scholarly journals Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy

2019 ◽  
Vol 10 ◽  
Author(s):  
Liu-qing Yang ◽  
Ru-yi Li ◽  
Xi-yan Yang ◽  
Qian-fei Cui ◽  
Fei-yun Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Chemotherapy Drugs ◽  
Shexiang Baoxin Pill

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

scholarly journals A Copay Foundation Assistance Support Program for Patients Receiving Intravenous Cancer Therapy

2011 ◽  
Vol 7 (2) ◽  
pp. 100-102 ◽  
Author(s):  
Swapnil P. Rajurkar ◽  
Cary A. Presant ◽  
Linda D. Bosserman ◽  
Wendy J. McNatt
Keyword(s):  
Cancer Therapy ◽  
Financial Assistance ◽  
Financial Hardship ◽  
Support Program ◽  
Chemotherapy Drugs ◽  
Patients With Cancer ◽  
Appropriate Treatment

Copay for chemotherapy drugs is a financial hardship for many patients with cancer. The authors have developed a support program to work closely with copay assistance foundations to secure financial assistance for appropriate treatment.

scholarly journals Versatile Types of Polysaccharide-Based Drug Delivery Systems: From Strategic Design to Cancer Therapy

2020 ◽  
Vol 21 (23) ◽  
pp. 9159
Author(s):  
Yanzhen Sun ◽  
Xiaodong Jing ◽  
Xiaoli Ma ◽  
Yinglong Feng ◽  
Hao Hu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Effective Means ◽  
Delivery Systems ◽  
Research Progress ◽  
Natural Polymers ◽  
Chemotherapy Drugs ◽  
Strategic Design ◽  
Good Biocompatibility

Chemotherapy is still the most direct and effective means of cancer therapy nowadays. The proposal of drug delivery systems (DDSs) has effectively improved many shortcomings of traditional chemotherapy drugs. The technical support of DDSs lies in their excellent material properties. Polysaccharides include a series of natural polymers, such as chitosan, hyaluronic acid, and alginic acid. These polysaccharides have good biocompatibility and degradability, and they are easily chemical modified. Therefore, polysaccharides are ideal candidate materials to construct DDSs, and their clinical application prospects have been favored by researchers. On the basis of versatile types of polysaccharides, this review elaborates their applications from strategic design to cancer therapy. The construction and modification methods of polysaccharide-based DDSs are specifically explained, and the latest research progress of polysaccharide-based DDSs in cancer therapy are also summarized. The purpose of this review is to provide a reference for the design and preparation of polysaccharide-based DDSs with excellent performance.

Nanoparticle Therapy for Prostate Cancer: Overview and Perspectives

2019 ◽  
Vol 19 (1) ◽  
pp. 57-73 ◽  
Author(s):  
Junfu Zhang ◽  
Liying Wang ◽  
Xinru You ◽  
Tuzeng Xian ◽  
Jun Wu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Influencing Factors ◽  
Treatment Effects ◽  
Tumor Site ◽  
Chemotherapy Drugs ◽  
Imaging Examination ◽  
Prostate Cancer Therapy ◽  
Rapid Clearance

Traditional prostate cancer therapy and especially chemotherapy has faced many challenges. Low accumulation levels, rapid clearance or drug resistance at the tumor site have been central to why the effect of chemotherapy drugs has declined. Applications of nanotechnology to biomedicine have enabled the development of nanoparticle therapeutic carriers suited for the delivery of chemotherapeutics in cancer therapy. This review describes the current nature of nanoparticle therapeutic carriers for prostate cancer. It describes typical nanocarriers commonly used for the delivery of chemotherapy or for imaging examination. Targeting strategies and related influencing factors are investigated to find ways of enhancing treatment effects of nanoparticles. The overall purpose of this review is to further understanding and to offer recommendations on the design and development of therapeutic nanoparticles for prostate cancer.

scholarly journals Chemotherapy and Dietary Phytochemical Agents

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Katrin Sak
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
Multiple Organ ◽  
The Body ◽  
Cytotoxic Agents ◽  
Adverse Side Effects ◽  
Chemotherapy Drugs ◽  
Normal Tissues ◽  
Organ Systems

Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way.

scholarly journals Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

Open Biology ◽  
2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Fatemeh Aliabadi ◽  
Beheshteh Sohrabi ◽  
Ebrahim Mostafavi ◽  
Hamidreza Pazoki-Toroudi ◽  
Thomas J. Webster
Keyword(s):  
Cancer Therapy ◽  
Ubiquitin Proteasome System ◽  
Tumour Suppressor ◽  
The Other ◽  
Cancer Development ◽  
Chemotherapy Drugs ◽  
Advantages And Disadvantages ◽  
Fundamental Understanding ◽  
Ubiquitin Proteasome

Despite all the other cells that have the potential to prevent cancer development and metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin–proteasome system (UPS) by which they can degrade tumour suppressor proteins and avoid apoptosis. This system plays an extensive role in cell regulation organized in two steps. Each step has an important role in controlling cancer. This demonstrates the importance of understanding UPS inhibitors and improving these inhibitors to foster a new hope in cancer therapy. UPS inhibitors, as less invasive chemotherapy drugs, are increasingly used to alleviate symptoms of various cancers in malignant states. Despite their success in reducing the development of cancer with the lowest side effects, thus far, an appropriate inhibitor that can effectively inactivate this system with the least drug resistance has not yet been fully investigated. A fundamental understanding of the system is necessary to fully elucidate its role in causing/controlling cancer. In this review, we first comprehensively investigate this system, and then each step containing ubiquitination and protein degradation as well as their inhibitors are discussed. Ultimately, its advantages and disadvantages and some perspectives for improving the efficiency of these inhibitors are discussed.

An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

2018 ◽  
Vol 42 (5) ◽  
pp. 3828-3832 ◽  
Author(s):  
Seyed A. R. Alavi-Tabari ◽  
Mohammad A. Khalilzadeh ◽  
Hassan Karimi-Maleh ◽  
Daryoush Zareyee
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Breast Cancer Therapy ◽  
Chemotherapy Drugs

Epirubicin (EB) and topotecan (TP) are two major anticancer drugs that are used in breast cancer therapy with many side effects.

scholarly journals Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Umme Tamanna Ferdous ◽  
Zetty Norhana Balia Yusof
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Treatment Effectiveness ◽  
Tumor Development ◽  
Cancer Therapeutics ◽  
Antioxidant Supplementation ◽  
Chemotherapy Drugs ◽  
Response To Chemotherapy ◽  
Nutritional Benefits

Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of these medications is mostly restricted to several deleterious side effects. Therefore, to alleviate these side effects, antioxidant supplementation is often warranted, reducing reactive species levels and mitigating persistent oxidative damage. Thus, it can impede the growth of cancer cells while protecting the normal cells simultaneously. Moreover, antioxidant supplementation alone or in combination with chemotherapeutics hinders further tumor development, prevents chemoresistance by improving the response to chemotherapy drugs, and enhances cancer patients’ quality of life by alleviating side effects. Preclinical and clinical studies have been revealed the efficacy of using phytochemical and dietary antioxidants from different sources in treating chemo and radiation therapy-induced toxicities and enhancing treatment effectiveness. In this context, algae, both micro and macro, can be considered as alternative natural sources of antioxidants. Algae possess antioxidants from diverse groups, which can be exploited in the pharmaceutical industry. Despite having nutritional benefits, investigation and utilization of algal antioxidants are still in their infancy. This review article summarizes the prospective anticancer effect of twenty-three antioxidants from microalgae and their potential mechanism of action in cancer cells, as well as usage in cancer therapy. In addition, antioxidants from seaweeds, especially from edible species, are outlined, as well.

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