scholarly journals Basic concepts of depression

2008 ◽  
Vol 10 (3) ◽  
pp. 279-289 ◽  

This paper reviews concepts of depression, including history and classification. The original broad concept of melancholia included all forms of quiet insanity. The term depression began to appear in the nineteenth century, as did the modern concept of affective disorders, with the core disturbance now viewed as one of mood. The 1980s saw the introduction of defined criteria into official diagnostic schemes. The modern separation into unipolar and bipolar disorder was introduced following empirical research by Angst and Perris in the 1960s. The partially overlapping distinctions between psychotic and neurotic depression, and between endogenous and reactive depression, started to generate debate in the 1920s, with considerable multivariate research in the 1960s. The symptom element in endogenous depression currently survives in melancholia or somatic syndrome. Life stress is common in various depressive pictures. Dysthymia, a valuable diagnosis, represents a form of what was regarded earlier as neurotic depression. Other subtypes are also discussed.

2017 ◽  
Vol 1 (1) ◽  
pp. 01-03
Author(s):  
Addison Rosli

Depression is the most common of the affective disorders (disorders of mood rather than disturbances of thought or cognition); it may range from a very mild condition, bordering on normality, to severe (psychotic) depression accompanied by hallucinations and delusions. Worldwide, depression is a major cause of disability and premature death. Unipolar depression is commonly (about 75% of cases) non-familial, clearly associated with stressful life-events and accompanied by symptoms of anxiety and agitation; this type is sometimes termed reactive depression. Other patients (about 25%, sometimes termed endogenous depression) show a familial pattern, unrelated to external stresses, and with a somewhat different symptomatology. This distinction is made clinically, but there is little evidence that antidepressant drugs show significant selectivity between these conditions.


2016 ◽  
Vol 6 (2) ◽  
Author(s):  
Rosa Jaitin

This article covers several stages of the work of Pichon-Rivière. In the 1950s he introduced the hypothesis of "the link as a four way relationship" (of reciprocal love and hate) between the baby and the mother. Clinical work with psychosis and psychosomatic disorders prompted him to examine how mental illness arises; its areas of expression, the degree of symbolisation, and the different fields of clinical observation. From the 1960s onwards, his experience with groups and families led him to explore a second path leading to "the voices of the link"—the voice of the internal family sub-group, and the place of the social and cultural voice where the link develops. This brought him to the definition of the link as a "bi-corporal and tri-personal structure". The author brings together the different levels of the analysis of the link, using as a clinical example the process of a psychoanalytic couple therapy with second generation descendants of a genocide within the limits of the transferential and countertransferential field. Body language (the core of the transgenerational link) and the couple's absences and presence during sessions create a rhythm that gives rise to an illusion, ultimately transforming the intersubjective link between the partners in the couple and with the analyst.


2020 ◽  
Vol 63 (6) ◽  
pp. 40-50
Author(s):  
Hugo Enrique Hernández-Martínez ◽  
Marta Georgina Ochoa-Madrigal

The diagnosis and treatment of bipolar disorders (BPD) in children is currently one of the biggest challenges and area of controversy in the field of child psychiatry. Bipolar disorders encompass several affective disorders that involve alterations in the degree of activity, content and form of thinking that are characterized by biphasic episodes of mood. This group of disorders affect approximately 1% of the world population and begin in youth (the average age of onset of ~20 years). However, in some studies a delay of 5 years has been observed since the presentation of symptoms at the beginning of the treatment. Currently, the diagnosis of TBP in children and adolescents should be based on the same set of symptoms applied to adults, as well as the general principles of the treatment. The research carried out around this disorder has resulted in changes in the conceptualization and approach of this pathology, now conceived as a group of disorders that share changes in mood and other cardinal symptoms, of a chronic and progressive nature that impacts in a negative way in those who suffer them. Key words: Bipolar disorder; childhood; mania; hypomania; depression.


Author(s):  
Hazel Gray

This chapter sets out the analytical framework of political settlements and elaborates the framework to account for the socialist experiences of Tanzania and Vietnam in the 1960s and 1970s. A political settlement, as defined by Mushtaq Khan, is a combination of power and institutions that is mutually compatible and also sustainable in terms of economic and political viability. The chapter clarifies the core building blocks of the approach and sets out the main differences between political settlements and new institutional economics. The chapter then defines a socialist political settlement where productive rights are formally held by the collective and formal institutions protect common and collectively owned assets. The attempts to construct a socialist political settlement left important institutional, political, and economic legacies. These shaped incentives and constraints which influenced a number of critical processes at the heart of economic development—related to technological learning, accumulation for investment, and political stabilization.


Author(s):  
Roy Livermore

Despite the dumbing-down of education in recent years, it would be unusual to find a ten-year-old who could not name the major continents on a map of the world. Yet how many adults have the faintest idea of the structures that exist within the Earth? Understandably, knowledge is limited by the fact that the Earth’s interior is less accessible than the surface of Pluto, mapped in 2016 by the NASA New Horizons spacecraft. Indeed, Pluto, 7.5 billion kilometres from Earth, was discovered six years earlier than the similar-sized inner core of our planet. Fortunately, modern seismic techniques enable us to image the mantle right down to the core, while laboratory experiments simulating the pressures and temperatures at great depth, combined with computer modelling of mantle convection, help identify its mineral and chemical composition. The results are providing the most rapid advances in our understanding of how this planet works since the great revolution of the 1960s.


2006 ◽  
Vol 18 (5) ◽  
pp. 193-209 ◽  
Author(s):  
Richard J. Porter ◽  
Peter Gallagher

Background:New evidence is emerging regarding abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function in subtypes of affective disorders. Adverse effects of HPA axis dysregulation may include dysfunction of monoaminergic transmitter systems, cognitive impairment and peripheral effects. Newer treatments specifically targeting the HPA axis are being developed.Objective:To review these developments focusing particularly on the glucocorticoid receptor (GR) antagonist mifepristone.Method:A selective review of the literature.Results:The function of GRs is increasingly being defined. The role of corticotrophin-releasing hormone (CRH) and dehydroepiandrosterone (DHEA) in the brain is also increasingly understood. HPA axis function is particularly likely to be abnormal in psychotic depression and bipolar disorder, and it is in these conditions that trials of the GR antagonist mifepristone are being focused. CRH antagonists and DHEA are also being investigated as potential treatments.Conclusion:Initial studies of mifepristone and other HPA-axis-targeting agents in psychotic depression and bipolar disorder are encouraging and confirmatory studies are awaited.


2003 ◽  
Vol 25 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Rolf Rolli

Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality-control laboratories. Recent research works lead to the development of in-vitro dissolution tests as replacements for human and animal bioequivalence studies. For many years, a lot of time and effort has been invested in automation of dissolution tests. There have been a number of in-house solutions from pharmaceutical companies and many have created task forces or even departments to develop automation. Robotic solutions with sequential operation were introduced as well as the simultaneous operation concept developed by SOTAX. Today, pharmaceutical companies focus their resources mainly on the core business and in-house engineering solutions that are very difficult to justify. Therefore, it is important to know the basic considerations in order to plan an automation concept and implement it together with a vendor.


2020 ◽  
Vol 3 (117) ◽  
pp. 161-174
Author(s):  
B.J. Parıdınova ◽  

The problem of developing the spiritual worldview and spirituality was the development of society at all stages. The spiritual worldview and spirituality of the individual, teachers in society changed depending on the level of the social structure of the state and its ideology, religious and secular views, the development of pedagogical science. Therefore, the spiritual worldview and spirituality of the whole society is one of the most important characteristics of the pedagogical preparation of the individual. The research problem is relevant in the framework of the program «Rukhani zhangyru». Therefore, we believe that a set of activities under the program is the core of this topic. Spiritual worldview and spirituality is the most important issue in the context of globalization. The purpose of this article is to generalize and systematize this problem, to determine the role and place of the spiritual worldview and spirituality. To achieve the purpose, this study discusses some of the findings of scientists on the problem of spiritual worldview and spirituality in education. The discussed fundamental principles of development and existing scientific works on the problem of spiritual worldview and spirituality. Many actual issues can be considered in the notion of concept since these categories has not yet been studied in science. In this article special attention is paid to spiritual worldview and spirituality and its basic concepts, which is one of the most important problems in pedagogy and psychology. The article the relevance and importance of theoretical understanding of the data category. Presented some theoretical problems of the formation and preservation of spiritual worldview and spirituality. Рухани дүниетанымның даму мәселесі және руханилық қоғам дамуының барлық салаларында өзекті болып саналады. Қоғамдағы тұлғаның, мұғалімнің рухани дүниетанымы мен руханилығы мемлекеттің әлеуметтік құрылысы мен оның идеологиясы, діни және зайырлы көзқарастары, педагогикалық ғылымның дамуы деңгейіне байланысты өзгеріп отырады. Сондықтан барлық қоғам мүшелерінің рухани дүниетанымы мен руханилығы тұлғаның педагогикалық дайындығының маңызды сипаттамалық белгісі болып табылады. Зерттеу мәселесі «Рухани жаңғыру» бағдарламасы аясында өзекті болып саналады. Сол себепті бағдарлама шеңберіндегі шаралар кешені берілген тақырыптың өзегі деп ойлаймыз. Жаһандану шарттарында «Рухани дүниетаным» және «Руханилық» категориялары маңызды мәселе болып табылады. Осы мақаланың мақсаты болып берілген мәселені жинақтау және жүйелеу, рухани дүниетаным мен руханилықтың рөлін, орнын анықтау болып саналады. Мақсатқа жету үшін берілген жұмыста білім берудегі рухани дүниетаным мен руханилық мәселесіне байланысты кейбір қорытындылары қарастырылады. Рухани дүниетаным мен руханилық мәселесіне байланысты дамытудың негізгі қағидалары мен ғылымда бар жұмыстар талқыланады. Өйткені берілген категориялар ғылымда толықтай зерттелмеген және зерттелуі тиіс көптеген өзекті мәселелері жетерлік. Берілген мақалада рухани дүниетаным және руханилықтың, оның педагогикадағы және психологиядағы негізгі түсініктеріне ерекше назар аударылады. Мақалада берілген категорияларды теориялық түсінудің өзектілігі мен маңыздылығы дәйектеледі. Рухани дүниетаным мен руханилықтың қалыптасуы мен сақтаудағы кейбір теориялық мәселелері ұсынылған.


2014 ◽  
Vol 20 (2) ◽  
pp. 2 ◽  
Author(s):  
Pankaj Kumar Mittal ◽  
Shubham Mehta ◽  
Ram Kumar Solanki ◽  
Mukesh Kumar Swami ◽  
Parth Singh Meena

<p><strong>Background.</strong> Researchers have evinced interest in the effect of seasonal variations on mood and behavioural patterns in affective disorders. </p><p><strong>Objective. </strong>To study seasonality in bipolar disorder (BD) patients and also the factors affecting this seasonality. </p><p><strong>Method. </strong>Forty-nine patients with BD in euthymic phase were recruited and analysed using<strong> </strong>the<strong> </strong>Seasonal Pattern Assessment Questionnaire and Morningness-Eveningness Questionnaire. </p><p><strong>Results. </strong>Most of the patients were morning types but chronotype had no influence on seasonality. Age of patient and number of episodes were the most important factors affecting seasonality in BD. </p><p><strong>Conclusion. </strong>Seasonality and its influencing factors must be considered while managing bipolar disorder.</p>


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