scholarly journals Research of acute toxicity of the drug HEXIA

2018 ◽  
pp. 88-94
Author(s):  
V. L. Karbovskyy ◽  
I. A. Shevchuk ◽  
O. V. Kurkina ◽  
T. Ye. Makovska
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Daily Basis ◽  
Relative Mass ◽  
Intragastric Administration ◽  
Internal Organs ◽  
Laboratory Rats ◽  
Rats And Mice ◽  
The Impact ◽  
Female Laboratory

Diseases of the genitourinary system caused by pathogenic and potentially pathogenic microorganisms, which result into disbiosis of urinary organs, remain an urgent problem of dermatovenereology, gynecology and urology, despite the fact that there is a significant number of available and new medicines to treat them. The aim of the work was to determine the safety of the preparation Hexia within experiments on animals. The acute toxicity of Hexia has been determined on 20 adult female laboratory rats under the conditions of hourly intravaginal administration of the preparation with a dose of 70 mg/kg during 12 hours, as well as on 20 female laboratory rats and 20 female laboratory mice with a single intragastric administration in a dose of 145 mg/kg. The assessment of the impact of the preparation studied was performed on the basis of the following parameters: a) mortality (terms of death of animals in each group, on a daily basis); b) assessment of toxicity development (on a daily basis), including an assessment of the visual environment of the area of injection (the presence of irritation, redness, edema); c) dynamics of body weight changes (in the initial state, on the 4th, 7th and 14th day after application); d) macroscopy of internal organs, mass coefficients of internal organs within rats (on the 14th day). It has been found that intravaginal application and a single intragastric administration of the preparation Hexia in the form of pessaries, which contain chlorhexidine digluconate, does not result into death of rats and mice, brings no effect on body weight gain, integrative parameters of the functional state of laboratory animals as well as on the relative mass of internal organs, which implies the absence of significant toxic effect of the preparation. Thus, the results of the studies conducted indicate that the median lethal dose for Hexia in case of intravaginal application to rats or intragastric administration to rats and mice is beyond the rate of 500 mg/kg. According to the toxicological classification of substances Hexia belongs to the IV class of toxicity – low toxic substances.

scholarly journals Impact of polyvinyl chloride, polystyrene, and polyethylene on the organism of mice

2019 ◽  
Vol 10 (1) ◽  
pp. 50-55 ◽  
Author(s):  
M. A. Lieshchova ◽  
V. V. Brygadyrenko ◽  
N. M. Tishkina ◽  
P. M. Gavrilin ◽  
A. A. Bohomaz
Keyword(s):  
Body Weight ◽  
Toxic Effect ◽  
Polyvinyl Chloride ◽  
The Body ◽  
Laboratory Animals ◽  
Relative Mass ◽  
Internal Organs ◽  
Peripheral Organs ◽  
Group I ◽  
The Impact

Goods of plastic, due to their durability, universality and economical properties are broadly used in all spheres of life. On the whole, polymers are inert and nontoxic, but in the process of their production, various additives are used, which on contact or introduction into an organism has a negative effect on it. In our study, we determined the impact of some types of plastic (polyvinyl chloride, polysterene and polyethylene) on the organism of laboratory animals according to changes in their body weight, indices of mass of the internal organs, and blood parameters. For the experiment, we formed four groups of white male mice at the age of 3 weeks and average body weight of 50 g. For each group, we used different litter. For group I, the litter was sawdust; and for the other groups we added plastic products in different volumes to the sawdust; for group II finely cut polyvinyl chloride, for group III cut polyethylene, and for group IV granules of polystyrene. Every 3 days, we determined the body weight of the animals, and 32 days later we determined mass of the organs, clinical and biochemical parameters of the blood. Addition of polyvinyl chloride, polyethylene, and polystyrene into the substrate for mice did not have a significant effect on tempi of growth of body weight, and also relative mass of heart and lungs. Polyvinyl chloride and polystyrene have an immune-suppressive effect, and polyvinyl chloride affects both central and peripheral organs, and polystyrene mostly harms the peripheral organs. All used types of plastic cause leukocytopenia, following which neutrophilia of band neutrophils and monocytosis takes place as a result of damage to the biological barriers. We determined the systemic toxic effect of the studied types of plastic on the internal organs, which manifested in increase in their mass (liver, kidneys), steep increase in the activity of liver enzymes (AST, ALT), simultaneous decrease in activity of alkaline phosphatase and content of cholysterol and glucose in the blood serum of the mice. Also polyvinyl chlorine, polyethylene and polystyrene cause degeneration of the epithelium of the uriniferous tubule, which is manifested in reduction of globulins and creatinine in the blood of animals from the experimental groups following increase in relative mass of the kidneys. The results of our research allow us to state that different types of plastic can cause toxic effect on animals, as well as people who are in frequent contact with them.

scholarly journals Determination of acute toxicity parameters of the drug ‘MEGASTOP for dogs’ on white rats and mice

2020 ◽  
Vol 6 (2) ◽  
pp. 20-26
Author(s):  
O. L. Orobchenko ◽  
M. Ye. Romanko ◽  
M. O. Yaroshenko ◽  
I. O. Gerilovych ◽  
N. A. Zhukova ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Clinical Symptoms ◽  
Liver Volume ◽  
Male Rats ◽  
Toxic Substances ◽  
Main Experiment ◽  
Polyethylene Glycol 400 ◽  
White Rats ◽  
Rats And Mice

The experiments were performed on 58 males of nonlinear white rats 3–4 months old and weighing 180–200 g and 64 females of nonlinear white mice 2.5–3 months old and weighing 18–22 g. In the main experiment on rats, six experimental groups were formed, the animals of which were injected intragastrically with the drug ‘MEGASTOP for dogs’ (by absolute weight) in doses of 1,000.0, 2,000.0, 3,000.0, 4,000.0, 5,000.0, and 6,000.0 mg/kg body weight; in the main experiment on mice, seven experimental groups were formed, the animals of which were administered the drug in doses of 100.0, 500.0, 1,000.0, 1,500.0, 2,000.0, 2,500.0, and 3,000.0 mg/kg body weight. Control rats and mice were injected with 2.0 cm3 and 0.2 cm3 of polyethylene glycol-400, respectively. Clinical symptoms of poisoning with the drug ‘MEGASTOP for dogs’ of white rats (at doses of 2,000.0–6,000.0 mg/kg body weight) and mice (at doses of 1,000.0–3,000.0 mg/kg body weight) were refusals of food and water, loss of coordination, sitting in one place, a dose-dependent increase in depression with subsequent complete depression, lack of response to external stimuli and death on the first or fourth day after administration. During autopsy in rats and mice that died as a result of poisoning with the drug ‘MEGASTOP for dogs’, we recorded pallor of the mucous membranes of the mouth, trachea, pharynx, and esophagus; increase in heart volume, atrial blood supply; pulmonary hyperemia; uncoagulated blood; increase in liver volume, dark cherry color, flabby consistency; catarrhal inflammation of the mucous membrane of the small intestine. According to the results of determining the parameters of acute toxicity of the drug ‘MEGASTOP for dogs’ in the case of a single intragastric injection, LD50 for male rats is 3,384.98 ± 444.94 mg/kg, and for female mice — 2,025.88 ± 279.46 mg/kg body weight, which allows to classify it to class IV by the toxicity — low-toxic substances (LD50 — 501–5,000 mg/kg) and by the degree of danger to class III— moderately dangerous substances (LD50 — 151–5,000 mg/kg)

scholarly journals Study of the Acute Toxicity of a New Dosage Form of Naloxone Hydrochloride for Intranasal Administration

Drug Research ◽  
2019 ◽  
Vol 70 (01) ◽  
pp. 23-25
Author(s):  
Eduard A. Bariev ◽  
Ivan I. Krasnyuk ◽  
Maria N. Anurova ◽  
Elena O. Bakhrushina ◽  
Valery V. Smirnov ◽  
...  
Keyword(s):  
Body Weight ◽  
Protein Metabolism ◽  
Intranasal Administration ◽  
Wistar Rats ◽  
Relative Mass ◽  
General State ◽  
Initial Body Weight ◽  
Internal Organs ◽  
Naloxone Hydrochloride ◽  
Observation Period

AbstractThe experiment was conducted on 10 Wistar rats, male and female, with initial body weight 270–280 g (males) and 250–260 g (females). The drug was administered using a spray cap in 10 doses of 0.1 mg at 45 min intervals. The average cumulative dose of the drug per naloxone hydrochloride was 36.6 mg/kg for males and 39.4 mg/kg for females. The animals were monitored for 2 weeks after the exposure and then euthanized by a gentle decapitation.We noticed that after each drug administration the animals showed a decrease in motor activity. During the observation period there were no animal deaths or signs of abnormalities in their general state or behavior. Beginning on day 7 a significant increase in body weight of the animals was noted in comparison with the initial data. The relative mass of the internal organs of the treated rats remained within the physiological norm.We conclude that naloxone hydrochloride after an intranasal administration at 36.6 mg/kg for males and 39.4 mg/kg for females does not cause death of animals and or have a toxic effect on their general state, does not change their protein metabolism characteristics or the appearance of the internal organs and their mass.

scholarly journals Study of acute toxicity of the drug «Kolidev 8M» with a single intragastric injection in laboratory animals

2021 ◽  
pp. 44-48
Author(s):  
Roman Sachuk ◽  
Yaroslav Stravskyy ◽  
Bogdan Gutyj ◽  
Tetiana Velesyk ◽  
Orest Katsaraba ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Oral Administration ◽  
Veterinary Drug ◽  
Control Group ◽  
Intragastric Administration ◽  
Toxic Substances ◽  
Class Iii ◽  
Absolute Weight ◽  
Class Iv

«Kolidev 8M» (powder for oral use) is a veterinary drug used to treat ornamental birds (pheasants, peacocks) in diseases of the digestive tract caused by microorganisms sensitive to colistin. In the study of the drug «Kolidev 8M» for oral administration, along with the confirmation of therapeutic properties, it is necessary to determine the LD50 obtained in the process of studying acute toxicity. The aim of research. The aim of research was to determine the acute toxicity of the veterinary drug «Kolidev 8M» (powder for oral administration) under the conditions of intragastric administration to white mice. Materials and methods of research. To achieve this aim, an experiment was conducted on 114 males of nonlinear white mice kept under optimal conditions in the vivarium of DEVIE LLC (Rivne, Ukraine). In the first series of experiments on the principle of analogues was formed control and three experimental groups of 6 animals each (n=6). The drug in the form of a solution was administered once orally using a esophageal gastric tube in doses of 500,0; 2000,0 and 4000,0 mg/kg body weight by absolute weight of the drug. The animals of the control group were injected with distilled water. After taking into account the results of the first experiment in the next experiment, 6 experimental groups were formed – mice, which were administered the drug «Kolidev 8M» in the form of a solution in doses (by absolute weight of the drug) – 500,0; 1000,0; 1500,0; 2000.0; 2500,0; 3000,0; 3500 and 4000,0 mg/kg body weight, as well as the control group – animals that were injected with distilled water with a volume of 0.5 cm3 according to similar regulations (Zapadniuk, 1983; Kotsiumbas, 2005; Karkyshchenko & Hrachev, 2010). There were 6 animals in each group (n=6). After their death, a pathological autopsy was performed (Zharov A. et al., 2003). The average lethal dose of LD50 was calculated by the method of probit analysis by Prozorovsky V.B. Research results. According to the results of research, it was found that the LD50 of the drug «Kolidev 8M» (powder for oral administration) under the conditions of its single intragastric administration to male mice is 2024,72±232,45 mg/kg, LD10 – 392,87 mg/kg, LD16 – 751,56 mg/kg, LD84 – 3297,88 mg/kg, LD90 – 3656,57 mg/kg, LD100 – 3934,47 mg/kg body weight, respectively. According to the results of an acute toxicological experiment with intragastric administration of the drug «Kolidev 8M» to white male mice, LD50 was 2024,72±232,45 mg/kg body weight. This allows, according to toxicity, to refer this drug to class IV – low-toxic substances (LD50 501,0-5000,0 mg/kg body weight), and the degree of danger to class III – moderately safe substances (LD50 151,0-5000,0 mg/kg body weight). Conclusions and prospects for further research. The drug «Kolidev 8M» in terms of toxicity belongs to class IV – low-toxic substances, and the degree of danger to class III – moderately safe substances. Further studies will be the next stage of pre-registration trials aimed at studying the subacute toxicity of the drug «Kolidev 8M»

scholarly journals Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”

2019 ◽  
pp. 54-58
Author(s):  
R. M. Sachuk ◽  
S. V. Zhyhalyuk ◽  
I. M. Lukyanik ◽  
M. S. Mandyhra ◽  
Ya. S. Stravsky ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Behavioral Responses ◽  
Physiological Parameters ◽  
Laboratory Animals ◽  
Veterinary Drug ◽  
Intragastric Administration ◽  
Toxic Substances ◽  
Treatment And Prevention ◽  
Mucous Membranes

The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mice, DL50 values exceed 8,000 mg/kg body weight and have no effect on the behavioral responses and physiological parameters of laboratory animals. It has been investigated that “Yodosol” aerosol has no local toxic and irritant effects on the skin and mucous membranes of laboratory animals (rabbits). Conclusions. The use of the drug «Yodosol», in doses above 8,000 mg/kg body weight, does not affect the behavioral responses and physiological parameters of laboratory animals. The drug has no local toxic and irritant effects on the skin and mucous membranes. According to the requirements of SOU 85.2-37-736:2011 and GOST 12.1.007-76, the newly developed drug “Yodosol” belongs to low-toxic substances — 4 toxicity classes

scholarly journals Combined effect of glyphosphate, saccharin and sodium benzoate on rats

2018 ◽  
Vol 9 (4) ◽  
pp. 591-597 ◽  
Author(s):  
M. A. Lieshchova ◽  
N. M. Tishkina ◽  
A. A. Bohomaz ◽  
P. M. Gavrilin ◽  
V. V. Brygadyrenko
Keyword(s):  
Body Weight ◽  
Sodium Benzoate ◽  
Food Additives ◽  
Combined Effect ◽  
Male Rats ◽  
Laboratory Animals ◽  
Relative Mass ◽  
Control Group ◽  
Expiry Date ◽  
The Impact

Herbicides and food additives are included in many food products for humans. Non-used products or products beyond their expiry date are deposited in places of utilizatioin of solid municipal wastes, where they can take effects on the organisms of mouse-like rodents. Among the herbicides, glyphosphate takes first place in the world for volume of production, and is the most intensely used in agricultural farming. The discussion about negative impact on the organisms of mammals, especially against the background of using various substances and environmental factors, continues. In this study, we determined the combined effect of glyphosphate and food additives on the organism of laboratory animals, which manifested in changes in body weight, condition and indices of mass of the internal organs and blood parameters. Four groups of laboratory male rats were formed, which over 42 days received: unlimited access to clean water; 1% aqueous solution of glyphosate; 1% solution of glyphosphate and 1% solution sodium benzoate; 1% solution of glyphosphate with 1% solution of saccharin. Glyphosphate and glyphosphate with sodium benzoate and saccharin significantly reduced the daily increases in body weight of animals compared to the control group. The studied substances have notable suppressive effect on the immune system and haematopoiesis in general, which is manifested in reduce of relative mass of the thymus and spleen against the background of increase in the amount of lymphocytes in the peripheral blood. The inhibition of haematopoiesis is indicated by decrease in the amount of erythrocytes, neurophils and hemoglobin of blood of animals from the experimental groups. The impact on the digestive system of glyphosphate and food additives is indicated by occurance of the effect of “irritation” of mucous membranes, and, as a result, disorders in absorption followed by the disorder in metabolic processes. A dysbalance occurs in enzymic systems of the organism, which is manifested in distrophic processes, especially in the liver parenchyma, indicated by the activity of blood enzymes (ALT, AST, alkaline phosphatase), total number and ratio of proteins of blood plasma. We determined the impact of glyphosphate and its mixes with benzoate and saccharin on the pancreas, which manifests in severe pancreatitis with steep increase in the level of glucose of blood. The results of the study allow us to state that mixture of glyphosphate and food additives can cause toxic effect in animals and humans, which often contact with herbicides.

scholarly journals Acute toxicity parameters of a highly-dispersive silica and pgmg-gc composite in mice after intragastric administration

2018 ◽  
pp. 69-76
Author(s):  
A. Doroshenko
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Wide Spectrum ◽  
Guanidine Hydrochloride ◽  
Health Concern ◽  
Control Group ◽  
Steady Increase ◽  
Intragastric Administration ◽  
Global Public Health ◽  
Dispersive Silica

The emerging and steady increase of microbes that are resistant to antimicrobial treatments has become a global public health concern that threatens the effective treatment of infectious diseases, therefore, the development of new medicines with antimicrobial properties is one of the priorities of the health systems. Cationic detergents, which, as a result of the combination of their surface activity and bactericidal properties, are promising for use in pharmacy and medicine. One of the representatives of the cationic surfactant group is polyhexamethylene guanidine hydrochloride (PGMG-GC) which was shown to be less toxic compared to some other disinfectants and effective against a wide spectrum of microbes. The aim of the study was to determine the acute toxicity parameters of a highly-dispersive silica (HDS) and PGMG-GC composite in mice after intragastric administration. The study was carried out on 23 BALB/c female mice weighing 18–22 g. To determine the toxicity, the animals were divided into the following groups. The first group was intragastrically injected with a composite of HDS and PGMG-GH, the second group was given a suspension of HDS, the third group was given a solution of PGMG-GC, and the fourth (control) group was treated with water for injection. The mass of the animals was determined before and on the 3rd, 7th, and 14th day after the composite administration. Administration of PGMG-GC or PGMG-GC + HDS composite caused significant decrease in body weight at 3rd and 7th day compared to control with further normalization on day 14. No significant changes of body weight were found in HDS group. No death of mice occurred after a single intragastric injection of the HDS + PGMG-GC composite during 14 days of the study. For the solution of PGMG-GC (without HDS), lethal cases were reported 2 h after the treatment at a dose level of 400 mg/kg. The condition of the animals survived normalized and, by the day 14, it corresponded to that in the control group for the most of the signs of toxicity indicating the reversibility of the toxic effect of PGMG-GC. Therefore, PGMG-GC is less toxic whet it is used as a part of the composite. Since no lethal cases were reported after a single intragastric administration of the composite at a dose of 2 000 mg/kg of body weight, the composite HDS + PGMG-GC appears to be low toxic according to the classification of substances by toxicity.

scholarly journals Toxicological characteristics of the preparation FORTICEPTTM Hoof Oinment

2018 ◽  
Vol 20 (92) ◽  
pp. 117-120
Author(s):  
V. D. Ishchenko ◽  
A. M. Shevchenko ◽  
N. M. Slobodyuk ◽  
R. O. Vasiv ◽  
H. V. Yarova ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
The Body ◽  
Average Weight ◽  
Intragastric Administration ◽  
Laboratory Mice ◽  
White Rats ◽  
Medicinal Preparations ◽  
Medicinal Substances

Antibiotic resistance of the main infectious disease pathogens is one of the biggest problems of present time, which causes the need for searching for new antimicrobial medicinal substances and developing effective medicinal agents. One of the innovative medicinal preparations with the antimicrobial action, which is recommended for application for animals with hoof diseases, is ForticeptTM Hoof Oinment. Integration in the practice new medicinal preparations needs their strict toxicological control, which involves the exploring of acute and chronic toxicity and remote effects of possible side effect. The purpose of work was the determination of the acute toxicity parameters of the ForticeptTM Hoof Oinmentduring the oral administration to white laboratory mice and evaluation of the skin resorptive action of the preparation after it was administrated on rats’ skin. For determination of the acute toxicity there were used male laboratory mice with the average weight of the body 20 g – two groups with 10 animals in each. For the first group (the control one) with the help of the probe there was injected the distilled water (0.1 ml) into stomach. For the second group there was injected ForticeptTM Hoof Oinment (0.1 g), where the dose of the preparation is equal 500 mg/kg. For evaluation of the skin resorptive action of the preparation there were used 6 white rats with the average weight of the body 175 g. On the pre-prepared patch of skin there was administrated the preparation in the number that is equal 2857 mg/kg of body weight. For control there was leaved a free from preparation patch of bare skin. Exposition lasted for 4 hours. The indicators were explored in dynamics after 6, 24, 48 hours from the exposition started. After the research results there was established that ForticeptTM Hoof Oinment doesn’t cause death after its intragastric administration to the white laboratory mice in the number that is equal 5000 mg/kg of the body weight, that’s why depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). After one-time application of the preparation to the white rats in the number which is equal 2857 mg/kg of the body weight there wasn’t observes no death or pronounced changes in the behavior reactions, motor activity, state of the nervous system, amount of the consumed food and water. Therefore ForticeptTM Hoof Oinmentaccording to the results of the determination of the acute toxicity after its administration on the skin to the white rats depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). ForticeptTM Hoof Oinment doesn’t detect skin resorptive action, that points on the absence of toxic effects of the preparation due to its application on the skin.

Toxicological characteristics of a medicinal product for veterinary «Ketoprofen 10%» in laboratory rats (subchronic toxicity)

2021 ◽  
Vol 1 (6) ◽  
pp. 34-41
Author(s):  
A. N. Shkatova ◽  
◽  
D. A. Devrishov ◽  
O. B. Litvinov ◽  
V. E. Brylina ◽  
...  
Keyword(s):  
Body Weight ◽  
Medicinal Product ◽  
Intramuscular Injection ◽  
Study Drug ◽  
The Body ◽  
Subchronic Toxicity ◽  
Internal Organs ◽  
Experimental Animals ◽  
Laboratory Rats

In a subchronic experiment with intramuscular injection in rats, it was found that a dose of 70,7 mg/kg is toxic, and doses of 35,4 and 17,2 mg/kg are inactive (safe). It was noted that the 14 day administration of the drug «Ketoprofen 10%» in a dose 70,7 mg/kg caused a decrease in the body weight of experimental animals, contributed to the development of hepatotoxic action, a change in the mass coefficients of internal organs. The above effects were reversible 10 days after discontinuation of the study drug.

The effect of the drug "Hepaton" on the reaction of lipid peroxidation

2020 ◽  
Vol 2 ◽  
pp. 112-115
Author(s):  
V.S. Ponamarev ◽  
◽  
O.S. Popova ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Body Weight ◽  
Toxic Hepatitis ◽  
Antioxidant Properties ◽  
The Body ◽  
Intragastric Administration ◽  
Bile Formation ◽  
Laboratory Rats ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

The composition of the drug "Hepaton" includes many bioactive compounds that provide the antioxidant properties of the drug, manifested by the neutralization of reactive oxygen species (ROS) with the breakaway chain free radical reactions. The aim of the study was to determine the effect of the Hepaton preparation on lipid peroxidation reactions in laboratory rats. Evaluation of the antioxidant effect of the drug was carried out on twenty laboratory rats of both sexes with a body weight of 180-220 g, divided into 2 groups. Acute toxic hepatitis in rats was induced by a single intragastric administration of 1.0 ml of a dichloroethane solution. At the same time, rats of the experimental group (n = 10) 1 hour before the introduction of di-chloroethane were injected with a solution of the drug “Hepaton” in the amount of 10 ml / kg body weight and then 1 time per day for 21 days after the use of toxicants [1]. On the 21st day after the administration of toxicants, a blood was drawn for a biochemi-cal study, which took into account the pa-rameters of the antioxidant system (diene conjugates (DC), ketodienes (CD) and malondialdehyde (MDA), as well as the level of endogenous intoxication (according to the content of MSM). Based on the results obtained, it can be con-cluded that the use of “Hepaton” in modeling acute toxic hepatitis made it possible to re-store the disturbed homeostasis of the labora-tory animal organism, the structure and in-tegrity of the hepatocyte membranes, inhibit lipid peroxidation as one of the links in the pathogenesis of hepatitis, stimulate antioxi-dant defense and power the endogenous anti-oxidant system of the body, bile formation and biliary excretion, as well as activate the reparative processes of the liver tissue at the cellular and intracellular levels.

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