Sero-Epidemiological Investigation on Peste Des Petits Ruminants in Black Bengal Goats

A natural outbreak suspecting PPR (peste des petits ruminants) was thoroughly investigated and confirmed by monoclonal antibody (mAb)-based enzyme immuno slide assay (EISA). Nasal discharge in early stage of disease course, diarrhoeic faeces and lung as a post-mortem sample was a source of sufficient virus to be detected by this technique. Convalescent polyclonal sera from the recovered animal diagnosed as PPR by EISA revealed high antibody titre by competitive-ELISA. It was found that EISA is suitable, sensitive and specific to confirm PPR infection in both field and laboratory conditions especially in developing country. In the affected houses morbidity and mortality rate was 74.13% and 54.83% respectively and observed high in the age group of 5-8 weeks, but sex difference was not significant. Early rainy season (July 2006) was the period of the present outbreak. Sero-positive animal closer to the outbreak area concluded that virus was circulating in the experimental area of Mymensingh district. Vaccinated sero-nagative animal could withstand the natural disease onset. Purchase of new animal from market and grazing in the same field with infected goats was the source of present outbreak.DOI: http://dx.doi.org/10.3329/bjm.v24i2.1260 Bangladesh J Microbiol, Volume 24, Number 2, December 2007, pp 143-145

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Breast carcinoma in young females below the age of 35 years - histopathological and prognostic significance

Journal of Pathology of Nepal ◽

10.3126/jpn.v2i3.6021 ◽

1970 ◽

Vol 2 (3) ◽

pp. 198-202

Author(s):

D Ghartimagar ◽

A Ghosh ◽

OP Talwar ◽

R Narasimhan

Keyword(s):

Breast Carcinoma ◽

Young Women ◽

Early Stage ◽

Prognostic Significance ◽

Age Group ◽

Breast Cancers ◽

Young Females ◽

Younger Age ◽

Grade 3 ◽

Group Grade

Background: Breast cancers rarely occur in young women but are known to have more aggressive behaviors and poorer outcome. We here compare the significance of breast carcinoma in female below the age of 35 to the age over 35 whose specimens were submitted to Manipal teaching hospital, Pokhara. Materials and Methods: All cases of mastectomy with carcinoma from January 2000 to September 2011 were included in the study. Clinical and histopathological datas of all cases were reviewed and collated. Results: A total of 148 mastectomy specimens were received, among which, 23 cases (16%) were below 35 years; whereas 125 cases (84%) were above 35 years of age. In both groups, Stage II was the commonest stage but stage III was much more common in older group (33% versus 9%) and stage I was more common in younger age group (39% versus 27%). Bloom Richardson grading showed that in the older age group, grade 1 is the commonest grade (50%) while in the younger group; grade 3 is the commonest (39%). Patients were followed for a varying period of 6 months to 5 years. Two cases (2% of followed up cases) in older group and 3 cases (15% of followed up cases) in the younger group showed recurrence. Conclusion: Breast carcinoma in the patients younger than 35 years though presented at an early stage has higher grade tumor and poorer outcome. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6021 JPN 2012; 2(3): 198-202

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Seasonality in extra-pulmonary tuberculosis notifications in Germany 2004-2014- a time series analysis

BMC Public Health ◽

10.1186/s12889-021-10655-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Tanja Charles ◽

Matthias Eckardt ◽

Basel Karo ◽

Walter Haas ◽

Stefan Kröger

Keyword(s):

Time Series ◽

Time Series Analysis ◽

Disease Onset ◽

Age Groups ◽

Age Group ◽

Pulmonary Tb ◽

Series Analysis ◽

Disease Site ◽

Extra Pulmonary

Abstract Background Seasonality in tuberculosis (TB) has been found in different parts of the world, showing a peak in spring/summer and a trough in autumn/winter. The evidence is less clear which factors drive seasonality. It was our aim to identify and evaluate seasonality in the notifications of TB in Germany, additionally investigating the possible variance of seasonality by disease site, sex and age group. Methods We conducted an integer-valued time series analysis using national surveillance data. We analysed the reported monthly numbers of started treatments between 2004 and 2014 for all notified TB cases and stratified by disease site, sex and age group. Results We detected seasonality in the extra-pulmonary TB cases (N = 11,219), with peaks in late spring/summer and troughs in fall/winter. For all TB notifications together (N = 51,090) and for pulmonary TB only (N = 39,714) we did not find a distinct seasonality. Additional stratified analyses did not reveal any clear differences between age groups, the sexes, or between active and passive case finding. Conclusion We found seasonality in extra-pulmonary TB only, indicating that seasonality of disease onset might be specific to the disease site. This could point towards differences in disease progression between the different clinical disease manifestations. Sex appears not to be an important driver of seasonality, whereas the role of age remains unclear as this could not be sufficiently investigated.

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Performance of case definitions and clinical predictors for influenza surveillance among patients followed in a rural cohort in Senegal

BMC Infectious Diseases ◽

10.1186/s12879-020-05724-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Mamadou Aliou Barry ◽

Florent Arinal ◽

Cheikh Talla ◽

Boris Gildas Hedible ◽

Fatoumata Diene Sarr ◽

...

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Sore Throat ◽

Predictive Value ◽

Influenza Infection ◽

Clinical Signs ◽

Influenza Virus Infection ◽

Nasal Discharge ◽

Age Group ◽

Case Definitions

Abstract Background Influenza is a major cause of morbidity and mortality in Africa. However, a lack of epidemiological data remains for this pathology, and the performances of the influenza-like illness (ILI) case definitions used for sentinel surveillance have never been evaluated in Senegal. This study aimed to i) assess the performance of three different ILI case definitions, adopted by the WHO, USA-CDC (CDC) and European-CDC (ECDC) and ii) identify clinical factors associated with a positive diagnosis for Influenza in order to develop an algorithm fitted for the Senegalese context. Methods All 657 patients with a febrile pathological episode (FPE) between January 2013 and December 2016 were followed in a cohort study in two rural villages in Senegal, accounting for 1653 FPE observations with nasopharyngeal sampling and influenza virus screening by rRT-PCR. For each FPE, general characteristics and clinical signs presented by patients were collected. Sensitivity, Specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) for the three ILI case definitions were assessed using PCR result as the reference test. Associations between clinical signs and influenza infection were analyzed using logistic regression with generalized estimating equations. Sore throat, arthralgia or myalgia were missing for children under 5 years. Results WHO, CDC and ECDC case definitions had similar sensitivity (81.0%; 95%CI: 77.0–85.0) and NPV (91.0%; 95%CI: 89.0–93.1) while the WHO and CDC ILI case definitions had the highest specificity (52.0%; 95%CI: 49.1–54.5) and PPV (32.0%; 95%CI: 30.0–35.0). These performances varied by age groups. In children < 5 years, the significant predictors of influenza virus infection were cough and nasal discharge. In patients from 5 years, cough, nasal discharge, sore throat and asthenia grade 3 best predicted influenza infection. The addition of “nasal discharge” as a symptom to the WHO case definition decreased sensitivity but increased specificity, particularly in the pediatric population. Conclusion In summary, all three definitions studies (WHO, ECDC & CDC) have similar performance, even by age group. The revised WHO ILI definition could be chosen for surveillance purposes for its simplicity. Symptomatic predictors of influenza virus infection vary according the age group.

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Characteristics and attitudes of family planners in Khartoum, Sudan

Journal of Biosocial Science ◽

10.1017/s002193200001381x ◽

1982 ◽

Vol 14 (1) ◽

pp. 7-16 ◽

Cited By ~ 2

Author(s):

M. A. Khalifa

Keyword(s):

Family Planning ◽

Birth Control ◽

Early Stage ◽

Significant Proportion ◽

Large Family ◽

Capital City ◽

Age Group ◽

African Countries ◽

The Mean ◽

Almost All

SummaryIn a survey of 1475 urban Moslem wives in the age group 15–49 living in the capital city of the Sudan, knowledge of birth control was reported by almost all respondents while a significant proportion had used contraception at least once. The mean age of the users was 32·8 years, their duration of marriage was 15·1 years and their mean number of surviving children was 4·6. Those who had never used contraception had a higher mean age, a longer duration of marriage and more surviving children. Most of the users had an urban residential background and belonged to the high socioeconomic class. They held favourable attitudes to family planning. Although they thought that having a large family (more than five children) was not desirable, their mean preferred family size was no different from that of the never users.The results indicate that contraception is used for the purpose of spacing births rather than limiting their ultimate number. At this early stage of contraceptive adoption in Sudan, the characteristics of the pioneer acceptors are similar to those observed in other African countries.

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Juvenile Granulosa Cell Tumour of Ovary in Young Females- A Clinico-pathological Evaluation of 11 Patients

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/45128.13955 ◽

2020 ◽

Author(s):

Deepa Hatwal ◽

Chitra Joshi ◽

Ranjan Agrawal

Keyword(s):

Granulosa Cell ◽

Precocious Puberty ◽

Early Stage ◽

Tertiary Care ◽

Cell Tumour ◽

Age Group ◽

Granulosa Cell Tumour ◽

Ovarian Mass ◽

Care Teaching ◽

Medical College

Introduction: Ovarian sex cord-stromal tumours, including Granulosa Cell Tumours (GCTs), are a group of neoplasm that occurs rarely, especially in children. Only 0.1% of all ovarian tumours and 4-5% of GCTs occur in children. They commonly present as precocious puberty especially in prepubertal girls. Aim: To analyse the clinico-pathological features along with the laboratory findings of ovarian mass. Materials and Methods: A prospective study in tertiary care teaching institutions was carried out during a three year study period starting from April 2017 to March 2020. The study was carried out in tertiary care teaching institutions i.e., VCSGG Medical Sciences and Research Institute, Srinagar Garhwal, PauriGarhwal, Doon Medical College, Dehradun and Rohilkhand Medical College, Bareilly. A total of 11 cases of Juvenile Granulosa Cell Tumour (JGCT) among girls in the age group of 5-13 years who presented with precocious puberty were included in the present study. The results were analysed especially the clinico-laboratory parameters including histopathology and Immunohistochemistry (IHC) findings. All the patients underwent resection of the ovarian mass and were subjected to histopathological examination. Microscopy and IHC was compatible with the diagnosis of juvenile GCT in all the 11 cases. Results: Majority of the patients with GCTs of the ovary presented in the early stage. Of the 11 cases included, only one patient was aged 13 years; seven were in the age group of 5-8 years and three in the 9-12 years of age group. The laboratory profile in all showed an elevated Estradiol level, low Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) levels. Among the thyroid profile only the Triiodothyronine (T3) levels were raised while Thyroid Stimulating Hormone (TSH) and Thyroxine (T4) levels were within normal limits. All cases were histopathologically proved and confirmed using IHC markers. Surgery is the primary treatment modality for GCTs. Conclusion: Histopathology along with specific IHC is important in the diagnosis of JGCT. A careful search provides good insight of the tumour and its final outcome. Diagnosing JGCT especially in the early stage is important as they carry a favourable prognosis when treated in the initial phase.

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The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients

Cancers ◽

10.3390/cancers13164157 ◽

2021 ◽

Vol 13 (16) ◽

pp. 4157

Author(s):

Giovanni Paolino ◽

Veronica Huber ◽

Serena Camerini ◽

Marialuisa Casella ◽

Alberto Macone ◽

...

Keyword(s):

Fatty Acid ◽

Extracellular Vesicles ◽

Ad Hoc ◽

Early Stage ◽

Disease Onset ◽

Protein Composition ◽

Disease Stage ◽

Biological Macromolecules ◽

Healthy Donors ◽

Melanoma Patients

The early detection of cutaneous melanoma, a potentially lethal cancer with rising incidence, is fundamental to increasing survival and therapeutic adjustment. In stages II–IV especially, additional indications for adjuvant therapy purposes after resection and for treatment of metastatic patients are urgently needed. We investigated whether the fatty acid (FA) and protein compositions of small extracellular vesicles (sEV) derived from the plasma of stage 0–I, II and III–IV melanoma patients (n = 38) could reflect disease stage. The subpopulation of sEV expressing CD81 EV marker (CD81sEV) was captured by an ad hoc immune affinity technique from plasma depleted of large EV. Biological macromolecules were investigated by gas chromatography and mass spectrometry in CD81sEV. A higher content of FA was detectable in patients with respect to healthy donors (HD). Moreover, a higher C18:0/C18:1 ratio, as a marker of cell membrane fluidity, distinguished early (stage 0–I) from late (III–IV) stages’ CD81sEV. Proteomics detected increases in CD14, PON1, PON3 and APOA5 exclusively in stage II CD81sEV, and RAP1B was decreased in stage III–IV CD81sEV, in comparison to HD. Our results suggest that stage dependent alterations in CD81sEV’ FA and protein composition may occur early after disease onset, strengthening the potential of circulating sEV as a source of discriminatory information for early diagnosis, prediction of metastatic behavior and following up of melanoma patients.

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Research into Early-Stage Identification of Entrepreneurs and Innovators with Development of an Identification Guidance Framework

10.3233/atde210052 ◽

2021 ◽

Author(s):

Stephen Robert Pearson ◽

Mahmoud Shafik

Keyword(s):

Private Sector ◽

Tertiary Education ◽

Early Stage ◽

Youth Unemployment ◽

Age Group ◽

British Economy ◽

Identification Process

Youth unemployment is increasing and some countries are exhibiting unprecedented levels of youth unemployment, which according to research from Price Waterhouse Cooper (PwC), is costing the British economy £45bn per year, as well as blighting the careers of workers who miss out on a job in their teens and twenties. Unemployment exists because jobs do not, therefore one way to act to reduce it is to create jobs. It isn’t the governments remit to create jobs, not in the private sector therefore this responsibility is falling more and more on entrepreneurs. This paper seeks to establish a paradigm as to what it is that makes someone entrepreneurial, primarily focussed on positively identifying traits exhibited by entrepreneurs which can be used to assist in that identification process. It seeks to identify the traits and characteristics that make individuals entrepreneurs with a view to devising a framework of identifiable indicators for the tertiary education age group of 16–18-year-olds, leading potentially to early-stage identification of entrepreneurs.

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Incidence of Peste des Petits Ruminants in Rangpur sadar of Bangladesh

Asian Journal of Medical and Biological Research ◽

10.3329/ajmbr.v3i4.35345 ◽

2018 ◽

Vol 3 (4) ◽

pp. 529-533 ◽

Cited By ~ 1

Author(s):

Md Mamunur Rahman ◽

Md Zakir Hassan ◽

Salma Sultana ◽

Md Karim Uddin ◽

SM Sarwar Hossain

Keyword(s):

Clinical Signs ◽

Postmortem Examination ◽

Nasal Discharge ◽

Peste Des Petits Ruminants ◽

Aged Group ◽

Infected Goat ◽

The Common ◽

Spleen And Lymph Nodes ◽

Veterinary Hospital ◽

Black Bengal Goat

This epidemiological study was conducted to find out the incidence of Peste des Petits Ruminants (PPR) in goat and sheep at Upazilla Veterinary Hospital, Rangpur sadar, Rangpur during the period of January to April, 2014. In this period, 236 clinically infected goat and sheep were examined in which 22 (9.32%) PPR cases were diagnosed on the basis of history, clinical signs and gross pathological lesions. High fever (104-107 oC), mucopurulent oculo-nasal discharge, rapid and labored breathing, mouth lesion and diarrhea were the common clinical sign of PPR infected goat and sheep. The postmortem examination findings were dark red areas and congestion in different lobes of lungs, enlargement of spleen and lymph nodes, erosion of abomasums and characteristics zebra striping in the mucosa of colon. This present study reveals that about 7-12 months aged group of goats were more prone (40.91%) to PPR compare to adult (above 1 year) and Black Bengal goat was more susceptible (72.32%) than Jamunapari (27.78%) goat where the occurrence of PPR disease was more in goat (81.82%) than sheep (18.18%).Asian J. Med. Biol. Res. December 2017, 3(4): 529-533

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The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

Case Reports in Medicine ◽

10.1155/2010/845671 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 15

Author(s):

Detlef Brehmer ◽

Randolf Riemann

Keyword(s):

Differential Diagnosis ◽

Nasal Cavity ◽

Foreign Bodies ◽

Early Stage ◽

Diagnostic Techniques ◽

Nasal Discharge ◽

Rare Occurrence ◽

The Past ◽

Stage Of Development ◽

The Right

Rhinoliths are mineralised foreign bodies in the nasal cavity that are a chance finding at anterior rhinoscopy. Undiscovered, they grow appreciably in size and can cause a foul-smelling nasal discharge and breathing problems. Giant nasal stones are now a very rare occurrence, since improved diagnostic techniques, such as endoscopic/microscopic rhinoscopy, now make it possible to identify foreign bodies at an early stage of development. We report the case of a 37-year-old patient who, at the age of 5-6 years, introduced a foreign body, probably a stone, into his right nasal cavity. On presentation, he complained of difficulty in breathing through the right nostril that had persisted for the last 10 years. For the past four years a strong fetid smell from the nose had been apparent to those in his vicinity. Under general anaesthesia, the stone was removed in toto from the right nasal cavity. The possible genesis of the rhinolith is discussed, our case compared with those described in the literature, and possible differential diagnoses are considered.

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An observational study of benign oral lesions in central India

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20173201 ◽

2017 ◽

Vol 3 (4) ◽

pp. 816

Author(s):

Prashant N. Keche ◽

Nishikant P. Gadpayle ◽

Surendra H. Gawarle ◽

Gaurav A. Chamania

Keyword(s):

Oral Cavity ◽

Malignant Tumors ◽

Early Stage ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Oral Lesions ◽

Age Group ◽

Cross Sectional ◽

Male Predominance ◽

Malignant Lesions

Background: The oral mucosa serves as a protective barrier against trauma, pathogens and carcinogenic agents. It can be affected by a wide variety of lesions and conditions, some of which are harmless while others may have serious complications. The appearance of benign oral soft tissue masses can occasionally resemble malignant tumors. Methods: Present study is an observational and cross sectional study under taken in the Department of ENT in Shri Vasant Rao Naik Government Medical College, Yavatmal. All cases of benign oral lesions were included in the study and following cases were excluded: malignant oral lesions, immunocompromised state and benign Oral lesions due to systemic diseases. Results: Present study included 235 lesions of oral cavity which were clinically or histo-pathologically found to be benign in nature. Benign oral lesions were more commonly found in males with (70.2%) than females (29.8%), and M:F ratio was 2.3:1. most common benign oral lesions were found to be Oral Sub Mucus Fibrosis (26.8%) followed by Apthous ulcers (20.4%), Leukoplakia (18.3%) and Mucocele (17.1%). Least common benign oral lesions were found to be Minor Salivary Gland Tumor (MSGT) (1.7%) followed by Squamous Papilloma (2.1%), Ranula (2.1%) and Hemangioma (2.1). There was a male predominance in oral sub mucus fibrosis with M:F ratio of 9.5:1 followed by Leukoplakia with M:F ratio of 4.4:1. OSMF was found most commonly in 21-30 years age group with (57.1%). Followed by 11-20 years with (20.6%). No cases were found in ≤10 years, 51-60 and >60 years age group. Conclusions: Most of the benign oral lesions have a predilection to transform into malignant lesions therefore imperative to diagnose the pre malignant lesions of oral cavity in an early stage where appropriate treatment can be given.

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