Age-related features of the immune status associated with the development of arterial hypertension in employees of an oil production enterprise

2020 ◽  
Vol 60 (11) ◽  
pp. 842-844
Author(s):  
Natalia A. Nikonoshina
Keyword(s):  
Blood Pressure ◽  
Work Experience ◽  
Blood Cells ◽  
Immune Status ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Age Related ◽  
Specific Igg ◽  
Perm Region

Introduction. Arterial hypertension (AH) is a multifactorial disease, the main risk factors of which are environmental determinants, the duration and level of their exposure, as well as the age of the examined population. The conditions of the production environment are characterized by a more pronounced effect of technogenic factors compared to the environment, which creates prerequisites for the development of adaptation disorders and an increased risk of hypertension among employees of the oil production enterprise. The aim of study was to analyze age - related features of the immune status associated with the development of AH in employees of an oil production enterprise in the Perm region. Materials and methods. 150 oil production operators exposed to chronic exposure to harmful production factors were examined. The observation group consisted of 67 people over 40 years of age with more than 10 years of work experience who had episodes of increased blood pressure (BP). The comparison group consisted of 73 men under 45 years of age with less than 10 years of experience and no cardiovascular pathology. Determination of the total IgE, IgG to benzene, and VEGF content was performed by the ELISA method. The content of CD3+CD25+, CD127-, CD3+CD95+, and Bax was determined by flow cytometry. Phagocytic activity of white blood cells was studied using formalized sheep red blood cells. The relationship between age and seniority with the development of episodes of increased blood pressure was evaluated using the odds - OR ratio indicator. Statistical processing of the results was performed using the Statistica 6.0 software package. Differences between groups were considered significant at p<0.05. Results. Episodes of increased blood pressure in employees of an oil production enterprise in the Perm region are significantly associated with work experience of more than 10 years when they reach the age of 40 years (p<0.05). The observation group is characterized by an increased (p<0.05) level of General (IgE General) and specific (IgG to benzene) sensitization. A decrease (p<0.05) in the CD3+CD25+ content relative to the comparison group was found against the background of an increase (p<0.05) in the level of regulatory CD127 lymphocytes. Episodes of increased blood pressure in the observation group are associated (p<0.05) with a reduced (p<0.05) level of the Bax protein and CD95+-receptor of lymphocytes relative to the comparison group. At the same time, signs of phagocytosis activation (p<0.05) were established according to the criteria of phagocytosis percentage, phagocytic number, and absolute phagocytosis relative to the comparison group. Conclusions. Detected changes in immune regulation: an increase in the level of General (IgE General) and specific (IgG to benzene) sensitization, suppression of the immune response (CD3+CD25+, CD127-) and apoptosis (CD3+CD95+, Bax) against the background of phagocytosis activation characterize the development of hypertension in employees of an oil production enterprise older than 40 years with more than 10 years of experience in this industry.

scholarly journals Analysis of comorbid pathology in oil producers

2021 ◽  
Vol 100 (5) ◽  
pp. 464-470
Author(s):  
Olga Y. Ustinova ◽  
Nina V. Zaitseva ◽  
Vitalii G. Kostarev ◽  
Elena M. Vlasova ◽  
Alyona A. Vorobyova ◽  
...  
Keyword(s):  
Working Conditions ◽  
Work Experience ◽  
Oil And Gas ◽  
Comparison Group ◽  
Significant Risk ◽  
Oil Production ◽  
Gas Production ◽  
Observation Group ◽  
Oil And Gas Production ◽  
Average Work

Aim of the study. To analyze the patterns of the comorbidity pathology formation in employees occupied in oil production. Materials and methods. Observation group - 292 employees of the oil production enterprise (100% men). The average age was 39.4 ± 10.6 (20-65) years. Average work experience is 13.1 ± 9.6 (3-22) years. The comparison group included 65 employees working in the management of the enterprise. The average age is 40.2 ± 9.8 (20-65) years. Average work experience is 18.5 ± 9.5 (5-23) years. Observation group - 292 oil and gas production operators (OGP) - 100% men. The study involved a comprehensive research program, results analysis, and mathematical modeling. Results. It is typical for oil and gas production operators to be exposed to a complex impact of harmful production factors: industrial noise, the intensity of work, and physical overload combined with chemical factors. A prior occupational risk to the employees under mentioned working conditions was classified from low (moderate) risk to medium (significant) risk. The age of employees with developed comorbid pathology in the observation group was 31.7 ± 5.4 years, work experience in the specified working conditions was 4.6 ± 1.1 years; the age of workers in the comparison group was 35.4 ± 3.9 years, work experience was 7.4 ± 2.7 years. The results of functional studies have demonstrated a complex of abnormalities in workers with little expressed clinical symptomatology. Analysis of comorbid pathology showed an increase in n according to CIRS score, increasing the working experience among oil and gas operators. Conclusion. Comorbid pathology occurs in oil production workers within ten years of working experience under conditions of combined occupational and non-occupational factors. In the comorbid pathology development, both induced intrasystemic and intersystemic disorders significantly worsens the working life prognosis.

Immune profile of oil production enterprise employees

2019 ◽  
pp. 937-939
Author(s):  
I. N. Alikina ◽  
O. V. Dolgikh
Keyword(s):  
Cell Death ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
The State ◽  
Observation Group ◽  
Immune Profile ◽  
Cellular Immunodeficiency ◽  
Perm Region ◽  
Male Workers

Introduction. The assessment of the immune profile of employees of the oil-producing enterprise, the formation of the immunological status of which is determined by the conditions of harmful production factors affecting their health.The aim of the study was to assess the state of cellular immunity in oil-producing enterprise employees (on the example of the Perm region).Materials and methods. 60 men working at the oil-producing enterprise of the Perm region were examined. In the observation group (n=30) were included surveyed male workers-operators of oil production, in the comparison group — surveyed male workers — representatives of the administrative apparatus. The state of cellular immunity was assessed by indicators of cellular regulation and apoptosis. Cell differentiation marker T-reg-CD4+CD127 -, expression level of Bcl–2, Bax, p53 proteins, TNFR receptors and AnnexinV-FITC+7AAD negative cells were determined by flow cytometry.Results. The comparative analysis with physiological norm indicators allowed to reveal reliable hyperproduction of membrane and intracellular factors of cellular immunity in oil production operators. Expression of regulatory marker CD127-, proteins Bax, Bcl–2 and p53, TNFR receptor content and AnnexinV-FITC+7AAD negative cells responsible for natural cell death (p<0.05) was established. The indicators of the observation group differed significantly from those of the comparison group. There was a significant inhibition of expression of CD-marker CD127-and apoptic protein Bcl–2 by more than 10%, an increase in TNFR, AnnexinV-FITC+7AAD negative cells, protein Bax and p53 by 1.3, 1.6 and 1.2 times, respectively.Conclusions. The results of immunological screening allowed to establish an imbalance of cellular immunity in oil-producing enterprise workers — a deficiency of regulatory cells and a protein-controller of cell death with simultaneous excessive activation of cell reception, which later forms the phenomenon of cellular immunodeficiency. The high sensitivity of the membrane and cytoplasmic components of the immune profile allows them to be used as indicators of the health status of oil production operators, timely identify the development of regulatory imbalance of the immune system, early violations of cell-associated pathological processes (cellular immunodeficiency, autoimmune and proliferative processes), as well as timely and effective implementation of measures to prevent the development of production-related diseases working at oil production facilities.

Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

Features of the long-term dynamics of heart rate variability among workers of a potash ore processing enterprise

2021 ◽  
Vol 61 (7) ◽  
pp. 442-450
Author(s):  
Alexandr E. Nosov ◽  
Nina V. Zaitseva ◽  
Vitalii G. Kostarev ◽  
Julia A. Ivashova ◽  
Maksim A. Savinkov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Significant Relationship ◽  
Work Experience ◽  
Fine Particles ◽  
Comparison Group ◽  
Stress Index ◽  
Observation Group ◽  
Ore Processing ◽  
Processing Enterprise

Introduction. Currently, the violation of heart rate variability as one of the main pathogenetic mechanisms of the damaging effect of pollutants, associated effects on the cardiovascular system. The study aims to explore the dynamics of the influence of the autonomic nervous system (ANS) on heart rate variability (HRV) in workers of a potassium ore processing enterprise exposed to industrial pollutants (fine fractions of potassium chloride dust, formaldehyde, hexane, heptane) with an assessment of changes in dependence from work experience, establishment of cause-and-effect relationships of violations of heart rate variability with exposure to chemical compounds. Materials and methods. The object of the study was 140 employees of a potash ore processing enterprise, assigned to the observation group, and 76 employees of the administrative and technical apparatus, who made up the comparison group. Samples were taken from the air of the working medium for the content of saturated hydrocarbons (hexane, heptane), the vapors of formhehyde were considered, and the presence of fine particles PM2.5 and PM10 was established. Investigation of biological media (blood, urine) of workers at the enterprise determination of formaldehyde in blood, hexane and heptane in urine. Evaluation of heart rate variability was carried out on a computer electrocardiograph "Poli-Spectr-8/EX" using a cardiorhythmographic program using the method of time analysis, variation pulsometry and spectral analysis. Results. The concentration of fine particles in the air at the workplaces of the observation group was 12-111 times higher for PM2.5, and 5.6-74.6 times higher for PM10 than for the work places of the comparison group. The concentration of formaldehyde, hexane and heptane in the air did not exceed hygienic standards. In the observation group relative to the comparison group, formaldehyde blood was 1.5 times (p<0.001), in the urine of hexane - 1.2 times (p=0.011), heptane - 1.3 times (p=0.046). It was found that with an experience of up to 10 years, formaldehyde in the blood of workers in the observation group was 1.4 times higher than that in the comparison group (p=0.011), with an experience of more than 10 years - 1.7 times (p=0.005). In the urine of workers in the observation group with work experience of up to 10 years, an excess of 1.3 (p=0.026) relative to the comparison group of hexane was found. HRV data analysis. With damage to the length of service in the observation group, there was a significant decrease in the temporal analysis indicators (SDNN, ms, RMSSD, ms, pNN50, %, CV, %), while in the comparison group, only the CV, % decrease was statistically significant; the values of IN conventional units, AMo, % significantly increased (p=0.03 and p=0.003, respectively). A statistically significant relationship was established between the likelihood of an increase depending on the content of heptane in urine (b0=0.22; b1=10.6; F=21.5; R2=0.09; p=0.0001) and formaldehyde in the blood (b0=0.02; b1=6.55; F=69.6; R2=0.25; p=0.0001) in the surveyed workers. Conclusions. Activation of central ergotropic and humoral-metabolic mechanisms, a tendency towards a decrease in parasympathetic influences. The method of logistic regression analysis established a statistically significant relationship between the probability of an increase in the stress index depending on the heptane content in the blood of the surveyed suppliers.

Immune status markers dynamics during rotational diet therapy in obesity

2020 ◽  
Vol 74 (6) ◽  
pp. 423-429
Author(s):  
Camilat M. Gapparova ◽  
Yulia G. Chekhonina ◽  
Tatyana B. Sentsova ◽  
Ilya V. Vorozhko ◽  
Irina A. Lapik
Keyword(s):  
Inflammatory Markers ◽  
Immune Status ◽  
Comparison Group ◽  
Diet Therapy ◽  
Main Group ◽  
Food Intolerance ◽  
Food Allergies ◽  
Food Allergens ◽  
Specific Igg ◽  
Immune Inflammation

BACKGROUND: Сhronic immune inflammation in obesity is pathogenetically associated with the development insulin resistance and the metabolic syndrome. However, there are a number of works devoted to the relationship of obesity and allergic diseases, in which data were obtained on models of bronchial asthma and allergic rhinitis. In obesity against a background of chronic immune inflammation, a more severe course of concomitant allergic disease is observed, accompanied by an increase in pro-inflammatory cytokine levels. In this regard, obesity and food allergies should be considered from the standpoint of comorbidity, and the study of immune status markers dynamics in obese patients with concomitant food allergies at the background of diet therapy will create prerequisites for determining the criteria of the effectiveness of the treatment. AIM: To study the of immune status markers dynamics on the background of rotational diet therapy for obesity. METHODS: A single-site, randomized controlled trial was conducted. The duration of observation of the patients was 14 days. There were 68 patients with obesity, aged 47.4 5.4 years, randomly divided into 2 homogeneous groups. Levels of allergen-specific IgG to 90 food allergens were measured to all patients of the main group by enzyme immunoassay method. The comparison group received a standard low-calorie diet. In both groups, the levels of pro-inflammatory markers (IL-1, TNF, IL-6) were determined using commercial Biosource kits (Belgium). RESULTS: In evaluating of the cytokine status and the level of non-specific markers of inflammation at the initial stage of the study, patients with a body mass index above 35 showed a significant increase in concentrations of C-reactive protein, IL-1, and IL-6. Analysis of allergen-specific IgG to 90 food allergens showed that food intolerance was found often to milk, dairy products, gluten. Analyzing the dynamics of the level of pro-inflammatory markers during treatment, a significant decrease in the level of CRP, IL-6, IL-1 was detected in the main group 15 % (p 0.05), 14 % (p 0.05), 10 % respectively, while in the comparison group the decrease in the level of IL-6 was 9 %, IL-1 by 6 %,CRP by 10 % (p 0.05). CONCLUSION: In patients with obesity with concomitant food intolerance there are changes in the immune status in the form of increased levels of pro-inflammatory markers. During the observation a more significant decrease was found in the studied parameters in the main group was detected at the background of rotational diet therapy in relation to the comparison group. The decrease in the concentrations of the studied markers in the serum during the study is an indicator of the effectiveness of rotational diet therapy.

scholarly journals Assessment of immune status in children with functional respiratory system disorders, living in aerogenic aluminium exposure zone

2019 ◽  
Vol 36 (5) ◽  
pp. 44-51
Author(s):  
Oleg V. Dolgikh ◽  
Inga N. Alikina ◽  
Maxim A. Guselnikov
Keyword(s):  
Respiratory System ◽  
Immune Status ◽  
Comparison Group ◽  
Clinical Signs ◽  
Allergic Diseases ◽  
Receptor Expression ◽  
Immune Reactivity ◽  
Functional Reserves ◽  
Specific Igg ◽  
Differentiation Marker

Aim. To assess the immune status in children of primary school age with functional disorders of the respiratory system, who live in the territory with location of industrial enterprise, producing aluminium. Materials and methods. Fifty-two children aged 711 years with respiratory system disorders, who live in the zone of exposure of aluminium-producing enterprise were examined. Cellular differentiation marker CD127, protein Bcl-2 and TNFR receptor expression levels were identified using the method of flow cytometry. Phagocytic activity of the cells was studied using formalinized sheep erythrocytes; IgG content was determined with radial immunodiffusion method; beta2-microglobulin level with enzyme immunoassay. Functional status of respiratory system was assessed using spirometry, rhinomanometry methods but functional reserves with calculated Skibinskaya index. Results. The prevalence of allergic diseases in the examined children was 2,4 times higher and allergic rhinitis was diagnosed 3,2 times more often than in the group of comparison. The prevalence of bronchial asthma, clinical signs of chronic lympho-proliferative diseases reliably exceeded the level observed in children of comparison group (29.4 %, р = 0.001). There were established the changes in immune reactivity versus the comparison group, manifested by increase in percentage of phagocyting cells, beta2-microglobulin protein, IgG, CD127, TNFR and specific IgG to aluminium by 1.1, 1.2, 1.0, 1.7, 2.5 and 1.2 times, respectively; suppression of protein Bcl-2 expression by 2,6 times (p 0.05) was registered. Conclusions. Among children aged 711 years, who live in the territory with localized aluminium-producing enterprise, the diseases of respiratory organs with allergic component, reliably associated with aluminium compound contamination, were diagnosed more often than in children of comparison group. Immunologic study detected imbalance between humoral and cellular components of immunity: hyperproduction of specific IgG to aluminium, excess expression of proteins and beta2-microglobulin receptors, IgG, CD127, TNFR and deficit of Bcl-2.

scholarly journals Features of the immune profile and polymorphism of candidate genes in children population of an industrially developed region with excessive contamination of the biological medium with mercury

2021 ◽  
Vol 100 (10) ◽  
pp. 1133-1138
Author(s):  
Nina V. Zaitseva ◽  
Natalya A. Nikonoshina ◽  
Oleg V. Dolgikh
Keyword(s):  
Candidate Genes ◽  
Phagocytic Activity ◽  
Comparison Group ◽  
Mercury Exposure ◽  
Mercury Contamination ◽  
Biological Medium ◽  
Observation Group ◽  
Immune Profile ◽  
Specific Igg ◽  
Polymorphic Variants

Introduction. Analyzing the negative impact of technogenic chemicals on the health of the children’s population of industrially developed regions is an urgent problem of preventive medicine. Excessive accumulation of mercury in the human body causes disadaptation changes in the immune regulation of physiological processes. Therefore, the analysis of the features of the immune profile associated with polymorphic variants of candidate genes as markers of early disorders of the child population’s health status is relevant in preserving the health of the population of industrialized regions. Materials and methods. A clinical and laboratory examination of the biological environment of 215 children aged 4-6 years was carried out. The observation group consisted of 133 people living in an industrially developed region. The comparison group consisted of 82 people living in a relatively clean territory. The level of contamination of the biological medium with mercury was determined by inductively coupled plasma mass spectrometry. Identification of CD3+CD4+ -, CD3+CD8+- and CD19+ - lymphocytes was performed by flow cytofluorometry. The study of the phagocytic activity of leukocytes was carried out using formalized ram erythrocytes. The level of IgG production was determined using radial immunodiffusion by Mancini, specific IgG to mercury was carried out using allergosorbent testing with an enzyme label. Identification of single-nucleotide polymorphic variants (SNP) of the GSTA4 (rs3756980), FOXP3 (rs3761547), MTR (rs1805087), TERT (rs10054203) genes was carried out by real-time PCR. Results. Children living near the territory of the chemical industry enterprise in conditions of mercury exposure at a level not exceeding hygienic standards are characterized by an increased level of mercury contamination of urine, exceeding the reference level and the level of the comparison group by 1.8 times (p<0.05). The immune profile of children in the observation group is characterized by a decrease in the CD4+/CD8+ immunoregulatory index due to the decline of CD3+CD4+ helpers and hyperproduction of CD3+CD8+ cytotoxic lymphocytes, inhibition of the phagocytic activity of leukocytes (percentage of phagocytosis, phagocytic number, phagocytic index) against the background of an increase in CD19+ lymphocytes, serum IgG and a marker of specific sensitization - IgG to mercury (p<0.05). Changes in the immune profile of children with an increased level of mercury contamination are associated with the C-allele and TC-heterozygous and CC-homozygous genotypes of the GSTA4 gene (rs3756980), the C-allele and CC-genotype of the FOXP3 gene (rs3761547), the A-allele and AA-genotype of the MTR gene (rs1805087) (OR>1, p<0.05), the G-allele and GG-genotype of the TERT gene (rs10054203) (p<0.05). These genes are responsible for the features of detoxification processes, immunoregulation and longevity programs. Conclusion. The established features of cellular (decrease in CD4+/CD8+ due to CD3+CD4+ deficiency with simultaneous increase in CD3+CD8+, inhibition of phagocytosis) and humoral (hyperproduction of IgG, specific IgG to mercury, CD19+) immunity associated with polymorphic variants of the glutathione S-transferase GSTA4 (rs3756980), transcription factor FOXP3 (rs3761547), MTR (rs1805087), TERT telomerase (rs10054203) in children with excessive contamination of the biological medium with mercury, a complex of immune and genetic markers of the effect and sensitivity of mercury exposure is formed.

scholarly journals Features of the immune status of pupils under the influence of heterogeneous physical factors of a non-ionizing nature

2021 ◽  
pp. 219-227
Author(s):  
Dmitry V. Lanin ◽  
◽  
Konstantin N. Likhachev ◽  
Oleg V. Dolgikh ◽  
Albina A. Sabitova ◽  
...  
Keyword(s):  
Immune System ◽  
Comparative Analysis ◽  
School Environment ◽  
Immune Status ◽  
Physical Factors ◽  
Observation Group ◽  
Age Dependent ◽  
Comparison Groups ◽  
Permissible Levels ◽  
Perm Region

A hygienic assessment of a number of physical factors of the school environment was carried out and the features of the immune status of students under the influence of these factors in the gymnasium of Perm (observation group) were described in comparison with the features of the same indicators in students of a school in one of the cities of the Perm Region. All the studied physical factors, with the exception of the aeroionic composition of the air, did not exceed the maximum permissible levels established by sanitary requirements. In the air of all the examined classrooms of the gymnasium, the number of negative and positive aeroions was found to be inconsistent with the norm; at school, in a number of classrooms, the aeroion composition of the air corresponded to the norm. A comparative analysis of the immune system indicators revealed the presence of age-dependent changes in the expression of CD-receptors of lympho-cytes in the presence of additional sources of physical factors. In the students of the observation groups in primary, primary and high school, changes in individual classes of immunoglobulins were found both in relation to the comparison groups and in relation to the physiological norm. An imbalance of pro- and an-ti-inflammatory cytokines was found in children in primary and secondary schools of the gymnasium.

Arterial hypertension and cardiovascular risk factors in employees of underground mining ore minerals

2019 ◽  
pp. 945-949 ◽  
Author(s):  
A. S. Baydina ◽  
N. V. Zaitseva ◽  
V. G. Kostarev ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Features ◽  
Work Experience ◽  
Comparison Group ◽  
Underground Mining ◽  
Observation Group ◽  
Permanent Disability ◽  
Production Factors ◽  
The Impact

Introduction. The wide spread of mining in Russia determines the high relevance of the preservation of labor resources in this industry, the prevention of occupational and production-related morbidity, reducing cases of temporary and permanent disability. Mine mining is characterized by the impact on workers of several nonspecific harmful (dangerous) factors: industrial noise, general and local vibration, the severity of labor, heating or cooling microclimate, low light. The impact of these factors predisposes to the development of pathology of the cardiovascular system.The aim of the study was to study the prevalence of hypertension among underground miners, clinical features and changes in the complex of biochemical risk factors for cardiovascular complications.Materials and methods. The observation group consisted of 98 employees of underground chrome ore mining. The comparison group (working in conditions outside the influence of the studied production factors) consisted of 75 employees of this enterprise. All employees surveyed are male. To study the impact of working conditions on the health of workers, workplaces with a characteristic set of harmful production factors (chrome, dust, noise, vibration, labor severity, labor intensity, cooling microclimate) and the same working modes (sliding three-shift schedule with a shift duration of eight hours) were selected. The study of laboratory parameters (markers of risk of cardiovascular disease) was performed by unified General clinical, biochemical and enzyme immunoassay methods.Results. In the group of underground miners, the prevalence of arterial hypertension was established (in 31.3% in the observation group and in 17.2% of the surveyed in the comparison group, p=0.042), which becomes statistically significant when the work experience is more than 10 years. The study established the clinical features of the anamnesis and objective status of employees of the mine for the extraction of chrome ore. The laboratory study in the group of miners revealed the presence of a number of paraclinic syndromes: systemic inflammation and immune activation syndrome, dyslipidemia syndrome, oxidative stress syndrome, hormonal profile disorder, renal dysfunction syndrome.Conclusions. Employees of underground mining of chrome ore are characterized by a high incidence of hypertension with experience of more than 10 years. The clinical and instrumental changes revealed in the work in the observation group give grounds for the development of directed preventive programs in this category of ore mine workers.

Risk assessment of occupational and occupationally conditioned diseases connection to noise when exceeding maximum permissible levels

2019 ◽  
pp. 17-19
Author(s):  
Vladimir A. Fokin ◽  
Dmitrii M. Shlyapnikov ◽  
Svetlana V. Red’ko
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
High Blood Pressure ◽  
Noise Exposure ◽  
Physical Factors ◽  
Autonomic Nervous ◽  
Permissible Levels ◽  
The Relationship ◽  
Perm Region

In accordance with the requirements of paragraph 3.2.6 of sanitary rules and norms «Sanitary and epidemiological requirements for physical factors at workplace», in the event of exceeding noise level at workplace above 80 dBA, an employer is obliged to assess the health risk of workers and confirm an acceptable risk to their health. The connection between the incidence of occupational and occupationally conditioned diseases with noise exposure exceeding the maximum permissible levels (80 dBA) was estimated. The assessment was carried out at a food industry enterprise of Perm Region. Assessing the relationship between morbidity and noise exposure is the first step in evaluation of occupational health risks for workers exposed to noise exceeding MAL. If a reliable relationship between morbidity and noise exposure is established, an assessment of occupational risk is conducted. The odds ratio (OR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1 (confidence interval CI=0.11–1.61 and CI=0.08–2.78, respectively). The relative risk (RR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1. The received data testify absence of connection of morbidity with exposure to industrial noise, calculation of etiological share of responses and levels of risk is not required.

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