scholarly journals Relationship between 25-Hydroxy Vitamin D Levels and Type of Morbus Hansen

2021 ◽  
Vol 5 (9) ◽  
pp. 883-889
Author(s):  
Theresia L. Toruan ◽  
Mutia Devi ◽  
Theodorus ◽  
Allin Marlina Rivai
Keyword(s):  
Vitamin D ◽  
Significant Relationship ◽  
Case Series ◽  
Skin Lesions ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Relationship ◽  
Bacterial Index

Background: Morbus Hansen is a chronic granulomatous infection of Mycobacterium leprae (M. leprae) which is characterized by cardinal signs in the form of numbness of the skin, thickening of peripheral nerves and acid-fast bacteria (AFB) were found on bacterioscopic examination. WHO has classified MH into paucibasilar MH (MH-PB) and multibasilar MH (MH-MB) based on the number of skin lesions or bacterial index (IB). Vitamin D in MH is known to act as an immunomodulator. This study aims to determine the relationship between serum 25(OH)D levels with Morbus Hansen type at RSUP Dr. Mohammad Hoesin and Leprosy Hospital Dr. Rivai Abdullah Palembang. Methods: A laboratory observational study with a case series design was undertaken at the Dermatology and Venereology (DV) Polyclinic of Infectious Dermatology (DI) Mohammad Hoesin Hospital Palembang since December 2019 to January 2020. A sample of 33 patient MH met the inclusion criteria, consisting of 22 patients with Morbus Hansen (MH) type MB and 11 patients with Morbus Hansen (MH) type PB. Comparison of serum 25(OH)D levels between MB and PB type MH patients was analyzed using the Independent T Test, the relationship between serum 25(OH)D levels and MH type was analyzed using the Fisher Exact Test and the correlation between serum 25(OH)D levels with type of MH was analyzed using Spearman Rho's test. Data analysis using SPSS version 22.0. Results: In this study, there were no differences in demographic characteristics of gender, age, age category, body mass index, education and occupation between MB and PB type MH patients (p > 0.05). There were no difference in duration of therapy (p = 0.155), ENL reaction (p = 0.276) and patient status (p = 0.304) between MB and PB type MH patients, but there were differences in bacterial index (p = 0.000) and clinical spectrum (p = 0.000) between MB and PB type MH patients. There is a difference in the mean level of 25(OH)D between MB and PB type MH patients (p = 0.006), there is a significant relationship between 25 (OH)D levels and MH type patients, (OR = 9.643 ; p = 0.010) and there is a significant moderate positive correlation between levels of 25 (OH)D and the type of MH (r = 0.467; p = 0.006). Conclusion: It can be concluded that there are differences in serum 25(OH)D levels among Morbus Hansen type. In addition, there is a significant relationship between serum 25(OH)D levels with Morbus Hansen type.

scholarly journals Relationship between 25-Hydroxy Vitamin D Levels and Type of Morbus Hansen

2021 ◽  
Vol 5 (4) ◽  
pp. 1173-1179
Author(s):  
Theresia L. Toruan ◽  
Mutia Devi ◽  
Theodorus ◽  
Allin Marlina Rivai
Keyword(s):  
Vitamin D ◽  
Significant Relationship ◽  
Case Series ◽  
Skin Lesions ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Relationship ◽  
Bacterial Index

Background: Morbus Hansen is a chronic granulomatous infection of Mycobacterium leprae (M. leprae) which is characterized by cardinal signs in the form of numbness of the skin, thickening of peripheral nerves and acid-fast bacteria (AFB) were found on bacterioscopic examination. WHO has classified MH into paucibasilar MH (MH-PB) and multibasilar MH (MH-MB) based on the number of skin lesions or bacterial index (IB). Vitamin D in MH is known to act as an immunomodulator. This study aims to determine the relationship between serum 25(OH)D levels with Morbus Hansen type at RSUP Dr. Mohammad Hoesin and Leprosy Hospital Dr. Rivai Abdullah Palembang. Methods: A laboratory observational study with a case series design was undertaken at the Dermatology and Venereology (DV) Polyclinic of Infectious Dermatology (DI) Mohammad Hoesin Hospital Palembang since December 2019 to January 2020. A sample of 33 patient MH met the inclusion criteria, consisting of 22 patients with Morbus Hansen (MH) type MB and 11 patients with Morbus Hansen (MH) type PB. Comparison of serum 25(OH)D levels between MB and PB type MH patients was analyzed using the Independent T Test, the relationship between serum 25(OH)D levels and MH type was analyzed using the Fisher Exact Test and the correlation between serum 25(OH)D levels with type of MH was analyzed using Spearman Rho's test. Data analysis using SPSS version 22.0. Results: In this study, there were no differences in demographic characteristics of gender, age, age category, body mass index, education and occupation between MB and PB type MH patients (p > 0.05). There were no difference in duration of therapy (p = 0.155), ENL reaction (p = 0.276) and patient status (p = 0.304) between MB and PB type MH patients, but there were differences in bacterial index (p = 0.000) and clinical spectrum (p = 0.000) between MB and PB type MH patients. There is a difference in the mean level of 25(OH)D between MB and PB type MH patients (p = 0.006), there is a significant relationship between 25 (OH)D levels and MH type patients, (OR = 9.643 ; p = 0.010) and there is a significant moderate positive correlation between levels of 25 (OH)D and the type of MH (r = 0.467; p = 0.006). Conclusion: It can be concluded that there are differences in serum 25(OH)D levels among Morbus Hansen type. In addition, there is a significant relationship between serum 25(OH)D levels with Morbus Hansen type.

Association of serum 25-hydroxy vitamin D and body mass index in cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6625-6625
Author(s):  
D. Gupta ◽  
K. Trukova ◽  
P. G. Vashi ◽  
A. Adams ◽  
G. M. Lambert ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Cancer Patients ◽  
Body Mass ◽  
Case Series ◽  
Spearman Correlation ◽  
Dietary Recommendations ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
The Relationship

6625 Background: The association between vitamin D and obesity remains unsettled with studies reporting conflicting findings on the relationship between the two. This association assumes even greater importance in cancer because of the alleged role of vitamin D in cancer risk and survival. Currently, the dietary recommendations for Vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in a large sample of cancer patients. Methods: A consecutive case series of 740 cancer patients seen at Cancer Treatment Centers of America from Jan 08 to June 08. Serum 25(OH)D was measured at presentation to the hospital. The cohort was divided in 4 BMI groups (<18.5, 18.5–24.9, 25–29.9, and >30.0 kg/m2). Correlation between 25(OH)D and BMI was evaluated using Spearman correlation coefficient. Mean 25(OH)D was compared across the 4 BMI groups using ANOVA. Linear regression was used to quantify the relationship between BMI and 25(OH)D. Results: Of 740 patients, 303 were males and 437 females. The mean age at presentation was 55.7 years (SD = 10.2). The mean BMI was 27.9 kg/m2 (SD = 6.7). Most common cancers were lung (134, 18.1%), breast (131, 17.7%), colorectal (97, 13.1%), pancreas (86, 11.6%), prostate (45, 6.1%) and ovarian (39, 5.3%). The mean serum 25(OH)D was 21.9 ng/ml (SD = 13.5). Analysis revealed that as BMI groups increased from normal to overweight or obese classifications, there was a significant decrease in 25(OH)D (Table). The Spearman correlation between 25(OH)D and BMI was -0.20 (p = 0.001). Every 1 kg/m2 increase in BMI was significantly associated with a 0.43 ng/ml decline in serum 25(OH)D (p = 0.001). Conclusions: We found that obese cancer patients (BMI >=30 kg/m2) had significantly lower levels of serum 25(OH)D as compared to nonobese patients (BMI <30 kg/m2). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients. [Table: see text] No significant financial relationships to disclose.

scholarly journals MUTU PELAYANAN GIZI DENGAN TINGKAT KEPUASAN PASIEN

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Iin Rachmawati ◽  
Wiwik Afridah
Keyword(s):  
Significant Relationship ◽  
Fisher Exact Test ◽  
Hospital Service ◽  
Test Statistic ◽  
Cross Sectional ◽  
Exact Test ◽  
Patient’S Satisfaction ◽  
Independent Variable ◽  
The Relationship

The quality of nutritional service is one of the indicators of the quality hospital service. Therefore, the purpose of this research was to find out the relationship between the quality of hospital nutritional service and the level of patient’s satisfaction hospitalized in Teratai Room of Islamic Hospital located on Jemursari, Surabaya.The design of research was analytic cross sectional. The population of patient’s hospitalized ≥ 3 days in Teratai Room of Islamic Hospital located on Jemursari, Surabaya by 40 respondents, a sample of 36 respondents, taken using a consecutive sampling.The independent variable was the quality of hospital nutritional service, where as the dependent one was the level of patient’s satisfaction. Instrument using a questionnaire sheet. Analysis of the data by the Fisher Exact Test. The result of research showed that most of the respondent (52,2%) said the quality of nutritional hospital service is good and nearly half (47,2%) said they were satisfied. Fisher’s Exact Test statistic test value obtained ρ = 0.007 describing that there was a significant relationship between the quality of hospital nutritional service and the level of patient’s satisfaction hospitalized in the hospital. The research has concluded that most of the quality nutritional of hospital service is have good and patient’s have satisfaction. The nutritional official must be through, when process and prepare a dish up a food a patient

scholarly journals The Correlation between icaA and icaD Genes with Biofilm Formation Staphylococcus epidermidis In Vitro

2021 ◽  
Vol 55 (4) ◽  
pp. 251
Author(s):  
Dian Rachmawati ◽  
Kuntaman Kuntaman ◽  
Lindawati Alimsardjono
Keyword(s):  
Significant Relationship ◽  
Staphylococcus Epidermidis ◽  
Biofilm Formation ◽  
Statistical Tests ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Icad Gene ◽  
The Relationship ◽  
Icaa Gene

This study was conducted to identify the presence of icaA and icaD genes in S. epidermidis and to analyze the relationship between the presence of icaA and icaD genes with the ability of in vitro biofilm formation in S. epidermidis. S. epidermidis isolates from patients and healthy people were collected and PCR was examined to detect icaA and icaD genes. which then continued to examine the ability of biofilm formation by the method of Congo Red Agar. The results of this genotypic and phenotypic examination were then tested for correlation with statistical tests using SPSS 23.0. A total of 40 S. epidermidis isolates were collected, consisting of 20 clinical isolates and 20 isolates of normal flora. The icaA gene was positive in 5 isolates (12.5%), and 8 isolates (20%) were positive for the icaD gene, 3 isolates with icaA and icaD were both positive. One hundred percent of isolates with icaA or icaD positively formed biofilms, but there were 15 isolates (42.9%) who did not have the icaA gene but showed the ability to form biofilms, while 12 isolates (37.5%) who did not have the icaD gene also formed biofilms. Fifty percent of S. epidermidis isolates showed the ability to form biofilms at CRA. The Fisher Exact test showed a significant relationship between the icaA gene and the ability of biofilm formation (p=0.047 (p<0.05)) as well as the icaD gene (p=0.03 (p<0.05)). The icaA and icaD genes have a significant relationship to biofilm formation in S. epidermidis. There was another mechanism in the formation of biofilms that are not dependent on the ica gene.

scholarly journals The Correlation between icaA and icaD Genes with Biofilm Formation Staphylococcus epidermidis In Vitro

2020 ◽  
Vol 55 (4) ◽  
pp. 251
Author(s):  
Dian Rachmawati ◽  
Kuntaman Kuntaman ◽  
Lindawati Alimsardjono
Keyword(s):  
Significant Relationship ◽  
Staphylococcus Epidermidis ◽  
Biofilm Formation ◽  
Statistical Tests ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Icad Gene ◽  
The Relationship ◽  
Icaa Gene

This study was conducted to identify the presence of icaA and icaD genes in S. epidermidis and to analyze the relationship between the presence of icaA and icaD genes with the ability of in vitro biofilm formation in S. epidermidis. S. epidermidis isolates from patients and healthy people were collected and PCR was examined to detect icaA and icaD genes. which then continued to examine the ability of biofilm formation by the method of Congo Red Agar. The results of this genotypic and phenotypic examination were then tested for correlation with statistical tests using SPSS 23.0. A total of 40 S. epidermidis isolates were collected, consisting of 20 clinical isolates and 20 isolates of normal flora. The icaA gene was positive in 5 isolates (12.5%), and 8 isolates (20%) were positive for the icaD gene, 3 isolates with icaA and icaD were both positive. One hundred percent of isolates with icaA or icaD positively formed biofilms, but there were 15 isolates (42.9%) who did not have the icaA gene but showed the ability to form biofilms, while 12 isolates (37.5%) who did not have the icaD gene also formed biofilms. Fifty percent of S. epidermidis isolates showed the ability to form biofilms at CRA. The Fisher Exact test showed a significant relationship between the icaA gene and the ability of biofilm formation (p=0.047 (p<0.05)) as well as the icaD gene (p=0.03 (p<0.05)). The icaA and icaD genes have a significant relationship to biofilm formation in S. epidermidis. There was another mechanism in the formation of biofilms that are not dependent on the ica gene.

HUBUNGAN PENGETAHUAN IBU TENTANG IMUNISASI DENGAN KELENGKAPAN PEMBERIAN IMUNISASI DASAR PADA BAYI DI POSYANDU KELURAHAN PANIKI WILAYAH KERJA PUSKESMAS ONDONG KABUPATEN KEPULAUAN SIAU TAGULANDANG BIARO

e-NERS ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Martha Revy Sarame ◽  
A. Y. Ismanto ◽  
Abram Babakal
Keyword(s):  
Significant Relationship ◽  
The Body ◽  
Fisher Exact Test ◽  
Maternal Knowledge ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Chi Square Test ◽  
Relationship Of ◽  
The Relationship

Abstract: Immunization is the vaccine into the body in the form of weakened germs that cause the body to produce antibodies but not cause disease, even children become immune.  The research objective was to determine the relationship of maternal knowledge about immunization with complete basic immunization in infants at IHC Health Center Village Paniki working area Ondong Tagulandang Biaro Siau Islands District . The study design was cross sectional method and using Chi-Square test on the value of the Fisher Exact Test. The study was conducted on 32 mothers of infants aged 9-12 months. Sampling with a total sampling instrument in the form of a questionnaire study to determine the motherʾs knowledge and KMS (Card Towards Health) to determine the completeness of immunization. The analysis shows there is a significant relationship between maternal knowledge about immunization with complete basic immunization in infants (p = 0,000). Conclusion that mothers with a good knowledge of immunization will do complete basic immunization in children compared to mothers with less knowledge about immunization. Keywords: Knowledge mother, Completed Basic Immunization.   Abstrak: Imunisasi  adalah pemberian vaksin ke dalam tubuh berupa bibit penykit  yang  dilemahkan yang menyebabkan tubuh memproduksi antibodi tetapi tidak menimbulkan penyakit, bahkan anak menjadi kebal. Tujuan penelitian adalah untuk mengetahui  hubungan pengetahuan ibu tentang imunisasi dengan kelengkapan pemberian imunisasi dasar pada bayi di Posyandu Kelurahan Paniki wilayah kerja Puskesmas Ondong Kabupaten Kepulauan Siau Tagulandang Biaro. Desain penelitian ini menggunakan metode Cross Sectional dan menggunakan  uji Chi-Square pada nilai Fisher Exact Test. Penelitian dilakukan pada 32 ibu yang memiliki bayi berusia 9-12 bulan. Pengambilan sampel secara total sampling dengan instrument penelitian berupa kuesioner untuk mengetahui pengetahuan ibu dan KMS (Kartu Menuju Sehat) untuk mengetahui kelengkapan imunisasi. Hasil analisis menunjukkan  terdapat hubungan bermakna antara pengetahuan ibu tentang imunisasi dengan kelengkapan pemberian imunisasi dasar pada bayi (p=0.000). Kesimpulan yaitu ibu dengan pengetahuan tentang imunisasi yang baik akan melakukan pemberian imunisasi dasar lengkap pada anaknya dibandingkan ibu dengan  pengetahuan tentang imunisasi yang kurang. Kata kunci: Pengetahuan ibu, Kelengkapan Imunisasi Dasar.

scholarly journals The Role of Ultrasonography for Diagnosing Wilms Tumor in Developing Country

2021 ◽  
Author(s):  
Aulia Rahmani ◽  
Nur Melani Sari ◽  
Vita Indriasari
Keyword(s):  
Developing Countries ◽  
Significant Relationship ◽  
Wilms Tumor ◽  
Imaging Modality ◽  
Abdominal Mass ◽  
P Value ◽  
Fisher Exact Test ◽  
Cross Sectional ◽  
Exact Test ◽  
The Relationship

Background: Overall five-year survival rate of Wilm’s Tumor (WT) in developing countries is still poor. Delayed diagnosis is one of the contributing factors, whereas early diagnosis is an important thing for the outcome. It is caused by the WT burden in developing countries that was not comparable with the number of facilities for diagnosis and treatment. Ultrasonography (USG) is the mandatory first-line imaging modality in children with a suspected abdominal mass and an overall sensitivity of 76%. Additionally, it can be found in many health facilities at a lower cost, quick, non-invasive, and carries no risk of radiation. Therefore, the relationship between USG and histopathology should be measured. Materials and Methods: A cross-sectional study with an analytical approach was performed in pediatric (0 untill 18 year of age) renal malignancy and neuroblastoma that admitted to Dr. Hasan Sadikin Hospital, Bandung between 2015-2018. Data were collected from medical records. Statistical analyses using Fisher exact test were done to determine the significance of the relationship between USG and histopathology. Results: Forty-three samples were obtained based on inclusion criteria, such as WT (n=33), neuroblastoma (n=6), renal clear cell carcinoma (n=2) and no specific type of renal malignancy (n=2). Fisher exact test revealed no-significant relationship between USG and histopathology with p-value > 0.05 Conclusion: There is no significant relationship between USG and histopathology. Therefore, centralized unity for USG interpretation is recommended.

scholarly journals Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)

2021 ◽  
Vol 12 ◽  
Author(s):  
João Soares Felício ◽  
Hana Andrade de Rider Britto ◽  
Pedro Celeira Cortez ◽  
Fabrício de Souza Resende ◽  
Manuela Nascimento de Lemos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Glycemic Control ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Patients With Diabetes ◽  
25 Hydroxy Vitamin D ◽  
The Relationship

BackgroundThe effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified.ObjectiveEvaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM).Patients and MethodsCross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function.ResultsPatients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c &lt;7% (29.7 ± 10.2 vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D &lt;20 ng/ml and 25(OH)D &lt;30 ng/ml were at a higher risk of presenting albuminuria [OR = 2.8 (95% CI = 1.6 – 4.9), p&lt;0.001, and OR = 2.1 (95% CI = 1.3 - 4.6), p&lt;0.001, respectively]. In our regression model, albuminuria was influenced by HbA1c (r² = 0.076, p&lt;0.00001) and 25(OH)D (r² = 0.018, p = 0.002) independently.ConclusionOur study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function.

Serum 25-hydroxy vitamin D and nutritional status: Implications for vitamin D assessment and dietary supplementation in oncology

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9638-9638
Author(s):  
K. Trukova ◽  
D. Gupta ◽  
P. G. Vashi ◽  
A. Adams ◽  
G. M. Lambert ◽  
...  
Keyword(s):  
Vitamin D ◽  
Nutritional Status ◽  
Serum Albumin ◽  
Vitamin D Deficiency ◽  
Cancer Survival ◽  
Case Series ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D ◽  
The Mean

9638 Background: There is emerging evidence in the literature to suggest a protective role of vitamin D in cancer survival. Vitamin D status is not routinely assessed, despite the high prevalence of malnutrition in this population. We hypothesized that malnutrition could contribute to vitamin D deficiency, and therefore expected mean serum 25-hydroxy-vitamin D [25(OH)D] levels to be significantly lower in malnourished oncology patients. Methods: A consecutive case series of 737 cancer patients seen at Cancer Treatment Centers of America between Jan-June 08. Nutritional status was assessed using Subjective Global Assessment (SGA) and serum albumin. SGA categorizes patients into 3 distinct classes of nutritional status; well nourished (SGA-A), moderately malnourished (SGA-B) and severely malnourished (SGA-C). Serum albumin was divided into 2 groups: >=3.6 g/dl and <=3.5 g/dl. Mean serum 25(OH)D was compared across 3 categories of SGA using ANOVA and across 2 categories of serum albumin using 2 sample t test. Results: Of 737 patients, 302 were males and 435 females. The mean age at presentation was 55.7 years (SD = 10.2). The most common cancer types were lung (133, 18%), breast (131, 17.8%), colorectal (97, 13.2%), pancreas (86, 11.7%), prostate (44, 6%) and ovarian (38, 5.2%). The mean serum albumin and serum 25(OH)D was 3.5g/dl (SD = 0.6) and 21.9 ng/ml (SD = 13.5) respectively. There was no significant difference in the mean vitamin D levels across serum albumin (p = 0.76). The mean vitamin D levels across the 3 classes of SGA also showed no statistically significant difference ( Table ). Conclusions: Contrary to what we expected, vitamin D deficiency was found to be prevalent in cancer regardless of nutritional status. No significant differences were found across the 3 classes of SGA. Based on these results, screening for vitamin D deficiency and aggressive vitamin D repletion should be considered for all people with cancer. [Table: see text] No significant financial relationships to disclose.

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