methanol mixture. The metabolites were then checked for their antimicrobial activity by disk diffusion and also minimum inhibitory concentration was determined. Out of 20 bacterial strains, only one strain selected based on the good inhibitory activity against pathogens and the strain was identified as Pseudomonas alcaliphila based on the biochemical and16S rRNA sequencing. The results revealed that the metabolites exhibited high activity and it was found that Klebsiella pneumoniae was inhibited high with the diameter of 22 mm followed by Salmonella Typhi (15 mm), E.coli (12 mm), and Bacillus subtilis (15 mm). The MIC was observed at 31.25 µg/ml against all pathogens. Results of TLC exhibited the Rf value at 0.86 and the FTIR results revealed the presence of C=o, amide bond, amino acids and methoxy groups. In GC-MS results showed that the metabolites mostly contain fatty acids and alkenes compounds. Thus, this marine active compound was considered as a novel compound for biological applications and may be a potential drug for therapeutic use.

scholarly journals SCREENING OF ANTIBACTERIAL ACTIVITY OF FIVE DIFFERENT SPICES (AJWAIN, CORIANDER, CUMIN, FENNEL, AND FENUGREEK) AGAINST PATHOGENIC BACTERIAL STRAINS

2018 ◽  
Vol 11 (2) ◽  
pp. 252
Author(s):  
Salma S ◽  
Lalitha Ramakrishnan ◽  
Vinothini J
Keyword(s):  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Antibacterial Effects ◽  
Foeniculum Vulgare ◽  
Trachyspermum Ammi ◽  
And Staphylococcus Aureus ◽  
Paper Disc

 Objective: This study was focussed on an evaluation of antibacterial activities of aqueous and alcoholic extracts of commonly consumed spices, namely, Ajwain (Trachyspermum ammi), Coriander (Coriandrum sativum), cumin (Cuminum cyminum), fennel (Foeniculum vulgare), and Fenugreek (Trigonella foenum-graecum).Methods: This study includes the antibacterial effects of spices against six bacterial strains, namely, Escherichia coli, Klebsiella pneumonia, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus to compare their antibacterial effects by the paper disc agar diffusion method with three antibiotics such as amikacin, chloramphenicol, and vancomycin.Results: According to findings, it is determined that inhibitory activity was detected on aqueous and alcoholic extracts of Ajwain, aqueous extract of cumin and on alcoholic mixed spice sample.

Antibacterial Activity of Extracts from Plants of the Family Cucurbitaceae against Common Bacterial Strains

2021 ◽  
Vol 16 (8) ◽  
pp. 103-109
Author(s):  
Eoghan Reilly ◽  
Ekta Menghani
Keyword(s):  
Antibacterial Activity ◽  
Rural Areas ◽  
Primary Source ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Therapeutic Effects ◽  
Bacterial Strains ◽  
Therapeutic Uses ◽  
The Family ◽  
Based Medicine

Traditional plant based medicine plays a very important role in promoting healthcare in people living in remote and rural areas around the world. Dependence on this medicine as a primary source of healthcare is seen mainly in underdeveloped and developing countries. The acknowledgement of the importance and effectiveness of such medicine by modern research has led to the promotion of evidence-based incorporation of traditional medicine into mainstream clinical practice. Plants in the family Cucurbitaceous are often cited in traditional medicinal systems having many important therapeutic effects. In this study, the antibacterial activity of 46 plant extracts from ten plants from the family Cucurbitaceae was investigated against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia using agar well diffusion method. Most extracts did not show significant positive results, however, some extracts from Praecitrullus fistulosus (tinda), Luffa acutangula (ridged gourd), Luffa aegyptiaca (smooth gourd), Momordica charantia (bitter gourd) and Coccinia grandis (kundru) showed strong antibacterial activity and hence should be further studied for potential therapeutic uses.

scholarly journals Antimicrobial Activity of Aqueous Extracts of Potentilla Reptans L. Rhizome and Aerial Part

2018 ◽  
Vol 19 (4) ◽  
pp. 321-324 ◽  
Author(s):  
Marina Tomovic ◽  
Marija Popovic-Milenkovic ◽  
Slobodan Jankovic
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Aerial Part ◽  
Antimicrobial Effect ◽  
Diffusion Method ◽  
Aqueous Extracts ◽  
Bacterial Strains ◽  
The Family ◽  
Potentilla Reptans

Abstract Potentilla reptans is a little studied plant of the genus Potentilla, the family Rosaceae. The aim of this study is to determine antimicrobial effects of aqueous extracts of P. reptans aerial part and rhizome against standardized bacterial strains. The antimicrobial activity of aqueous extracts of P. reptans aerial part and rhizome was tested against one fungus, Candida albicans, and two standard bacterial strains, Staphylococcus aureus and Escherichia coli, using an agar diffusion method. Both examined extracts showed a significant antimicrobial activity against Escherichia coli and Staphylococcus aureus at the concentrations of 10 to 150 mg/ml. The rhizome extract showed stronger antimicrobial effect against the tested strains of bacteria than the aerial part extract. The obtained results represent preliminary results of antimicrobial activity of this plant and suggest that in future, the studies should examine antimicrobial activity against other bacterial strains and minimum inhibitory concentration.

Extraction and characterization of sea anemones compound and its Anti bacterial and hemolytic studies

2020 ◽  
Vol 10 (4) ◽  
pp. 93-97
Author(s):  
Anil Kumar A ◽  
Raja Sheker K ◽  
Naveen B ◽  
Abhilash G ◽  
Akila CR
Keyword(s):  
Antibacterial Activity ◽  
Focal Point ◽  
Haemolytic Activity ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Sea Anemones ◽  
Marine Plants ◽  
Heteractis Magnifica ◽  
Trididemnum Solidum

Seas assets that give us a variety of characteristic items to control bacterial, contagious and viral ailment and mostly utilized for malignancy chemotherapy practically from spineless creatures, for example, bryozoans, wipes, delicate corals, coelenterates, ocean fans, ocean bunnies, molluscs and echinoderms. In the previous 30 - 40 years, marine plants and creatures have been the focal point of overall endeavours to characterize the regular results of the marine condition. Numerous marine characteristic items have been effectively exceptional to the last phases of clinical preliminaries, including dolastatin-10, a group of peptides disengaged from Indian ocean rabbit, Dollabella auricularia. Ecteinascidin-743 from mangrove tunicate Ecteinascidia turbinata, Didemnins was isolated from Caribbean tunicate Trididemnum solidum and Conopeptides from cone snails (Conus sp.), and a developing number of up-and-comers have been chosen as promising leads for expanded pre-clinical appraisals. Sea anemones possess numerous tentacles containing stinging cells or cnidocytes. The stinging cells are equipped with small organelles known as nematocysts. The two species of sea anemones namely, Heteractis magnificaandStichodactyla haddoni, were collected from Mandapam coastal waters of Ramanathapuram district, Tamilnadu, India. The Nematocyst was collected and centrifuged, and the supernatant was lyophilized and stored for further analysis. The amount of protein from Heteractis Magnifica and Stichodactyla haddoni was estimated. The crude extract has shown haemolytic activity on chicken blood and goat blood. In the antibacterial activity of the sea anemone against six bacterial strains Staphylococcus aureus, Salmonella typhii, Salmonella paratyphii, Klebsiella pneumonia, Vibrio cholerae, Pseudomonas aeruginosa. Antibacterial activity of H. Magnifica and S.haddoni was measured as the radius of the zone of inhibition.

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