Ophthalmic gene and cell therapies

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Vision Loss ◽  
Diagnostic Tools ◽  
Clinical Environment ◽  
Cell Therapies ◽  
Disease Mechanisms ◽  
Tremendous Progress ◽  
Resolution Imaging ◽  
Disease Pathways ◽  
Made In

In the field of ocular gene and cell therapy, tremendous progress has been made in both research and clinical testing. In the laboratory, researchers have uncovered potential new ways of treating glaucoma holistically by decreasing IOP and providing retinal and optic nerve neuroprotection. As we get a better understanding of the disease mechanisms, we will be able to target specific glaucoma disease pathways with gene and cell therapies in order to achieve safe, effective, and long-term vision loss prevention. Improved diagnostic tools such as high-resolution imaging and continuous tonometry will make it simpler to detect glaucoma early and obtain better treatment outcomes. Translation of innovative medicines from the laboratory to the clinical environment is a significant problem, particularly for veterinary ophthalmic applications, due to restricted resources for generating animal-specific drugs.

scholarly journals Management of Intracranial Abscess - Study of 30 cases

1970 ◽  
Vol 16 (2) ◽  
pp. 73-75
Author(s):  
Md L Rahman ◽  
ML Rahman ◽  
S Hossain ◽  
ASMS Ali ◽  
SK Pramanik ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Antibiotic Therapy ◽  
Brain Abscess ◽  
Diagnostic Tools ◽  
Intracranial Abscess ◽  
Multiple Abscess ◽  
Brain Abscesses ◽  
Burr Hole Evacuation ◽  
Made In

Brain abscess may be solitary or multiple. They appear as areas of ill-defined cerebritis tomature well defined focal suppurative lesion with capsulated abscesses. Multiple brain abscessrecognized in as many as 50% of patients. In this study 30 patients were analyzed. Solitary brainabscess were more than multiple abscess. Age ranges from 6 years to 35 years. Male to femaleratio was 5:1. Intra parenchymal brain abscess occurred in all cases (100%), subdural orextradural lesions were nil. Brain abscesses were associated with CSOM. CT scan done in all(100%) patients as diagnostic tools. All (100%) patients under went Burr-hole evacuation withbroad-spectrum antibiotic therapy and 2 patients (06.66%) treated with long term anti tuberculartherapy. V-P shunt was made in 1 patient (03.33%) who had persistent venriculomegaly. In thisstudy mortality rate was zero.doi: 10.3329/taj.v16i2.3887TAJ December 2003; Vol.16(2): 73-75

scholarly journals The Role of Interleukin-1β in Destruction of Transplanted Islets

2020 ◽  
Vol 29 ◽  
pp. 096368972093441
Author(s):  
Cheng Chen ◽  
Pengfei Rong ◽  
Min Yang ◽  
Xiaoqian Ma ◽  
Zhichao Feng ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Graft Loss ◽  
Innate Immune ◽  
Interleukin 1Β ◽  
Cell Replacement Therapy ◽  
Tremendous Progress ◽  
Made In

Islet transplantation is a promising β-cell replacement therapy for type 1 diabetes, which can reduce glucose lability and hypoglycemic episodes compared with standard insulin therapy. Despite the tremendous progress made in this field, challenges remain in terms of long-term successful transplant outcomes. The insulin independence rate remains low after islet transplantation from one donor pancreas. It has been reported that the islet-related inflammatory response is the main cause of early islet damage and graft loss after transplantation. The production of interleukin-1β (IL-1β) has considered to be one of the primary harmful inflammatory events during pancreatic procurement, islet isolation, and islet transplantation. Evidence suggests that the innate immune response is upregulated through the activity of Toll-like receptors and The NACHT Domain-Leucine-Rich Repeat and PYD-containing Protein 3 inflammasome, which are the starting points for a series of signaling events that drive excessive IL-1β production in islet transplantation. In this review, we show recent contributions to the advancement of knowledge of IL-1β in islet transplantation and discuss several strategies targeting IL-1β for improving islet engraftment.

The desperate plea of women with the nutcracker syndrome

Phlebologie ◽  
2010 ◽  
Vol 39 (02) ◽  
pp. 104-111
Author(s):  
J. L. Villavicencio
Keyword(s):  
Renal Vein ◽  
Imaging Techniques ◽  
Left Renal Vein ◽  
Diagnostic Tools ◽  
Nutcracker Syndrome ◽  
Treatment Techniques ◽  
Children And Young Adults ◽  
Good Number ◽  
Pelvic Congestion

Summary Objective: To increase awareness on the severe impact of the nutcracker syndrome in women with undiagnosed disease. Patients and methods: We reviewed the medical literature and analyzed six representative series with 73 patients with nutcracker syndrome. Women with left flank pain, dyspareunia, dysuria, dysmenorrhea, micro- or macrohaematuria and pelvic congestion symptoms, should be carefully investigated for evidence of meso aortic left renal vein compression. A good number of our colleagues do not believe in the existence of the nutcracker syndrome and send these patients in a long pilgrimage in search of someone who can help them to get relief to their pain. New and improved imaging techniques can assist in the diagnosis but retrograde reno-gonadal phlebography and renocaval gradient are the most reliable diagnostic tools. Results: Among an assortment of treatment techniques, renal vein transposition and endovenous stenting were the two most commonly used procedures. There are no long term studies on renal vein stenting in children and young adults. Its use in these cases should be carefully considered. The nutcracker syndrome may present with pelvic congestion symptoms and its diagnosis missed. The patient's age, severity of symptoms and haemo dynamic renal studies should guide the treatment. Conclusion: An increased awareness of the existence of the nutcracker syndrome may prevent many unfortunate undiagnosed women from spending many months and often years of suffering.

Soil and ecological division into districts of the Baikal region

2018 ◽  
Vol 940 (10) ◽  
pp. 54-64 ◽  
Author(s):  
I.A. Belozertseva ◽  
A.A. Sorokovoj
Keyword(s):  
Baikal Region ◽  
Soil Cover ◽  
Soil Formation ◽  
Forest Steppe ◽  
Leading Role ◽  
Soil Cover Structure ◽  
Reflecting Surface ◽  
Heat And Moisture ◽  
Made In

On the basis of long-term researches of soils in the territory of Russia and Mongolia soil and ecological division into districts of the Baikal region is carried out. At division into districts the whole set of an environment of soil formation was considered. On the map of soil and ecological division into districts 13 mountain, mid-mountain, low-mountain taiga, foothill, hollow-valley, forest-steppe and steppe provinces reflecting surface device originality as the ratio of balance of heat and moisture forming a basis to zoning is shown against the background of difficult orography are allocated. In total 42 districts on lithologic-geomorphological features are allocated. In formation of distinctions of a soil cover of these provinces the leading role is played by bioclimatic factors and inside them the lithologic-geomorphological ones. In the view of structural approach of the district they are considered as territories with a certain natural change of several types of the soil cover structure caused by features of a relief and the parent rock. The map is made in the MapInfo program. It is revealed that on ill-defined width zoning of soils the vertical one which has a greater influence on soils of this region is imposed. Soils of the Baikal region are not similar to the soils located at the same latitude of the flat European territory of Russia. Zone soils of this territory are specific and original.

scholarly journals Mechanical Properties of Cement-Treated Soil Mixed with Cellulose Nanofibre

2021 ◽  
Vol 11 (14) ◽  
pp. 6425
Author(s):  
Hidenori Takahashi ◽  
Shinya Omori ◽  
Hideyuki Asada ◽  
Hirofumi Fukawa ◽  
Yusuke Gotoh ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Flexural Strength ◽  
Geotechnical Engineering ◽  
Strength Development ◽  
Soft Ground ◽  
Wood Cellulose ◽  
Treated Soil ◽  
Made In ◽  
Cement Treatment

Cellulose nanofibre (CNF), a material composed of ultrafine fibres of wood cellulose fibrillated to nano-order level, is expected to be widely used because of its excellent properties. However, in the field of geotechnical engineering, almost no progress has been made in the development of techniques for using CNFs. The authors have focused on the use of CNF as an additive in cement treatment for soft ground, where cement is added to solidify the ground, because CNF can reduce the problems associated with cement-treated soil. This paper presents the results of a study on the method of mixing CNF, the strength and its variation obtained by adding CNF, and the change in permeability. CNF had the effect of mixing the cement evenly and reducing the variation in the strength of the treated soil. The CNF mixture increased the strength at the initial age but reduced the strength development in the long term. The addition of CNF also increased the flexural strength, although it hardly changed the permeability.

scholarly journals Designing organic solvent separation membranes: Polymers, porous structures, 2D materials, and their combinations

2021 ◽  
Author(s):  
Ameya Manoj Tandel ◽  
Wenji Guo ◽  
Kelly Bye ◽  
Liang Huang ◽  
Michele Galizia ◽  
...  
Keyword(s):  
Organic Solvent ◽  
High Selectivity ◽  
2D Materials ◽  
Porous Structures ◽  
Membrane Materials ◽  
Term Stability ◽  
Long Term Stability ◽  
Separation Membranes ◽  
Tremendous Progress

As interest for membrane-based organic solvent separation increases, membrane materials exhibiting high permeance, high selectivity, and long-term stability against solvents are sought. Membrane technology has experienced tremendous progress by integrating...

No Justice Without Peace, But What Peace Is on Offer?

2020 ◽  
Author(s):  
Mark Kersten
Keyword(s):  
Middle East ◽  
International Criminal Court ◽  
International Criminal ◽  
Criminal Court ◽  
Term Stability ◽  
Long Term Stability ◽  
Peace Processes ◽  
Lasting Peace ◽  
Made In

Abstract Does the potential investigation into Palestine by the International Criminal Court (ICC) threaten the chances of a lasting ‘peace’ between Israel and Palestine? This article endeavours to answer that question and critically assesses claims that the Court could undermine peace in the Middle East. I first examine the key claims made in the so-called ‘peace versus justice’ debate. I then outline some of the specific arguments made in the context of a possible ICC investigation in Palestine that touch upon concerns over the Court’s impacts on peace processes and negotiations. Following this, I try to assess critically the validity of these claims, arguing that while it would be wrong to conclude that the ICC will invariably have positive impacts on efforts to establish peace, there is no evidence that the Court will undermine whatever ‘peace’ is currently on offer for Palestinians and Israelis. On the contrary, this ‘peace’ may itself be a threat to resolving the conflict peaceably and to long-term stability in the region. Finally, I conclude the article with some reflections on the peace-justice debate and its applicability to the Israel–Palestine situation.

Heads-up 3D eye surgery: Safety outcomes and technological review after 2 years of day-to-day use

2021 ◽  
pp. 112067212110128
Author(s):  
Claudia Del Turco ◽  
Giuseppe D’Amico Ricci ◽  
Marco Dal Vecchio ◽  
Caterina Bogetto ◽  
Edoardo Panico ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Case Series ◽  
Depth Of Field ◽  
Procedural Complication ◽  
Long Time ◽  
Procedural Complications ◽  
Resolution Imaging ◽  
Visualization Systems ◽  
3D Surgery

Background: 3D heads-up visualization systems are aimed to improve the surgical experience by providing high-resolution imaging. Objective of our study is to analyze, over a long-time span, the grade of satisfaction and safety of day-to-day 3D surgery compared to standard surgery and to investigate the technical distinctiveness between the heads-up systems currently in use. Methods: In this retrospective observational case series. we reviewed all surgical records of our ophthalmology-dedicated operatory rooms since the arrival of 3D heads-up viewing system, in November 2017. In particular, we compared the procedural complications of 3D-equipped operatory room (3DR) with the standard microscope operatory room (2DR). Moreover, a satisfaction questionnaire was administered to those surgeons shifting on both rooms to test their preferences on seven specific parameters (comfort, visibility, image quality, depth perception, simplicity of use, maneuverability and teaching potential). Results: 5483 eye surgeries were considered. 2777 (50.6%) were performed in 3DR and 2706 (49.3%) in 2DR. Procedural complication rate was comparable in 3DR and 2DR, also when considering different subtypes of surgery. Twelve surgeons (100% of our surgery team) participated in our satisfaction survey, expressing highest satisfaction score for 3D when applied in retina surgery. For cataract surgery, 3D scored best in all the parameters except for facility in use and depth of field perception. Conclusion: Long-term day-to-day use of 3D heads-up visualization systems showed its safety and its outstanding teaching potential in all ophthalmic surgical subtypes, with higher surgeons confidence for retina and cataract surgery.

Commentary: The Broader Context of Long-Term Care Ethics

2016 ◽  
Vol 25 (3) ◽  
pp. 554-556
Author(s):  
Jason Lesandrini ◽  
Carol O’Connell
Keyword(s):  
Care Setting ◽  
Long Term Care ◽  
Ethical Issues ◽  
Term Care ◽  
Ethical Concerns ◽  
Healthcare Settings ◽  
Care Facilities ◽  
Ethics Program ◽  
Made In

Ethical issues in long-term care settings, although having received attention in the literature, have not in our opinion received the appropriate level they require. Thus, we applaud the Cambridge Quarterly for publishing this case. We can attest to the significance of ethical issues arising in long-term care facilities, as Mr. Hope’s case is all too familiar to those practicing in these settings. What is unique about this case is that an actual ethics consult was made in a long-term care setting. We have seen very little in the published literature on the use of ethics structures in long-term care populations. Our experience is that these healthcare settings are ripe for ethical concerns and that providers, patients, families, and staff need/desire ethics resources to actively and preventively address ethical concerns. The popular press has begun to recognize the ethical issues involved in long-term care settings and the need for ethics structures. Recently, in California a nurse refused to initiate CPR for an elderly patient in a senior residence. In that case, the nurse was quoted as saying that the facility had a policy that nurses were not to start CPR for elderly patients.1 Although this case is not exactly the same as that of Mr. Hope, it highlights the need for developing robust ethics program infrastructures in long-term care settings that work toward addressing ethical issues through policy, education, and active consultation.

Will Strategy Prevail over Economics? An Analysis of Charanka Solar Park in Gujarat

2016 ◽  
Vol 5 (2) ◽  
pp. 162-167
Author(s):  
Saif Siddiqui ◽  
Sumaira Jan
Keyword(s):  
Solar Energy ◽  
Solar Power ◽  
Power Production ◽  
Energy Crisis ◽  
Energy Sources ◽  
Potential Source ◽  
The World ◽  
Made In

The Charanka Solar Park, one of the world’s largest multi-developer and multi-beneficiary solar parks, is the hub of solar power production in India. It contributes about 6 per cent to the total solar power production in the country. Although solar power is more expensive than the traditional power in the country, its sheen is still not high to make it a potential source to eliminate energy crisis not just in India but all across the world. Researchers are continuously pushing their envelope to explore as to why solar energy should be adopted over traditional energy sources irrespective of the fact that it is more expensive. The war between its financial and strategic viability is going on. Efforts are being made in the direction of reducing its costs and making it as a financially viable and strategically active option. This case is an attempt in the same direction. We are using Charanka Solar Park as a base to explore if there is any future for such projects in the country. There are projects which are no doubt operational but their long-term viability is truly questionable.

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