Volume and surface coil simultaneous reception (VSSR) method for intensity inhomogeneity correction in MRI

2021 ◽  
pp. 1-12
Author(s):  
Lin Wu ◽  
Tian He ◽  
Jie Yu ◽  
Hang Liu ◽  
Shuang Zhang ◽  
...  
Keyword(s):  
Bias Field ◽  
Correction Method ◽  
Surface Coil ◽  
Intensity Inhomogeneity ◽  
Acquisition Time ◽  
Surface Coils ◽  
In Vivo Experiments ◽  
Inhomogeneity Correction ◽  
Volume Coil

BACKGROUND: Addressing intensity inhomogeneity is critical in magnetic resonance imaging (MRI) because associated errors can adversely affect post-processing and quantitative analysis of images (i.e., segmentation, registration, etc.), as well as the accuracy of clinical diagnosis. Although several prior methods have been proposed to eliminate or correct intensity inhomogeneity, some significant disadvantages have remained, including alteration of tissue contrast, poor reliability and robustness of algorithms, and prolonged acquisition time. OBJECTIVE: In this study, we propose an intensity inhomogeneity correction method based on volume and surface coils simultaneous reception (VSSR). METHODS: The VSSR method comprises of two major steps: 1) simultaneous image acquisition from both volume and surface coils and 2) denoising of volume coil images and polynomial surface fitting of bias field. Extensive in vivo experiments were performed considering various anatomical structures, acquisition sequences, imaging resolutions, and orientations. In terms of correction performance, the proposed VSSR method was comparatively evaluated against several popular methods, including multiplicative intrinsic component optimization and improved nonparametric nonuniform intensity normalization bias correction methods. RESULTS: Experimental results show that VSSR is more robust and reliable and does not require prolonged acquisition time with the volume coil. CONCLUSION: The VSSR may be considered suitable for general implementation.

scholarly journals Implantable NMR Microcoils in Rats: A New Tool for Exploring Tumor Metabolism at Sub-Microliter Scale?

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 176
Author(s):  
Justine Deborne ◽  
Noël Pinaud ◽  
Yannick Crémillieux
Keyword(s):  
Magnetic Resonance ◽  
Tumor Model ◽  
Surface Coil ◽  
Regions Of Interest ◽  
7 Tesla ◽  
Resonance Spectroscopy ◽  
Volume Coil ◽  
Detection Volume ◽  
The Right

The aim of this study was to evaluate the potential of a miniaturized implantable nuclear magnetic resonance (NMR) coil to acquire in vivo proton NMR spectra in sub-microliter regions of interest and to obtain metabolic information using magnetic resonance spectroscopy (MRS) in these small volumes. For this purpose, the NMR microcoils were implanted in the right cortex of healthy rats and in C6 glioma-bearing rats. The dimensions of the microcoil were 450 micrometers wide and 3 mm long. The MRS acquisitions were performed at 7 Tesla using volume coil for RF excitation and microcoil for signal reception. The detection volume of the microcoil was measured equal to 450 nL. A gain in sensitivity equal to 76 was found in favor of implanted microcoil as compared to external surface coil. Nine resonances from metabolites were assigned in the spectra acquired in healthy rats (n = 5) and in glioma-bearing rat (n = 1). The differences in relative amplitude of choline, lactate and creatine resonances observed in glioma-bearing animal were in agreement with published findings on this tumor model. In conclusion, the designed implantable microcoil is suitable for in vivo MRS and can be used for probing the metabolism in localized and very small regions of interest in a tumor.

scholarly journals Now you see it, now you don't: optimal parameters for interslice stimulation in concurrent TMS-fMRI

2021 ◽  
Author(s):  
Catriona L Scrivener ◽  
Jade B Jackson ◽  
Marta Morgado Correia ◽  
Marius Mada ◽  
Alexandra Woolgar
Keyword(s):  
Single Channel ◽  
Signal To Noise Ratio ◽  
Brain Activity ◽  
Surface Coil ◽  
Acquisition Time ◽  
Surface Coils ◽  
Human Participant ◽  
Set Up ◽  
Promising Avenue ◽  
Slice Acquisition

The powerful combination of transcranial magnetic stimulation (TMS) concurrent with functional magnetic resonance imaging (fMRI) provides rare insights into the causal relationships between brain activity and behaviour. Despite a recent resurgence in popularity, TMS-fMRI remains technically challenging. Here we examined the feasibility of applying TMS during short gaps between fMRI slices to avoid incurring artefacts in the fMRI data. We quantified signal dropout and changes in temporal signal-to-noise ratio (tSNR) for TMS pulses presented at timepoints from 100ms before to 100ms after slice onset. Up to 3 pulses were delivered per volume using MagVenture's MR-compatible TMS coil. We used a spherical phantom, two 7-channel TMS-dedicated surface coils, and a multiband (MB) sequence (factor=2) with interslice gaps of 100ms and 40ms, on a Siemens 3T Prisma-fit scanner. For comparison we repeated a subset of parameters with a more standard single-channel TxRx (birdcage) coil, and with a human participant and surface coil set up. We found that, even at 100% stimulator output, pulses applied at least -40ms/+50ms from the onset of slice readout avoid incurring artifacts. This was the case for all three setups. Thus, an interslice protocol can be achieved with a frequency of up to ~10 Hz, using a standard EPI sequence (slice acquisition time: 62.5ms, interslice gap: 40ms). Faster stimulation frequencies would require shorter slice acquisition times, for example using in-plane acceleration. Interslice TMS-fMRI protocols provide a promising avenue for retaining flexible timing of stimulus delivery without incurring TMS artifacts.

scholarly journals Single breath-hold saturation recovery 3D cardiac T1 mapping via compressed SENSE at 3T

2020 ◽  
Vol 33 (6) ◽  
pp. 865-876
Author(s):  
Tiago Ferreira da Silva ◽  
Carlos Galan-Arriola ◽  
Paula Montesinos ◽  
Gonzalo Javier López-Martín ◽  
Manuel Desco ◽  
...  
Keyword(s):  
Heart Rate ◽  
Saturation Recovery ◽  
Acquisition Time ◽  
Breath Hold ◽  
Post Contrast ◽  
In Vivo Experiments ◽  
Single Breath ◽  
Single Breath Hold ◽  
Phantom Experiments

Abstract Objectives To propose and validate a novel imaging sequence that uses a single breath-hold whole-heart 3D T1 saturation recovery compressed SENSE rapid acquisition (SACORA) at 3T. Methods The proposed sequence combines flexible saturation time sampling, compressed SENSE, and sharing of saturation pulses between two readouts acquired at different RR intervals. The sequence was compared with a 3D saturation recovery single-shot acquisition (SASHA) implementation with phantom and in vivo experiments (pre and post contrast; 7 pigs) and was validated against the reference inversion recovery spin echo (IR-SE) sequence in phantom experiments. Results Phantom experiments showed that the T1 maps acquired by 3D SACORA and 3D SASHA agree well with IR-SE. In vivo experiments showed that the pre-contrast and post-contrast T1 maps acquired by 3D SACORA are comparable to the corresponding 3D SASHA maps, despite the shorter acquisition time (15s vs. 188s, for a heart rate of 60 bpm). Mean septal pre-contrast T1 was 1453 ± 44 ms with 3D SACORA and 1460 ± 60 ms with 3D SASHA. Mean septal post-contrast T1 was 824 ± 66 ms and 824 ± 60 ms. Conclusion 3D SACORA acquires 3D T1 maps in 15 heart beats (heart rate, 60 bpm) at 3T. In addition to its short acquisition time, the sequence achieves good T1 estimation precision and accuracy.

scholarly journals A Robust Brain MRI Segmentation and Bias Field Correction Method Integrating Local Contextual Information into a Clustering Model

2019 ◽  
Vol 9 (7) ◽  
pp. 1332
Author(s):  
Zhe Zhang ◽  
Jianhua Song
Keyword(s):  
Contextual Information ◽  
Brain Mri ◽  
Brain Magnetic Resonance Imaging ◽  
Bias Field ◽  
Correction Method ◽  
Intensity Inhomogeneity ◽  
Mri Segmentation ◽  
Robust Clustering ◽  
Clustering Model ◽  
Central Pixel

The segmentation results of brain magnetic resonance imaging (MRI) have important guiding significance for subsequent clinical diagnosis and treatment. However, brain MRI segmentation is a complex and challenging problem due to the inevitable noise or intensity inhomogeneity. A novel robust clustering with local contextual information (RC_LCI) model was used in this study which accurately segmented brain MRI corrupted by noise and intensity inhomogeneity. For pixels in the neighborhood of the central pixel, a weighting scheme combining local contextual information was used to generate the corresponding anisotropic weight to update the current central pixel and thus remove noisy pixels. Then, a multiplicative framework consisting of the product of a real image and a bias field could effectively segment brain MRI and estimate the bias field. Further, a linear combination of basis functions was introduced to guarantee the bias field properties. Therefore, compared with state-of-the-art models, the segmentation result obtained by RC_LCI was increased by 0.195 0.125 in terms of the Jaccard similarity coefficient. Both visual experimental results and quantitative evaluation demonstrate the superiority of RC_LCI on real and synthetic images.

scholarly journals Multi T1-weighted contrast imaging and T1 mapping with Compressed sensing FLAWS at 3T

2021 ◽  
Author(s):  
Jeremy Beaumont ◽  
Jurgen Fripp ◽  
Parnesh Raniga ◽  
Oscar Acosta ◽  
Jean-Christophe Ferre ◽  
...  
Keyword(s):  
Compressed Sensing ◽  
T1 Mapping ◽  
Spin Echo ◽  
Acquisition Time ◽  
Contrast Imaging ◽  
Parallel Acquisition ◽  
In Vivo Experiments ◽  
Sequence Parameters

The Fluid And White matter Suppression (FLAWS) MRI sequence allows for the acquisition of multiple T1-weighted contrasts in a single sequence acquisition. However, its acquisition time is prohibitive for use in clinical practice when the k-space is linearly downsampled and reconstructed using the Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA) technique. This study proposes a FLAWS sequence optimization tailored to allow for the acquisition of FLAWS images with a Cartesian phyllotaxis k-space undersampling and compressed sensing (CS) reconstruction at 3T. The CS FLAWS sequence parameters were determined using a method previously employed to optimize FLAWS imaging at 1.5T and 7T. In-vivo experiments show that the proposed CS FLAWS optimization allows to reduce the FLAWS sequence acquisition time from 8 mins to 6 mins without decreasing the FLAWS image quality. In addition, this study demonstrates for the first time that T1-weighted imaging with low B1 sensitivity and T1 mapping can be performed with the FLAWS sequence at 3T for both GRAPPA and CS reconstructions. The FLAWS T1 mapping was validated using in-silico, in-vitro and in-vivo experiments with comparison against the inversion recovery turbo spin echo and MP2RAGE T1 mappings. These new results suggest that the recent advances in FLAWS imaging allow to combine the MP2RAGE imaging benefits (T1-weigthed imaging with low B1 sensitivity and T1 mapping) and with the previous version of FLAWS imaging benefits (multi T1-weighted contrast imaging) in a single 6 mins sequence acquisition.

In vivo spatially localized surface-coil NMR spectroscopy utilizing a fourier series window function and two surface coils

1986 ◽  
Vol 69 (3) ◽  
pp. 576-581 ◽  
Author(s):  
Michael Garwood ◽  
Kâmil Uǧurbil ◽  
Thomas Schleich ◽  
Mark Petein ◽  
Eugene Sublett ◽  
...  
Keyword(s):  
Fourier Series ◽  
Nmr Spectroscopy ◽  
Surface Coil ◽  
Window Function ◽  
Surface Coils

Stem Cell Cure for Kidney Injury: Therapy to Solve Most Complex Issues in Renal System

2020 ◽  
Author(s):  
Prithiv K R Kumar
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Kidney Injury ◽  
Cell Types ◽  
Tissue Remodelling ◽  
Major Health Problem ◽  
In Vivo Experiments ◽  
Renal Regeneration ◽  
Induced Pluripotent

Renal failure is a major health problem. The mortality rate remain high despite of several therapies. The most complex of the renal issues are solved through stem cells. In this review, different mechanism for cure of chronic kidney injury along with cell engraftment incorporated into renal structures will be analysed. Paracrine activities of embryonic or induced Pluripotent stem cells are explored on the basis of stem cell-induced kidney regeneration. Several experiments have been conducted to advance stem cells to ensure the restoration of renal functions. More vigour and organised protocols for delivering stem cells is a possibility for advancement in treatment of renal disease. Also there is a need for pressing therapies to replicate the tissue remodelling and cellular repair processes suitable for renal organs. Stem cells are the undifferentiated cells that have the ability to multiply into several cell types. In vivo experiments on animal’s stem cells have shown significant improvements in the renal regeneration and functions of organs. Nevertheless more studies show several improvements in the kidney repair due to stem cell regeneration.

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

2018 ◽  
Vol 68 (12) ◽  
pp. 2747-2751
Author(s):  
Marioara Nicula ◽  
Nicolae Pacala ◽  
Lavinia Stef ◽  
Ioan Pet ◽  
Dorel Dronca ◽  
...  
Keyword(s):  
Aquatic Environment ◽  
Iron Homeostasis ◽  
Iron Concentration ◽  
Antagonistic Effect ◽  
Tissue Samples ◽  
Antagonistic Effects ◽  
In Vivo Experiments ◽  
Living Organisms ◽  
Toxic Potential

Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.

ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES

2019 ◽  
Vol 65 (5) ◽  
pp. 760-765
Author(s):  
Margarita Tyndyk ◽  
Irina Popovich ◽  
A. Malek ◽  
R. Samsonov ◽  
N. Germanov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Human Tumor ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Ehrlich Carcinoma ◽  
In Vivo Experiments

The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control.

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