scholarly journals Cannabinoids and their therapeutic applications in mental disorders

2020 ◽  
Vol 22 (3) ◽  
pp. 271-279
Keyword(s):  
Mental Disorders ◽  
Synthetic Cannabinoids ◽  
Endocannabinoid System ◽  
Substantial Impact ◽  
Public Health Burden ◽  
Therapeutic Applications ◽  
Physiological Processes ◽  
Past Half Century ◽  
High Prevalence ◽  
Significant Public Health

Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life. Despite growing knowledge of the pathological mechanisms that underlie the development of these disorders, a high percentage of patients do not respond to first-line clinical treatments; thus, there is a strong need for alternative therapeutic approaches. During the past half-century, after the identification of the endocannabinoid system and its role in multiple physiological processes, both natural and synthetic cannabinoids have attracted considerable interest as putative medications in pathological conditions such as, but not exclusive to, mental disorders. Here, we provide a summary of cannabinoid effects in support of possible therapeutic applications for major depression, bipolar disorder, anxiety, posttraumatic stress disorder, and schizophrenia. Considering this evidence, highlighted benefits and risks of cannabinoid use in the management of these illnesses require further experimental study.

scholarly journals Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Inusha Panigrahi ◽  
Manoj Dhanorkar ◽  
Renu Suthar ◽  
Chanchal Kumar ◽  
Mullai Baalaaji ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Insertion Mutation ◽  
Lysosomal Storage ◽  
Exon 2 ◽  
Public Health Burden ◽  
Niemann Pick Disease ◽  
High Prevalence ◽  
Significant Public Health ◽  
Niemann Pick ◽  
Pick Disease

Lysosomal storage disorders (LSDs) collectively constitute a significant public health burden in developing countries. Commoner LSDs include Gaucher, Fabry, and Niemann-Pick disease (NPD), but many cases remain undiagnosed. With the high incidence of consanguineous marriages, South East Asian countries are expected to have high prevalence of these LSDs. Here we report 4 cases of NPD type A/B in 3 families presenting with hepatosplenomegaly and cytopenias including one family with two sibs having hypertension and mitral valve prolapse. The diagnosis of NPD was proven by mutation analysis with identification of novel mutations, including a novel 4 bp insertion mutation (C>CCTGG) in exon 2 of the SMPD1 gene. We also had two cases of NPD type C, confirmed on mutation analysis.

Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?

2018 ◽  
Vol 17 (9) ◽  
pp. 644-653 ◽  
Author(s):  
Nandkishor K. Mule ◽  
Jitendra N. Singh
Keyword(s):  
Public Health ◽  
Oxidative Stress ◽  
Ros Generation ◽  
World Population ◽  
Progressive Dementia ◽  
Public Health Burden ◽  
Altered Glucose ◽  
High Prevalence ◽  
Significant Public Health ◽  
Aging World

Background & Objective: Diabetes and neurodegenerative diseases (ND) are progressive morbidities and represent a major public health burden. A growing body of evidence points towards the comorbidity of diabetes and NDs with a possible exacerbation of latter by former. Considering the high prevalence of both morbidities in aging world population, even a modest impact of diabetes on NDs could lead to significant public health implications. Several hypotheses and mechanistic evidence were proposed linking altered glucose metabolism to the risk of progressive dementia. Unregulated production of reactive oxygen species (ROS) and resultant oxidative stress (OS) are the common features of diabetes as well as NDs. Conclusion: This review explores the concept of altered glucose metabolic pathways leading to ROS increase and its possible link to NDs, with a special emphasis on Alzheimer’s diseases (AD). We also discuss the detailed mechanistic link between hyperglycemia, ROS generation, and neurodegeneration to highlight potential therapeutic avenues for better prevention and treatment.

scholarly journals Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Shweta R Singh ◽  
Bunsoth Mao ◽  
Konstantin Evdokimov ◽  
Pisey Tan ◽  
Phana Leab ◽  
...  
Keyword(s):  
Final Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Middle Income ◽  
E Coli ◽  
Middle Income Countries ◽  
Siem Reap ◽  
High Prevalence ◽  
Significant Public Health ◽  
History Of

Abstract Background The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. Methods We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage. Results Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts. Conclusions The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread.

scholarly journals Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Savannah Mwesigwa ◽  
◽  
Lesedi Williams ◽  
Gaone Retshabile ◽  
Eric Katagirya ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Diversity Index ◽  
Strong Association ◽  
Community Diversity ◽  
Added Value ◽  
Sequencing Platform ◽  
Public Health Burden ◽  
Survival Status ◽  
Significant Public Health

AbstractHuman immunodeficiency virus (HIV) infection remains a significant public health burden globally. The role of viral co-infection in the rate of progression of HIV infection has been suggested but not empirically tested, particularly among children. We extracted and classified 42 viral species from whole-exome sequencing (WES) data of 813 HIV-infected children in Botswana and Uganda categorised as either long-term non-progressors (LTNPs) or rapid progressors (RPs). The Ugandan participants had a higher viral community diversity index compared to Batswana (p = 4.6 × 10−13), and viral sequences were more frequently detected among LTNPs than RPs (24% vs 16%; p = 0.008; OR, 1.9; 95% CI, 1.6–2.3), with Anelloviridae showing strong association with LTNP status (p = 3 × 10−4; q = 0.004, OR, 3.99; 95% CI, 1.74–10.25). This trend was still evident when stratified by country, sex, and sequencing platform, and after a logistic regression analysis adjusting for age, sex, country, and the sequencing platform (p = 0.02; q = 0.03; OR, 7.3; 95% CI, 1.6–40.5). Torque teno virus (TTV), which made up 95% of the Anelloviridae reads, has been associated with reduced immune activation. We identify an association between viral co-infection and prolonged AIDs-free survival status that may have utility as a biomarker of LTNP and could provide mechanistic insights to HIV progression in children, demonstrating the added value of interrogating off-target WES reads in cohort studies.

scholarly journals Antioxidant Therapy in Inflammatory Bowel Diseases

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 412
Author(s):  
Katarzyna Dziąbowska-Grabias ◽  
Małgorzata Sztanke ◽  
Przemysław Zając ◽  
Michał Celejewski ◽  
Katarzyna Kurek ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Nitrosative Stress ◽  
Treatment Options ◽  
Chemical Compounds ◽  
Continuous Increase ◽  
Public Health Burden ◽  
Bowel Diseases ◽  
Significant Public Health ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract, the etiology of which remains unclear to this day. IBD result in significant repercussions on the quality of patients’ life. There is a continuous increase in the incidence and prevalence of IBD worldwide, and it is becoming a significant public health burden. Pharmaceuticals commonly used in IBD management, for example, mesalamine, sulfasalazine, corticosteroids, and others, expose patients to diverse, potentially detrimental side effects and frequently do not provide sufficient disease control. The chronic inflammation underlies the etiology of IBD and closely associates with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Relative to this, several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Representatives of several different groups, including natural and chemical compounds will be characterized in this dissertation.

scholarly journals Bovine tuberculosis in Rwanda: Prevalence and economic impact evaluation by meat inspection at Société des Abattoirs de Nyabugogo-Nyabugogo Abattoir, Kigali

2014 ◽  
Vol 85 (1) ◽  
Author(s):  
Gervais Habarugira ◽  
Joseph Rukelibuga ◽  
Mark O. Nanyingi ◽  
Borden Mushonga
Keyword(s):  
Economic Impact ◽  
Bovine Tuberculosis ◽  
Meat Inspection ◽  
Control Measures ◽  
Meat Industry ◽  
Biochemical Tests ◽  
Tissue Samples ◽  
Public Health Burden ◽  
Significant Public Health ◽  
Lowenstein Jensen

Despite the significant public health burden of bovine tuberculosis (bTB) in Rwanda, the prevalence of bTB is poorly documented. This study was conducted to estimate the prevalence of bTB in cattle using gross examination of granulomatous lesions, to identify mycobacteria species in suspected samples, and to evaluate the economic impact of meat condemnation based on bTB-like lesions in the meat industry in Rwanda. Routine meat inspection was conducted at Société des Abattoirs de Nyabugogo (SABAN)-Nyabugogo Abattoir. Tissue samples including 31 lymph nodes, 3 lungs and 2 livers were obtained from cattle of different ages with gross tuberculous lesions. Mycobacterium bovis was identified using microscopy with Kinyoun staining and isolation of mycobacterial species in culture on Löwenstein–Jensen and Colestos media, further identified using biochemical tests. Our findings, based on culture and postmortem results, show that the prevalence of bTB is 0.5%(0.587*148/16753), with an overall gross tuberculous lesion prevalence of 0.9% (148/16753). The presence of lesions were higher in cattle aged 2 years and older (1.6% vs. 0.6%, p < 0.05) and higher in females than in males (1.4% vs. 0.6%, p < 0.05). Of the 36 samples tested, 26 (72.2%) were positive by microscopic examination with Kinyoun staining while M. bovis was culture-confirmed in 21 (58.7%) cases. Bovine tuberculosis caused condemnation of 1683.5 kg of meat, resulting in an estimated loss of $4810. Our findings indicate that the prevalence of bTB in Rwanda is significant, and that bTB is a major cause of meat condemnation requiring continued implementation of surveillance and control measures. Furthermore, the results from this study also show important variations in sensitivity of the different tests that were used to determine the prevalence of bTB in cattle in Rwanda.

scholarly journals Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders?

2020 ◽  
Vol 21 (12) ◽  
pp. 4221
Author(s):  
Tomasz Charytoniuk ◽  
Hubert Zywno ◽  
Karolina Konstantynowicz-Nowicka ◽  
Klaudia Berk ◽  
Wiktor Bzdega ◽  
...  
Keyword(s):  
Physical Activity ◽  
Neurodegenerative Disorders ◽  
Therapeutic Approach ◽  
Cannabinoid Receptor ◽  
Synthetic Cannabinoids ◽  
Endocannabinoid System ◽  
Antidepressant Effect ◽  
Brain Physiology ◽  
Current State ◽  
Neurological Effects

The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and different aspects of brain physiology, such as memory or neurogenesis. Moreover, the endocannabinoid system is widely regarded as a crucial factor in the development of neuropathologies. Thus, targeting those disorders via synthetic cannabinoids, as well as phytocannabinoids, becomes a widespread research issue. Over the last decade, the endocannabinoid system has been extensively studied for its correlation with physical activity. Recent data showed that physical activity correlates with elevated endocannabinoid serum concentrations and increased cannabinoid receptor type 1 (CB1R) expression in the brain, which results in positive neurological effects including antidepressant effect, ameliorated memory, neuroplasticity development, and reduced neuroinflammation. However, none of the prior reviews presented a comprehensive correlation between physical activity, the endocannabinoid system, and neuropathologies. Thus, our review provides a current state of knowledge of the endocannabinoid system, its action in physical activity, as well as neuropathologies and a possible correlation between all those fields. We believe that this might contribute to finding a new preventive and therapeutic approach to both neurological and neurodegenerative disorders.

scholarly journals Chronic back pain and mental disorders

2019 ◽  
Vol 11 (2S) ◽  
pp. 17-24
Author(s):  
B. A. Volel ◽  
D. S. Petelin ◽  
D. O. Rozhkov
Keyword(s):  
Back Pain ◽  
Mental Disorders ◽  
Chronic Back Pain ◽  
Negative Impact ◽  
Clinical Manifestations ◽  
Somatoform Disorder ◽  
Socioeconomic Indicators ◽  
Post Traumatic Stress ◽  
High Prevalence ◽  
Post Traumatic

Chronic back pain is a significant biomedical problem due to its high prevalence and negative impact on quality of life and socioeconomic indicators. Mental disorders play a substantial role in the genesis of chronic pain. This review discusses the issues of back pain comorbid with depressive, anxiety disorders, post-traumatic stress disorder, and somatoform disorder. It also considers the features of the clinical manifestations of pain associated with mental disorders. There are data on the neurobiological relationship between pain and mental disorders and on the personality traits of patients with chronic back pain.

scholarly journals Indian agriculture, air pollution, and public health in the age of COVID

2020 ◽  
Author(s):  
Andrew J McDonald ◽  
Balwinder-Singh ◽  
M.L. Jat ◽  
Peter Craufurd ◽  
Jon Hellin ◽  
...  
Keyword(s):  
Public Health ◽  
Air Pollution ◽  
Crop Residues ◽  
Health Conditions ◽  
Public Health Burden ◽  
Pollution Levels ◽  
Indian Agriculture ◽  
Significant Public Health ◽  
Agricultural Burning ◽  
Northwest India

Emerging evidence supports the intuitive link between chronic health conditions associated with air pollution and the vulnerability of individuals and communities to COVID-19. Poor air quality already imposes a highly significant public health burden in Northwest India, with pollution levels spiking to hazardous levels in November and early December when rice crop residues are burned. The urgency of curtailing the COVID-19 pandemic and mitigating a potential resurgence later in the year provides even more justification for accelerating efforts to dramatically reduce open agricultural burning in India.

High Prevalence of Mental Disorder Symptoms Among Medical and Other Health Specialty Residents During the COVID-19 Pandemic (Preprint)

2021 ◽  
Author(s):  
Nayane Miranda Silva ◽  
Rebeca da Nobrega Lucena Pinho ◽  
Thais Ferreira Costa ◽  
Adriana Ferreira Barros Areal ◽  
André De Mattos Salles ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Postgraduate Students ◽  
Symptoms Of Depression ◽  
High Prevalence ◽  
Patient Health ◽  
Psychological Pressure ◽  
Coping Scale ◽  
Potential Stressor

BACKGROUND The coronavirus (SARS-CoV-2) epidemic was first identified in Wuhan, China, at the end of 2019, and spread across the world in a fast and disordered manner. Because of the pandemic, health professionals, including residents in medicine and other health specialties, began working under intense physical and psychological pressure daily and were exposed to a greater risk of developing mental disorders and psychological distress. OBJECTIVE This study evaluated the prevalence of symptoms indicative of mental disorders such as depression, anxiety and stress among postgraduate students who were residents in medicine and other health specialties during the COVID-19 pandemic in Brazil and identified possible associated predisposing factors. METHODS This was a cross-sectional study that included postgraduate students in medical and other health residency programmes in Brazil. The recruitment period was from July 29 to September 5, 2020. Epidemiological and clinical data, including evaluations of psychological and affective aspects, following a predefined protocol, were collected after the participants filled out an electronic form via the Microsoft Forms platform. RESULTS In total, 1,313 medical and other health residents participated in the study. The Depression, Anxiety and Stress Scale-21 (DASS-21) identified depression, anxiety and stress in 51.3%, 53.4% and 52.6% of the participants, respectively. Based on the Brief Resilient Coping Scale (BRCS), 61.9% of the participants had low resilience. A total of 60.9% of the residents had high scores on the Patient Health Questionnaire 9‐item depression module (PHQ-9). CONCLUSIONS We found a high prevalence of symptoms of depression, anxiety and stress among medical and non-medical residents during the COVID-19 pandemic in Brazil. Mental disorders are complex in nature, and the particular academic environment of residency, altered by the need to care for patients with COVID-19, can be a potential stressor and be associated with the high prevalence of these symptoms among residents. INTERNATIONAL REGISTERED REPORT RR2-10.2196/24298

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