scholarly journals Study of dynamic changes in the parameters of liver function tests in COVID-19 patients: A hospital-based study in Eastern Nepal

2021 ◽  
Vol 8 (2) ◽  
pp. 60-64
Author(s):  
Ankush Mittal ◽  
Mohammad Shamim Farooqui
Keyword(s):  
Liver Function ◽  
Total Protein ◽  
College Teaching ◽  
Liver Function Tests ◽  
Mean Values ◽  
Medical College ◽  
Global Pandemic ◽  
Organ Systems ◽  
Severe Group ◽  
Using Data

Background: COVID-19 has become a focus of healthcare practitioners worldwide after it was declared as a global pandemic. Although SARS-CoV-2 is primarily affecting the respiratory system, numerous studies have documented its impact on other organ systems, including the liver. This study aims to assess liver function in COVID-19 patients in light of SARS-CoV-2's extremely infectious and pathogenic character. Material and methods: It was a hospital-based retrospective study conducted between January 1, 2021, and July 31, 2021, using data from the Department of Biochemistry at Birat Medical College Teaching Hospital in Nepal. Age, gender, total protein, albumin, AST, ALT, and the AST/ALT ratio were all measured. Results: The median age of COVID-19 patients was 36 years (CI, 25–51), 60 patients (60.0%) were male, 31 patients (31.0%) were obese, and 20 patients (20%) had comorbidities, such as hypertension (14%) and diabetes mellitus (6.0 %). Compared to the non-critical group, the mean values of ALT, AST, ALP, GT, LDH, TBIL, and DBIL were significantly higher in the severe group. On the other hand, total protein and albumin were significantly lower in the severe group than the non-severe group. Conclusion: In COVID-19, aberrant liver function, primarily AST increase, appears to be common. Therefore, direct viral hepatotoxicity during a systemic viral infection must be considered, as well as the possibility of sepsis or worsening of existing liver disease.

scholarly journals Assessment of Liver Function Tests in Children with Typhoid Fever: A Hospital Based Study

2019 ◽  
Vol 17 (2) ◽  
pp. 21-22
Author(s):  
Shakil Ahmad
Keyword(s):  
Liver Function ◽  
Typhoid Fever ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Medical College ◽  
Endemic Diseases ◽  
Function Tests ◽  
Function Test ◽  
Loss Of Appetite

Background: Typhoid fever is among the most endemic diseases in the tropics and which causes significant morbidity and mortality. It can lead to liver damage if not properly treated. Therefore, the liver function test assessment was conducted in children with typhoid fever. Our study aimed to evaluate the liver function test abnormalities in typhoid fever. Material and methods: This was a prospective observational study conducted at the department of paediatrics, Nepalgunj Medical College and Teaching hospital, Nepalgunj for a period of one year August 2018-July 2019.In the present study total 60 children of Typhoid fever were included on the basis of inclusion and exclusion criteria. On admission a detailed history and complete physical examination was carried out. Routine investigations were also carried out. The diagnosis was confirmed by serum Widal test. Liver function tests were performed i.e. Serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] estimation. Result: In the present study total children were 60 in which 43.33% were boys and 56.66% were girls. Fever was present in all the cases loss of appetite, cough, vomiting was present in majority of cases. On admission, SGOT and SGPT levels were found > 35 IU/L in 26 cases (43.33%) and 34 cases (56.66%) respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L. Conclusion: Our study concluded that on admission of children SGOT and SGPT levels were found > 35 IU/L in 43.33% and 56.66% respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L.

scholarly journals Chordoma in the Nasopharynx- Treated with Radiotherapy after Surgical Resection

2009 ◽  
Vol 22 (2) ◽  
pp. 295-297
Author(s):  
Dayem Uddin ◽  
AB MA Hannan ◽  
Saber Ali ◽  
S Kundu
Keyword(s):  
Renal Function ◽  
Liver Function ◽  
Surgical Resection ◽  
Liver Function Tests ◽  
Medical College Hospital ◽  
College Hospital ◽  
Medical College ◽  
Function Tests ◽  
Renal Function Tests

Chordoma is very rare bony tumour which arises from the notochordal remnants .Nine cases of Chordoma in the nasopharynx were identified in Rajshahi Medical College Hospital since January 1997 to December 2009. All the patients were non-diabetic and 2 of them were hypertensive. Their renal function tests and liver function tests were normal.TAJ 2009; 22(1): 295-297

CLINICOPATHOLOGICAL STUDY OF A CRITICAL EVALUATION ON LIVER FUNCTIONS IN POSTCHOLECYSTECTOMY CASES

2021 ◽  
pp. 4-6
Author(s):  
Anil Kumar ◽  
Nyemwang W Konyak ◽  
Debarshi Jana
Keyword(s):  
Liver Function ◽  
Gall Bladder ◽  
Critical Evaluation ◽  
Liver Function Tests ◽  
General Surgeon ◽  
Normal Range ◽  
Medical College ◽  
Asymptomatic Patients ◽  
The Uk ◽  
Almost All

Introduction: Gallstones [cholelithiasis] are the most common biliary pathology. It is estimated that gallstones affect 10-15% of the population in Western societies. They are asymptomatic in majority of cases (780). In the UK, the prevalence of gallstones at the time of death is estimated to be 17% and may be increasing. Approximately 1-2% of asymptomatic patients will develop symptoms requiring surgery per year, making cholecystectomy one of the most common operations performed by general surgeon. Aims and objectives: To investigate the clinico-pathological analysis of calculous cholecystitis in relation to liver function tests in all preoperative and post operative cases. Patients are required to undergo liver function test prior to and after their line of management in order to facilitate the investigation. Patients with cholelithiasis as the main cause must undergo a cholecystectomy either open or laparoscopic. Comparative evaluations of derangement of hepatic parameters in the preoperative period of patient undergoing different forms of gallbladder operations (conventional or laparoscopic cholecystectomy). Materials and methods: The study was conducted in a series of 60 cases of chronic calculus cholecystitis. Patients were selected from surgical outpatient Department of Darbhanga Medical College and Hospital. Laheriasarai. The tenure of study was from April 2019 to December 2020. Result: The above study also showed 82% increase in ALT level. In our study ALT was increased in 60 % patients (6% within normal range and 54% more than the normal range) at deation and 70% patients (4% within normal range and 66% more than the normal range) on the second postoperative day in LC. In MC and CC it was about 16-32% and 32-40% respectively during the same period. Conclusion: Ultrasonography was the mainstay in conrmatory diagnosis of gall bladder pathologies and the ndings correlated well with clinical ndings in almost all the cases. It not only revealed the evidence of gall stones in gall bladder with signs of acute or chronic cholecystitis but also other changes in the common bile duct, liver, pancreas and so on.

scholarly journals COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

2020 ◽  
pp. 8-9
Author(s):  
Shayista Gull
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Serum Total Protein ◽  
Function Tests ◽  
Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

scholarly journals Drug eruptions and hepatic involvement: a study

2018 ◽  
Vol 4 (4) ◽  
pp. 501
Author(s):  
Vimala Manne ◽  
Padmaja Pinjala
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Medical College ◽  
Hepatic Involvement ◽  
Function Tests ◽  
Drug Eruptions ◽  
Function Test ◽  
Drug Rash

<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p><p class="abstract"><strong>Methods:</strong> 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.</p><p class="abstract"><strong>Conclusions:</strong> To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.</p>

scholarly journals Effect of Chemotherapy on Liver Function During Induction of Remission in Children with Acute Lymphoblastic Leukemia Receiving Standard Protocol

2021 ◽  
Vol 29 (1) ◽  
pp. 33-37
Author(s):  
Meftahul Jannat ◽  
AKM Amirul Morshed ◽  
Sayeeda Anwer ◽  
Shahnoor Islam
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Liver Function ◽  
Serum Albumin ◽  
Lymphoblastic Leukemia ◽  
Liver Function Tests ◽  
Medical College Hospital ◽  
Standard Protocol ◽  
College Hospital ◽  
Medical College ◽  
Pediatric Hematology

Objective: The present study was undertaken to assess liver function (using markers like SGPT, serum bilirubin, prothrombin time, serum albumin) in children suffering from Acute Lymphoblastic Leukemia. Materials & Methods: This study was carried out in the Department of Pediatric Hematology & Oncology, Dhaka Medical College Hospital, Dhaka, over a period 12 months from the day of approval of the protocol. All acute lymphoblastic leukaemia children admitted in Pediatric Hematology & Oncology Department in Dhaka Medical College Hospital and receiving chemotherapy of standard protocol for induction of remission were the study population. A total of outcome variable was hepatotoxicity resulting from chemotherapy given for induction of remission. Result: The mean age of the children was 4.4 years (range 2- 8 years). Males were a bit higher in the series with male to female ratio being 11:9. Liver function tests before therapy revealed that none of the children exhibited raised serum billirubin and only 2(4.5%) children had increased SGPT. However, 50% of the children had raised prothrombin and 43.2% had reduced serum . albumin. Liver function tests after therapy after induction of remission shows that 9(20.5%) children exhibited raised serum billirubin, the proportion of children with raised prothrombin remained almost same as before but the status of serum billirubin improved to some extent. However, proportion of children with raised SGPT was increased to 25%. Comparison of liver function in children after therapy during induction of remission with that before induction did not show any significant difference, except that the serum SGPT was significantly raised during induction of remission (p < 0.001). Conclusion: The study concluded that the current therapy for induction of remission of ALL cases does not produce any toxic effect on liver. Although, enzymes like SGPT take a sharp rise during induction of remission, it is transient and does produce any deleterious effect on liver. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 33-37

scholarly journals Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

2018 ◽  
Vol 7 (12) ◽  
pp. 5102
Author(s):  
Rashid Lodhi ◽  
Navanil Roy
Keyword(s):  
Blood Pressure ◽  
Liver Function ◽  
Pregnant Women ◽  
Total Protein ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Mean Value ◽  
Function Tests ◽  
The Mean

Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema.  Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls,  it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.

scholarly journals Influence of Thyroid Disorders on Liver Function Tests in –Diyala Governorate

2021 ◽  
Vol 21 (1) ◽  
pp. 13-19
Author(s):  
Noor Ibrahem Jalil ◽  
◽  
Raya S Baban ◽  
Alaa A Mahmoud
Keyword(s):  
Liver Function ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Liver Function Tests ◽  
Thyroid Disorder ◽  
Mean Values ◽  
Function Tests ◽  
Healthy Control ◽  
Age Range

Background: Thyroid diseases may disturb liver function; liver disease modulates thyroid hormone metabolism, and a range of systemic diseases disturb both organs. There are clinical and laboratory relations between thyroid and liver diseases. Patients with chronic liver disease may have thyroiditis, hyperthyroidism, or hypothyroidism.aPatients with subacute thyroiditis or hyperthyroidism may have abnormalities in liver function tests, which return to normal as the thyroid disorder improves. Objective: The present study is designed to investigate the effects of thyroid disorders on liver function tests. Patients and Methods: In this study sixty patients were employed and categorized into two groups, thirty patients with hyperthyroidism (13 male and 17female) with age range of 25-45years, (mean 33.38) and thirty patients with hypothyroidism (11male and 19 female) with age range 25-45 years (mean 36.78),while 30 normal healthy individuals were chosen as a control group (15male and 15 female) in the same age range (mean 34.44) were taken for comparison. Blood samples were collected from the patients at Baqubah Teaching Hospital , between April 2020 to July 2020. Basic serum biochemical parameters including, thyroid stimulation hormone (TSH), triiodothyronine(T3) and thyroxin (T4)were assayed for patients and control groups by Cobas e 411 autoanalyzer within eight weeks. Serum normal values for alanine aminotransferase (ALT). ALT (Alanine Aminotransferase), Aspartate aminotransferase (AST), alkaline phosphatase test (ALP), direct bilirubin (DB) and total bilirubin( TSB) were assayed within four days by Cobas integra 400 plus autoanalyzer. Results: The mean value of ALT, AST, ALP,TSB, and DB in patients with hyperthyroidism, and hypothyroidism was significantly increased when compared with their mean values of healthy control (p <0.05).A significant difference was also found in mean values of T3,T4,TSH in hyperthyroidism and hypothyroidism when compared with their mean values of healthy control(p <0.05). Results of this work revealed a significant negative correlation of TSH with ALP and TSB (p<0.05). Further, T4 showed a significant positive correlation with ALP (P<0.05).The same results revealed that there was a significant positive correlation between T3 and ALP with (p<0.05).There was no significant correlations between ALT,AST,DB with TSH,T3,T4.Further,no significant correlations between TSB and T3,T4 (p >0.05). Conclusion: The current study shows that thyroid disorder might cause significant effect on the metabolism of hepatocytes reflected by an increase in biochemical parameters of liver function test AST, ALT ALP,TSB and DB in both hyperthyroidism and hypothyroidism subjects. Keywords: Thyroid diseases ,Alanine aminotransferase , hyperthyroidism, Tetraiodothyronin ,Thyroid stimulating hormone,hypothyroidism

scholarly journals Assessment of liver function test and associated factors among visceral leishmaniasis patients attending university of gondar leishmaniasis research and treatment center, Northwest Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260022
Author(s):  
Hiwot Tezera Endale ◽  
Tiget Ayelgn Mengstie ◽  
Dilargachew Dessie Dawit ◽  
Rezika Mohammed ◽  
Gashaw Dessie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Function ◽  
Total Protein ◽  
Total Bilirubin ◽  
Liver Function Tests ◽  
The Other ◽  
Treatment Center ◽  
Function Tests ◽  
Specialized Hospital ◽  
Associated Risk Factors

Background Visceral leishmaniasis (VL) is one of the major public health burden, mainly distributed throughout tropical and subtropical regions of the world. Among the Sub-Saharan African countries, Ethiopia is the second most affected country with VL. An Alteration of liver function is a typical manifestation of the disease. Objective The purpose of conducting this study was to assess liver function tests and associated risk factors among VL patients at Leishmaniasis Research and Treatment Center of University of Gondar Comprehensive Specialized Hospital, North West Ethiopia. Method Hospital based comparative cross-sectional study design was conducted. A total of 102 study participants were involved in this study. Newly diagnosed VL patients who were attended at Leishmaniasis Research and Treatment Center of University of Gondar Comprehensive Specialized Hospital from 21st February 2020 to 30th September 2020 were included under case group category. On the other hand, age-sex matched apparently healthy study subjects were categorized as control group. Written consent was obtained willingness of patients to participate after ethical clearance was obtained from the Institutional Review Board of School of Medicine, University of Gondar. After overnight fasting, 5ml venous blood was drawn from both VL patients and controls to evaluate liver function tests, including AST, ALT, total bilirubin, albumin, and total protein. Thus, senior health professionals (laboratory technologist) investigate the results using Cobas Integra 400 Plus clinical chemistry analyzer. Data was entered into Epi-data version 4.6 and exported to STATA 14 for analysis of liver function tests and associated risk factors. Result The result of this study showed that significant mean difference was exhibited in aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, serum albumin, and total protein level among VL patients and controls. It showed that there was a statistically significant elevation in the level of AST, ALT, and total bilirubin among cases as compared to control. The serum AST level was significantly (p<0.001) elevated among cases as compared to controls. Serum ALT was significantly (p<0.001) elevated among cases compared to controls. Additionally, the total serum bilirubin level was significantly increased (P<0.001) among cases as compared to controls. There was a statistically significant (P<0.001) reduction of serum albumin level among VL patients as compared to controls. Similarly, serum total protein was significantly (P<0.001) reduced in VL patients than control groups. Conclusion There were significantly higher mean levels of serum AST, ALT, and total bilirubin among VL patients as compared to controls. On the other hand, VL patients showed significantly lowered level of albumin and total protein as compared to controls.

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