scholarly journals Staphylococcal Colonisation of Intravenous Cannula and Antimicrobial Patterns of Isolated Staphylococcus Species

2014 ◽  
Vol 14 (2) ◽  
pp. 131-136
Author(s):  
R Mahto ◽  
J Amatya ◽  
R Amatya ◽  
D Adhikari
Keyword(s):  
Multidrug Resistant ◽  
Diffusion Method ◽  
Coagulase Negative Staphylococci ◽  
Intravenous Cannula ◽  
Antimicrobial Susceptibility Pattern ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
Antibiotic Susceptibility Test ◽  
Slide Test ◽  
Vancomycin Resistant

Cannula-related infections are amongst the most important nosocomial infections. Staphylococcus aureus and coagulase negative Staphylococci (CONS) are the most frequent causes of colonizing the intravenous cannula through which infection may occur. The aim of the study was to isolate the colonized staphylococci and to study the antimicrobial sensitivity pattern against them. Cultures of cannula tips were raised by semi-quantitative method. Antibiotic susceptibility test was performed by Kirby Bauer disc diffusion method as per The Clinical and Laboratory Standard Institute (CLSI) guidelines. Coagulase positive Staphylococcus was confirmed by coagulase slide test followed by tube test. CONS were distinguished by novobiocin sensitivity test. Out of 200 samples of cannula tips collected and processed, 45 (22.5%) isolates were S. aureus, 15 (7.5%) were S. epidermidis and 16 (8%) were other CONS. The highest occurance (30.7%) of S. aureus and the CONS (18.4%) was found in the nephrology ward and the surgical ward respectively. All the 76 isolates were tested for antimicrobial susceptibility pattern. Novobiocin was used to differentiate S. epidermidis from other CONS. All isolates were sensitive to ampicillin and ofloxacin. Out of total, 46.7% isolates of S. aureus and 12.9% isolates of CONS were multidrug resistant; 35.5% and 20 % isolates of S. aureus were oxacillin (methicillin) resistant and vancomycin resistant respectively. Four (12.9%) isolates of CONS [2(13.3%) of other CONS and 2(12.5%) of S. epidermidis] were oxacillin (methicillin) and vancomycin resistant. In our study, vancomycin resistant staphylococci were found and it was concluded that the precautions for inserting intravenous cannula is necessary as different kinds of pathogens may colonize such devices. DOI: http://dx.doi.org/10.3126/njst.v14i2.10426   Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 131-136

scholarly journals Antimicrobial Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media

2020 ◽  
Vol 22 (2) ◽  
pp. 90-95
Author(s):  
Salah Uddin Ahmmed ◽  
AKM Asaduzzaman ◽  
Basir Ahmed ◽  
Monsur Alam ◽  
Misbah AL Kabir ◽  
...  
Keyword(s):  
Otitis Media ◽  
Antimicrobial Susceptibility ◽  
Chronic Suppurative Otitis Media ◽  
Diffusion Method ◽  
Bacterial Isolates ◽  
Suppurative Otitis Media ◽  
Antimicrobial Susceptibility Pattern ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
High Level

Background: Chronic suppurative otitis media (CSOM) is one of the common diseases of the middle ear especially in developing countries. Early and effective treatment based on the knowledge of causative micro-organisms and their antimicrobial sensitivity pattern ensures prompt clinical recovery and possible complications may be avoided. Objectives: This study was done to determine the pattern of bacterial isolates and to detect their antibiogram. Methods: A total of 103 patients clinically diagnosed of CSOM were enrolled in the study and the samples were obtained from each patient using sterile cotton swabs and cultured for bacterial isolates. Antimicrobial susceptibility test of the isolates were performed using Kirby- Bauer disc diffusion method. Results: Among the cases females were more affected than males. Out of the 103 cases, bacteriological investigation revealed that Pseudomonas aeruginosa 42 (44.68%) and Staphylococcus aureus 31(32.97%) were the predominant bacteria. Ciprofloxacin and Ceftazidime revealed high level of sensitivity whereas high resistance rates were observed for Amoxycillin, Gentamicin and Cephalexin. Conclusion: The study concluded that an appropriate knowledge of the etiological agents and antibacterial susceptibility of microorganisms would contribute to a rational use of antibiotics, success of treatment and reduce the complications of CSOM. Bangladesh J Otorhinolaryngol; October 2016; 22(2): 90-95.

scholarly journals Molecular Typing and Antimicrobial Susceptibility of Methicillin-ResistantStaphylococcus aureusIsolated from Bovine Milk in Tanzania

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Jibril Mohammed ◽  
Michael Henry Ziwa ◽  
Yaovi Mahuton Gildas Hounmanou ◽  
Adela Kisanga ◽  
Huruma Nelwike Tuntufye
Keyword(s):  
Antimicrobial Susceptibility ◽  
Bovine Milk ◽  
Raw Milk ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Molecular Characteristics ◽  
Coagulase Negative Staphylococci ◽  
Methicillin Resistant ◽  
Local Markets ◽  
Antimicrobial Susceptibility Pattern

Methicillin-resistantStaphylococcus aureus(MRSA) in raw milk can be transmitted from animals to humans, and in Tanzania raw milk is sold in local markets and consumed as purchased. This study was performed to determine the molecular characteristics and antimicrobial susceptibility pattern of MRSA strains isolated from raw bovine milk sold at local markets in Tanzania. A total of 117 raw milk samples were cultured on Baird-Parker medium to isolateS. aureusand PCR was used for amplification ofgltBgene forS. aureusidentification and the presence ofmecAgene for methicillin-resistant strains. Coagulase-negative (CN)S. aureuswere reconfirmed using tube coagulase, DNase, and API Staph tests. MRSA isolates werespatyped whereas antimicrobial susceptibility testing was performed by the disc diffusion method. Forty-six coagulase positives (CP) and two CNS. aureuswere identified. Most strains were resistant to penicillin (72%), and 3 isolates: 2 CNS. aureusand 1 coagulase-negative Staphylococci (CNS), were phenotypically resistant to vancomycin, oxacillin, and cefoxitin and were confirmed to carrymecA.Resistance to clindamycin, trimethoprim-sulfamethoxazole, and tetracycline was 23.9%, 30.4%, and 41.3%, respectively. Twelve isolates exhibited multidrug resistance; however, only onemecApositive strain among the three was typeable and belonged tospatype t2603. This study reports for the first time the presence of CN variant of MRSA, which was assigned the spa type t2603, and the presence of multidrug resistantS. aureusisolates from bovine milk in Morogoro, Tanzania.

scholarly journals Vancomycin-resistant enterococci and coagulase-negative staphylococci prevalence among patients attending at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249823
Author(s):  
Degu Ashagrie ◽  
Chalachew Genet ◽  
Bayeh Abera
Keyword(s):  
Venous Blood ◽  
Multidrug Resistant ◽  
Vancomycin Resistance ◽  
World Health ◽  
Diffusion Method ◽  
P Value ◽  
Coagulase Negative Staphylococci ◽  
Vancomycin Resistant Enterococci ◽  
Specialized Hospital ◽  
Vancomycin Resistant

Background Vancomycin resistant enterococci (VRE) and vancomycin resistance coagulase negative staphylococci (VRCoNS) are common pathogens causing difficult to treat health care associated infections (HAI). Hence, the World Health Organization listed VRE as one of the high priority pathogens for new antibiotic discovery and antimicrobial resistance surveillance. Despite this, data on the prevalence of VRE and VRCoNS in Ethiopia is scarce. Thus, the present study determined prevalence of VRE and VRCoNS among patients attending Felege-Hiwot comprehensive specialized hospital, Ethiopia. Methods A hospital based cross-sectional study was conducted on 384 patients selected conveniently from February to March 2020. Data on demographic and clinical variables were collected using a structured questionnaire by face-to-face interview. Simultaneously urine, venous blood and wound swab were collected and processed following standard bacteriological technique. Antimicrobial susceptibility test was performed by minimum inhibitory concentration method using E-test for vancomycin and Kirby-Bauer disc diffusion method for other classes of antibiotics. Data was entered and analyzed using SPSS version 23. Logistic regression was performed to identify factors associated with VRE infection. P. value < 0.05 was considered as statistically significant. Results The prevalence of enterococci and CoNS were 6.8% and 12% respectively. The prevalence of VRE was 34.61% (9/26), while all CoNS (46 isolates) were susceptible to vancomycin. The majority (66.7%) of VRE was isolated from blood samples. Furthermore all VRE (100%), 58.8% of vancomycin susceptible enterococci and 45.7% of CoNS were multidrug resistant (MDR). Having educational level of secondary school and below (AOR = 12.80, CI = 1.149–142.5), previous exposure to catheterization (AOR = 56.0, CI = 4.331–724.0) and previous antibiotic use practice (AOR = 26.25, CI = 3.041–226.2) were a significant associated explanatory factor for VRE infection. Conclusions The prevalence of vancomycin resistance enterococci, which is also multidrug resistant, was significantly high. Though no vancomycin resistance CoNS detected, the MDR level of CoNS was high. Thus to limit enterococci and CoNS infections and MDR development, focused infection prevention measures should be implemented.

scholarly journals Evaluation of Pathogens Causing Urinary Tract Infection and Their Sensitivity Pattern

2022 ◽  
Vol 8 (1) ◽  
pp. 31-37
Author(s):  
Vijay Kumar ◽  
Swayambhu Shubham ◽  
Satyendra Narayan Singh
Keyword(s):  
Tract Infection ◽  
Antibiotic Sensitivity ◽  
Public Health Problem ◽  
Diffusion Method ◽  
Major Public Health Problem ◽  
Sensitivity Testing ◽  
Antimicrobial Susceptibility Pattern ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
Improper Use

Background: UTI constitute a major public health problem in India accounting 2nd most common infection next to respiratory tract infection. They are responsible for increasing treatment cost and significant morbidity.Aim:-To determine the incidence of UTI, evaluation of pathogens responsible and their antimicrobial susceptibility pattern in the population.Methods:Urine samples were collected from 300 patients attending the OPD Patna medical college, Patna during the period of 18 months (January 2017 to June 2018) Antimicrobial sensitivity testing was done for the bacterial isolates present in the sample by Kirby- Bauer disc diffusion method. Only those samples were taken into consideration which develops count equal to or greater than 1*105CFU/ml as indicated by Kass.Results:Out of 300 samples collected 146 (48.66%)) yielded bacterial growth. Out of 146 culture isolates E.Coli was the most common pathogen followed by klebsiella, CoNS and staphylococcus. Antibiotic sensitivity was performed on all the isolates. It was observed that highest sensitivity was 49.31% to amikacin, gentamycin (45.89%), nitrofurantoin (38.35%) meropenem (27.39%).Conclusions:It was observed that high grade of resistance to ampicillin, cotrimoxazole, ciprofloxacin, cefuroxime, chloramphenicol, cefotaxime, cefazolin, amoxicillin + clavulanic acid and gentamycin is present as a result of misuse or improper use of antibiotic in the community. Hence urine culture is necessary for the diagnostic screening of UTI before the treatment.

scholarly journals A Detailed Study of Antimicrobial Sensitivity Pattern of Penton Valentine Leucocidin Gene Positive and Negative Staphylococcus aureus from Pus Samples

2020 ◽  
Vol 34 (3) ◽  
pp. 24-28
Author(s):  
Mateen Izhar
Keyword(s):  
Staphylococcus Aureus ◽  
Tertiary Care ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Care Hospital ◽  
Sensitivity Testing ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
One Year ◽  
Biology Laboratory

Introduction: Staphylococcus aureus harboring Panton Valentine Leucocidin gene are emerging and spreading worldwide. PVL gene was first identified by Noel Panton and Francis Valentine in 1932 who IC Pakistan only limited data is available regarding the effect of PVL gene on sensitivity pattern of Staphylococcus aureus. Therefore, this study was conducted to understand the antimicrobial sensitivity pattern of both PVL positive and negative Staphylococcus aureus isolates. Aims & Objectives: This study was conducted to understand the antimicrobial sensitivity pattern of both PVL positive and PVL negative Staphylococcus aureus isolated from pus samples received from various indoor and outdoor departments of a tertiary care hospital of Lahore. Place and duration of study: Microbiology and Molecular Biology Laboratory Shaikh Zayed Hospital Lahore. Duration of study is one year after the approval of research topic. Material & Methods: A total of 384 Staphylococcus aureus isolates from skin and soft tissue infections were identified and selected. Their antimicrobial sensitivity testing was done by Kirby disc diffusion method using Muller Hinton agar. Results: Frequencies of PVL gene in MRSA and MSSA were 51% and 44% respectively. Frequency of PVL gene was also found to be high in Ciprofloxacin sensitive, Gentamicin sensitive, Erythromycin resistant and fusidic acid resistant isolates. Conclusion: Almost half of Staphylococcus aureus isolates were found PVL positive. They were mostly multidrug resistant. The PVL positive Staphylococcus aureus isolates showed high resistance against antibiotics than PVL negative isolates

scholarly journals Antibiotic sensitivity Pattern of Salmonella Species I1o-laJed by Btood culture in BangabandhuSheikhMujibMedicalUniversity

2016 ◽  
Vol 2 (2) ◽  
pp. 22-26
Author(s):  
Ahmed Abu Saleh ◽  
Naser Ibne Sattar ◽  
Sharmeen Ahmed ◽  
Md. Ruhul Amin Miah
Keyword(s):  
Typhoid Fever ◽  
Brain Heart Infusion ◽  
Antibiotic Sensitivity ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern ◽  
Antibiotic Susceptibility Test ◽  
Microbiological Techniques

Typhoid fever occurs in all parts of the world where water supplies and sanitation are sub-standard. Despite the availability of newer antibiotics, emerging antimicrobial resistance has become an increasing problem in the management of Typhoid fever cases. The aim of this study was to determine the antibiotic sensitivity pattern of Salmonella species isolated by blood culture. This was a retrospective study considering the period of January to December 2007  at Bangahandhu Sheikh Mujib Medical University, Shahbag, Dhaka. Blood samples for culture were collected by venepuncture, immediately inoculated into Brain Heart infusion broth and incubated at 370 C. After 24 hours incubation, subcultures were done twice on Blood agar and MacConkey’s agar plates. Any growth on the sulrcultured plates were identified by standard microbiological techniques. All of the isolates were then subjected to antibiotic susceptibility test performed by disk diffusion method. A total 2424 specimens of blood collected from patients suspecting of fever, were cultured, out of which 218 (8.99%) were found positive for Salmonella species. In vitro sensitivity test showed that cefixime was highly sensitive (99.41%) followed by  ceftriaxote (97.03%), Azithromycin (83.58%), Ciprofloxacin (67.47%), cefuroxime (73.3%), chloramphenicol (72.62%), co-trimoxazole (69.59%), Amoxicillin (64.33%) and Nalidixic acid (19.26%).  The results call for nationwide surveillance programme to monitor microbial trends and antimicrobial susceptibility pattern of salmonella species in Bangladesh.Bangladesh J Med Microbiol 2008; 02 (02):22-26

scholarly journals Antimicrobial drug sensitivity pattern of Pseudomonas aeruginosa in respiratory infections

2017 ◽  
Vol 6 (7) ◽  
pp. 1591
Author(s):  
Syed S. Ameen ◽  
Shanmukananda Prakash ◽  
Laxminarayana Bairy K. ◽  
Shahabuddin Soherwardi
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Respiratory Infections ◽  
Tertiary Care ◽  
Empirical Therapy ◽  
Multidrug Resistant ◽  
Resistance Rate ◽  
Mortality And Morbidity ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern ◽  
Male Preponderance

Background: Pseudomonas aeruginosa, a gram-negative pathogen commonly associated with nosocomial infections is the most widespread multidrug-resistant pathogen causing pneumonia in hospitalized patients. Inadequate empirical therapy has been associated with high mortality and morbidity. Objective: To evaluate and analyze the antimicrobial susceptibility pattern of P. aeruginosa in respiratory infections in a tertiary care hospital.Methods: The study was carried out at Kasturba Hospital, Manipal from Jan 2011 to Dec 2011. Specimens of 63 in-patients were analyzed who were culture positive for P. aeruginosa.Results: Majority of patients were aged above 40yrs with a male preponderance. Specimens were taken from patients who were diagnosed with bronchiectasis, pneumonia, COPD, bronchial asthma etc. Overall the organism was most sensitive to carbapenems (87.3%) followed by cefoperazone-sulbactam combination (85.7%). Sensitivity to ceftazidime and cefepime was equal (82.5%) and was more when compared to piperacillin-tazobactam (81.5%). Overall resistance rate was highest for fluoroquinolones (23.8%) followed by aztreonam (22.2%).Conclusions: Hence we would like to recommend cefoperazone-sulbactam as the preferred antipseudomonal agent and carbapenems as reserved drugs in treating pseudomonal lung infections. Use of fluoroquinolones and aztreonam as monotherapy in resistant P. aeruginosa infections should be restricted.

scholarly journals Susceptibility Pattern of Pathogens Causing Blood Stream Infections in a Tertiary Care Hospital: A Two-year Retrospective Study from Southern Nigeria

2021 ◽  
pp. 53-60
Author(s):  
Bassey Ewa Ekeng ◽  
Ubleni Ettah Emanghe ◽  
Bernard Ekpan Monjol ◽  
Anthony Achizie Iwuafor ◽  
Ernest Afu Ochang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Blood Culture ◽  
Blood Stream ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Blood Stream Infections ◽  
Gram Negative ◽  
Antimicrobial Sensitivity ◽  
Culture Positive

Aim: Bloodstream infections are a major cause of morbidity and mortality worldwide. The prevalence of causative microorganisms varies from one geographical region to another. This study was aimed at determining the etiological agents prevalent in our environment and their susceptibility profile. Study design: This is a retrospective study carried out at the University of Calabar Teaching Hospital, Calabar, Nigeria. Methodology: Blood culture results of patients documented over a two-year period were retrieved and analyzed. Blood culture positive isolates were detected using conventional method and Oxoid signal blood culture systems. Antimicrobial sensitivity tests were carried out by Kirby-Bauer disc diffusion method. Methicillin resistance in Staphylococcus aureus and coagulase negative Staphylococcus species (CoNS) was detected by disk diffusion method using 30 µg cefoxitin disk. ESBL production was detected by phenotypic confirmatory disc diffusion test (PCDDT) and the double disc synergy test (DDST). Results: A total of 413 blood culture antimicrobial susceptibility test results were analyzed, of which 116 (28.09%) were identified as culture positive. Sixty-nine (59%) of the positive isolates were from female patients. Out of 116 positive cultures, 58.62% (68/116) were Gram positive organisms, 40.52% (47/116) were Gram negative organisms, non albicans Candida accounted for 0.86% (1/116).  Staphylococcus aureus (n=41, 35.3%) was the predominant isolate and showed high sensitivity to levofloxacin (100%), Linezolid (100%) and Amikacin (100%). Twelve isolates of S. aureus were methicillin resistant, while 1 isolate was inducible clindamycin resistant. Of the 116 isolates identified in this study, forty-three (43) were multidrug resistant with highest number of multidrug resistant isolates from Staphylococcus aureus (n=20). 21.28% (n=10) of the Gram-negative isolates were positive for extended spectrum beta lactamases. Conclusion: A high rate of antimicrobial resistance is observed among microorganisms causing blood stream infections. This emphasizes the need for antimicrobial sensitivity testing in the management of blood stream infections.

scholarly journals Antimicrobial Sensitivity Pattern of Microorganisms Isolated from Vaginal Infections at a Tertiary Hospital in Bangalore, India

2015 ◽  
Vol 3 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Nagalakshmi Narayana-Swamy ◽  
Padmasri Ramalingappa ◽  
Urvashi Bhatara
Keyword(s):  
Low Frequency ◽  
Antibiotic Sensitivity ◽  
Tertiary Hospital ◽  
Vaginal Swab ◽  
Diffusion Method ◽  
Sensitivity Testing ◽  
Vaginal Infections ◽  
Treatment Protocols ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern

Background: The vagina contains dozens of microbiological species in variable quantities and is, therefore, considered a complex environment. Among the microorganisms, bacteria have important repercussions on women’s health. The present study was conducted to elucidate this type of vaginal isolates and their sensitivity towards currently used antibiotics. Methods: This was a retrospective study conducted at the Department of Obstetrics and Gynaecology, Sapthagiri Hospital, Bangalore, India from January 2012 to December 2013. All symptomatic women who had a high vaginal swab taken for culture and sensitivity testing were included in this study. Antibiotic susceptibility was tested using disc diffusion method (modified Kirby-Bauer’s method). The antibiotic sensitivity patterns of isolated microorganisms were studied. Results: Out of 200 patients, 95% had positive vaginal cultures. Fifteen types of microorganisms were isolated. The highest frequency of infection was seen at the age of 20-30 years, followed by 41-50 years and 31-40 years, and a low frequency of infection was observed above 50 years of age. The most prevalent pathogen was Escherichia coli, followed by Streptococcus agalactiae and diphtheroids with equal incidence. Among the antibiotics tested, isolated pathogens were completely resistant to nalidixic acid and highly sensitive to meropenem and imepenem. Conclusion: The high prevalence of gynaecological infections demands that patients with symptoms undergo thorough investigation with cultures and sensitivity essays. Changes in treatment protocols are required to treat vaginal infections effectively.

scholarly journals 2267. Epidemiology of Candida auris Candidemia in a Teaching Hospital in North of Oman: One-Year Survival

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S776-S776
Author(s):  
Arash Eatemadi ◽  
Aiman Al Wahibi ◽  
Hilal Al shibli ◽  
Ali Al reesi
Keyword(s):  
Public Health ◽  
Teaching Hospital ◽  
Multidrug Resistant ◽  
Hospital Environment ◽  
Fungal Treatment ◽  
Candida Auris ◽  
Coagulase Negative Staphylococci ◽  
Central Public Health ◽  
Antibiotic Susceptibility Test ◽  
Recent Emergence

Abstract Background Recent emergence of Candida auris as a multidrug resistant fungal pathogen, is a serious concerns for public health. However, there is a paucity of reported cases from Oman. Literature search resulted in finding only 7 cases from Oman, reporting C. auris infections in the articles first published in 2017. However, the rate of isolatin is increasing. Methods In this study, we included the results of all positive blood cultures of C. auris in Suhar teaching hospital from May 2018 (date of first detection) till end of April 2019. Further confirmation of the species was performed by MALDI-TOF and antibiotic susceptibility test (AST) by Vitek 2 in central public health laboratory (CPHL) of Oman. Results We detected 13 patients (9 females, 4 males). The mean age was 58.61% years (28–76 years). All candidemic patients had serious underlying conditions, including prolonged hospital stay or extensive and prolonged antimicrobial exposure or medical comorbidities (8 of 13). The time from hospital admission to onset of C. auris candidemia was 8–49 days, with a median of approximately 27 days. The most common isolated co- pathogen from blood culture was K. pneumonia (without regard to Coagulase-negative staphylococci). As average, every patient received 4.8 kind of different antibiotics in mean 88 doses before candidemia developed and piperacillin–tazobactam was the most common used antibiotics. AST was done just for 5 patients and revealed high-level resistance to fluconazole and Amphotricin B while, Echinocandins (anidulafungin, caspofungin) were fully sensitive and voricunazole had intermediate sensitivity. Mean duration of anti-fungal treatment was 12.5 days (5 – 26 days). 8 patients treated by Echinocandins (4/8 died), 4 by Fluconazole (3/4 died) and one without treatment discharged. 30-day all-cause mortality was 61.5%. Conclusion In Oman, C. auris has been reported from many hospitals. Resistance to several antifungal agents and persistence in the hospital environment make this organism a potential menace for the treating physician and the infection control personnel. In our hospital, every candidemic patient should be treated with Echinocandins and assumed to be resistant to Fluconazole until proven otherwise according to results of AST. Disclosures All authors: No reported disclosures.

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