Changes in biochemical parameters in workers exposed to chemical production factors (heptane and hexane)

2021 ◽  
Vol 61 (6) ◽  
pp. 379-384
Author(s):  
Marina A. Zemlyanova ◽  
Juliya V. Koldibekova ◽  
Ekaterina V. Peskova ◽  
Victor M. Ukhabov
Keyword(s):  
Blood Serum ◽  
Blood Plasma ◽  
Biochemical Parameters ◽  
Comparison Group ◽  
Processing Plant ◽  
Observation Group ◽  
Chemical Production ◽  
Production Factors ◽  
Nasal Secretions

Introduction. Long-term constant exposure to certain representatives of aliphatic hydrocarbons during the extraction and processing of potash ore can lead to pathological changes on critical organs and systems in production workers. The study aims to evaluate the change in biochemical parameters in workers exposed to chemical production factors (heptane and hexane). Materials and methods. The study of the content of hexane, heptane in the air of the working area and the urine of workers, the establishment of changes in several biochemical (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyltransferase, epinephrine, and norepinephrine) and general clinical (eosinophils, neutrophils and the eosinophilia index) indicators, modeling of cause-and-effect relationships. Results. Specialists found in the observation group relative to the comparison group: increased levels of heptane and hexane in the urine up to 1.7 times; increased levels of adrenaline and norepinephrine in the blood plasma up to 1.8 times, up to 1.4 times ALAT and γ-GT in the blood serum, up to 1.9 times neutrophils in the nasal secretions associated with increased concentrations of heptane and hexane in the urine; an increase of up to 4.4 times in the frequency of diseases of the nervous system, respiratory organs, and digestion. Conclusions. In the air of the working area of the workers of the flotation shop of the sylvinite processing plant, the concentrations of the studied limit hydrocarbons were below the detection limit; there is an increased concentration of heptane and hexane in the urine. In the workers of the studied production, an increase of 1.4-1.8 times in the level of adrenaline and norepinephrine in blood plasma, 1.2-1.4 times in ALAT and γ-GT in blood serum, 1.9 times in the content of neutrophils in nasal secretions, which characterizes adverse effects from the respiratory, digestive and nervous systems. We proved the dependence of the increased frequency of diseases of the listed organs and systems on the increased concentration of heptane in the urine (R2=0.26-0.43; p=0.0001-0.028).

Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

scholarly journals Biochemical parameters of blood plasma of the male population living on the territory of the Aral Sea

2020 ◽  
Vol 100 (4) ◽  
pp. 100-105
Author(s):  
Zhanbol Sabirov ◽  
◽  
Aliya Eshmagambetova ◽  
Gul'zhazira Turlybekova ◽  
Nazira Duzbayeva ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Biochemical Parameters ◽  
Negative Impact ◽  
Metabolic Stress ◽  
The Body ◽  
Ecological Crisis ◽  
Aral Sea ◽  
Male Population ◽  
Significant Percentage

The Aral Sea ecological disaster zone affects the health status of the population living in this zone. Biochemical parameters are indicators of the metabolic functionality of the body. The article presents data about the biochemical parameters of blood plasma in the male population living in the ecological crisis zone of the Aral Sea region. It is shown that when determining the majority of indicators of biochemical analysis within the physiological norm, there is a significant percentage of people with deviations in these indicators. Such data make it possible to assume about the factors that can affect the entire population and have massive manifestations. Certainly, these factors, include the negative impact of the environment on public health. An increase in gamma — glutamyltransferase was found in 41 % of the subjects, an increase in cholesterol in 38 % and an increase in triglycerides in 34 %. In the inhabitants of the Aral Sea, a correlation was found between the biochemical parameters of blood serum from the dose of chemicals. It was shown that long-term chemical load in the crisis zone of the Aral Sea region causes a deviation of protein metabolism. The results obtained indicate a significant percentage of people with metabolic stress in the process of adaptation to high chemical load.

Features of risk factors of development of the production caused pathology at workers of metallurgical production

2019 ◽  
pp. 926-930 ◽  
Author(s):  
E. M. Vlasova ◽  
E. A. Polevaya ◽  
M. M. Poroshina ◽  
M. I. Tiunova ◽  
V. B. Alekseev
Keyword(s):  
Risk Factors ◽  
Hydrogen Chloride ◽  
Metabolic Disorders ◽  
Comparison Group ◽  
Working Life ◽  
Observation Group ◽  
Industrial Enterprises ◽  
Production Factors ◽  
Respiratory Pathology ◽  
Chemical Factors

Introduction. The relevance of the study of cardiovascular diseases (CVD) as a production-related pathology in workers at industrial enterprises is due to the presence in the technological process of production factors (noise, general vibration, microclimate, severity of labor, chemical factors), potentially capable of provoking the development of CVD.The aim of the study was to assess respiratory and metabolic disorders, which are risk factors for CVD, in workers exposed to dust, chlorine and hydrogen chloride.Materials and methods. 139 patients working under the influence of dust, chlorine and hydrogen chloride were examined. Among the surveyed 74 women and 65 men. The comparison group (45 people) consisted of 20 women and 25 men who were not exposed to harmful factors of production during their working life.Results. In the group of workers exposed to occupational exposure to dust, chlorine and hydrochloride vapors, it was revealed that the proportion of workers with arterial hypertension was 33.3%, in the comparison group–17.6%, p<0.05 (RR 1.99; 95% CI 1.01–3.93; EF=47%; the degree of professional conditioning is average). The volume of forced exhalation per 1 second (FEV1) in the observation group was 3.18±0.14 l, and in the comparison group–4.1±0.20 l (p<0.001). The level of total cholesterol in the observation group was 5.72±0.13 mmol / l, and in the comparison group–5.16±0.23 mmol / l (p<0.05). The observation group showed a decrease in HDL (1.35±0.04 mmol / l vs. 1.64±0.10 mmol / l in the comparison group, p<0.05) and an increase in triglycerides (2.3±0.17 mmol/l versus 1.51±0.16 mmol/l in the comparison group, p<0.05).Conclusions. In the group of workers exposed to professional dust, chlorine and hydrochloride vapors, a decrease in the speed parameters of the external respiratory function, the development of proatherogenic metabolic disorders, and an increase in laboratory indicators of inflammation were revealed. These changes can lead to early manifestation of cardiovascular and respiratory pathology in this category of workers.

The duration of labor activity of workers in the production of phthalic anhydride and the imbalance of cellular immunity indicators

2021 ◽  
Vol 61 (2) ◽  
pp. 97-102
Author(s):  
Dina G. Dianova ◽  
Oleg V. Dolgikh
Keyword(s):  
Phthalic Anhydride ◽  
Work Experience ◽  
Dynamic Monitoring ◽  
Production Factor ◽  
Observation Group ◽  
Chemical Production ◽  
Associated Production ◽  
Production Factors ◽  
Study Results ◽  
Professional Contact

Introduction. The phthalic anhydride, which widely used in chemical industry in conditions of chronic ingestion, chronically leads to a disadaptation of immunity, which is a risk factor in the formation of associated production related pathology. The aim of the work is to study the subpopulation profile of lymphocytes and cytokine status in workers engaged in the production of phthalic anhydride with their work experience. Materials and methods. The observation group, totally 68 men, consisted of employees working at the main phthalic anhydride production facility. The workers of the observation group were divided into two subgroups with their work experience at the enterprise: 44 persons with 0 to 10 years of work experience and 24 persons with more than 10 years of work experience. The comparison group - 40 men who had no professional contact with harmful production factors. The chemical-analytical, cytofluorimetric, immunoenzyme methods use during the study. Results. The workers being exposed to phthalic anhydride with up to 10 and more than 10 years of work experience at the enterprise have a phthalic acid content in their blood that is 2.3 and 3.3 times higher, respectively than related to persons who are not in contact with the analyzed harmful production factor (p=0.002-0.033). It was found that longtime workers, engaged in the production of phthalic anhydride, manifested the immune response cellular link dysfunction. Workers employed in the main production of phthalic anhydride with more than 10 years of work experience revealed a prevalence of activation processes (according to CD25+ criterion), inhibition of cytotoxic cell-mediated response (according to CD3+CD16+CD56+ criterion), gyperexpression of Th2-cytokines (according to criterion IL4) relative to values obtained from workers of the production with less than 10 years of work experience in hazardous production conditions (p=0.002-0.033). Conclusions. The duration of employment of the workers, contacting with excessive concentrations of phthalic anhydride in workplace air, contributes to negative dynamics in the imbalance between T-cells and cytokine products. The dynamic monitoring of immunoregulatory indicators in workers occupied in the production of phthalic anhydride will contribute to just-in-time revealing of the immune system violations in order to reduce the risks of formation of associated production-related pathology induced by the chemical production factors.

Arterial hypertension and cardiovascular risk factors in employees of underground mining ore minerals

2019 ◽  
pp. 945-949 ◽  
Author(s):  
A. S. Baydina ◽  
N. V. Zaitseva ◽  
V. G. Kostarev ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Features ◽  
Work Experience ◽  
Comparison Group ◽  
Underground Mining ◽  
Observation Group ◽  
Permanent Disability ◽  
Production Factors ◽  
The Impact

Introduction. The wide spread of mining in Russia determines the high relevance of the preservation of labor resources in this industry, the prevention of occupational and production-related morbidity, reducing cases of temporary and permanent disability. Mine mining is characterized by the impact on workers of several nonspecific harmful (dangerous) factors: industrial noise, general and local vibration, the severity of labor, heating or cooling microclimate, low light. The impact of these factors predisposes to the development of pathology of the cardiovascular system.The aim of the study was to study the prevalence of hypertension among underground miners, clinical features and changes in the complex of biochemical risk factors for cardiovascular complications.Materials and methods. The observation group consisted of 98 employees of underground chrome ore mining. The comparison group (working in conditions outside the influence of the studied production factors) consisted of 75 employees of this enterprise. All employees surveyed are male. To study the impact of working conditions on the health of workers, workplaces with a characteristic set of harmful production factors (chrome, dust, noise, vibration, labor severity, labor intensity, cooling microclimate) and the same working modes (sliding three-shift schedule with a shift duration of eight hours) were selected. The study of laboratory parameters (markers of risk of cardiovascular disease) was performed by unified General clinical, biochemical and enzyme immunoassay methods.Results. In the group of underground miners, the prevalence of arterial hypertension was established (in 31.3% in the observation group and in 17.2% of the surveyed in the comparison group, p=0.042), which becomes statistically significant when the work experience is more than 10 years. The study established the clinical features of the anamnesis and objective status of employees of the mine for the extraction of chrome ore. The laboratory study in the group of miners revealed the presence of a number of paraclinic syndromes: systemic inflammation and immune activation syndrome, dyslipidemia syndrome, oxidative stress syndrome, hormonal profile disorder, renal dysfunction syndrome.Conclusions. Employees of underground mining of chrome ore are characterized by a high incidence of hypertension with experience of more than 10 years. The clinical and instrumental changes revealed in the work in the observation group give grounds for the development of directed preventive programs in this category of ore mine workers.

EVALUATION OF THE EFFECTIVENESS OF THE PREPARATION GEPRASAN IN PREVENTION OF MYCOTOXYCOSIS OF BROILER CHICKENS

2018 ◽  
Vol 1 (1) ◽  
pp. 95-98
Author(s):  
M. P. Semenenko ◽  
◽  
M. N. Sokolov ◽  
E. V. Kuzminova ◽  
P. V. Miroshnichenko ◽  
...  
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Dry Matter ◽  
Experimental Period ◽  
Liver Necrosis ◽  
Negative Effects ◽  
Complex Preparation ◽  
Positive Effect

The article presents materials on the use of a new complex preparation geprasan for the prevention of mycotoxicosis of broiler chickens and its influence on safety, results of biochemical parameters of the blood serum and data of necropsy of the poultry liver. According to the scheme of the experiment, three groups of chickens were formed with 50 goals in each. Bird of the 1st group (control) during the whole experimental period received only feed of the main diet, chickens of the 2nd and 3rd groups for 21 days in the feed were added geprasan in amount of 1 and 2%, respectively, of the dry matter of the feed. During the experiment the following parameters were taken into account: safety, biochemical parameters of blood serum and data of liver necrosis. We found out that a long-term introduction of geprasan to feed diets of broilers at various doses has a positive effect on the biochemical parameters of blood serum and the indicators, characterizing the functional activity of hepatocytes of liver and reduce the negative effects of mycotoxins on the poultry organism.

scholarly journals ANALYSIS OF INTERMEDIATE RESULTS OF A COMPARATIVE MULTICENTER RANDOMIZED TENDERA STUDY INVESTIGATING THE DISTAL RADIATION ACCESS

2021 ◽  
Vol 29 (3) ◽  
pp. 285-295
Author(s):  
A.V. Korotkikh ◽  
◽  
A.M. Babunashvili ◽  
A.L. Kaledin ◽  
R.V. Akhramovich ◽  
...  
Keyword(s):  
Radial Artery ◽  
Primary Endpoint ◽  
Comparison Group ◽  
Entry Point ◽  
Long Term Results ◽  
Observation Group ◽  
Endovascular Interventions ◽  
Intermediate Results ◽  
Distal Radial Artery

Objective. To prove the safety and efficacy of distal radial artery (DRA) puncture for endovascular interventions versus the traditional forearm radial artery (RA) puncture site by comparing immediate and long-term results. Methods. In 2017, a multicenter, open, randomized (1:1) study TENDERA (Comparison between Traditional Entry Point and Distal Puncture of Radial Artery) was started. During 2 years, 520 patients were included, mean age 63.4±10.0 years. The observation group (DRA puncture) included 271 patients, the comparison group (RA puncture) - 249 patients. The study included both stable patients and those with NSTEMI: the observation group - 39 (14.4%), the comparison group - 34 (13.7%), p=0.809. The primary endpoint is immediate (hospital) or late radial thrombosis. Secondary endpoints are: 1 - composite point, complications from the access artery; 2 - puncture parameters. Results. The average difference in the diameters of the RA and DRA was 0.3 mm and 0.4 mm, in some patients the DRA diameter corresponded to the RA or even exceeded it. The diameter of RA and DRA in men and women significantly differs, 2.65±0.44 mm and 2.36±0.36 mm (p=0.001), 2.31±0.39 mm and 2.13±0.38 mm (p=0.001). Technical success of DRA access requre the number of attempts. 94.1% - the percentage of successful cardiac catheterization performed through the distal radial artery approach, which is significantly less than via RA - 100% (p<0.001). In the observation group, significantly fewer rebleedings and rehemostasis were occured. In the long-term period, there were registered outstandingly more hematomas in the observation group at the time of discharge and after 1 week. Conclusion. Intermediate analysis of the results of the TENDERA study shows that there is no significant difference in the primary endpoint, but the number of complications in the observation group associated with the puncture markedly - hematoma more than 5 cm to the day of discharge and after 7 days. What this paper adds Intermediate results of the first multicenter open randomized (1:1) study devoted to the comparison of distal puncture of the radial artery versus the traditional entry point of puncture of the radial artery on the forearm during the endovascular interventions have been presented. A significant reduction of the number of local complications has been revealed in the group of distal puncture of the radial artery and the absence of differences according to the primary endpoint: early and late radial artery thrombosis.

Influence of NPK fertilization on weed flora in maize field

2014 ◽  
Vol 63 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Éva Lehoczky ◽  
M. Kamuti ◽  
N. Mazsu ◽  
J. Tamás ◽  
D. Sáringer-Kenyeres ◽  
...  
Keyword(s):  
Plant Nutrition ◽  
Crop Production ◽  
N Availability ◽  
Weed Species ◽  
Negative Effects ◽  
Production Factors ◽  
Maize Field ◽  
Weed Flora ◽  
Npk Fertilization

Plant nutrition is one of the most important intensification factors of crop production. The utilization of nutrients, however, may be modified by a number of production factors, including weed presence. Thus, the knowledge of occurring weed species, their abundance, nutrient and water uptake is extremely important to establish an appropriate basis for the evaluation of their risks or negative effects on crops. That is why investigations were carried out in a long-term fertilization experiment on the influence of different nutrient supplies (Ø, PK, NK, NPK) on weed flora in maize field.The weed surveys recorded similar diversity on the experimental area: the species of A. artemisiifolia, S. halepense and D. stramonium were dominant, but C. album and C. hybridum were also common. These species and H. annuus were the most abundant weeds.Based on the totalized and average data of all treatments, density followed the same tendency in the experimental years. It was the highest in the PK treated and untreated plots, and significantly exceeded the values of NK fertilized areas. Presumably the better N availability promoted the development of nitrophilic weeds, while the mortality of other small species increased.Winter wheat and maize forecrops had no visible influence on the diversity and the intensity of weediness. On the contrary, there were consistent differences in the density of certain weed species in accordance to the applied nutrients. A. artemisiifolia was present in the largest number in the untreated control and PK fertilized plots. The density of S. halepense and H. annuus was also significantly higher in the control areas. The number of their individuals was smaller in those plots where N containing fertilizers were used. Contrary to them, the density of D. stramonium, C. album and C. hybridum was the highest in the NPK treatments.

Optimization of diagnostic system of hand diseases in employees working under combined effects of vibration and physical overloads

2019 ◽  
pp. 950-955
Author(s):  
M. M. Poroshina ◽  
E. M. Vlasova ◽  
A. Ya. Perevalov
Keyword(s):  
Working Conditions ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Diagnostic System ◽  
Pain Syndrome ◽  
Observation Group ◽  
Combined Effects ◽  
X Rays ◽  
Industrial Enterprises ◽  
Special Assessment

The results of research carried out by theFederalScientificCenterfor Medical and Preventive Technologies of Public Health Risk Management Technologies for the period 2013–2018 showed that diseases associated with the combined effects of vibration and physical overload, employees of hazardous industries develop with experience of 15 years or more. The risk group is women older than 35 years and men older than 40 years. Pathology at the stage of detailed clinical manifestations is characterized by persistent pain syndrome, and, as a consequence, a decrease in the ability to work of workers.The aim of the study was to optimize the system of diagnosis of hand diseases in workers of industrial enterprises engaged in labor activities under the combined effects of vibration and physical overload, for the development of primary prevention programs.The observation group consisted of 32 employees aged 39.3±4.3 years, with an experience of 17.4±4.3 years; the comparison group consisted of 30 employees whose working conditions are not related to the studied factors; the average age was 40.6±3.4 years, experience was 19.1±3.1 years. The examination included analysis of the results of a special assessment of working conditions; assessment of neurological status; functional tests; laboratory studies (assessment of inflammation), hand dynamometry, stimulation electroneuromyography; x-rays of the hands and wrist joints, ultrasound examination of the hands.More than half of the surveyed persons of the observation group and 3/4 of the workers of the comparison group did not make complaints. Indicators of dynamometry of workers in both groups corresponded to physiological norm (p>0.05). Analysis of the results of dynamometer with data from previous years of PMO showed a decrease in strength of muscles of the hand leading hands on 2je,0–16. 7% and from 83.3% of the employees of the monitoring group and in 44.4% of the comparison group (p<0.05), in 50 % of the cases there was a decrease in the percentage of changes in the hand force variation (HFV) in the observation group, and in 38.9% of the cases the indicators remained unchanged. According to ultrasound of the hands, signs of tendinopathy were established in 85% of the employees of the observation group in the absence of persons with similar changes in the comparison group.In order to optimize the diagnosis of diseases of the hand in industrial workers who carry out their work under the combined effects of vibration and physical overload, in the case of a decrease in the rate of carpal dynamometry by 5% or more during the year, it is recommended to conduct ultrasound of the tendon-ligamentous apparatus of the hand, which will allow timely identification of early signs of tendinopathy.

Gender differences in biochemical measurement reflecting the state of free-radical oxidation and antioxidant protection among workers in metallurgical production

2019 ◽  
Vol 1 (10) ◽  
pp. 877-881
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Gender Differences ◽  
Free Radical ◽  
Biochemical Parameters ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Metallurgical Production ◽  
Production Factors

Introduction. To date, age and sex differences have been established for many biochemical parameters. Gender differences in indicators for systems such as antioxidant, thiol-disulfide, oxidative stress and inflammation systems are absent or under study.The aim of the study was to identify gender differences in biochemical parameters reflecting the functioning of antioxidant systems of the body and free radical oxidation in workers of metallurgical production, in contact with harmful production factors.Materials and methods. The blood of men and women working at the metallurgical enterprise of the Nizhny Novgorod region (n=80) under the influence of a complex of physical and chemical production factors was studied. Total oxidative stress, total antioxidant capacity of serum, glutathione levels were studied by photometric biochemical methods. Levels of C-reactive protein and 8-hydroxy–2-deoxyguanosine were studied by ELISA.Results. The average amount of peroxides in the serum of women exceeded 1.6 times this figure in men. In the group of men, the content of 8-Ondg was higher by 26% (p=0.012), the level of GS-by 12% (p=0.019), the activity of SOD — by 1.5–2 times (p=0.0001), the level of CRP — by 2 times (p=0.008) compared to similar indicators in women.Conclusions. Studies of gender differences in workers under the influence of harmful production factors will allow more effective approach to the etiology, treatment and prognosis of production-related diseases. Indicators of oxidative stress and antioxidant protection can be indicators of the health of workers under the influence of harmful industrial factors and be important in the prevention of diseases associated with oxidative stress.

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