scholarly journals Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 778
Author(s):  
Roberta Fusco ◽  
Angela Trovato Salinaro ◽  
Rosalba Siracusa ◽  
Ramona D’Amico ◽  
Daniela Impellizzeri ◽  
...  

Background: Every year, men use cyclophosphamide to treat various cancers and autoimmune diseases. On the one hand, this chemotherapy often has the beneficial effect of regressing the tumor, but on the other hand, it leads to infertility due to excessive oxidative stress and apoptosis in the testes caused by its metabolite, acrolein. Methods: The objective of this study was to evaluate the beneficial power of a new compound called Hidrox®, containing 40–50% hydroxytyrosol, in counteracting the damage related to fertility induced by cyclophosphamide. The study was conducted using a single intraperitoneal injection of cyclophosphamide at a dose of 200 mg/kg b.w, in distilled water at 10 mL/kg b.w. The treatment was administered via the oral administration of Hidrox® at a dose of 50 mg/kg. Results: Our study confirms that the use of cyclophosphamide causes a series of sperm and histological alterations strongly connected with oxidative stress, lipid peroxidation, and apoptosis. Conclusion: Our results demonstrate for the first time that Hidrox® protects testes from CYP-induced alterations by the modulation of physiological antioxidant defenses.

Author(s):  
AI Kostyuk ◽  
DA Kotova ◽  
AD Demidovich ◽  
AS Panova ◽  
IV Kelmanson ◽  
...  

With each year, millions of people remain targeted by brain stroke, it still is by all means a global concern of the mankind. Despite all efforts to understand this disease better, there is still a lack of information on pathophysiology of ischemic stroke. Scrutinized data on biochemical changes at early stages of ischemia may help understand the mechanisms of the disorder and possibly reveal ways to finding the cure. The key role in the pathogenesis of stroke belongs to lipids as well as to the molecules associated with their biosynthesis and functionality. On the one hand, stroke evokes a deep oxidative stress leading to damage to biomolecules including lipids while on the other hand, due to the lack of reducing equivalents, the cellular biosynthesis processes are interrupted. The focus of this work was to study the changes taking place in the tissues of rat brain as a result of ischemia including estimation of levels of total cholesterol, FFA, MDA, GSH, and NADP(H). It was shown that in 24 hours from the onset of ischemia, there was a significant decrease in levels of FFA, total cholesterol and GSH, and an increase in the level of MDA, a marker of lipid peroxidation. NADP(H) pool level decreases twice in 6 hours from MCAO.


2021 ◽  
Vol 15 (2) ◽  
pp. 83-88
Author(s):  
M. S. Eliseev

Updated ACR recommendations for the treatment of gout concerning lifestyle are discussed. Factors related to a lifestyle, above all food habits, for many years were of leading importance in the treatment of patients with gout, even after application of effective drugs. The authors of the updated ACR recommendations for the first time offered to reconsider the role of environmental factors in the genesis of gout and objectively assess the possibility of its non-drug treatment. On the one hand, regardless of the activity of the disease, the need for restrictions of the alcohol, purine-rich products and fructose-containing beverages, as well as the decrease of body weight in obese patients and vitamin C usage unviability are confirmed. On the other hand, these recommendations are conditional. Their new version of ACR recommendations is significantly different from both its previous version and other international and national recommendations, including recommendations on the diagnosis and treatment of gout used in the Russian Federation.


2020 ◽  
Vol 12 (4) ◽  
pp. 358-367
Author(s):  
Nikolai V. Belenov

Introduction. The article presents the results of research of the geographical vocabulary of the Shilan dialect, one of the Erzya-Mordovian dialects of the Samara region, common among Erzya population of Shilan village in Krasnoyarsk region. The dialect belongs to rare Mordovian dialects of the Samara Volga region that were formed in the region since the middle of the XIX century, and therefore its research is of extra interest. Materials and Methods. The research methods are determined by the purpose and objectives of the study. The analysis of the geographical vocabulary of the Shilan dialect is carried out with the involvement of relevant items made in other Mordovian dialects of Samara region, adjacent territories of neighboring regions, as well as other territories of settlement of the Mordovians. Data on geographical vocabulary of the dialect introduced into research for the first time. The main source materials for the article is based on field studies in Silane village during the field seasons in 2017 and 2020, as well as in other Erzya-Mordovian and Moksha-Mordovian villages of Samara region and adjacent territories in 2015 – 2020. Results and Discussion. The study showed that the geographical vocabulary of the Shilan dialect of the Erzya-Mordovian language is significantly different from the corresponding lexical clusters in other dialects of the Mordovian region, which can be explained by natural geographical conditions surrounding Shilan village and the original composition of this lexical cluster of Erzya immigrants who founded this village. Conclusion. The analysis of the geographical vocabulary of the Shilan dialect allowed, on the one hand, to identify specific features of this cluster that distinguish it from the corresponding materials of other Mordovian dialects of the region, and, on the other hand, to identify common isoglosses between it and a number of the Erzya-Mordovian dialects of the Samara Volga region.


Author(s):  
Kseniya V. Donik

The article considers the role of Prince A. Menshikov as a specific type of agent of supreme authority in the process of reforming the maritime administration. The problem context of reforms resulted from the involvement of the naval generals and officials in abuses, which was a consequence of nepotism and unrest in the navy. The involvement of sailors in the Decembrist revolt significantly affected the attitude of the tsar to the general situation in the naval environment. Distrustful of the existing naval administration, Nicholas I needed an intermediary who would implement his idea of the arrangement of the navy on the one hand, and provide him with an objective “impartial” account of maritime problems, on the other hand. As a result of that, Adjutant General Prince A. Menshikov, who had had nothing to do with the naval service earlier, joined the navy to become the monarch’s agent in charge of the naval issues in the bodies of autocratic authority. The objective of the article is to identify the functions of such an agent based on the example of the Maritime Department. The sources of the article include official records and personal documents, some of which are introduced into scientific circulation for the first time. The principal methodological approach to the problem under study is an attempt to bring the appointment of Menshikov beyond the scope of narrow departmental history which was based on the unmotivated decision of the emperor and to propose an interpretation of the events in the context of tsarist government via agents, which has already been described in historiography. The author makes a conclusion about the interconnection between the crisis in the naval department, the attitude of the supreme authority towards it, and the appearance of the monarch’s agent with a number of his own functional characteristics.


2021 ◽  
pp. 104-116
Author(s):  
Ivan O. Volkov ◽  

For the first time, in the article, Vladimir Titov’s letter (dated 12/24 February 1869) is published and commented. In the 1820s, in Russia, Titov was well-known as a writer and literature theorist, the author of a romantic novella The Remote House on Vasilyevsky Island (1829) close to Society of Lyubomudriye. The letter extracted from the archives of the National Library of Russia is addressed to Duke Vladimir Odoevsky whose relationship with Titov was friendly from the very beginning of their acquaintance. The letter focuses on Ivan Turgenev’s speech published in the first issue of Sovremennik and titled “Hamlet and Don Quixote”. Reacting to Turgenev’s article, Titov shortly and critically accesses the comparison concentrating mainly on the image of Hamlet and thoroughly expresses his opinion on the essence of his tragic state. Titov’s opinion is just the opposite of Turgenev’s complex and multidimensional interpretation. Having experienced the great impact of the philosophy of German idealism at the beginning of his career, Titov to a great extent idealizes Shakespeare’s character whom he long knows and whom he is clearly eager to vindicate. Meanwhile, Titov does not pursue the aim to absolutely advocate the romantic halo of Hamlet as a Titanic personality (grandiose intellect and scale of feeling) and to enact the tragic pathos of the inner fight only. Developing Goethe’s definition of the essence of the character’s inner conflict, Titov, on the one hand, approaches its real understanding underlying the prince’s necessity to stay in a derogatory position of a “pitiful semiclown, indecisive grouch and shred”. On the other hand, the assessment can not be absolutely objective because Titov wants to see Hamlet as a victim of the fatal fortune which turns him into a character of an almost classical tragedy of fate. Titov’s bright and developed reaction (in the document of private nature) to Turgenev’s article is attractive and important first of all for its vividly demonstrated novelty and creativity of the writer’s view, wideness and multimodality of the author’s perception of Hamlet’s image. For the first time, Turgenev gave a developed interpretation of Shakespeare’s image in the tale “Hamlet of Shchigrovsky Province” (1848). Continuing his searches in the area of “Russian” (or “steppe”) Hamlet, Turgenev creates moral and philosophical problems of the English tragedy in the crisis socio-historical and cultural atmosphere of Russia of the 1840s. However, the principles of the artistic generalization and the peculiarities of the new reading, not mentioned and not fully comprehended by his contemporaries, were surprising and rejected when the speech “Hamlet and Don Quixote” appeared, in which Shakespeare’s character is presented ultimately vividly and lively in the then current interpretation.


Author(s):  
Tatiana A. Bystrova ◽  

The paper examines two key novels by Sandro Veronesi, the modern Italian writer, Calm Chaos (2006) and Colibri (2020). Both novels were awarded Italy’s main literary prize, the Premio Strega, which is a unique precedent. The relevance of the article comes from the high demand for research on contemporary Italian literature on the one hand and from the novelty of the proposed interpretation for the novel Calm Chaos on the other hand. For the first time, the protagonist of Calm Chaos, Pietro Palladini, is presented not as a preacher of eternal values, returning the reader to the theme of knowing oneself and the surrounding world, but as a mad visionary with clear signs of psychopathy and schizophrenia. The analysis of Veronesi’s latest novel Colibri reveals the character’s evolution and the writer’s narrative manner. The theme of psychiatry in the life of a modern person appears to be one of the key ones in Veronesi’s work.


Author(s):  
Paul Torremans

This chapter first discusses the two roots of copyright. On the one hand, copyright began as an exclusive right to make copies—that is, to reproduce the work of an author. This entrepreneurial side of copyright is linked in with the invention of the printing press, which made it much easier to copy a literary work and, for the first time, permitted the entrepreneur to make multiple identical copies. On the other hand, it became vital to protect the author now that his or her work could be copied much more easily and in much higher numbers. The chapter then outlines the key concepts on which copyright is based.


1994 ◽  
Vol 68 (3) ◽  
pp. 207-210 ◽  
Author(s):  
M.Y. Manga-González ◽  
M.P. Morrondo-Pelayo

AbstractDevelopment of Neostrongylus linearis larvae was studied in the snail intermediate hosts Oestophora (Oestophora) barbula, Oestophorella buvinieri, Cepaea nemoralis and Helix (Cryptomphalus) aspersa. The molluscs of each species, all adults, were divided into groups of 40 for infection purposes. The infection doses for the first two snail species were 90 and 50 first stage larvae (L1) of N. linearis, respectively. For C. nemoralis two batches were tested: one with 200 L1 kept at 19°C and the other with 250 L1 at a temperature of 21°C. The same was done with Helix (C.) aspersa with 200 L1 at a temperature of 21°C, on the one hand and 300 L1 at 24°C on the other. One or two molluscs of each species were killed in series from the 6th day post-infection (p.i.) until the 44th. Percentage values for total larvae (1, 2 and 3) and L3 were higher with the lower dose for C. nemoralis, whilst the same was true with the higher dose in Helix (C.) aspersa. In both cases, the higher temperature appeared to contribute to cycle acceleration. Using one way analysis of variance, statistically significant differences were detected between the species of molluscs tested concerning percentages of L1 which penetrated, total larvae and L3. According to our results, the decreasing order of susceptibility of these species of molluscs as experimental intermediate hosts of N. linearis is: O. buvinieri, Oestophora (O.) barbula, C. nemoralis and Helix (C.) aspersa. It is the first time that Oestophora (O.) barbula and Oestophorella buvinieri have been named as experimental intermediate hosts of N. linearis.


1966 ◽  
Vol 7 (2) ◽  
pp. 93-99 ◽  
Author(s):  
S.A.M. Adshead

This paper examines three aspects of the Opium trade in Szechwan from 1881, when for the first time there is evidence that China consumed as much native as foreign opium and that Szechwan was both the largest producer and consumer, until 1911, when the cultivation of the poppy was completely suppressed in the province as a result of the vigorous imperial campaign against the trade. It will consider first, the demand for opium who smoked it and why; second, the production of opium, how it fitted into and contributed toward the economy of the province; finally, the character of the suppression campaign of 1906–1911 as it affected Szechwan will be considered. The conclusions of the paper may be summarised as follows. (1) While the expansion of the opium habit in Szechwan, as in the rest of China, had no one cause, in Szechwan it has for its background a prospering society whose values and accepted goals had not kept pace with its economic expansion, a society which provided increasing wealth and leisure on the one hand, but only limited opportunities for socially approved spending on the other. (2) The rapid expansion of opium production in late nineteenth century Szechwan was part of the development of a market economy both within the province and in its relations with the rest of China. (3) The opium suppression campaign, because it undermined a developing economy, was much less popular in Western China than it was in the east, and contributed to the widespread unrest in those parts, which in turn led to the revolution of 1911.


2016 ◽  
Vol 37 (3) ◽  
pp. 1431 ◽  
Author(s):  
Claudia Russo ◽  
Ana Paula F. Rodrigues Loureiro Bracarense

Reactive oxygen species (ROS), also known as free radicals, are generated during cellular respiration. Under normal conditions, the body has the ability to neutralize the effects of free radicals by using its antioxidant defenses. In the case of an imbalance between oxidants and antioxidants, free radical production exceeds the capacity of organic combustion, resulting in oxidative stress. Of all the cellular components compromised by the harmful effects of ROS, the cell membrane is the most severely affected owing to lipid peroxidation, which invariably leads to changes in the membrane structure and permeability. With lipid peroxidation of the cell membrane, some by-products can be detected and measured in tissues, blood, and other bodily fluids. The measurement of biomarkers of oxidative stress is commonly used to quantify lipid peroxidation of the cell membrane in humans, a species in which ROS can be considered as a cause or consequence of oxidative stress-related diseases. In dogs, few studies have demonstrated this correlation. The present review aims to identify current literature knowledge relating to oxidative stress diseases and their detection in dogs.


Sign in / Sign up

Export Citation Format

Share Document