scholarly journals SIGNIFICANT ASSOCIATION BETWEEN ANTI-THYROID PEROXIDASE (ANTI-TPO) ANTIBODIES AND LOW BIRTH WEIGHT IN EUTHYROID PREGNANT WOMEN

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Bhanwar Singh Meena ◽  
Harendra Kumar Netra ◽  
Amit Kumar Joshi ◽  
Krishna Priya Banerjee
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Placental Abruption ◽  
Venous Blood ◽  
Thyroid Peroxidase ◽  
Intrauterine Death ◽  
Negative Group ◽  
Low Birth Weight Babies ◽  
Induced Hypertension

Background: Maternal and perinatal morbidities are well-documented complications of pregnancy in women with thyroid dysfunction, both clinical and subclinical. About 2–5% of pregnant women suffer from thyroid disorders and timely intervention can be done if detected early. The presence of anti-TPO Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, pregnancy-induced hypertension, intrauterine death and low birth weight. Objectives: Study the effect of anti-TPO Ab positivity on pregnancy outcome especially birth weight and estimate the prevalence of anti-TPO Ab in euthyroid pregnant women. Methods: This observational study enrolled 500 euthyroid pregnant women, age 20-35 years, up to 20 weeks gestation. Venous blood samples collected and analyzed for the anti-TPO Ab levels. On the basis of Ab positivity they were divided into anti-TPO Ab positive and Ab negative group. These two groups were followed up till delivery and compared fetal outcomes for birth weight. Result: Prevalence of anti-TPO Ab positivity was 5.2% in euthyroid obstetric women. Most of anti-TPO Ab positive women were overweight. Incidence of low birth weight babies was 4 fold higher in anti-TPO Ab positive women. Conclusion: Anti-TPO Ab positivity significantly associated with prepregnancy BMI and low birth weight of newborns. Keywords: Thyroid peroxidase antibodies, Anti-TPO Ab, Euthyroid, Low birth weight.

scholarly journals An observational study of fetomaternal outcome in euthyroid women with anti-thyroid peroxidase antibodies at tertiary care hospital

2020 ◽  
Vol 9 (6) ◽  
pp. 2476
Author(s):  
Harendra K. Netra ◽  
Reena Pant ◽  
Krishna P. Banerjee
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Observational Study ◽  
Placental Abruption ◽  
Gestational Hypertension ◽  
Venous Blood ◽  
Tertiary Care ◽  
Thyroid Peroxidase ◽  
Intrauterine Death ◽  
Care Hospital

Background: Several changes are observed in maternal thyroid function during pregnancy and failure to adapt to these physiological changes results in thyroid dysfunction, especially if complicated by the presence of thyroid antibodies. The presence of TPO-Ab is associated with increased rate of pregnancy complications such as miscarriage, preterm delivery, placental abruption, pregnancy-induced hypertension, intrauterine death and low birth weight. Objective of this study was to study the effect of anti-TPO Ab positivity on pregnancy outcome and estimate the prevalence of anti-TPO Ab in euthyroid obstetric women.Methods: This observational study enrolled 500 euthyroid pregnant women, age 20-35 years, up to 20 weeks gestation. Venous blood samples collected and analyzed for the anti TPO Ab levels. On the basis of anti TPO Ab positivity they were divided into two groups, anti-TPO Ab positive and Ab negative group. These two groups were followed up till delivery or abortion and compared for maternal and fetal outcomes.Results: Prevalence of anti-TPO antibody positivity was 5.2% in euthyroid obstetric women. Most of anti-TPO Ab positive women were overweight. There were higher numbers of miscarriage (11.54%) in anti-TPO Ab positive euthyroid pregnancies than (2.53%) in antibody negative women. Incidence of low birth weight babies was 4-fold higher in anti-TPO Ab positive women. More than two-fold increase in incidence of placental abruption in anti-TPO Ab positive women. Parity, anaemia, gestational hypertension, preeclampsia, GDM, PROM, PPH, low Apgar scores, NICU admission, IUD and neonatal death were not significantly associated with anti-TPO Ab positivity.Conclusions: Anti TPO Ab positivity significantly associated with pre-pregnancy BMI, miscarriage rates and low birth weight of newborns. 

scholarly journals Faktor Risiko Bayi Berat Lahir Rendah di Rumah Sakit Umum Daerah Haji Makassar

2020 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Hatijar Hatijar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Status ◽  
Pregnant Women ◽  
Maternal Age ◽  
Health Workers ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Low Birth Weight Babies

Low birth weight babies are babies born with a weight less than 2500 grams. LBW (low birth weight) affects the high mortality rate in infants and is at risk of experiencing obstacles in growth and development. LBW is generally caused due to lack of nutrition and nutritional needs from mother to fetus while pregnant women aged less than 20 years and more than 35 years have the risk of giving birth to LBW. The purpose of this study is to determine the risk factors that cause LBW based on maternal age and nutritional status. The research method used was observational with a cross sectional study approach. The sampling technique was random sampling at the Regional Haji Makassar General Hospital in the January to July 2015 period with a total sample of 65 people. Analysis using the Chi Square Test. The results showed that there was a relationship between maternal age, nutritional status of LBW with a value (p value = 0.00 <α = 0.05). Maternal age and nutritional status are factors that influence low birth weight where the results of the study indicate that there is a relationship between maternal age and nutritional status on the incidence of low birth weight. To reduce the incidence of low birth weight, it is necessary to increase counseling about the causes of low birth weight babies by health workers, especially midwives to pregnant women to prevent the risk of low birth weight birth.

scholarly journals Comparison of risk factors for low birth weight among mothers with normal and low birth weight babies

2020 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Vinodkumar Mugada ◽  
Raj Kiran Kolakota ◽  
Abhilasha Sakalabathula ◽  
Bindu Pavani Kola
Keyword(s):  
Risk Factors ◽  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Statistical Significance ◽  
Pregnancy Induced Hypertension ◽  
Normal Birth Weight ◽  
Normal Birth ◽  
Low Birth Weight Babies ◽  
Induced Hypertension

Background: Low birth weight is an alarming problem in developing countries and has severe future complications. Aim of the study: Our study aimed to compare the risk factors among mothers with low and normal birth weight babies. Materials and Methods: A cross-sectional study was carried out on 1000 mothers with normal and low birth weight babies (500 per group) over two years. Maternal parameters including age, hemoglobin levels, gravida, maternal weight gain, height, pregnancy-induced hypertension, etc., were collected along with anthropometric data of the child. We compared risk factors among the low and normal birth weight babies using the chi-square test, determining statistical significance at p<0.05, and high statistical significance at p<0.01. Results: Highly statistically significant associations were observed between low birth weight and seven variables: maternal age (p=0.0074), maternal height (p<0.0001), weight (p<0.0001), weight gain (p<0.0001), hemoglobin (p<0.0001), severe anemia (p<0.0001), and pregnancy-induced hypertension (p<0.0001). Conclusion: Our study observed significant modifiable risk factors like weight gain, weight, hemoglobin, and anemia among mothers with low birth weight babies. If we focus on raising awareness surrounding these risk factors, there may be an improvement in the birth weight of babies in this population.

scholarly journals HUBUNGAN IBU HAMIL PEROKOK PASIF DENGAN KEJADIAN BAYI BERAT LAHIR RENDAH DI RUMAH BERSALIN IBU SRI PANUNTUN KLATEN

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Sri Aminingsih ◽  
Nadiya Istiqomah
Keyword(s):  
Blood Flow ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Blood Circulation ◽  
Hazardous Chemicals ◽  
Chi Square ◽  
Low Birth Weight Babies ◽  
Relationship Of ◽  
The Relationship

Background: Smoking affects blood circulation and makes mothers and babies exposedto hazardous chemicals. Every time a mother smokes, her baby gets less oxygen.Nicotine in cigarettes decreases blood flow to the placenta. At the same time carbonmonoxide (CO) lowers the amount of oxygen carried by blood. In addition, there are toxicchemicals that usually interfere the development of infants (Rahmalia, 2009). Apreliminary study conducted by the author at the Maternity House of Sri Panuntun, PedanKlaten District, there were 30 babies born in August to September 2017, revealed thatthere were 6 babies suffered from low birth weight, while 24 babies have normal birthweight.The purpose: Describing the relationship of pregnant women passive smokers with theincidence of Low Birth Weight was the aim of this study.The subjects : The population in this study was all mothers who gave birth at MaternityMother Sri Panuntun Klaten in January-March 2018 accounted for 55 respondents.The results: The result of this research by using Pearson Chi-Square correlation testobtained p = 0.000.The conclusion: There was a positive correlation between pregnant women who arepassive smokers with the incidence of low birth weight babies.Keywords: Pregnant women, Passive smokers, Low birth weight babies.

Association Between Pregnancy Induced Hypertension and Low Birth Weight; A Population Based Case-Control Study

2008 ◽  
Vol 20 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Latifah A. Rahman ◽  
Noran N. Hairi ◽  
Nooriah Salleh
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Case Control Study ◽  
Previous History ◽  
Population Based ◽  
Case Control ◽  
Pregnancy Induced Hypertension ◽  
Low Birth Weight Babies ◽  
Induced Hypertension ◽  
Control Study

The purpose of this study was to investigate the association between pregnancy-induced hypertension and low birth weight. A population-based case control study was conducted. Antenatal mothers who attended the government health centers in the district of Kuala Muda, Kedah, Malaysia from June 2003 to May 2004 were recruited. Cases were 312 mothers who delivered low birth weight babies, and controls were 312 mothers who delivered normal birth weight babies. Face-to-face interviews using a structured questionnaire and a review of medical records were carried out. After controlling for important confounders such as gestational age at delivery, maternal age, ethnicity, education, parity, and previous history of abortion, pregnancy-induced hypertension was found to be an independent risk factor (adjusted odds ratio = 5.06; 95% confidence interval: 2.63, 9.71) for low birth weight. There was a significant association of pregnancy-induced hypertension with low birth weight. Women who delivered low birth weight babies were 5 times more likely to have had pregnancy-induced hypertension.

scholarly journals Effect of low dose aspirin on fetal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 7 (4) ◽  
pp. 865
Author(s):  
Madhusmita Pradhan ◽  
Jyotiranjan Champatiray ◽  
Kishore V. S.
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Gestational Age ◽  
Low Dose ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Though pregnancy induced hypertension is a worldwide problem, it is more prevalent in developing countries particularly south east Asian and African countries. It contributes to 20% of perinatal death and 40-50% of low birth weight babies in India. Fetal salvage is also an important consideration in providing quality care. Low dose aspirin given between 12 weeks to 28 weeks of gestational age in high-risk women at Developing Pregnancy Induced Hypertension (PIH) is anticipated to prevent the development of PIH and complications that arises especially those regarding maternal and fetal mortality due to PIH.Methods: This prospective randomized controlled trial was conducted in the dept of O and G, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13 to 28 week were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group taking placebo.Results: Incidence of IUGR babies in low dose aspirin treated mothers was as low as 1%. Incidence of LBW babies is lower in low dose aspirin treated mothers than with those who were not treated. Mean birth weight in cases was 2780 gm±352 gm vs control 2592 gm±483 gm. There is increased incidence of still birth in high risk group not treated with aspirin. No significant difference in reducing incidence premature deliveries between case and control.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy and its complication like IUGR and low birth weight. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals CORRELATION BETWEEN BMI AND PREGNANCY OUTCOME AMONG POSTNATAL MOTHERS WITH PREGNANCY INDUCED HYPERTENSION IN SELECTED HOSPITALS BANGALORE

2015 ◽  
Vol 05 (01) ◽  
pp. 062-067
Author(s):  
Prathima P. ◽  
S Anuchitra
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcome ◽  
Normal Weight ◽  
Reproductive Age ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Low Birth Weight Babies ◽  
Induced Hypertension ◽  
Postnatal Mothers

Abstract Title : Correlation between BMI and pregnancy Outcome among postnatal mothers with pregnancy Induced hypertension in selected hospital Bangalore. Objectives: To identify and correlate BMI and pregnancy Outcome among postnatal mothers with pregnancy Induced hypertension. Method: A non experimental correlation design was utilized among 80 postnatal mothers who were diagnosed as Pregnancy induced hypertension during their antenatal period selected as samples by using purposive sampling technique. Demographic data were collected by interview method, their BMI was calculated, pregnancy outcomes were identified from records by using an outcome checklist. Results : Underweight mothers had low birth weight babies and received NICU care. Among normal weight mothers 17.5 % delivered by LSCS, 15% babies were low birth weight babies 12.5 were preterm babies among them 10% received NICU care. In the overweight group 18.75% undergone LSCS, 18.75% were LBW and 1.25% VLBW, 8.75% babies were preterm, 12.5% newborn received NICU care. Among Obese mothers 8.75% delivered by LSCS, 6.25% of LBW babies, 5% were preterm and all of them received NICU care. There is a positive correlation between BMI and diagnosis and type of delivery. Significant at .01 and .05 Level (p value .008 and .019 respectively). Negative correlation between birth weight and diagnosis and gestational age. r = -.499 significant at .01 level (p value .000) Conclusion: Obesity and under weight is a leading, preventable cause of mortality worldwide. Preeclampsia increases maternal and perinatal morbidity and mortality rates. All women who are in reproductive age group and under risk to develop pregnancy induced hypertension need to be educated about to maintenance of normal weight before pregnancy. Nurses have more responsibility on creating awareness among women how to maintain normal weight to avoid development of complications to the mother and newborn.

scholarly journals The study of maternal and foetal outcome in pregnant women with thyroid disorder

2019 ◽  
Vol 8 (5) ◽  
pp. 1802
Author(s):  
Priya Maurya ◽  
Neeta Chaudhary ◽  
Natasha Tyagi ◽  
M. R. Kural ◽  
Kriti Bhatnagar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Adverse Effects ◽  
Pregnant Women ◽  
Thyroid Dysfunction ◽  
Thyroid Peroxidase ◽  
Thyroid Disorder ◽  
Neonatal Hypothyroidism ◽  
Foetal Outcome ◽  
In Pregnancy

Background: Thyroid disorder is one of the most common disorder in pregnancy. Thyroid disorder is known to be associated with abnormal maternal and foetal outcomes and overlooked in pregnant women because of non-specific symptoms and hypermetabolic state of pregnancy of pregnancy. It is well established that not only overt, but subclinical thyroid dysfunction also has adverse effects on mother and the foetus like miscarriages, preterm delivery, pre-eclampsia, eclampsia, polyhydramnios, placental abruption, postpartum haemorrhage, low birth weight, neonatal hypothyroidism. Decreased availability of thyroid hormones may also impair neurological and intellectual development of foetus. With this background, we are conducting a study to know the effect of thyroid disorder on pregnancy and its maternal and foetal outcome.Methods: The present study was conducted in Muzaffarnagar Medical College, Uttar Pradesh, India in collaboration of department of Gynecology and Obstetrics and Pediatrics Department. It is a prospective random cross-sectional study done over 400 pregnant women which includes known cases of thyroid disorder. Serum thyroid stimulating hormone (TSH) test was apart from the routine blood sample investigations as per FOGSI-ICOG good clinical practice recommendation. fT3, fT4 and thyroid peroxidase antibody test were done in patients with a deranged TSH value. Patients were followed up till delivery, and their obstetrics and perinatal outcomes were noted and managed.Results: In present study out of 400 cases, 25 cases are hypothyroidism and 16 cases are hyperthyroidism in pregnancy. Out of these 41 patients with thyroid dysfunction, complications associated were abortions (14.63%), maternal anaemia (9.7%), pre-eclampsia (12.2%), preterm labour (9.76%), abruption placenta (4.88%), IUGR (2.4%), Still birth (7.32%). Out of 41 patients with thyroid dysfunction, foetal complications seen were hyperbilirubinemia (12.2%), Foetal distress (4.88%), NICU admission (17.07%) and low birth weight (21.95%).Conclusions: Thyroid disorder in pregnancy have adverse effects on maternal and foetal outcome emphasizing the importance of routine antenatal thyroid screening.

Association of Alu I polymorphism in estrogen receptor beta gene with adverse pregnancy outcome in HEV infection

2016 ◽  
Vol 5 (11) ◽  
pp. 5021 ◽  
Author(s):  
Singh S. ◽  
Karra V. K. ◽  
Daga M. K. ◽  
Kumar A. ◽  
Husain S. A. ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Restriction Site ◽  
Estrogen Receptor Beta ◽  
Hepatitis E ◽  
Average Birth Weight ◽  
Low Birth Weight Babies ◽  
Beta Gene

Hepatitis E has both a high incidence and severe course in pregnant women in some geographic regions of HEV (Hepatitis E virus) endemic countries. Intrauterine fetal death, preterm delivery, and perinatal mortality are reported to be higher in pregnant women with HEV infection. Alteration in the steroid hormone levels show high incidence of FHF (Fulminant Hepatic Failure) with high mortality in hepatitis E during pregnancy. The present study is designed to look for the association between ESR (Estrogen Receptor)-beta gene polymorphism for Alu I restriction site and pregnancy outcome. The study group comprised of 142 pregnant women with HEV infection in third trimester, 103 AVH (Acute Viral Hepatitis) cases and 39 ALF (Acute Liver Failure) cases. The control group comprised of 142, age and gestation matched healthy pregnant women with no obstetrics and medical complications. The inclusion criteria for the study group are pregnant women in third trimester with positivity to HEV IgM and/or HEV RNA in the age group of 18-40 years. Genomic DNA is extracted from peripheral blood leukocytes using DNA extraction kit according to the manufacturer’s instructions. The polymorphism study is done by using ESR2 specific primers and its genotype is determined by Alu I restriction enzyme. The occurrence of variant A allele for AluI restriction site is significantly higher in mothers with HEV infection who had preterm (25%) than full term delivery (10%) with OR 2.989 (95% CI = 1.265-8.084, p<0.05) and low birth weight (26.6%) than average birth weight (6.3%) babies with OR 5.399 (95% CI= 2.01-18.26, p<0.05) in pregnant women with HEV infection. The occurrence of variant A allele of ESR beta for AluI restriction site is significantly higher in mother of low birth weight babies (23%) than average birth weight babies (5.5%) in AVH group with OR 5.056 (95% CI= 1.634-21.57, p<0.05) and preterm (40.5%) than full term (0%) delivery in ALF group (p= 0.04). The higher occurrence of variant A allele for AluI restriction site of ESR-beta gene polymorphism is found to be associated with preterm delivery and low birth weight in pregnant women with HEV infection, preterm delivery in ALF group and low birth weight babies in AVH group.

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