scholarly journals Peptides in COVID-19 Clinical Trials—A Snapshot

Biologics ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 300-311
Author(s):  
Kai Hilpert

Since the beginning of the COVID-19 pandemic, there has been a strong drive and desire to find effective treatments for and protection against the disease. On the webpage ClinicalTrials.gov, a total of 6505 clinical trials currently (September 2021) investigating various aspects of COVID-19 are registered. Of these, 124 studies involving peptides were identified. These 124 were further evaluated, and 88 trials that used peptides only for routine diagnostics were excluded. The remaining 36 trials were classified into 5 different classes according to their function: immunomodulatory (5 trials), regain homeostasis (10 trials), diagnostics/biomarkers (8 trials), vaccination (9 trials), and antiviral activity (4 trials, all overlap with immunomodulatory activities). In the current review, these 36 trials are briefly described and tabularly summarised. According to the estimated finish date, 14 trials have not yet finished. All of the finished trials are yet to report their results. Seven trials were based in the USA, and Egypt, France, the UK, Turkey, and the Russian Federation conducted three trials each. This review aims to present a snapshot of the current situation of peptides in COVID-19 clinical trials and provides a template to follow up on trials of interest; it does not claim to be a complete overview.

2020 ◽  
Vol 486 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Andrey Bulakh ◽  
Paavo Härmä ◽  
Elena Panova ◽  
Olavi Selonen

AbstractRapakivi granites were in use during the Middle Ages in Finland. Their most spectacular use, however, was for structures built in St Petersburg between 1760 and 1917. Remarkable examples are the majestic and slender Alexander Column and the 112 columns of St Isaac's Cathedral. All Rapakivi granite was extracted from the Wiborg Rapakivi granite batholith in several quarries around the municipality of Virolahti in SE Finland (old Russia). Today, the 1640 Ma-old Wiborg batholith is the most important area for natural stone production in Finland and in the Leningrad region, Russian Federation. The main quarried stone varieties of Rapakivi granite (Baltic Brown, Baltic Green, Carmen Red, Karelia Red, Eagle Red and Balmoral Red) are regularly produced in large quantities in Finland for the global stone market due to the stone's unique qualities. Examples of applications in Rapakivi granite from Finland can be found in the USA, China, South Africa, the UK, Italy, Austria, Ireland, Spain and Germany as well as in Scandinavia and Russia. There are also quarries near Vyborg, the Russian Federation: Vozrozhdenie and Ala-Noskua.


2019 ◽  
Vol 83 (5) ◽  
pp. 320-351
Author(s):  
Kayliegh Richardson ◽  
Ana Speed

In 2015, s 76 of the Serious Crime Act 2015 introduced the new criminal offence of ‘controlling or coercive behaviour in an intimate or family relationship’. This is just one of many steps the UK government have taken in recent years to acknowledge the different forms of domestic abuse and power imbalances that can be present in intimate relationships. In contrast, in February 2017, the Russian government passed an amendment to the Russian Criminal Code to decriminalise some forms of assault, a step which many human rights activists have opposed. This article will compare the seemingly dichotomous approaches to domestic abuse adopted by England and Wales and Russia and will examine the effectiveness of both approaches in deterring domestic violence, providing adequate support for victims and meeting state obligations under international law. There has been extensive commentary on the approach to domestic abuse in England, the USA and Australia. In comparison, consideration of the approach in the Russian Federation is limited. This is in part due to the approach taken in Russia to dealing with domestic abuse as a private issue and the associated lack of available data. This article seeks to go behind closed doors to explore the Russian approach to tackling domestic abuse in a way that it has not previously been considered.


Author(s):  
Alexander Varygin ◽  
Elena Chervonnykh ◽  
Alexander Klementev ◽  
Petr Pimenov

The authors examine the possibilities of the criminological analysis of criminal situation and show the value of using modern information systems to analyze and predict crimes for the improvement of the crime prevention work of internal affairs’ bodies. They study the analytical methods that make crime prevention more productive and the key software used for criminal analysis. The article presents the results of studying the work of criminal analysts in various legal systems (the UK, the USA, Canada, South Korea, New Zealand). It contains the data of an experts’ survey conducted in June 2017. The experts were 100 employees of investigation departments, centers of counteracting extremism, economic security and corruption counteraction, employees of organization and analytical departments of the Chief Directorate of Russian Ministry of the Interior in Moscow and Moscow Region. The analysis of the work of criminal analysts in other countries and the results of the survey of experts from law enforcement bodies are used to determine the prospects of introducing the institute of staff criminologists in the crime prevention system of the Russian Federation, to develop an algorithm of criminological support in Russian internal affairs’ bodies and to outline the prospective spheres of work for staff criminologists (criminal analysts). The authors conclude that the effectiveness of the work of Russian internal affairs’ bodies on the prevention, suppression and detection of crimes could be considerably improved through the introduction of modern means and methods of criminal analysis that are currently actively used by the police of some countries. They present a conceptually new approach to the criminological support of the work of internal affairs’ bodies based on the cumulative analysis of the current legislative base of the Russian Federation, the existing theoretical approaches and the experience of organizing the work of criminal analysts in other countries. The authors express their confidence that quality and professional work of using means and methods of crime prediction could help optimize the use of available resources and authority of law enforcement bodies and, consequently, either reduce the costs of law enforcement or use the available budgets more effectively.


2020 ◽  
pp. 245-265
Author(s):  
Арсен Артурович Григорян

Цель данной статьи - описать условия, в которых Армянская Апостольская Церковь вступила в эпоху правления Н. С. Хрущёва, начавшуюся в 1953 г. По содержанию статью можно поделить на две части: в первой даются сведения о количестве приходов на территории Советского Союза и за его пределами, а также о составе армянского духовенства в СССР; во второй излагаются проблемы, существовавшие внутри Армянской Церкви, и рассматриваются их причины. Методы исследования - описание и анализ. Ценность исследования заключается в использовании ранее неопубликованных документов Государственного архива Российской Федерации и Национального архива Армении. По итогам изучения фактического материала выделяются основные проблемы Армянской Апостольской Церкви на 1953 г.: финансовый дефицит, конфликт армянских католикосатов и стремление враждующих СССР и США использовать церковь в своих политических целях. The purpose of this article is to describe the conditions in which the Armenian Apostolic Church entered the epoch of the reign of N. S. Khrushchev, which began in 1953. The article can be divided into two parts: first one gives information about the number of parishes in the territory of the Soviet Union and beyond, and about the structure of the Armenian clergy in the USSR; the second one sets out the problems that existed in the Armenian Church and discusses their causes. Research methods - description and analysis. The value of the study lies in the use of previously unpublished documents of the State Archive of the Russian Federation and the National Archive of Armenia. Based on the results of studying the materials, the main problems of the Armenian Apostolic Church in 1953 are: financial deficit, the conflict of Armenian Catholicosates and the eagerness of USSR and the USA, that feuded with each other, to use the Сhurch for their political purposes.


2020 ◽  
pp. 69-87
Author(s):  
K.S. Teteryatnikov ◽  
S.G. Каmolov ◽  
D.A. Blashkina

The article is meant to analyze current problems and prospects for the development of effective tax policy as part of digital transformation of Russian economy. Introduction of a digital tax and the consequences of the digital tax reforms in the EU, the USA and OECD countries are highlighted. The necessity of qualitative transformation of the tax system of the Russian Federation in response to modern challenges is substantiated, taking into account the changes of the Tax Code of the Russian Federation adopted at the end of July 2020. The authors suggested their own concept of a digital tax and the prospects for its adoption in Russia, and consider it inappropriate to impose taxes on Internet users who do not use the Internet for business. Today, the main focus should be made on creating and testing effective technologies that allow on-line monitoring the tax basis of digital economy entities, taking into account the cross-border movement or use of digital products (goods and services). In addition, it would be extremely important to provide for a potential tax exemption for part of the profits of international ICT companies that are received on the territory of the Russian Federation and reinvested in joint with Russian companies projects in the high-tech for civil purposes area.


2020 ◽  
Vol 26 (1) ◽  
pp. 74-85 ◽  
Author(s):  
N. A. Putintseva ◽  
E. V. Ushakova

The presented study summarizes the results of the implementation of liberal market reforms in Russia and reviews tools of the market economy that could solve the problem of distrust within Russian society.Aim. The study aims to define the underlying problems that stem from the peculiarities of the historical development of the Russian Federation and now hinder the advancement of our country to a new level of development, and to propose directions for solving these problems.Tasks. The authors summarize the socio-economic consequences of the implementation of liberal market reforms; define the problems of the implementation of a rent-based economy in modern Russia; prove that Russia cannot advance to a new level of development without solving the problem of social distrust; review the tools that could change the current situation of global social distrust (publicprivate partnership, proactive budgeting, clusters, territorial marketing, Far Eastern Hectare program, smart cities, incident management).Methods. This study uses general scientific methods of cognition to examine the results of the implementation of liberal market reforms, identify the problems of modern Russia, and determine the possible directions and tools of development.Results. Russia’s development is historically based on finding and living off the natural rent. This perspective significantly narrows the range of ideas about the potential development directions for the Russian Federation. The rent-based development options proposed today expose another common Russian trait — uncertainty, lack of risk appetite, pessimism, and fear of “things getting worse”. Implementation of democratic reforms in the context of rent-based economic institutions, lack of mutual trust within society, poor performance of courts — all this aggravates the current situation.Conclusions. Nowadays, Russia needs an economy that would create a demand for human capital and inclusive political institutions that would make people engaged in the life of the nation, allowing them to capitalize on their creativity without leaving their homeland.


2018 ◽  
Vol 941 (11) ◽  
pp. 61-64
Author(s):  
A.M. Lelyuhina ◽  
М.V. Litvinenko ◽  
O.V. Miklashevskaya

The current issues of reforming the current tax system in the Russian Federation in the context of the transition to determining the amount of real estate taxes based on the cadastral value of real estate objects are discussed. The decision on adopting elements of a tax system in practice should be scientifically and methodologically based. The rational construction of the tax system of Russia contributes to the study of foreign tax systems’ models. In the article, the systems for calculating real estate tax established in the foreign countries under consideration are highlighted. Everything is based on analyzing the practice of real estate valuation in the UK, France, Belgium, Latvia, Finland, USA and Chile. A comparison is made of the grounds for calculating the property tax, their distinctive features. The main approaches to determining the cadastral value taking place in the cadastral systems of foreign countries are summarized. The conducted studies provide grounds for identifying trends in real estate valuation, which are being introduced into modern Russian cadastral valuation practice.


2021 ◽  
Vol 43 (1) ◽  
pp. 28-29

Abstract As a follow-up to the 2019 International Year of the Periodic Table of Chemical Elements (IYPT2019), the Government of the Russian Federation proposed to establish and fund the joint UNESCO/Russian Federation International Prize for the Basic Sciences in the name of the Russian chemist Dmitry Mendeleev. The initiative is to provide further support to the UNESCO’s International Basic Sciences Programme (IBSP).


2021 ◽  
Vol 1 (10) ◽  
pp. 149-166
Author(s):  
Dmitry V. Gordienko ◽  

The paper examines the interests of Russia, the United States and China in the regions of the world and identifies the priorities of Russia's activities in Europe, Central Asia and the Caucasus, the Asia-Pacific region, the Arctic, Africa, the Middle East and Latin America, their comparative assessment with the interests of the United States and China. An approach to assessing the impact of possible consequences of the activities of the United States and China on the realization of Russia's interests is proposed. This makes it possible to identify the priorities of the policy of the Russian Federation in various regions of the world. The results of the analysis can be used to substantiate recommendations to the military-political leadership of our country. It is concluded that the discrepancy between the interests of the United States and China is important for the implementation of the current economic and military policy of the Russian Federation.


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