Severe COVID-19 infection in a 32 weeks pregnant woman successfully treated with convalescent plasma therapy

Author(s):  
Ashraful Hoque ◽  
Talukder Mohammad Al Amin

From the beginning of corona virus disease 19(COVID-19) pandemic, there has been concern how to protect vulnerable group like pregnant women from severe acute respiratory syndrome corona virus 2(SARS-CoV-2). Historically, pregnant women experiences increased mortality during any pandemic situation. Pregnant women show almost the similar clinical features as that of non-pregnant adults with COVID-19 infection. Different systematic reviews have begun to focus light on pregnancy outcomes in COVID-19 patients, but knowledge is very limited and still the basis is case series and individual experiences. Apart from the scientifically proven therapeutic options used in COVID-19 such as steroid, low molecular weight heparin, the role of convalescent plasma therapy (CPT) has never been evaluated. We present a case of a pregnant woman of 32 weeks of conception, treated with CPT with favourable outcome in a private hospital of Dhaka, Bangladesh. BSMMU J 2021; 14 (COVID -19 Supplement): 64-66

2021 ◽  
pp. 29-30
Author(s):  
Venkatesh B. C. ◽  
Rajendra Rao K. M. ◽  
K. N. Mohan Rao

Corona virus Disease 2019 (COVID-19) pandemic is causing a major health crisis across the globe. With the increasing number of fungal infections associated with COVID-19 being reported, it is imperative to understand the spectrum of such infections. Most documented cases have been reported in patients with diabetes mellitus or treatment with immunomodulators. The most common causative agents are Aspergillus, Candida or Mucorales. This series aims to portray the spectrum of fungal infections associated with COVID-19.


2021 ◽  
Vol 14 (1) ◽  
pp. 01-05
Author(s):  
Putu Dyah Widyaningsih ◽  
Putu Gita Pranata Putra ◽  
DG Wedha Asmara ◽  
Erna Bagiari ◽  
Agus Santosa ◽  
...  

The treatment of corona virus disease 2019 (COVID-19)remains in debate, and the use of chloroquine has not been validated by accurate clinical trials.The aim of this study was to provide the possible cardiotoxicity effect of chloroquine in patients with COVID-19. This study was a case-series of prolonged QT interval of COVID-19 patients treated with chloroquine in a hospital in Bali, Indonesia. There were two cases of COVID-19 with exhibited a prolonged QT interval after being administrated of chloroquine. The prolonged QT interval returned to normal after chloroquine was stopped.These cases alert us the cardiotoxicity effect of chloroquine and the need for serial electro-cardiography monitoring before and during therapy. In conclusion, although antiviral and anti-inflammation properties of chloroquine on COVID-19 are promising, its cardiotoxicity effects should be monitored closely for less harm to the patients.


2021 ◽  
Vol 12 (4) ◽  
pp. 1285-1303
Author(s):  
Hend Hassan Ali ◽  
Amira Morsy Yousif ◽  
Sabah Abdo Abd El-Haleem

Author(s):  
Riska Nia Andriani ◽  
Gunawan A. Tohir ◽  
Vina Pramayastri

COVID-19 (Corona Virus Disease 2019) merupakan penyakit akibat infeksi SARS-CoV-2. Tenaga kesehatan merupakan kelompok yang paling rentan terpapar virus ini dikarenakan adanya kontak langsung dengan orang yang terinfeksi. Penelitian ini bertujuan untuk mengevaluasi kesehatan kerja petugas kesehatan di IGD RSUD Palembang BARI terhadap wabah COVID-19. Metode penelitian ini adalah penelitian kuantitatif dengan desain deskriptif case series. Hasil penelitian ini menunjukkan bahwa yang paling banyak ditemukan adalah karakteristik petugas kesehatan dengan usia antara 26–35 tahun, masa kerja >3 tahun dan lama kerja >8 jam, patuh menggunakan APD yang sesuai dengan rekomendasi WHO atau Kemenkes RI, jam kerja tetap, pendapatan yang tidak bertambah atau tetap, RT-PCR negatif, adanya rasa takut dan melakukan tindakan pencegahan terhadap COVID-19, serta motivasi kerja yang tidak rendah. Sehingga dapat disimpulkan bahwa petugas kesehatan di IGD RSUD Palembang BARI patuh menggunakan APD yang sesuai dengan rekomendasi WHO atau Kemenkes RI serta motivasi kerja yang tidak rendah. Saran bagi tenaga kesehatan diharapkan dapat terus mempertahankan kepatuhan dalam menggunakan APD, motivasi kerja maupun tindakan pencegahan.


Author(s):  
Abdul Rohim

Coronavirus disease is also known as Covid-19 (Corona Virus Disease 2019) and was discovered in the city of Wuhan, China at the end of December 2019. This virus spreads rapidly and has reached almost every country, including Indonesia, in just a few months. As a result, numerous countries have implemented regulations imposing lockdowns to prevent the spread of the Coronavirus. To control the spread of this virus, Indonesia implemented a Large-Scale Social Restriction (PSBB) policy. The method employed in this study is to analyze data from various reading sources. By comparing journals or articles, references are obtained from online publications with diverse studies. This study utilized five journals as references, all of which demonstrated that community participation in preventing the spread of Covid-19 was in a good category. According to the journals reviewed, information regarding the handling of Covid-19 necessitated the participation of all parties to prevent its spread. From the five journals obtained, all of these journals indicate that the role of the community is required in preventing the spread of the Covid-19 virus.


Author(s):  
Amrut.S. Salunke ◽  
Adarsh Ramkalap Sharma ◽  
Sonali Sunil Tadasarkar

Corona virus disease is caused by severe acute respiratory syndrome Corona virus 2[SARS-CoV-2] infections attacking multisystem of the human body at a time, of which respiratory system, immune system and circulatory system are most affected. The complications of the disease arise or it becomes more pronounced, after the cytokinine storm phase becomes established leading to hypercoagulative state affecting the circulatory and respiratory system. In Ayurveda, there is a holistic approach in treating the disease and the body as a whole. Drugs such as Haridra, Tulasi, Guduchi, Yashtimadhu, Twak, Triphala, Lavang, Maricha, Pippali etc and few Visha Dravyas like Langali, Dravanti etc can be used a single drug or a group of drugs with their phytochemical properties and active principles leading to delay and prevention of hyper coagulable states thereby preventing the cascade of complications caused by COVID, additionally having anti-inflammatory and immune-modulatory effect. Scientific research on these drugs may reveal a new approach for management and prevention of COVID related complications and can be a subject of future research interest.


2021 ◽  
Vol 7 (2) ◽  
pp. 30-32
Author(s):  
Z Habib ◽  
◽  
Y Hafeez ◽  
Imen Mbarek ◽  
M Ul Haque ◽  
...  

WHO declared Corona Virus disease 2019 (COVID-19) as a public health emergency on the 30th of January 2020. Soon afterward, COVID-19 cases started to emerge from all parts of the world. The state of Qatar was extremely vigilant from the very outset. Special measures were introduced immediately to restrict the influx of people from high-risk countries such as China and Iran. The Ministry of public health (MOPH), Qatar started preparing for an impending pandemic in the meantime. The first cluster of COVID-19 positive cases was declared on March the 11th 2019. A total of 238 cases were declared positive on this day. It raised the alarm to roll over all those preparations on the ground into practice


2021 ◽  
Vol 6 (2) ◽  
pp. 99
Author(s):  
Fadlilah Purdananto

Pandemi Corona Virus Disease (Covid-19) memiliki dampak yang signifikan ke perubahan perilaku masyarakat. Dampak tersebut memunculkan permasalahan berupa ketidakmampuan masyarakat dalam mengelola rasa curiga, takut, sikap over-protektif. Bila hal itu tidak diselesaikan dengan baik, maka dapat merusak hubungan sosial antar individu. Penelitian ini menggunakan metode deskriptif-analitis, dengan menggunakan teori psikodinamika. Hasil penelitian menunjukkan bahwa pekerja sosial berperan dalam mengubah perilaku masyarakat, sehingga mereka mampu menyelesaikan permasalahan sosial akibat dampak pandemi Covid-19. Peranan pekerja sosial, yakni: pertama, berperan dalam meningkatkan fungsi sosial individu-individu. Hal itu dilakukan pekerja sosial dengan memberikan pertolongan agar individu mampu memahami konflik (kepanikan/keresahan) pikiran-pikiran dan perasaannya. Kedua, pendampingan sosial kepada masyarakat. Hal itu dilakukan pekerja sosial dengan mengedukasi dan membantu mensosialisasikan kegiatan yang bertujuan untuk melakukan pencegahan atau penurunan penyebaran Covid-19.[The Corona Virus Disease (Covid-19) pandemic has a significant impact on changing people's behavior. This impact raises problems in the form of the community's inability to manage suspicion, fear, over-protection. If it is not resolved properly, it can damage social relations between individuals. This research uses descriptive-analytical method, using psychodynamic theory. The results of the study show that social workers play a role in changing people's behavior, so that they are able to solve social problems due to the impact of the Covid-19 pandemic. The role of social workers, namely: first, plays a role in improving the social function of individuals. This is done by social workers by providing assistance so that individuals are able to understand the conflict (panic/anxiety) of their thoughts and feelings. Second, social assistance to the community. This is done by social workers by educating and helping to disseminate activities aimed at preventing or reducing the spread of Covid-19.]


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Rosner-Tenerowicz ◽  
Tomasz Fuchs ◽  
Aleksandra Zimmer-Stelmach ◽  
Michał Pomorski ◽  
Martyna Trzeszcz ◽  
...  

Abstract Background Infection with SARS-CoV-2 during pregnancy can lead to a severe condition in the patient, which is challenging for obstetricians and anaesthesiologists. Upon severe COVID-19 and a lack of improvement after multidrug therapy and mechanical ventilation, extracorporeal membrane oxygenation (ECMO) is introduced as the last option. Such treatment is critical in women with very preterm pregnancy when each additional day of the intrauterine stay is vital for the survival of the newborn. Case presentation We report a case of a 38-year-old woman at 27 weeks of gestation treated with multidrug therapy and ECMO. The woman was admitted to the intensive care unit (ICU) with increasing fever, cough and dyspnoea. The course of the pregnancy was uncomplicated. She was otherwise healthy. At admission, she presented with severe dyspnoea, with oxygen saturation (SpO2) of 95% on passive oxygenation, heart rate of 145/min, and blood pressure of 145/90. After confirmation of SARS-CoV-2 infection, she received steroids, remdesivir and convalescent plasma therapy. The foetus was in good condition. No signs of an intrauterine infection were visible. Due to tachypnea of 40/min and SpO2 of 90%, the woman was intubated and mechanically ventilated. Due to circulatory failure, the prothrombotic activity of the coagulation system, further saturation worsening, and poor control of sedation, she was qualified for veno-venous ECMO. An elective caesarean section was performed at 29 weeks on ECMO treatment in the ICU. A preterm female newborn was delivered with an Apgar score of 7 and a birth weight of 1440 g. The newborn had no laboratory or clinical evidence of COVID-19. The placenta showed the following pathological changes: large subchorionic haematoma, maternal vascular malperfusion, marginal cord insertion, and chorangioma. Conclusions This case presents the successful use of ECMO in a pregnant woman with acute respiratory distress syndrome in the course of severe COVID-19. Further research is required to explain the aetiology of placental disorders (e.g., maternal vascular malperfusion lesions or thrombotic influence of COVID-19). ECMO treatment in pregnant women remains challenging; thus, it should be used with caution. Long-term assessment may help to evaluate the safety of the ECMO procedure in pregnant women.


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