Atopic dermatitis in children and adolescents with obesity and overweight: clinical, anthropometric data, psycho-emotional status and predictors of effective treatment

The results of a comprehensive analysis of clinical, anthropometric data and an assessment of the psycho-emotional status of 62 children and adolescents (mean age 11.8 ± 3.0 years) with atopic dermatitis and overweight or varying degrees of obesity (the main group) are presented. The control group included 60 patients (mean age 10.1 ± 3.6 years) with atopic dermatitis and body weight corresponding to age and gender standards. In the main group, 45.2% were children and adolescents with overweight, and with first-, second- and third-degree obesity were 25.8, 11.3 and 17.7% respectively. The severe course of dermatosis in the main group was recorded 1.4 times more often than in the control group. With the aid of univariate analysis of the treatment efficacy predictors, it was revealed that weight loss and improvement in psycho-emotional state can significantly increase the treatment efficacy of atopic dermatitis in children and adolescents with overweight and obesity, which indicates the advisability of interaction between a dermatologist, endocrinologist and psychotherapist in the treatment of this category of patients.

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Prevalence and temporal trends of overweight and obesity among children and adolescents in Jilin, Northeast China, 2011-2015

10.7287/peerj.preprints.3207 ◽

2017 ◽

Author(s):

Yan Li ◽

Zhijun Li ◽

Qing Sun ◽

Mengying Wang ◽

Meng Jiang ◽

...

Keyword(s):

Children And Adolescents ◽

Northeast China ◽

National Level ◽

Temporal Trends ◽

Developed Countries ◽

Overweight And Obesity ◽

Age Group ◽

Obesity Prevalence ◽

Obesity Epidemic ◽

And Gender

Objective: In China, the obesity epidemic is truly national and childhood obesity prevalence has rapidly increased and is close to the developed countries. This study aimed to estimate the prevalence and temporal trends of overweight and obesity among children and adolescents in Jilin City, China (2011-2015). Methods: The data derived from the census on students’ constitution and health in 2011-2015 carried out by the Jilin CDC, Jilin City. 191191 children and adolescents aged 7-18 years were included in the present survey, of which 37549 in 2011 to 41564 in the 2015. The newly developed age- and gender-specific BMI cutoffs by the working group on obesity in China were used to define overweight and obesity in children and adolescents. Results: The mean of BMI (body mass index) was significantly increasing from 20.9 kg/m2 in 2011 to 21.5 kg/m2 in 2015 in all subjects. Overweight and Obesity prevalence of total students aged 7-18 years had a significantly increasing from 2012 to 2015 (P<0.001), from 16.0% and 13.1% to 17.1% and 17.1%. The minimum value of BMI and overweight and obesity prevalence in overall age group all presented in 2012. Boys and girls all showed the significant increase in overweight and obesity prevalence in every age group from 2012 to 2015 and boys higher than girls (P<0.001). Regardless of girls and boys, the most likely of children and adolescents being overweight and obesity had been observed in the youngest age and lowest school grade category. Conclusion: In summary, our results indicate that all the overweight and obesity prevalence among children and adolescents over the past 5 years were higher than the 2010 Chinese National Level and Chinese large coastal cities’ level and a significantly increase from 2011-2015. Obesity epidemic is serious, at least not optimistic among children and adolescents in Jilin, Northeast China.

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PLASMA CONCENTRATION OF ENDOTHELIN-1 IN PATIENTS WITH HYPERTENSION ASSOCIATED WITH OBESITY, DEPENDING ON THE LYS198ASN POLYMORPHISM OF THE ENDOTHELIN-1 GENE

Eastern Ukrainian Medical Journal ◽

10.21272/eumj.2021;9(1):87-94 ◽

2021 ◽

Vol 9 (1) ◽

pp. 87-94

Author(s):

Yu.O. Smiianova

Keyword(s):

Body Weight ◽

Heart Rhythm ◽

Pathological Process ◽

Main Group ◽

Overweight And Obesity ◽

Control Group ◽

Endothelin 1 ◽

Normal Body ◽

Heart Rhythm Disorders ◽

Normal Body Weight

Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process. Endothelium is drawn into the pathological process at the earliest stages of AH development. ЕТ-1 is currently considered as a marker and predictor of the stage and consequences of AH, chronic heart failure (CHF), coronary heart disease (CHD), in particularly, acute myocardial infarction (MI), heart rhythm disorders, pulmonary hypertension, atherosclerotic vascular injury, target vascular disorders. One factor that may influence the level of ЕТ-1 is the endothelin-1 gene Lys198Asn polymorphism, which is considered by many researchers as a possible genetic marker of AH. However, the effect of this polymorphism on the level of plasma ЕТ-1 level in patients with AH of varying severity in Ukraine is understudied. The basis of this work were the materials of a complete examination of 160 patients with a verified diagnosis of AH I, stage II of 1, 2, 3 degrees (main group) and 110 apparently healthy persons (control group). Patients of the main group were divided into three subgroups: 1st group – 75 patients with normal body weight; 2nd group – 48 overweight patients; 3rd group – 37 patients with alimentary obesity. In obese patients, the waist circumference in women was around 103 (96–115) cm, and in men – 108 (105–116) cm, which indicates an abdominal type of obesity in these patients. As a result of the study, it was found that the level of ЕТ-1 is higher in patients with AH who suffer with overweight and obesity as compared with patients with AH and normal body weight. Also, the peptide level depends on the genotype of patients and is higher in AH patients with the genotype Asn198Asn and Lys198Asn as compared to carriers of the genotype Lys198Lys.

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Disease Severity Is Associated with Alexithymia in Patients with Atopic Dermatitis

Dermatology ◽

10.1159/000507246 ◽

2020 ◽

Vol 236 (4) ◽

pp. 329-335

Author(s):

Andrea Chiricozzi ◽

Maria Esposito ◽

Paolo Gisondi ◽

Mario Valenti ◽

Niccolò Gori ◽

...

Keyword(s):

Atopic Dermatitis ◽

Logistic Regression ◽

Disease Severity ◽

Healthy Subjects ◽

Sleep Disturbances ◽

Rating Scale ◽

Univariate Analysis ◽

Control Group ◽

Predicting Factor ◽

Tas 20

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction. Objectives: This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healthy subjects. Methods: This cross-sectional study assessed AD severity by the Eczema Area and Severity Index (EASI) score, sleeplessness and itch by a numeric rating scale (NRS), and alexithymia by the 20-item Toronto Alexithymia Scale (TAS-20) score. The association between disease characteristics and alexithymia was evaluated through several logistic regression models. Results: 202 AD patients and 240 healthy subjects were included in this study. The alexithymic personality trait (TAS-20 ≥51) was more frequently observed among AD patients compared to the control group (62.4% [126/202] vs. 29.2% [70/240], p < 0.0001). In particular, alexithymia (TAS-20 score ≥61) was detected in a significantly higher number of AD patients than in the controls (27.7% [56/202] vs. 7.5% [18/240]; p < 0.0001), whereas borderline alexithymia was detected in 34.6% (70/202) of AD patients compared to 21.7% of healthy controls. Alexithymia was more common among severe AD patients (43.6%) compared to mild AD patients (15.6%) and correlated with itch intensity and sleep disturbances. Among clinical variables, ordered logistic regression analyses revealed disease severity as predictor of alexithymia. Indeed, univariate analysis showed EASI score, sleep NRS, and itch NRS being significantly associated with alexithymia, while a multivariate model identified increased EASI score values as predicting factor. Conclusion:This study described alexithymia in AD patients correlating its occurrence with clinical AD severity markers (EASI score, itch, and sleeplessness) and identifying the increase in EASI score as predicting factor.

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PRIORITY RECOMMENDATIONS FOR SOLVING THE PROBLEM OF CHILDREN OBESITY BASED ON THE RESULTS OF THE RESEARCH

Wiadomości Lekarskie ◽

10.36740/wlek202105109 ◽

2021 ◽

Vol 74 (5) ◽

pp. 1099-1103

Author(s):

Viktor A. Ohniev ◽

Kateryna H. Pomohaibo ◽

Mihail I. Kovtun

Keyword(s):

Risk Factors ◽

Medical Care ◽

Children And Adolescents ◽

Overweight And Obesity ◽

Control Group ◽

Obese Children ◽

Primary Medical Care ◽

Children Obesity ◽

History Of ◽

And Control

The aim: Of the work was to study and evaluate the risk factors and the level of primary medical care for children with overweight and obesity. Materials and methods: A sociological survey was conducted in main (413 persons) and control group (396 persons) and the copying from the history of the child’s development (f.112/a) of 280 obese children was conducted. Results: It was defined that on the development of excess weight in children and adolescents, biological and social and hygienic factors had a significant impact (η ≥ 3%; p<0,001) and that the level of primary medical care for obese children (proved diagnosis of obesity in the history of the child (f. №.112/а) had only 61,7±2,7% of patients) was insufficient. Conclusions: Identification of comprehensive priority activities for solving problem of children overweight and obesity based on the results of conducted research were done.

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Associations of SNP rs_7927894 of FLG gene and TARC/CCL17 with atopic dermatitis in children

Modern pediatrics. Ukraine ◽

10.15574/sp.2021.118.12 ◽

2021 ◽

pp. 12-18

Author(s):

V.O. Dityatkovsky ◽

◽

O.E. Abaturov ◽

N.V. Naumenko ◽

O.O. Alifirenko ◽

...

Keyword(s):

Atopic Dermatitis ◽

Statistical Significance ◽

Venous Blood ◽

Clinical Signs ◽

Main Group ◽

Control Group ◽

Serum Concentrations ◽

Control Groups ◽

And Control ◽

Severity Degree

One of the main genetic factors of the development of atopic dermatitis (AD) in children are single nucleotide polymorphisms (SNP) of the filagrin gene (FLG), particularly rs_7927894 FLG. One of the mostly studied and promising AD marker chemokines (CK) is the thymusE and activation regulated chemokine (TARC/CCL17). Purpose – to detect the associations and role of different variants of SNP rs_7927894 FLG gene and TARC/CCL17 in children suffering different AD clinical proE files (CP) – isolated or combined with comorbid atopic disorders (AtD). Materials and methods. The main group comprised 39 patients aged 3 to 18 years, suffering the isolated AD or combined with comorbid AtD. The control group comprised 47 patients aged 3 to 18 years, suffering the pathology of gastrointestinal tract without clinical signs of atopy. All the patients of the main and control groups had undergone detection of the genotype variants of SNP rs_7927894 FLG gene by real-time polymerase chain reaction and detection of TARC/CCL17 serum concentrations in venous blood. The cutEoff value of statistical significance was set as p<0.05. Results. The incidence and association of genotype variants C/C, C/T and T/T SNP rs_7927894 FLG gene in patients of cohorts of the studied groups were detected as follows: C/T rs_7927894 FLG was significantly the most common in the general main group (56.4%, p<0.05), within the cohort of CP AD isolated (61.1%, p<0.05) and CP of AD combined with comorbid AtD (52.4%, p<0.05). There were detected the associations of studied SNP with AD: C/T rs_7927894 FLG is significantly directly associated with AD (r=0.291, p<0.05), C/C rs_7927894 FLG has a reverse association with a trend to significance (r=-0.194, p=0.07). Mean serum concentrations of TARC/CCL17 did not differ significantly among patients cohorts of the main and control groups, respectively: general main group — 615.8 pg/ml, main with a CP AD isolated — 651.3 pg/ml, main with a CP of AD combined with comorbid AtD — 585.4 pg/ml, control — 608.4 pg/ml (p>0.05). Associations of serum TARC/CCL17 concentrations were determined as follows: elevation trending to significance within increasing AD severity degree (r=0.290, p=0.07) and significant elevation within the AD exhacerbation period (r=0.426, p<0.05). No significant association of TARC/CCL17 as to AD patients compared to the control group was detected in our study (r=-0.027, p>0.05). Conclusions. The genotype heterozygote variant C/T rs_7927894 FLG is significantly the most common and associated with all AD CP in children — isolated and combined with comorbid AtD. Variant C/C rs_7927894 of FLG gene is significantly reversely associated with AD in children. Serum concentrations of TARC/CCL17 did not reveal any significant differences between the AD patients and nonEatopic ones. However, they significantly elevate within AD exacerbation phase and trending to significance within AD severity degree increase in children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: atopic dermatitis, children, associations, polymorphism, filaggrin, thymus- and activation regulated chemokine.

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The effects of overweight and obesity on oral health status in children and adolescents

New Medicine ◽

10.25121/newmed.2019.23.3.86 ◽

2019 ◽

Vol 23 (3) ◽

Author(s):

Katarzyna Deszczyńska ◽

Paweł Piątkiewicz ◽

Renata Górska

Keyword(s):

Risk Factors ◽

Body Weight ◽

Oral Cavity ◽

Children And Adolescents ◽

Oral Hygiene ◽

Overweight And Obesity ◽

Control Group ◽

Study Group ◽

Obese Children ◽

Periodontal Health

Introduction. Improper eating habits among children and adolescents often lead to overweight and obesity. Research indicates that these are risk factors for many diseases, including diseases in the oral cavity. Aim. To analyse the correlations of selected parameters of dental and periodontal health as well as oral hygiene status in overweight and obese children and adolescents versus control group. Material and methods. The study included 120 patients aged 11-18 years, who were classified into a study group with 60 overweight/obese individuals and a control group of 60 individuals with normal body weight based on BMI (Body Mass Index). Each patient underwent anthropometric measurements, such as height (cm), body weight (kg), which were used to calculate BMI. Additional measurements were taken of waist circumference (WC) and hip circumference (HC), to obtain the waist-hip ratio (WHR). Clinical examination of the oral cavity included an assessment of dentition (DMF), oral hygiene API (Approximal Plaque Index) and periodontal tissue (PD ? Pocket Depth, CAL ? Clinical Attachment Level, %BOP ? % Bleeding On Probing) and CPITN (The Community Periodontal Index for Treatment Needs). Results. Statistically significant differences were found between patient groups with BMI ≥ 25 and BMI < 25 in the values of the following parameters: DMF p = 0.005, API p < 0.001, %BOP p < 0.001, PD p < 0.001, CPI p < 0.001. Conclusions. Overweight and obese children were found to have worse parameters of dental and periodontal health as well as oral hygiene status compared to the group with normal weight. Our observations indicate that overweight and obesity may be potential risk factors for periodontal diseases in the study group.

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Cardiac implantable electronic devices: a marker for poor outcome in patients with COVID-19 infection

European Heart Journal ◽

10.1093/eurheartj/ehab724.0398 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

B Wizman ◽

M Haim ◽

N Yasoor ◽

I Peles ◽

V Novack ◽

...

Keyword(s):

Heart Failure ◽

Medical Center ◽

Electronic Devices ◽

Univariate Analysis ◽

Control Group ◽

Age And Gender ◽

Poor Outcome ◽

Cardiac Implantable Electronic Devices ◽

Cardiac Devices ◽

And Gender

Abstract Background A high percentage of SARS-CoV-2 patients suffer from comorbidities and there is increasing evidence that previous cardiac disease contributes to poor outcome in these patients (1,2). There is a paucity of information regarding the implications of the disease in patients with cardiac implantable electronic devices (CIEDs). Due to the increasing use of CIEDs in the management of arrhythmias and heart failure, determining the association between CIEDs and the severity of this disease is essential. Aim To obtain an adequate understanding regarding the association between cardiac devices and severity of COVID-19 infection in order to achieve optimum management of these patients. Methods All clinical and demographic parameters were collected retrospectively from a cohort of patients who underwent implantation of CIED in our Medical Center, Israel. We included 42 patients who tested positive for SARS-CoV-2, between January and December of 2020. Propensity score matching based on age and gender and adjusted Kaplan Meier curve of mortality were performed in order to evaluate the clinical outcome of patients with CIEDs and SARS- CoV-2 infection in comparison to the control group. Results The mean age of patients was 72.9 years, compose of 50% male and 50% female in both groups. In the group of patients with CIEDs, 11 (26.1%) patients had implantable defibrillator, and 31 (73.8%) had pacemaker. Univariate analysis revealed that patients with CIEDs suffered more from heart failure, coronary artery disease and atrial fibrillation, as well as hypertension, diabetes, and chronic kidney disease. Four patients (9.5%) with cardiac devices were hospitalized in the ICU due to critical illness, as compared to 1 (0.6%) patient in the control group (p=0.005). Moreover, 10 patients in the cardiac devices group (23.8%) died of SARS-CoV-2 infection, versus 25 (14.9%) in the control group. Conclusions CIEDs are a marker of poor outcome in patients with SARS-CoV-2 infection. Patients with CIEDs suffer from increased comorbidities in comparison with age and gender matched population and therefore should be managed with the utmost caution. FUNDunding Acknowledgement Type of funding sources: None. KM curve of all-cause mortality

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The Relationship between Physical Activity and Screen Time with the Risk of Hypertension in Children and Adolescents with Intellectual Disability

BioMed Research International ◽

10.1155/2017/1940602 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Justyna Wyszyńska ◽

Justyna Podgórska-Bednarz ◽

Katarzyna Dereń ◽

Artur Mazur

Keyword(s):

Physical Activity ◽

Intellectual Disability ◽

Children And Adolescents ◽

Screen Time ◽

Control Group ◽

Study Group ◽

Group Score ◽

And Gender ◽

The Relationship ◽

Hypertension In Children

Introduction. Children and adolescents with intellectual disability (ID) have significantly lower levels of physical activity compared to their peers without ID. Association between the level of physical activity and screen time with hypertension (HPT) in children and adolescents with ID has not been reported yet. Aim. To assess the relationship between the level of physical activity and screen time with the prevalence of HPT in students with ID. Material and Methods. The study group consisted of 568 children with ID aged 7 to 18. The control group matched for age and gender consisted of 568 students without ID. Blood pressure (BP), body mass and height, level of physical activity, and screen time were assessed. Results. The level of physical activity in the study group was significantly lower than in the control group (score 1.99 versus 3.02, resp., in Physical Activity Questionnaire). The risk of HPT in the students with ID with low levels of physical activity was more than 4 times higher (OR = 4.40) and more than 2 times higher when screen time was ≥2 h/day. Conclusion. Low level of physical activity and long screen time were associated with significantly higher HPT risk among children and adolescents with ID.

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Impact of a School-Based Intervention Protocol—ACORDA Project—On Adipokines in an Overweight and Obese Pediatric Population

Pediatric Exercise Science ◽

10.1123/pes.2015-0261 ◽

2016 ◽

Vol 28 (3) ◽

pp. 407-416 ◽

Cited By ~ 12

Author(s):

Henrique Nascimento ◽

Ana Inês Alves ◽

Ana Filipa Medeiros ◽

Susana Coimbra ◽

Cristina Catarino ◽

...

Keyword(s):

Children And Adolescents ◽

Body Fat ◽

Plasma Lipids ◽

Pediatric Population ◽

Substantial Reduction ◽

Overweight And Obesity ◽

Tnf Alpha ◽

Control Group ◽

Obese Children ◽

Intervention Protocol

Purpose:There are few reliable studies assessing the effect of physical exercise (PE) on adipokines levels at young ages. Our objective was to study the effects of regular PE on plasma adipokines in pediatric overweight and obesity.Method:117 overweight and obese children and adolescents (47% females; 10.2 years) participated in an 8-month longitudinal study divided in two groups: PE group (n = 80), engaged in an after-school PE program; control group (n = 37), with no PE program. Plasma lipids, C-reactive protein (CRP), adiponectin, resistin, leptin, IL-6, IL-1beta, TNF-alpha, insulin and glucose levels were determined.Results:contrarily to the control group, the PE group presented reductions in body mass index z-score (BMIzsc) and body fat percentage that were accompanied by an improvement in lipid profile and insulin resistance, a reduction in CRP and TNF-alpha and an increase in adiponectin levels. The reductions in BMIzsc were inversely correlated with changes in adiponectin (r=−0.329, p = .003) and positively correlated with changes in percentage body fat (r = .262, p = .032), triglycerides (r = .228, p = .042) and leptin (r = .285, p = .010).Conclusion:Moderate reductions in adiposity improve proinflammatory status in obese children and adolescents. A more substantial reduction in BMIzsc was associated with a greater increment in adiponectin and reduction in leptin.

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Food marketing and gender among children and adolescents: a scoping review

Nutrition Journal ◽

10.1186/s12937-021-00706-4 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Luciana Castronuovo ◽

Leila Guarnieri ◽

María Victoria Tiscornia ◽

Lorena Allemandi

Keyword(s):

Gender Differences ◽

Children And Adolescents ◽

Methodological Quality ◽

Overweight And Obesity ◽

Food Advertising ◽

Food Marketing ◽

Evidence Based ◽

Cross Sectional ◽

Gender Based ◽

And Gender

Abstract Background Pervasive marketing of unhealthy foods is a contributing factor to the growth of the global epidemic of childhood and adolescent overweight and obesity. Sex and gender differences come into play in the design of and responses to these marketing strategies, contributing to the perpetuation of stereotyped behavior and generating disparities in food choices and health. The purpose of this paper is to review the current literature regarding gender differences in food marketing design and perception among children and adolescents to facilitate evidence-based policy dialogues to address gender-based health disparities in NCD prevention. Methods Scoping review of articles published in scientific journals in English and Spanish, from 2003 to 2018, that addressed the influence of food marketing among children and adolescents including a gender perspective. The methodological quality of each article was assessed following criteria specific to each study design. Results From a total of 37 articles (39 studies) included in the review, 17 were experimental and 22 had descriptive, cross-sectional designs. Twenty-one studies were found to have low methodological quality, while 10 and 8 were of medium and high quality, respectively. A total of 23 studies among children and adolescents found gender-based differences. Differences were found in the following dimensions: food marketing on intake; responses to specific marketing; perceptions and attitudes towards food marketing and marketing regulation initiatives; exposure to food advertising and gendered marketing content. The evidence was not conclusive in any of the dimensions. Conclusions The evidence suggests that food marketing has a similar impact on the consumption of unhealthy foods on boys and girls, but boys were found to be exposed to food advertising more intensively and their preferences to be more affected by this exposure, coinciding with a male-dominant advertising content. Limitations of these studies include taking gender as an unproblematic construct equivalent to biological sex and the lack of studies focused on developing countries. As gender is a cross-sectional dimension that interacts with other factors driving health disparities, an integrated gender perspective is needed to develop effective, evidence-based policies to control food marketing and tackle the childhood overweight and obesity pandemic.

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