scholarly journals CLINICAL TRIAL OF THE ASSOCIATED VACCINE AGAINST PARAINFLUENZA-3, INFECTIOUS RHINOTRACHEITIS, VIRAL DIARRHEA, ROTA- AND CORONAVIRUS INFECTIONS OF CATTLE INACTIVATED EMULSION

2021 ◽  
Vol 247 (3) ◽  
pp. 249-255
Author(s):  
G.N. Spiridonov ◽  
◽  
V.G. Gumerov ◽  
A.F. Μakhmutov ◽  
V.V. Evstifeev ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Biologically Active ◽  
Production Environment ◽  
Viral Diarrhea ◽  
Intestinal Infections ◽  
Young Cattle ◽  
The Republic ◽  
Cattle Farms ◽  
Virus Strains ◽  
Coronavirus Infections

The paper presents the results of studying the efficacy of an associated emulsion vaccine against parainfluenza-3, infectious rhinotracheitis, viral diarrhea, rota- and coronavirus infections in cattle in a production environment. In the manufacture of the associated vaccine, biologically active substances were used in the form of inactivated, purified and concentrated antigens of the following virus strains: "ПТК-45/86" parainfluenza virus-3, "ТК-А (ВИЭВ)-В2" virus of infectious rhinotracheitis, "ВК-1" virus of viral diarrhea-diseases of the mucous membranes of cattle, "РМ" rotavirus and 2 "КЛ-2" coronavirus of cattle obtained in transplanted cell cultures. 8 batches of the associated vaccine were produced. A clinical trial of the effectiveness of the vaccine was carried out in 3 cattle farms of the Republic of Tatarstan, unfavorable for respiratory and intestinal infections of young cattle in terms of morbidity and safety of calves obtained from vaccinated and unvaccinated cows, as well as by titers of specific antibodies in blood serum and colostrum.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Specific prevention of rota-, coronavirus infections and colienteritis of young cattle

2019 ◽  
Vol 22 (3) ◽  
pp. 22-24
Author(s):  
I.N. Simanova ◽  
◽  
V.N. Makarova ◽  
O.B. Badeeva ◽  
M.V. Korukina ◽  
...  
Keyword(s):  
Young Cattle ◽  
Coronavirus Infections

scholarly journals Identification and genotyping of a new subtype of bovine viral diarrhea virus 1 isolated from cattle with diarrhea

2021 ◽  
Vol 166 (4) ◽  
pp. 1259-1262
Author(s):  
Bin Tian ◽  
Dongjie Cai ◽  
Weiqiang Li ◽  
Qinglong Bu ◽  
Mingshu Wang ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Nasal Swab ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Separate Branch ◽  
Genetic Subtype ◽  
Viral Diarrhea Virus ◽  
Cattle Farms ◽  
Subtype 1B

AbstractIn 2019, diarrhea cases occurred on cattle farms in Qionglai and Guang'an, Sichuan Province. Two out of 20 (10%) serum and nasal swab samples were positive when tested using a bovine viral diarrhea virus (BVDV) antigen-capture ELISA kit. Two non-cytopathic strains of BVDV were isolated and named QL1903 and GA190608, respectively. The nucleotide sequences of the genomes of the two isolates were 89.52% identical. Phylogenetic analysis based on the 5'-UTR sequence revealed that the BVDV isolate QL1903 belonged to BVDV subtype 1b, whereas isolate GA190608 clustered with strains HN1814, EN-19, and BJ09_26 in a separate branch, which has tentatively been classified as a new genetic subtype, "1v".

scholarly journals The Perspective of Croatian Old Apple Cultivars in Extensive Farming for the Production of Functional Foods

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 708
Author(s):  
Boris Duralija ◽  
Predrag Putnik ◽  
Dora Brdar ◽  
Anica Bebek Markovinović ◽  
Sandra Zavadlav ◽  
...  
Keyword(s):  
Functional Foods ◽  
Geographical Location ◽  
Nutritional Composition ◽  
Climatic Conditions ◽  
Biologically Active ◽  
Biological Potential ◽  
Apple Cultivars ◽  
The Republic ◽  
Processed Form ◽  
Extensive Farming

The Republic of Croatia has a long tradition of fruit growing due to its geographical location, climatic conditions, and high quality of fruit crops, especially apple fruits. Apples can be used for the formulation of functional foods either in processed form (e.g., juice), or as a by-product (e.g., apple pomace). However, there is a growing demand for functional foods derived from ancient and traditional plant sources as they are recognized as a very valuable source of health-promoting bioactive ingredients. Similarly, old apple cultivars (Malus domestica Borkh.) are characterized by good morphological and pomological properties, less need for chemicals during cultivation and the higher share of biologically active compounds (BACs) with better sensory acceptability compared to commercial cultivars. However, their nutritional and biological potential is underestimated, as is their ability to be processed into functional food. The importance in preserving old apple cultivars can also be seen in their significance for improving the nutritional composition of other apple cultivars through innovative cultivation strategies, and therefore old local apple cultivars could be of great importance in future breeding programs.

scholarly journals Senna leaves: component composition, pharmacological properties, standardization

2021 ◽  
Vol 24 (2) ◽  
pp. 53-65
Author(s):  
Anna A. Romanyuk ◽  
Dmitry V. Moiseev
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Component Composition ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Anthracene Derivatives ◽  
The Russian Federation ◽  
The Republic ◽  
Active Substances

Objective: generalization and analysis of scientific data on the component composition, pharmacological properties and standardization of senna leaves. Materials and methods. The article provides an overview of scientific publications in the journals of the search platforms Scopus and PubMed, as well as the databases of the Russian Science Citation Index. The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers of Medicines of the Republic of Belarus, the Russian Federation and the Republic of Kazakhstan using content analysis, comparison and generalization of data. Results. In addition to the laxative effect, determined by the presence of anthracene derivatives in senna leaves, the complex of their biologically active substances has antimicrobial, hypoglycemic, antioxidant, antifungal and antitumor effects. Also, the chemical composition of the plant is represented by fatty acids, triglycerides, flavonoids, macro- and microelements. The analysis of medicinal herbal preparations based on senna leaves registered in the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan has been carried out. The differences in the methods of their standardization, given in the normative documentation on quality, have been revealed. The scientific experience of using the method of high performance liquid chromatography for the determination of anthracene derivatives in senna leaves is generalized. Conclusion. The complex of biologically active substances of senna leaves exhibits various pharmacological effects, which, possibly, will expand the range of combined preparations based on them. The use of a modern and selective method of high-performance liquid chromatography in the analysis of senna leaves is a very promising direction in the field of standardization of this type of medicinal plant material.

scholarly journals Epidemiological situation on acute enteric infections in the Republic of Dagestan in 2011-2015

2016 ◽  
Vol 21 (5) ◽  
pp. 290-295
Author(s):  
Zarema G. Tagirova ◽  
D. R Akhmedov ◽  
N. M.-G Zulpukarova ◽  
Z. M Daniyalbecova
Keyword(s):  
Prevalence Rate ◽  
Morbidity Rate ◽  
Regional Feature ◽  
Epidemiological Features ◽  
Medical Institutions ◽  
Intestinal Infections ◽  
High Prevalence ◽  
Enteric Infections ◽  
The Republic ◽  
Epidemiological Situation

There were studied epidemiological features of the prevalence rate of acute intestinal infections (AII) in the Republic of Dagestan (RD). The prevalence rate of acute intestinal infections in RD was shown to correspond taken as a whole, to Russian indices, however, the regional feature is the high prevalence rate of shigellosis, there is remained a high proportion of the AII of unidentified etiology. There was substantiated the necessity of development and implementation of targeted programmes aimed at the decline in the morbidity rate in problematic territories. The solution to the problem of the AII in the Republic is possible only under the coordination of efforts of federal and local authorities, sanitary - epidemiological and medical institutions.

scholarly journals Enriching the diets of young cattle with a natural biologically active feed additive

2021 ◽  
Vol 22 (1) ◽  
pp. 94-103
Author(s):  
I. Yu. Kuzmina ◽  
L. S. Ignatovich
Keyword(s):  
Live Weight ◽  
Biologically Active ◽  
Raw Material ◽  
Wild Plants ◽  
Feed Additive ◽  
Feed Conversion ◽  
Holstein Bulls ◽  
Young Cattle ◽  
Feed Protein ◽  
Positive Effect

On the basis of the "Komarova" farm (Magadan, Magadan region), the effect of introducing a new non-traditional component feed additive of plant origin into the diets of young cattle was studied. The research was carried out during the stall period. For the experiment there were taken four groups of animals (14-16 months of age) divided at random in accordance with the genotype into control and experimental groups of ten animals each. The first two groups (control, experiment) included purebred Holstein bulls, the other two – hybrids of the 1st generation (1/2 Holstein × 1/2 Herefords). For the experimental groups, the main diet was supplemented with a component feed additive consisting of cedar elfin (Mountain pine) flour and lichens (alpine cladonia (Cladonia alpestris), Icelandic cetraria (Cetraria islandica)). The results of the experiment has shown that the feed additive, consisting of 120 g of cedar elfin needle flour and 50 g of lichen flour (80% of Cladonia alpestris and 20% of Cetraria islandica), has a positive effect on the intensification of metabolic processes in the animals. The digestibility of crude protein increased by 1.29-4,19 g (1.7-5.6 %); that of the organic matter – by 6.65-8.90 g (11.0-14.3 %); NFE (nitrogen-free extracts) – by 7.80-9.18 g (14.14-15.70 %). An increase in the digestibility of feed nutrients had a positive effect on an increase in live weight gain by 0.60-3.0 g (1.35-5.93 %). An increase in feed conversion was 0.24-6.8 MJ (0.20-6.74 %); feed protein – by 0.02-0.09 g (1.22-6.17 %). Crossbred bulls turned out to be more responsive to changes in the ration of feeding and showed better results in all studied parameters. The effectiveness of using the additive is due to the fact that the raw material for the production is obtained from wild plants growing in nature in sufficiently large volumes. They do not require significant costs for harvesting and preparation for feeding.

Comparative Histochemical analysis of above-ground parts of Filipendula vulgaris and Filipendula ulmaria growing in Central Kazakhstan

2021 ◽  
pp. 4863-4867
Author(s):  
Yerbolat Tulebayev A. ◽  
Margarita Ishmuratova Yu. ◽  
Irina Losseva V. ◽  
Wirginia Kukuła-Koch ◽  
Ewa Poleszak ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Raw Materials ◽  
Sesquiterpene Lactones ◽  
Biologically Active ◽  
Histochemical Analysis ◽  
Filipendula Ulmaria ◽  
Plant Raw Materials ◽  
Related Substances ◽  
Histochemical Tests ◽  
The Republic

The histochemical analysis of medicinal plants and raw materials makes it possible to establish the presence of certain groups of active and related substances or products of their metabolism, as well as to study their localization in tissues. The article presents the results of histochemical analysis of leaves, flowers, petioles and stems of Filipendula vulgaris and Filipendula ulmaria. These types of plant are used in traditional medicine as an anti-inflammatory, antipyretic and bactericidal agent. Our research objective - to determine the peculiarities of the localization features of individual groups of secondary metabolites in the aerial part of meadowsweet and meadowsweet growing in the territory of Central Kazakhstan at the microscopic level. Materials and Methods. Transverse sections of petioles, stem and whole flower; transverse and superficial sections of leaves of Filipendula vulgaris and Filipendula ulmaria were fixed in Strauss-Fleming solution, after which histochemical reactions were carried out to locate and identify essential oils, phenolic acids, flavonoids, sesquiterpene lactones, polysaccharides and alkaloids. The study of microscopic signs, as well as histochemical tests were carried out according to the methods of the State Pharmacopoeia of the Republic of Kazakhstan using a light microscope Biomed-4. Results and Discussion. The localization of biologically active substances in the studied types of plant raw materials was determined by histochemical methods using light microscopy. The presence of phenolic compounds, flavonoids, traces of essential oil, alkaloids and sesquiterpene lactones was established. The absence of polysaccharides in the investigated micropreparations was established. Conclusions. For the first time, the localization of secondary metabolites in the tissues of Filipendula vulgaris and Filipendula ulmaria was studied by histochemical tests. The results of histochemical studies can be used to confirm the authenticity, identification and standardization of the aerial parts of Filipendula vulgaris and Filipendula ulmaria.

A Study on the Characteristics of Healthy Volunteers who Participate in Phase I Clinical Trials in Korea

2021 ◽  
pp. 155626462110342
Author(s):  
Ji-Hye Seo ◽  
Ock-Joo Kim ◽  
Sang-Ho Yoo ◽  
Eun Kyung Choi ◽  
Ji-Eun Park
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Phase I ◽  
Healthy Volunteers ◽  
Health Science ◽  
Trial Participation ◽  
Phase I Clinical Trials ◽  
Financial Reward ◽  
Therapeutic Purpose ◽  
The Republic

The phase I trial is the first step in administering a drug to humans, but it has no therapeutic purpose. Under the absence of therapeutic purpose, healthy volunteers demonstrated different motivations, unlike the actual patients participating in trials. There were many reported motivations, such as financial motivation, contributing to the health science, accessing ancillary health care benefits, scientific interest or interest in the goals of the study, meeting people, and general curiosity. The aim of this study was to identify the motivation and characteristics of healthy volunteers participating in phase I trials in the Republic of Korea. We gave surveys to 121 healthy volunteers to study their demographic characteristics and the reasons of participation. We identified whether the decision to participate in the research was influenced by demographic factors and whether the perception and attitudes toward the research were influenced by the characteristics of the healthy volunteers. After completion of the first survey, 12 healthy volunteers who had participated in a phase I clinical trial were selected to answer the second interview. According to our survey, most healthy volunteers were unmarried men and economically dependent. Most of them participated in the study because of financial reward. The most important factor to measure financial reward was the research period. Also, 43% of the volunteers were university students, 42% answered “university graduation” and 55% were residing in family-owned houses. Many healthy volunteers were found to be living in family homes and to have a student status or lack of economic independence. Results of the survey showed that 64% of respondents indicated having more than one clinical trial participation. In-depth interviews showed that healthy volunteers had diverse motivation to participate in research and that healthy volunteer perceive the clinical trial positively. The main motivation for healthy volunteers’ participation in research was “financial reward.” Healthy volunteers also considered research schedules, processes, and safety, and had a positive perception of clinical trials, but they thought that the public has a negative perception.

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