scholarly journals Efficacy and Safety of Gabapentine and Duloxetine in Diabetic Peripheral Neuropathic Pain

2021 ◽  
Vol 33 (2) ◽  
pp. 108-113
Author(s):  
Hussain Ahmad ◽  
KM Hafizur Rahman ◽  
Miftaul Jannat Chowdhury ◽  
Monharul Islam Bhuiya ◽  
Nurjahan Ferdous ◽  
...  
Keyword(s):  
Rating Scale ◽  
Efficacy And Safety ◽  
Medical College ◽  
Comparative Clinical Study ◽  
Group Variation ◽  
Group A ◽  
Michigan Neuropathy Screening Instrument ◽  
Medicine Today ◽  
Group B ◽  
Global Impression Of Change

Introduction: Diabetic peripheral neuropathy (DPNP) is not uncommon now a days. As the pathophysiology is not completely understood, symptoms relief is still the main goal of treatment. Gabapentine and Duloxetine are being using around the world for this purpose. But clinical data regarding its efficacy and safety are not sufficiently available. Materials and Methods: This prospective comparative clinical study conducted in Sylhet MAG Osmani Medical College and Sylhet Diabetic Hospital, Bangladesh from January 2013 to December 2013. Diagnosis of DPNP confirmed by Michigan Neuropathy Screening Instrument (MNSI) and Douleur Neuropathic en-4 (DN4). Patients were treated by Gabapentine (Group-A) and Duloxetine (Group-B); and followed up at 4th, 8th and 12th week of treatment using 11-point numerical pain rating scale (NRS), clinical global impression of change (CGIC) score and patient’s global impression of change (PGIC) score. Results: A total of 72 patients with DPNP were recruited. Final comparison was done in 64 patients – 33 in Group-A and 31 in Group-B. Changes in NRS (p = <0.001), CGIC (p = <0.001) and PGIC (p = <0.001) were statistically significant during the course of treatment. However, inter-group variation of NRS, CGIC and PGIC were not statistically significant at the beginning and 4th, 8th and 12th week of treatment. Insignificant adverse effects were noted between the groups in this study except constipation (p = 0.022) and nausea-vomiting (p = 0.01) of Duloxetine taking group. Conclusion: Gabapentine and Duloxetine are equally effective in the treatment of DPNP with good safety profile. Medicine Today 2021 Vol.33(2): 108-113

scholarly journals Morphology of Right Atrioventricular Valve -A Postmortem Study

2020 ◽  
Vol 32 (1) ◽  
pp. 42-44
Author(s):  
Mahmuda Sultana ◽  
Md Tazul Islam ◽  
Pran Krishna Basak ◽  
Md Samir Uddin ◽  
Zakia Sultana
Keyword(s):  
Human Heart ◽  
Heart Valves ◽  
Age Group ◽  
Atrioventricular Valve ◽  
Inclusion Criteria ◽  
Mitral Valves ◽  
Medical College ◽  
Group A ◽  
Medicine Today ◽  
Group B

Introduction: Heart valves serve the important function of preventing backflow, or regurgitation, in the healthy heart. It is well known that cardiac valves can suffer from congenital and acquired disease. Most frequent acquired valvular abnormalities are stenoses of the aortic and mitral valves, which account for approximately 2/3rd of all valve disease. For the management of valvular disease morphology of right atrioventricular valve is essential. Materials and Methods: Study design was descriptive type of study. Place and period of study was Department of Anatomy, Sylhet MAG Osmani Medical College, Sylhet from July 2015 to June 2016. Results: Present study was performed on 70 post mortem human hearts of age ranging from 9 to 70 years. Human heart was collected from the unclaimed dead bodies autopsied in the department of Forensic medicine in Sylhet MAG Osmani Medical College during the study period fulfilling the inclusion criteria. Conclusion: The collected samples were divided into 3 groups depending on age. Group – A: (9 - 21 Years), Group - B: (22 - 41 Years), Group - C: ( 42 -70) Years. Each group was subdivided into two groups depending on their sex. Medicine Today 2020 Vol.32(1): 42-44

scholarly journals Intranasal Splint in Nasal Septal Surgery: Is It Necessary?

2020 ◽  
Vol 32 (2) ◽  
pp. 126-129
Author(s):  
Jahangir Alam Mazumder ◽  
Md Golam Mustafa ◽  
AHM Delwar ◽  
Shazibur Rashid ◽  
Md Mostafizur Rahaman ◽  
...  
Keyword(s):  
Complete Healing ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Septal Surgery ◽  
Significant Difference ◽  
Group A ◽  
Medicine Today ◽  
Group B ◽  
Male To Female

Introduction: After SMR/septoplasty with or without turbinate surgery, it needs to keep apart the septum and turbinates upto their complete healing otherwise there is a chance of adhesion (synechia) formation. To prevent this there are variousprocedures. To place an intranasal splint in one or both sides of the septum is one of them. Nowadays there raised thequestion of whether the splinting is necessary or not. There is no significant difference in result with or without anintranasal splint. Weighing against the co-morbidities the routine use of an intranasal splint can no longer be justified. Materials and Methods: This is a randomized control study of 200 patients of SMR/septoplasty, done for nasal septaldeviation causing symptoms in Cumilla Medical College Hospital in the period of January 2016 to December 2019. Theywere equally divided into two groups, group-A were operated placing an intranasal splint and group-B with no intranasalsplint. They were followed up for 6 weeks to detect any synechia and co-morbidities. Result: The age of our patients wasranged from 13-49 years with a mean age of 22.45 years. The male to female ratio is 1.78:1. Synechia was found in 4% ofthe splinted group and 6 of the nonsplinted groups. Co-morbidities were detected more in the splinted group than that ofnon-splinted. In INS group these were found as follows: pain in the nose, face and head (26%), faint during removal ofnasal splint (6%), nasal obstruction (38%), the anxiety of splint removal in the postoperative period (35%) and vestibulitisdue to persistent irritation by a splint (17%). Conclusion: There is little significant advantage of using intranasal splintroutinely in septal surgery to prevent synechia formation. Medicine Today 2020 Vol.32(2): 126-129

scholarly journals A Comparative Clinical Study of Jaladhara and Taildhara in the Management of Stress

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Neha G Tank
Keyword(s):  
Clinical Study ◽  
Rating Scale ◽  
Comparative Effect ◽  
Brief Psychiatric Rating Scale ◽  
Comparative Clinical Study ◽  
Group A ◽  
Psychiatric Rating ◽  
Effect Of Treatment ◽  
Psychiatric Rating Scale ◽  
Group B

In the present Era, stress is said to be one of the largest killers of man today. Stress is  related to our total health - physical, mental and emotional. In Ayurveda stress is a resultant condition due to pragyaparadha. In the present study total 137 patients were registered and randomly divided into 3 groups viz: Group A were subjected to Jaladhara 7days along with Mansyadi Kwatha for 30days; Group B were subjected to Tailadhara for 7 days along with Mansyadi Kwatha for 30days; Group C  received only Mansyadi Kwatha for 30days. The main aims & object of the study are: 1) To study the comparative effect of Jaladhara and Tailadhara in the management of stress. 2) To study the clinical efficacy of Shirodhara. Assessment of the effect of treatment was done on the basis of relief in the subjective & objective signs & symptoms of stress and on Brief psychiatric rating scale. The data were analysed statistically. It was observed that symptoms like insomnia, anxiety etc were almost completely relieved in Shirodhara group. In Breif Psychiatric rating scale statistically results of both the dhara group are highly significant. Taildhara provided better relief in all most all the symptoms of Stress and in Brief psychiatric rating scale compared to Jaladhara

scholarly journals Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

2017 ◽  
Vol 6 (4) ◽  
pp. 948 ◽  
Author(s):  
Mohit Trivedi ◽  
Vishal Dixit ◽  
Syed Esam Mahmood ◽  
Sunil Kumar Mishra ◽  
S. S. Keshari
Keyword(s):  
Rating Scale ◽  
Open Label ◽  
Treatment Groups ◽  
Medical College ◽  
Long Duration ◽  
Pain Scales ◽  
Group A ◽  
Numeric Pain Rating Scale ◽  
Group B ◽  
Pain Rating Scale

Background: Propranolol and flunarizine have proven to be useful tools in migraine prophylaxis. This trial aims the comparison of the efficacy of flunarizine, flunarizine and placebo and flunarizine and panchgavya ghrit in migraine prophylaxis.Methods: The present study was a prospective, randomized, open-label, blinded-endpoint trial. Patients with chronic migraine were randomized (1:1:1) to flunarizine and flunarizine and placebo and flunarizine and panchgavya ghrit in three treatment groups. The study was carried out in outdoor patients in the department of Psychiatry, T.S. Mishra Medical College and Hospital, Lucknow and K.G.M.U, Ayush Department, Lucknow after clearance from Institutional Ethical Committee. Data was analysed using SPSS software.Results: The prevalence of migraine was found to be higher in the age group greater than 30 years and females. Overall there was more reduction in CGI scores in flunarizine with panchgavya ghrit and the other two groups equally at the end of 4, 6 8 and 10 weeks. Decrease in MIDAS score was observed after the therapy. Clinical Global Impression rating scale employed revealed that to start with subjects scored 7 which stands for pathology interfering in many life functions which reduced drastically in Group C as compared to Group B and Group A in descending order. Pain scales namely VAS (visual analogue scale), NPRS (Numeric Pain Rating Scale), VRS (verbal rating scale) when employed denoted there was decreased migraine frequency, decreased perception of pain, less intake of abortive medication consumed by subjects implying there were reduction in number of migraine days and there was decrease in the abortive medications taken for the same. Group C scored better on pain scales followed by Group B and Group A. Lower proportion of individuals in group C had Behavioural Toxicity and Neurological Side effects as compared to Group A and B.Conclusions: Panch gavya ghrit when administered along with flunarizine was more efficacious and safe when compared with other two groups. However large multicentric RCTs of long duration and involving more number of subjects are required to ascertain these facts.

scholarly journals A Postmortem Study on the Weight of the Human Ovary

2014 ◽  
Vol 26 (1) ◽  
pp. 12-14
Author(s):  
Hosna Ara Perven ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Shamim Ara ◽  
Sunjida Shahriah ◽  
Gul Newaz Begum
Keyword(s):  
Age Groups ◽  
Age Group ◽  
Cross Sectional ◽  
Medical College ◽  
Group A ◽  
Human Ovaries ◽  
The Difference ◽  
Medicine Today ◽  
Group B ◽  
The Right

A cross-sectional, descriptive type of study was designed to find out the difference in weight of the ovary of Bangladeshi women in relation to age and to compare with the previous studies. This study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from January to December 2009. The study was performed on 140 post mortem human ovaries collected from 70 unclaimed female dead bodies which were in the morgue under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age-groups including group A (10-13 years), group B (14-45 years) & group C (46-52 years) and the weight of the ovaries were measured and recorded. The difference in mean weight between the right ovary and the left ovary was statistically significant in all age group (P <0.001). The difference in mean weight of the ovary between group A & group B, group A & group C and group B & group C were statistically significant (P <0.001) DOI: http://dx.doi.org/10.3329/medtoday.v26i1.21304 Medicine Today 2014 Vol.26(1): 12-14

A Comparative Study on the effect of Padabhyanga with Tila Taila and Nimba Taila in management of Vipadika w.s.r. to Padasputana

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Asha Karki ◽  
Dr.Mallikarjun S. Yalagond ◽  
Dr.Venkatesh Illal
Keyword(s):  
Food Habits ◽  
Complete Relief ◽  
Chi Square ◽  
Medical College ◽  
Comparative Clinical Study ◽  
Chi Square Test ◽  
Group A ◽  
Group B ◽  
Better Than

Background: Vipadika affects irrespective of age, sex and socioeconomic status. The causes may be excessive/barefoot walking, contact with dust, detergents and improper food habits. Here control over Vatadosha is important which can be achieved through Padabhyanga. Materials and Methods: It was a comparative clinical study of 30 patients, who were selected by random sampling from the OPD of S.M.V.V.S, R.K.M Ayurveda Medical College, Vijayapura, and categorized into 2 groups as 'A' and 'B', each consisting of 15 patients and were advised Tila Taila and Nimba Taila Padabhyanga for 30 days respectively. Follow up was advised on 45th day of treatment. Severities of the symptoms were assessed before, after treatment and after follow up. Results: In group-A 20% of patients showed complete relief and in group-B 0% have showed complete relief. Conclusion: Tila Taila is having Sara, Sukshma Guna and pacifies Vatakapha Dosha. Nimba Taila is Kushtagna, Krimigna. Both Tailas help in reducing Rukshata and Sputana. Vipadika can be correlated with cracked heels. The results were assessed statistically by Pooled chi square test. It was concluded that group-A patients were significantly better than group-B after follow up. Hence Tila Taila Padabhyanga is beneficial in Vipadika.

scholarly journals Clinical Efficacy and Safety Profile of Lurasidone Comparing with Risperidone: Randomized, Open Label, Clinical Study

2021 ◽  
pp. 20-27
Author(s):  
V. Sreedhar ◽  
L. Reddenna ◽  
T. Rajavardhana ◽  
J. Thippe Rudra ◽  
E. Pavan Kumar ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Clinical Efficacy ◽  
Safety Profile ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Function Test ◽  
Group A ◽  
Group B

There are diverse studies which afford evidences that risperidone is as effective as second generation antipsychotics in treating positive symptoms and more effective in treatment of negative symptoms. This study is intended to find the clinical efficacy and safety profile of lurasidone comparing with risperidone, a drug in common use nowadays. Patients aged between 18 to 60yrs, Patients with new onset of symptoms who fulfil the ICD-10 criteria for a primary diagnosis of schizophrenia and Patients having a total PANSS score of ≥80 including a score ≥4 (moderate) on two or more of positive subscale at baseline. Patients with acute exacerbation of schizophrenia who remained drug free for at least last 6 months also included. Demographic data of the patients were collected. Baseline investigations like BP, complete blood count, lipid profile, blood sugar, renal function test and liver function test were done. Severity of schizophrenia at baseline was assessed using positive and negative symptoms scale (PANSS). Patients were randomized by using computer generated random table in 1:1 ratio as group A and group B, with 25 patients in each group. The efficacy of group A and group B was analysed by applying rating scale Positive and negative syndrome scale (PANSS) at the end of 4 and 6 weeks. Adverse drug reactions were recorded and monitored by interviewing with patients, by physical examination and also by necessary lab investigations at the end of 6 weeks. Patients were insisted to maintain a diary to note any new occurrence of adverse drug reactions in between the follow up period. Suspected adverse drug reactions were documented in predesigned reporting form. In PANSS positive scale both groups had significant decrease in PANSS score both at week 4 and week 6 (p<0.05). Lurasidone is as equally efficacious as risperidone in reducing PANSS score, but produces less metabolic syndrome and other adverse effects than risperidone.

scholarly journals A Controlled and Comparative Study onVatari Guggulu and Shiva Guggulu in the Treatment ofGridhrasi.

2021 ◽  
Vol 04 (11) ◽  
pp. 38-48
Author(s):  
Veena C.S ◽  
Roopa Bhat
Keyword(s):  
Clinical Study ◽  
Oral Administration ◽  
Test Design ◽  
College Hospital ◽  
Medical College ◽  
Post Test ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
Single Blind

A single blind controlled comparative clinical study with pre test and post test design to evaluate the therapeutic efficacy of Shiva Gugguluand Vatari Gugguluin the management of Gridhrasi.The study carried out at Dhanvantari Ayurveda medical college Hospital; Siddapur, Uttara Karnataka. 40 patients suffering from Gridhrasi / SCIATICA of either sex were selected for the study were treated under two groups; A and B. Group A with oral administration of Shiva Guggulu, in a dose of 500 mg after food twice a day with sukhoshna jalaas anupana and the same is continued for 30 days. Group B with oral administration of Vatari Guggulu, in a dose of 500 mg after food twice a day with sukhoshna jalaas anupana for 30 days. The response following the intervention was assessed on 1st,15th, 21st, and 30thdays to find out the progress of theCondition in both the groups.Final conclusion of this controlled comparative clinical study says Group A is more effective than Group B (Shiva gugguluis more effective than Vatari guggulu) in the management of Gridhrasi.

scholarly journals Role of Ultrasound In The Management of De'Quervain's Disease

2013 ◽  
Vol 24 (1) ◽  
pp. 31-35
Author(s):  
Muhammad Kamrul Hassan ◽  
M Habibur Rahman ◽  
Fauzia Sobhan ◽  
Farzana Khan Shoma ◽  
Chowdhury Mohammad Walid
Keyword(s):  
Pain Score ◽  
Post Treatment ◽  
Ultrasound Therapy ◽  
College Hospital ◽  
Medical College ◽  
Vas Score ◽  
Number Of Patients ◽  
Group A ◽  
Medicine Today ◽  
Group B

This prospective type of experimental study was carried out to determine the improvement of symptoms by ultrasound therapy in management of de'Quervain's disease. It was done in the department of physical medicine and rehabilitation in Dhaka medical college hospital during the period of 30th January 2008 to 30th July 2008.The diagnosis of de'Quervain's disease confirmed by history and clinical examination(Finkelstein test). 50 patients were selected and randomly divided into two groups. Group-A patients were treated with thumb splint,NSAIDS and ADL. Group-B patients were treated with thumb splint, NSAIDS, ADL and ultrasound therapy. Each patients was assessed by pain score, visual analogue scale(VAS), grading of tenderness and swelling. Mean age was 41.02 years. Female and male ratio was 7.5:1. Most patients occupation was housewife 40(80%) and had a precipitating factor as wringing of cloths 31(62%). History of recurrence was found in 7(14%). Most of the patients developed pain gradually 72%(36). Post treatment VAS score improved significantly in group B(p<0.05), in groupB 96%(24) and in group A 52%(13) patients had VAS score 0 to 4. Post treatment significantly (p<0.01) higher number of patients were in swelling score. So in group B(84%) compared to group A (44%), After treatment pain score showed significant improvement (p<0.01) in group B patients (72%) compared to group A(24%). In group A, 16%(4) and in group B 32%(8) patient were completely cured(No pain,no tenderness and no swelling). DOI: http://dx.doi.org/10.3329/medtoday.v24i1.14112 Medicine TODAY Vol.24(1) 2012 pp.31-35

Comparative Study Between Clean Intermittent Self-Catheterization (Cisc) and Continuous Indwelling Catheterization (Cidc) in Relieving Acute Refractory Retention of Urine Due to Benign Enlargement of Prostate (Bep)

2020 ◽  
Vol 21 (2) ◽  
pp. 105-110
Author(s):  
Md Shawkat Alam ◽  
Sudip Das Gupta ◽  
Hadi Zia Uddin Ahmed ◽  
Md Saruar Alam ◽  
Sharif Muhammod Wasimuddin
Keyword(s):  
Comparative Study ◽  
Acute Urinary Retention ◽  
Bladder Capacity ◽  
Inclusion Criteria ◽  
College Hospital ◽  
Medical College ◽  
High Incidence ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: To compare the clean intermittent self-catheterization (CISC) with continuous indwelling catheterization (CIDC) in relieving acute urinary retention (AUR) due to benign enlargement of prostate (BEP). Materials and Methods :A total 60 patients attending in urology department of Dhaka Medical college hospital were included according to inclusion criteria ,Patients were randomized by lottery into two groups namely group –A and group –B for CISC and IDC drainage respectively . Thus total 60 patients 30 in each group completed study. Results : Most men can safely be managed as out-patients after AUR due to BPH. The degree of mucosal congestion and inflammation within the bladder was found to be lower in those using CISC and the bladder capacity in these patients was also found higher.Patients with an IDC had a high incidence of UTIs then that of patients with CISC. During the period of catheterization the incidence of UTI was 43.3% in group B in comparison to 40% in group A; before TURP 36% in group B in comparison to 10% incidence in group A.According to patient’s opinion CISC is better than IDC in the management of AUR. Experiencing bladder spasm, reporting blood in urine, management difficulties, incidence and severity of pain were less in CISC group, and the method of CISC was well accepted by patients as well as their family members. Conclusion: From the current study it may be suggested that CISC is better technique for management of AUR patient due to BPH than IDC. It can also be very helpful when surgery must be delayed or avoided due to any reasons in this group of patients. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p.105-110

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