scholarly journals Effects of Griseofulvin in the Treatment of Lichen Planus -A Study in BSMMU

1970 ◽  
Vol 6 (2) ◽  
pp. 86-88
Author(s):  
KG Sen ◽  
RM Hira ◽  
AZMM Islam ◽  
SK Sarker ◽  
MN Sarker ◽  
...  

Lichen Planus (LP) is an inflammatory disorder of skin, mucous membranes, nails and hair. There are various modalities of treatment but none is curative. This prospective therapeutic trial was done among patients with lichen planus at the outpatient department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka between November 2001 and April 2002. Total 20 patients were taken of them 12 were male and 8 were female with male to female ratio 3:2. Age of the patients was between 10 to 50 years. Patients were diagnosed clinically & confirmed histologically. They were treated with griseofulvin 500 mg daily for 6 months. Out of 20 patients, 8 had only oral lesions, of them 2 (25%) showed complete response, 3(37.5%) showed moderate improvement and 4 (37.5%) showed no response. Other 12 patients had lichen planus involving skin without oral mucosa, of them 4 (33.3%) showed moderate improvement, 4 (33.3%) showed no response and 4 (33.3%) patients worsens with treatment. So, success in patients with cutaneous lichen planus is less likely; however, griseofulvin may afford relief in selected patients with oral lesion. This study indicates that further prospective placebo controlled studies are needed to clarify the efficacy of griseofulvin in lichen planus. Key words: Lichen planus; Griseofulvin DOI: http://dx.doi.org/10.3329/fmcj.v6i2.9207 FMCJ 2011; 6(2): 86-88

2019 ◽  
Vol 47 (1) ◽  
pp. 33-36
Author(s):  
Mohammad Golam Masum ◽  
ABM Sarwar Jahan ◽  
Md Rezwanul Haque Robbani ◽  
Fayed Chowdhuray ◽  
Mohammed Faroque Hossain

Obstructive jaundice is a condition in which there is blockage of the flow of bile out of the liver. To find out the correlation between clinical diagnosis and operative findings of patients having obstructive jaundice. This prospective observational study was conducted at the Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from January 2008 to April 2009. Fifty clinically diagnosed obstructive jaundice cases were enrolled in this study. A detailed history was taken and thorough physical examination was done. Also necessary haematological, biochemical, radiological and other special investigations were carried out.  In this study, mean age of the patients was 42.9 years and male to female ratio was 1:1.17. The most frequent cause was choledocholithiasis (40%), stricture of CBD (6.0%), retained stone (14.0%), parasitic obstruction (4.0%), carcinoma (30.0%) and other cause (6.0%). Serum bilirubin level was below 10mg/dl in all cases of stricture of CBD. It was above 15mg/dL in cases of carcinoma head of the pancreas. The rise of Serum alkaline phosphates level was up to 3 folds in cases with choledocholithiasis, biliary stricture and pancreatic head malignancy. The average rise in other cases was 1 to 2 folds. Sensitivity and specificity of pre operative clinical diagnosis of choledocholithiasis, carcinoma and retain stone was 86.4 & 96.4%, 92.3 & 91.9% and 71.4 & 95.3% respectively. Pre operative clinical diagnosis of obstructive jaundice is a good diagnosis tool in diagnosis of causes of obstructive jaundice. Bangladesh Med J. 2018 Jan; 47 (1): 33-36


2019 ◽  
Vol 47 (2) ◽  
pp. 12-16
Author(s):  
Abida Sultana ◽  
Mohammed Saiful Islam Bhuiyan ◽  
Md Mostaque Mahmud

Facial acanthosis nigricans (FAN) is an ignored dermatological entity. Nowadays it occurs more frequently than previous days may be due to changing economic and social status of our country. Aim of this study was to assess the rate of metabolic syndrome in cases of facial acanthosis nigricans. This observational study was conducted in the outpatient department (OPD) of dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU) in the year 2017 among thirty clinically diagnosed cases of FAN. After taking their informed written consent; BMI, random plasma glucose, fasting lipid profile and serum insulin level was estimated in venous blood and recorded accordingly. To confirm metabolic syndrome we followed NCEP ATP III guideline (2005) where 3 of 5 positive criteria confirmed the diagnosis. All data was preserved in a secured computer device and was analyzed with SPSS program with appropriate statistical tools. Mean (±SD) age of patients was 35.63 ± 14.26 years and male to female ratio was 1:1.14. The mean BMI of cases was 33.73±3. We found 11 cases with hypertension, 8 with type II diabetes mellitus and 9 with dyslipidemia. Among the 30 cases of FAN 12 zygomatic type, 8 generalized type and 5 had band like pigmentation on the forehead. Twenty-three patients had acanthosis nigricans on both sides of body. According to our preset criteria we found 26.66% cases had metabolic syndrome. The rate of metabolic syndrome is higher in facial acanthosis nigricans patients. A further large scale study is recommended for strengthening this study findings. Bangladesh Med J. 2018 May; 47 (2): 12-16


2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Frank Ondrey

Objective. The characteristics of oral lichen planus (OLP) provoke investigators to explore possible biomarkers by which to monitor disease activity and therapeutic efficacy. Oral fluids may provide an accessible medium for analysis of such biomarkers. Previous studies have shown that activation of nuclear factor-kappa B (NF-κB) plays an important role in the pathogenesis of oral lichen planus (OLP), which is a chronic inflammatory disorder mediated by T cells. Prior to the present investigation, reports of the levels of NF-κB and its dependent cytokines in oral fluids have not been forthcoming. The purpose of this study was to detect the level of NF-κB dependent cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in tissue transudates directly from lesions of OLP, and explore the feasibility of the data for clinical application.Study design. Thirteen definitively diagnosed OLP subjects were enrolled in the study as were 13 age-sex matched controls. In each subject, lesion tissue transudates (TTs) were collected by a novel collection technique with a filter paper. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids were determined by ELISA.Results. In the tissue transudate(TT), there were significantly higher level of cytokines TNF-alpha, IL-1-alpha, IL-6, and IL-8 detected in OLP patients than in controls: (TT:40.0±9.8versus4.5±0.7,710±114versus305±78,150±25versus1.7±0.5,2800±260versus1450±130,P<.0001; unit: pg/mL).Conclusions. These results indicate that NF-κB dependent inflammatory cytokines may be detected at increased levels in oral lesion tissue transudates which may have diagnostic and prognostic potentials for monitoring disease activity and making therapeutic decisions in patients with OLP.


2012 ◽  
Vol 30 (3) ◽  
pp. 132-136
Author(s):  
Umme Habiba Begum ◽  
Afiqul Islam

Objectives: To describe the clinical profile as well as  histopathological sub-types of Rhabdomyosarcoma in  children.Methods: A hospital base prospective observational study  was conducted among 20 diagnosed cases of  Rhabdomyosarcoma in children, those attending in  Hemato-Oncology department of Bangabandhu Sheikh  Mujib Medical University (BSMMU), Dhaka in the period  between January to December 2009.Results: The peak incidence of Rhabdomyosarcoma was  in 1-5 years of age group (n=9, 45%) with mean age 6.83  years with male to female ratio 5.66:1. The common sites  of primary tumor was in head and neck region (40%, n=08),  followed by genito-urinary tract, 30% (n=06), extremities  20% (n=04), trunk 10% (n=02). The most common clinical  presentation was mass lesion 100% (n=20), followed by local  pain 25% (n=05), urinary obstructions 15% (n=03)  dysphagia, chronic otorrhea, dysuria, haematuria, and  proptoses were 10% each (n=02, each); The histological  sub-types were Embryonal 60% (n=12), alveolar 30% (n=6),  and Botryoid 10% (n=02); Of Embryonal variety in head  and neck region 58.33% (n=7), and Genito-urinary sites  41.67% (n=5); of Alveolar variety in trunk 66.67% (n=4),  and in extremities33.33% (n=2), of Botryoid sub-type  frequency was equal in head - neck region and genitourinary  site 50% each (n=1).Conclusion: Children with Rhabdomyosarcoma presented mostly in 1 to 5 years of age, with mass lesion (100%),  predominantly in head and neck region (40%) and the  commonest histological sub-type was Embryonal variety  (60%). DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12461 J Bangladesh Coll Phys Surg 2012; 30: 132-136


Author(s):  
Devendra Parmar ◽  
Kinnari Thacker ◽  
Jay Shah

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Oral lichen planus (OLP) is a common mucocutaneous disorder that affects 1-2% of the adult general population and slight predominance in females has been observed. The success rate is not satisfactory with these modalities of treatment, so there is a clear need for alternative therapy. This study was done to evaluate the efficacy of griseofulvin in the treatment of lichen planus.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The present study was conducted in the department of dermatology in the medical institution for the period of one year. The study included the initial assessment of 60 patients who were diagnosed with lichen planus (LP). Patients with both sexes and age between 15-60 years who agreed to come on follow up examination were included. All patients were treated with griseofulvin 500 mg/day for 6 months. Response of treatment was assessed by clinical examination at each subsequent visit (every two weeks)</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Among patients with OLP, there was complete response in 27%, moderate improvement in 51%, and no response in 22% of cases. Complete clinical response of cutaneous LP was seen in 18% cases, no response was found in same number of patient, 64% no. of cases showed moderate response. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Griseofulvin gives complete improvement in 27% cases and moderate improvement in 51% cases in OLP and it gives complete improvement in 16% cases in cutaneous LP after treatment of 6 months. This study was done on a small scale and without any control group, so conclusive comments could not be passed.</span></p>


2022 ◽  
pp. 002581722110381
Author(s):  
Qasim Mehmood ◽  
Fatima Yasin ◽  
Arif Rasheed Malik

The deliberate killing of a foetus in the womb, or a child from the first 24 h of birth to one month of age, or within the first year of life, is called foeticide, neonaticide and infanticide, respectively. Socioeconomic stress, mental illness, gender selection, shame or fear of punishment of adultery or illegitimacy, grudge and jealousy with parents and negligent delivery by dai are major causative factors in such cases. This is a retrospective, descriptive, observational study, and the sample pool consisted of 35 cases. Foeticide cases were 42.9% of the total and the same percentage of cases were neonaticides, while 14.3% of cases were of infanticide. The male-to-female ratio was 1.26:1 and the major cause of death was head injury. The study shows a prevalence of foeticide and neonaticide as compared to infanticide. It also displays the prevalence of males in overall cases and a higher number of unknown cases in our setting.


2021 ◽  
pp. 17-20
Author(s):  
Sravani Ponnada ◽  
Lakshmi Latchupatula ◽  
Tadikonda Krishna Srivathsav ◽  
Bhagyalakshmi Atla

Background: Oral cavity is a common site for various non-neoplastic and neoplastic lesions. Majority of lesions were neoplastic. Tobacco chewing, smoking and alcohol consumption were the common risk factors implicated in the etiology of malignant oral lesions. Squamous cell carcinoma was the most common lesion of the oral cavity. Aims&Objectives: To study the clinicopathological lesions of the oral cavity with respect to age, gender, location, clinical presentation, histopathological patterns and various risk factors. Materials And Methods: A retrospective study of 274 oral cavity lesions conducted for period of 2 years from January 2019 to December 2020 in the department of pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh. Results: In our study, the age range of the patients was from 3 years to 87 years. Majority of cases were seen in age group of 41- 50 years. Males were more commonly affected than females with a male to female ratio of 2.51:1. Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Tongue was the most common site involved in oral lesions. Mucocele was the commonest non-neoplastic lesion and squamous papilloma was the most common benign lesion. Leucoplakia was the most common premalignant lesion and Squamous cell carcinoma was the commonest malignant lesion. Conclusion: Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Early and accurate identication of potentially malignant oral lesions is important and essential for prevention of morbidity, mortality and for proper treatment of cases. Along with clinical examination and laboratory investigations, histopathological examination is still the gold standard to establish a denitive diagnosis and for conrmation of the nature and origin of oral lesions.


2012 ◽  
Vol 6 (2) ◽  
pp. 11-14 ◽  
Author(s):  
Mst. Rummana Rahim ◽  
Ahmed Abu Saleh ◽  
Md. Ruhul Amin Miah ◽  
Shaheda Anwar ◽  
Md. Muzibur Rahman

Dermatophytes are by far the most significant fungi because of their widespread involvement of population at large and their prevalence all over the world. This is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of Dermatology and Venereology, Bangabandhu Sheik Mujib Medical University, Dhaka. Three hundred and twenty clinically suspected cases of dermatophytosis were subjected to mycological studies. One hundred and five cases (32.8%) were positive for fungus in direct microscopy while 97(30.3%) were culture positive. Tinea unguium was the most common clinical type encountered followed by tinea corporis. Dermatophytosis was more common in the age group of 21-30 years. The male to female ratio was 1.54:1. Trichophyton rubrum 84(86.6%) was found common etiological dermatophyte species followed by Trichophyton mentagrophytes 8(8.2%) and Epidermophyton floccosum 5(5.2%).DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19370 Bangladesh J Med Microbiol 2012; 06(02): 11-14


2013 ◽  
Vol 21 (2) ◽  
pp. 58-59
Author(s):  
Rajib Barua ◽  
Dewan Saifuddin Ahmed ◽  
ASMA Raihan ◽  
Mohammad Abul Kalam Azad ◽  
Sadesh Kumar Chakrovortty ◽  
...  

Crohn’s disease has been considered to be uncommon in Asia Pacific region The study was undertaken to know the extraintestinal manifestations of Crohn’s disease in Bangladesh and to compare the result with that of other Asian and Western countries. This was an observational study consisting of patients seen in the department of gastroenterology, Bangabandhu Sheikh Mujib Medical University for 20 years (between 1991 and 2010). Individual case records were carefully reviewed with regard to gender, sex and extraintestinal manifestations. A total of 41 patients with Crohn’s disease were identified. 70.7% were male and 29.3% were female with male to female ratio was 2.4:1. Mean age was 34±11.8 years and peak age group was 21-30 years. The chief extraintestinal manifestations were arthritis, aphthous ulcer in the oral cavity, erythema nodosum and episcleritis. Arthritis was the most frequent among the extraintestinal manifestations. So, Crohn’s disease should be considered as an important differential diagnosis when a patient presents with bowel symptoms associated with extraintestinal manifestation and thus early recognition and treatment could be possible. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13611 Bangladesh J Medicine 2010; 21: 58-59


2020 ◽  
Vol 4 (1) ◽  
pp. 3-7
Author(s):  
Adnan Hasan Masud ◽  
Md. Kamrul Hasan ◽  
Saradindu Kanti Sinha ◽  
Kazi Mohammad Kamrul Islam ◽  
Md. Jalilur Rahman

Beta thalassaemia is one of the most prevalent haemolytic disorders worldwide which poses serious economic burden to the society. Study on clinical and demographic pattern of this disorder will help the concern authorities to figure out the problem. This cross-sectional descriptive study was carried out to determine the socio-demographic and clinical characteristics as well as to find out the existence of other co-morbidities among the ?-thalassaemic patients (n-101). The study was carried out at the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from June 2010 to January 2011. Data were collected from 3 tertiary care hospitals of Dhaka city. Almost all the patients were young, age ranged from 10 to 32 years with the mean age of 16. Male to female ratio was almost equal (52.5:47.5) and 80% of the respondents were Muslims. Forty-five (45%) percent of patients were illiterate and 37% respondents had primary education only. Almost 90% were unmarried and majority had a family of 6-8 members. Forty-seven percent (47%) of patients had monthly income 5000-7000 BDT and 56% of the respondents were unemployed. The major clinical features were pallor (72.3%), palpitation (60%), and breathlessness (52.5%). The haemoglobin (Hb) concentration ranged from 7gm/dl to 12gm/dl and 57% patients had an Hb concentration of 8 gm/dl. Sixty percent of the respondents had jaundice with majority had enlarged spleen (86%) and some had enlarged liver too (23%). Ninety percent (90%) respondents had co-morbidities among which arrhythmia is more prevalent (54%).


Sign in / Sign up

Export Citation Format

Share Document