Metabolic responses in endurance horses at exhausted syndrome

The article shows the results of the study of biochemical blood indices in sports horses. It is shown that in horses after exercise developing the metabolic syndrome which is a result of insufficient supply of organs and tissues of energy accompanied by development of dehydration, cytolysis syndrome, uremic syndrome, electrolyte imbalance. Evaluation of cardiac output in horses must be performed during and after physical exertion, when during latent disease manifests itself clinically. It is important to know the ways of flowing the course of metabolic processes that occur in the body of horses during physical activity of varying intensity. The most common reason for excluding horses from sports events is metabolic disorders and cardiovascular dysfunction. The aim of the work was to investigate changes in biochemical blood parameters in sports horses after physical exertion. The material for research was horses, which are used in classical equestrian sports. In all horses the general analysis and biochemical parameters of blood, characterizing the functional state of the organs (heart, liver, kidneys) were investigated. The most frequent in horses for physical overstrain is registered increased fatigue, dyspnea, tachycardia, less frequent arrhythmias. In sports horses after exercise develops dehydration (hyperproteinemia), uremic syndrome (increasing the concentration of urea and creatinine), cytolysis syndrome (activity increase of AST and ALT), electrolyte imbalance (decrease in serum sodium and potassium). Hyperlactatemia that occurs in horses during exercise causes changes in the permeability of cardiomyocytes and exit enzymes in the blood and can play a key role in the pathogenesis of myocardial dystrophy. Installed tests can serve for early diagnosis of metabolic syndrome in horses for exercise.

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Metabolic Syndrome: What is the difference between the two definitions IDF and NCEP ATP III in Morocco? Case of the population of Marrakech

E3S Web of Conferences ◽

10.1051/e3sconf/202131901072 ◽

2021 ◽

Vol 319 ◽

pp. 01072

Author(s):

Zineb Hannoun ◽

Meryem Makdad ◽

Khouloud Harraqui ◽

Imane Boussenna ◽

Ikram Kenfaoui ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Healthy Lifestyle ◽

Blood Parameters ◽

The Body ◽

Prevention Strategies ◽

The Metabolic Syndrome ◽

The Mean ◽

Spss Software ◽

The Difference

The purpose of this study was to determine the frequency of metabolic syndrome according to the two definitions: NCEP-ATP III and IDF 2005 and to analyze their differences in a population in Marrakech, Morocco. The study was carried out at Ibn Zohr hospital in Marrakech. The body mass index (BMI) was calculated to assess the degree of obesity of each subject. The blood parameters were measured by an appropriate biochemistry automaton. The diagnosis of metabolic syndrome was made according to the definitions of NCEP-ATP III and IDF 2005. All statistical analyzes were performed using SPSS software. A total of 300 subjects participated in the study, including 57.3% of women and 42.7% of men, with a sex ratio of 0.74. The mean age of our population was 51.6 ± 13.42 years. According to NCEP-ATP III, 79 of the participants (26.3%) had the metabolic syndrome, with a predominance of women: 60 women (20.0%) and 19 men (6.3%); according to the IDF, 139 or (46.3%) of the participants had MS, in which 31.0% were women and 15.3% were men. Waist circumference and hyperglycemia were the two predominant criteria according to both definitions. The study showed that all criteria were statistically associated with the presence of MS. The metabolic syndrome is common in our population regardless of the definition criteria used. The implementation of prevention strategies and the encouragement of a healthy lifestyle will minimize serious health problems in Marrakech city.

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Abstract 1125: Mulberry Leaf Ameliorates The Production Of Adipocytokines By Inhibiting Oxidative Stress In White Adipose Tissue In db/db Mice

Circulation ◽

10.1161/circ.116.suppl_16.ii_226-c ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Masayuki Sugimoto ◽

Hidenori Arai ◽

Yukinori Tamura ◽

Toshinori Murayama ◽

Koh Ono ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

White Adipose Tissue ◽

Metabolic Disorders ◽

The Body ◽

Mulberry Leaf ◽

The Metabolic Syndrome ◽

Pparγ Agonist ◽

Tnf Α

Mulberry leaf (ML) is commonly used to feed silkworms. Previous study showed that ML ameliorates atherosclerosis. However, its mechanism is not completely understood. Because dysregulated production of adipocytokines is involved in the development of the metabolic syndrome and cardiovascular disease, we examined the effect of ML on the production of adipocytokines and metabolic disorders related to the metabolic syndrome, and compared its effect with that of a PPARγ agonist, pioglitazone (Pio). By treating obese diabetic db/db mice with ML, Pio, and their combination, we investigated the mechanism by which they improve metabolic disorders. In this study, db/+m (lean control) and db/db mice were fed a standard diet with or without 3% (w/w) ML and/or 0.01% (w/w) Pio for 12 weeks from 9 weeks of age. At the end of the experiment we found that ML decreased plasma glucose and triglyceride by 32% and 30%, respectively. Interestingly, administration of ML in addition to Pio showed additive effects; further 40% and 30% reduction in glucose and triglyceride compared with Pio treatment, respectively. Moreover, administration of ML in addition to Pio suppressed the body weight increase by Pio treatment and reduced visceral/subcutaneous fat ratio by 20% compared with control db/db mice. Importantly, ML treatment increased expression of adiponectin in white adipose tissue (WAT) by 40%, which was only found in db/db mice, not in control db/+m mice. Combination of ML and Pio increased plasma adiponectin concentrations by 25% and its expression in WAT by 17% compared with Pio alone. In contrast, ML decreased expression of TNF-α and MCP-1 by 25% and 20%, respectively, and the addition of Pio resulted in a further decrease of these cytokines by about 45%. To study the mechanism, we examined the role of oxidative stress. ML decreased the amount of lipid peroxides by 43% and the expression of NADPH oxidase subunits in WAT, which was consistent with the results of TNF-α and MCP-1. Thus our results indicate that ML ameliorates adipocytokine dysregulation by inhibiting oxidative stress in WAT of obese mice, and that ML may have a potential for the treatment of the metabolic syndrome as well as reducing adverse effects of Pio.

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Exercise Induced Adipokine Changes and the Metabolic Syndrome

Journal of Diabetes Research ◽

10.1155/2014/726861 ◽

2014 ◽

Vol 2014 ◽

pp. 1-16 ◽

Cited By ~ 71

Author(s):

Saeid Golbidi ◽

Ismail Laher

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

The Body ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Before And After ◽

Inflammatory State ◽

Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

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BIOCHEMICAL DISORDER OBSERVED IN A DYSAUTONOMIC: ABOUT A CASE

International Journal of Advanced Research ◽

10.21474/ijar01/12148 ◽

2020 ◽

Vol 8 (12) ◽

pp. 280-282

Author(s):

Z. Tahiri ◽

◽

A. Boukhira ◽

G. Kassal ◽

S. Chellak ◽

...

Keyword(s):

Metabolic Syndrome ◽

Nervous System ◽

Autonomic Nervous System ◽

The Body ◽

Military Hospital ◽

Sympathetic Hyperactivity ◽

Autonomic Nervous ◽

The Metabolic Syndrome ◽

Cardiology Department ◽

Valuable Role

The autonomic nervous system (SNA) innervates all the organs and ensures the homeostasis of the body, the disorder of the latter causes a pathology called dysautonomy in this work we will try to report the biochemical disorders observed in a dysautonomic patient. This is a 32-year-old patient who went back to the cardiology department of the 3rd military hospital of Laayoune for high Blood pressure and headaches a complete etiological assessment is done and who found hyperlipidemia and hyperglycemia echocardiography is normal, holter tensionel showed high diastolic arterial pressure exploration of the autonomic nervous system gave sympathetic hyperactivity. Biochemical disorders have defined the metabolic syndrome, which is strongly related to morbidity and cardiovascular mortality. The laboratory plays a valuable role in determining the criteria defining metabolic syndrome.

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REPRODUKSI WACANA METABO LAW DALAM PEMBENTUKAN STEREOTYPE FAT CHARACTER PADA ANIME JEPANG

IZUMI ◽

10.14710/izumi.7.1.11-21 ◽

2018 ◽

Vol 7 (1) ◽

pp. 11

Author(s):

Santi Andayani ◽

Ni Made Savitri Paramita

Keyword(s):

Metabolic Syndrome ◽

Life Style ◽

Japanese Government ◽

The Body ◽

Healthy Life ◽

The Public ◽

The Metabolic Syndrome ◽

Healthy Life Style ◽

Normalization Process ◽

Health Guidance

(Title: The Reproduction Of Metabo Law Discourse In Constructing Fat Characters Stereotype In Japanese Animes) Japanese government through Ministry of Health, Labor and Welfare (MHLW) in 2008 issued the Metabo Law regulation, which is the standard of medical and health guidance that is done specifically with the purpose to decrease the number of obesity which cause the metabolic syndrome. This regulation put the body of each individual to be open to the public. Using Foucault’s perception, this study look how Metabo Law works and how the reproduction of Metabo Law discourses constructing stereotype of fat character in Japanese anime. This study took data from 14 fat character in 13 anime, airing in 2008’s until 2015’s. To complete the data, interview were conducted on 5 Japanese about their understanding about Metabo Law. This study shows that with the normalization process using yearly general checkup and the reproduction of Metabo Law discourses, Japanese government successfully change the Japanese mindset and their behavior in maintained a healthy life style and to stay slim. The stereotype of the fat character that emerge as the product of reproduction of Metabo Law discourses is greedy, careless, cowardly, shy/ have low self-confident, and an otaku.

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Obesity and Body Composition in Man and Woman: Associated Diseases and the New Role of Gut Microbiota

Current Medicinal Chemistry ◽

10.2174/0929867326666190326113607 ◽

2020 ◽

Vol 27 (2) ◽

pp. 216-229 ◽

Cited By ~ 12

Author(s):

Ennio Avolio ◽

Paola Gualtieri ◽

Lorenzo Romano ◽

Claudio Pecorella ◽

Simona Ferraro ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Composition ◽

Gut Microbiota ◽

Disease Risk ◽

Intestinal Flora ◽

Disease Process ◽

The Body ◽

Heart Attacks ◽

The Metabolic Syndrome ◽

Pubmed Database

Background: Obesity is now recognized as a worldwide health issue and has reached epidemic proportions, affecting both developed and developing countries. The World Obesity Federation stated that “Obesity is a chronic relapsing disease process”: as a result, obesity has been recognized internationally as a chronic disease. : The primary cause of the metabolic syndrome and increase of the cardiovascular risk have been identified in "sick fat", a condition then defined as adiposopathy. Heart attacks, strokes and renal failures are pathologies that have mid-risk factors such as dyslipidemia, hypertension and diabetes, which in turn are caused by obesity, whose primary risk factor is represented by the diet. The aim of the present review is to consider the importance of body composition, together with chronic inflammation and a new gut microbiota data that may turn out to be crucial elements of some target treatment of human obesity. Methods: In this review, we performed research using PubMed database reviewing the evidence in the literature of evidence information regarding the link between obesity and body composition in the development of metabolic disease via inflammation markers and in particular, the new role exerted by gut microbiota. Results: Several papers were evaluated searching for differences in fat mass and disease risk. We also identified the same papers dealing with differences in body composition and metabolic syndrome. Our attention focuses also on a new frontier of gut microbiota composition in the body weight decrease and anti-inflammatory effects. Conclusion: To the saving of lean mass, for the prevention of cardiometabolic diseases, also considering the relationship with obesity, it is necessary to reduce the inflammatory state, acting on the gut-microbiota and on the intestinal permeability. To improve the health of the intestinal flora, we propose a 4P medicine and treatment with probiotics, prebiotics, postbiotics, and polyphenols.

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TESTOSTERONE AND METABOLIC SYNDROME IN MEN

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2013.5.1 ◽

2013 ◽

pp. 5-14

Author(s):

Hai Thuy Nguyen

Keyword(s):

Metabolic Syndrome ◽

Testosterone Level ◽

Subsequent Development ◽

Well Being ◽

The Body ◽

Testosterone Replacement Therapy ◽

Aromatase Activity ◽

Metabolic Markers ◽

The Metabolic Syndrome ◽

Low Testosterone

Testosterone is vital hormone for men’s health and a keyplayer in glucose homeostasis, lipid metabolism, and cardiovascular pathology. Testosterone deficiency is associated with age, many chronic health conditions and other metabolic disorders. There is strong evidence that a low testosterone level has a high prevalence in men with metabolic syndrome. Many components of metabolic syndrome are adversely affected especially in relation to cardiovascular risk in the presence of hypogonadism.Testosterone deficiency is a risk factor in itself for the subsequent development of the metabolic syndrome. The hypothesis suggests that low testosterone as a result of high aromatase activity leads to a cycle which promotes increasing adipocyte number and fat deposition which gradually leads to a lower testosterone level. The hypogonadal-obesity-adipocytokine hypothesis explains why the body cannot respond to low testosterone levels by a compensatory production of the hormone. The interventional studies have shown that testosterone administration on hypogonadal men with metabolic syndrome has beneficial effects. These benefits have not only found that hypogonadal symptoms such as sexual function improve, but key metabolic markers also improve. It must also not be forgotten that testosterone replacement therapy in hypogonadal men with metabolic syndrome can have a major impact on the patient’s quality of life and well-being. Key words: testosterone, metabolic syndrome.

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Hematological Indicators of Moose in Domestication Process

International Journal of Veterinary Science ◽

10.37422/ijvs/037 ◽

2020 ◽

Keyword(s):

Hematological Parameters ◽

Physiological State ◽

Blood Parameters ◽

The Body ◽

Sex Characteristics ◽

Hematological Indices ◽

Blood Indices ◽

Hematological Indicators ◽

Age And Sex ◽

Selection Of

Presented hematological indices for a stress-free selection of material from moose in the process of domestication depending on age and sex characteristics. Fluctuations in the blood parameters of moose have been established within various limits, taking into account the influence of various factors - the climatic, environmental, technological, physiological state of the animal, and age and sex characteristics. Considerable attention is paid to the selection of blood from moose, one of the most labor-intensive processes when working with them. Some tendency to fluctuations in hematological parameters in young moose has been recorded. This, possibly, is associated with a decrease in the action of colostral immunity, the formation of a specific defense of the body. Differences in blood indices in moose depending on gender were unreliable. However, in males, some of them - in terms of the content of erythrocytes, basophils, and monocytes - was higher than in females, and vice versa, in females - the number of leukocytes, lymphocytes, and eosinophils. It was shown that in young animals of 21-50 days of age, a neutrophilic profile prevails with increased content of segmented forms, and in adults - a lymphocytic profile. Compared with moose, which are in the process of domestication in animals living in natural conditions, expressed leukocytosis was recorded. As a result of the studies, the estimated norms of morphological parameters of the blood of moose in the process of domestication are established, depending on age and gender.

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