scholarly journals Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline—A Review

Biomolecules ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1546
Author(s):  
Hendrik Nieraad ◽  
Nina Pannwitz ◽  
Natasja de Bruin ◽  
Gerd Geisslinger ◽  
Uwe Till
Keyword(s):  
Cognitive Performance ◽  
Clinical Studies ◽  
Animal Studies ◽  
Large Scale ◽  
Causal Link ◽  
Metabolic Role ◽  
Human Disorders ◽  
Potential Impact ◽  
One Carbon Metabolism ◽  
The One

Disturbances in the one-carbon metabolism are often indicated by altered levels of the endogenous amino acid homocysteine (HCys), which is additionally discussed to causally contribute to diverse pathologies. In the first part of the present review, we profoundly and critically discuss the metabolic role and pathomechanisms of HCys, as well as its potential impact on different human disorders. The use of adequate animal models can aid in unravelling the complex pathological processes underlying the role of hyperhomocysteinemia (HHCys). Therefore, in the second part, we systematically searched PubMed/Medline for animal studies regarding HHCys and focused on the potential impact on cognitive performance and decline. The majority of reviewed studies reported a significant effect of HHCys on the investigated behavioral outcomes. Despite of persistent controversial discussions about equivocal findings, especially in clinical studies, the present evaluation of preclinical evidence indicates a causal link between HHCys and cognition-related- especially dementia-like disorders, and points out the further urge for large-scale, well-designed clinical studies in order to elucidate the normalization of HCys levels as a potential preventative or therapeutic approach in human pathologies.

scholarly journals Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation Levels

2019 ◽  
Vol 20 (15) ◽  
pp. 3754 ◽  
Author(s):  
Coppedè ◽  
Stoccoro ◽  
Tannorella ◽  
Gallo ◽  
Nicolì ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Healthy Subjects ◽  
Metabolic Disorders ◽  
Tandem Repeats ◽  
Methylenetetrahydrofolate Reductase ◽  
High Resolution Melting ◽  
Human Disorders ◽  
One Carbon Metabolism ◽  
Inborn Defects ◽  
The One

Methylenetetrahydrofolate reductase (MTHFR) is a pivotal enzyme in the one-carbon metabolism, a metabolic pathway required for DNA synthesis and methylation reactions. MTHFR hypermethylation, resulting in reduced gene expression, can contribute to several human disorders, but little is still known about the factors that regulate MTHFR methylation levels. We performed the present study to investigate if common polymorphisms in one-carbon metabolism genes contribute to MTHFR methylation levels. MTHFR methylation was assessed in peripheral blood DNA samples from 206 healthy subjects with methylation-sensitive high-resolution melting (MS-HRM); genotyping was performed for MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), MTRR 66A>G (rs1801394), MTR 2756A>G (rs1805087), SLC19A1 (RFC1) 80G>A (rs1051266), TYMS 28-bp tandem repeats (rs34743033) and 1494 6-bp ins/del (rs34489327), DNMT3A -448A>G (rs1550117), and DNMT3B -149C>T (rs2424913) polymorphisms. We observed a statistically significant effect of the DNMT3B -149C>T polymorphism on mean MTHFR methylation levels, and particularly CT and TT carriers showed increased methylation levels than CC carriers. The present study revealed an association between a functional polymorphism of DNMT3B and MTHFR methylation levels that could be of relevance in those disorders, such as inborn defects, metabolic disorders and cancer, that have been linked to impaired DNA methylation.

First grammar books in the Habsburg Monarchy: individual initiative and regulatory interference by the state (1760s–1770s)

2020 ◽  
Vol 2019 (2 (11)) ◽  
pp. 137-157
Author(s):  
Olga V. Khavanova ◽  
Keyword(s):  
Eighteenth Century ◽  
State Policy ◽  
Large Scale ◽  
Language Use ◽  
Linguistic Diversity ◽  
Mother Tongue ◽  
German Language ◽  
Habsburg Monarchy ◽  
Private Initiative ◽  
The One

The second half of the eighteenth century in the lands under the sceptre of the House of Austria was a period of development of a language policy addressing the ethno-linguistic diversity of the monarchy’s subjects. On the one hand, the sphere of use of the German language was becoming wider, embracing more and more segments of administration, education, and culture. On the other hand, the authorities were perfectly aware of the fact that communication in the languages and vernaculars of the nationalities living in the Austrian Monarchy was one of the principal instruments of spreading decrees and announcements from the central and local authorities to the less-educated strata of the population. Consequently, a large-scale reform of primary education was launched, aimed at making the whole population literate, regardless of social status, nationality (mother tongue), or confession. In parallel with the centrally coordinated state policy of education and language-use, subjects-both language experts and amateur polyglots-joined the process of writing grammar books, which were intended to ease communication between the different nationalities of the Habsburg lands. This article considers some examples of such editions with primary attention given to the correlation between private initiative and governmental policies, mechanisms of verifying the textbooks to be published, their content, and their potential readers. This paper demonstrates that for grammar-book authors, it was very important to be integrated into the patronage networks at the court and in administrative bodies and stresses that the Vienna court controlled the process of selection and financing of grammar books to be published depending on their quality and ability to satisfy the aims and goals of state policy.

The Green New Deal

2019 ◽  
Author(s):  
Robert C. Hockett
Keyword(s):  
New Deal ◽  
Large Scale ◽  
Public Investment ◽  
Climate Science ◽  
Time Frame ◽  
White Paper ◽  
Good News ◽  
Carbon Neutrality ◽  
The One ◽  
In Virtue Of

This white paper lays out the guiding vision behind the Green New Deal Resolution proposed to the U.S. Congress by Representative Alexandria Ocasio-Cortez and Senator Bill Markey in February of 2019. It explains the senses in which the Green New Deal is 'green' on the one hand, and a new 'New Deal' on the other hand. It also 'makes the case' for a shamelessly ambitious, not a low-ball or slow-walked, Green New Deal agenda. At the core of the paper's argument lies the observation that only a true national mobilization on the scale of those associated with the original New Deal and the Second World War will be up to the task of comprehensively revitalizing the nation's economy, justly growing our middle class, and expeditiously achieving carbon-neutrality within the twelve-year time-frame that climate science tells us we have before reaching an environmental 'tipping point.' But this is actually good news, the paper argues. For, paradoxically, an ambitious Green New Deal also will be the most 'affordable' Green New Deal, in virtue of the enormous productivity, widespread prosperity, and attendant public revenue benefits that large-scale public investment will bring. In effect, the Green New Deal will amount to that very transformative stimulus which the nation has awaited since the crash of 2008 and its debt-deflationary sequel.

Methods for the Quantification of Salivary Cortisol and of a-amylase in Biosensors and Portable Devices

2018 ◽  
Vol 68 (12) ◽  
pp. 2857-2859
Author(s):  
Cristina Mihaela Ghiciuc ◽  
Andreea Silvana Szalontay ◽  
Luminita Radulescu ◽  
Sebastian Cozma ◽  
Catalina Elena Lupusoru ◽  
...  
Keyword(s):  
Real Time ◽  
Medical Practice ◽  
Salivary Cortisol ◽  
Clinical Studies ◽  
Large Scale ◽  
Psychological Research ◽  
Portable Devices ◽  
Salivary Amylase ◽  
Specificity And Sensitivity

There is an increasing interest in the analysis of salivary biomarkers for medical practice. The objective of this article was to identify the specificity and sensitivity of quantification methods used in biosensors or portable devices for the determination of salivary cortisol and salivary a-amylase. There are no biosensors and portable devices for salivary amylase and cortisol that are used on a large scale in clinical studies. These devices would be useful in assessing more real-time psychological research in the future.

“Community Interests” and the Role of International Law in the Creation of a Global Market for Agricultural Land

2018 ◽  
Author(s):  
Jochen von Bernstorff
Keyword(s):  
International Law ◽  
Large Scale ◽  
Agricultural Land ◽  
Food Sovereignty ◽  
Global Market ◽  
Negative Consequences ◽  
Cultural Rights ◽  
Land Grab ◽  
Large Scale Land ◽  
The One

The chapter explores the notion of “community interests” with regard to the global “land-grab” phenomenon. Over the last decade, a dramatic increase of foreign investment in agricultural land could be observed. Bilateral investment treaties protect around 75 per cent of these large-scale land acquisitions, many of which came with associated social problems, such as displaced local populations and negative consequences for food security in Third World countries receiving these large-scale foreign investments. Hence, two potentially conflicting areas of international law are relevant in this context: Economic, social, and cultural rights and the principles of permanent sovereignty over natural resources and “food sovereignty” challenging large-scale investments on the one hand, and specific norms of international economic law stabilizing them on the other. The contribution discusses the usefulness of the concept of “community interests” in cases where the two colliding sets of norms are both considered to protect such interests.

scholarly journals Efficacy and Underlying Mechanism of Acupuncture in the Treatment of Posttraumatic Stress Disorder: A Systematic Review of Animal Studies

2021 ◽  
Vol 10 (8) ◽  
pp. 1575
Author(s):  
Chan-Young Kwon ◽  
Boram Lee ◽  
Sang-Ho Kim
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Responses ◽  
Methodological Quality ◽  
Animal Studies ◽  
Large Scale ◽  
Stress Disorder ◽  
Spatial Learning And Memory ◽  
Expectancy Effects ◽  
Therapeutic Mechanisms

Acupuncture is a nonpharmacological intervention that can be useful in the clinical management of posttraumatic stress disorder (PTSD), especially in situations with a lack of medical resources, including large-scale PTSD events such as disasters. Some clinical studies have reported the clinical effect of acupuncture in improving PTSD symptoms, but the underlying therapeutic mechanism has yet to be explored. Therefore, this review summarized the underlying therapeutic mechanisms of acupuncture in animal PTSD models. A comprehensive search was conducted in 14 electronic databases, and two independent researchers performed study selection, data extraction, and the methodological quality assessment. Twenty-four relevant studies were included in this review and summarized according to the proposed main mechanisms. In behavioral evaluation, acupuncture, including manual acupuncture and electro-acupuncture, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated disturbance of spatial learning and memory of PTSD animal models. The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. However, the methodological quality of the included animal studies was not high enough to produce robust evidence. In addition, mechanistic studies on specific aspects of acupuncture that may affect PTSD, including expectancy effects, in human PTSD subjects are also needed.

scholarly journals State Management for Cloud-Native Applications

Electronics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 423
Author(s):  
Márk Szalay ◽  
Péter Mátray ◽  
László Toka
Keyword(s):  
Large Scale ◽  
Distributed Databases ◽  
Access Time ◽  
Replica Placement ◽  
State Management ◽  
Placement Decisions ◽  
Dynamic Replication ◽  
Cloud Databases ◽  
Placement Algorithm ◽  
The One

The stateless cloud-native design improves the elasticity and reliability of applications running in the cloud. The design decouples the life-cycle of application states from that of application instances; states are written to and read from cloud databases, and deployed close to the application code to ensure low latency bounds on state access. However, the scalability of applications brings the well-known limitations of distributed databases, in which the states are stored. In this paper, we propose a full-fledged state layer that supports the stateless cloud application design. In order to minimize the inter-host communication due to state externalization, we propose, on the one hand, a system design jointly with a data placement algorithm that places functions’ states across the hosts of a data center. On the other hand, we design a dynamic replication module that decides the proper number of copies for each state to ensure a sweet spot in short state-access time and low network traffic. We evaluate the proposed methods across realistic scenarios. We show that our solution yields state-access delays close to the optimal, and ensures fast replica placement decisions in large-scale settings.

scholarly journals Constructing Large-Scale Genetic Maps Using an Evolutionary Strategy Algorithm

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 2269-2282
Author(s):  
D Mester ◽  
Y Ronin ◽  
D Minkov ◽  
E Nevo ◽  
A Korol
Keyword(s):  
Discrete Optimization ◽  
High Performance ◽  
Large Scale ◽  
Simulated Data ◽  
Real Data ◽  
Genetic Maps ◽  
Chromosome 1 ◽  
Evolutionary Strategy ◽  
Group A ◽  
The One

Abstract This article is devoted to the problem of ordering in linkage groups with many dozens or even hundreds of markers. The ordering problem belongs to the field of discrete optimization on a set of all possible orders, amounting to n!/2 for n loci; hence it is considered an NP-hard problem. Several authors attempted to employ the methods developed in the well-known traveling salesman problem (TSP) for multilocus ordering, using the assumption that for a set of linked loci the true order will be the one that minimizes the total length of the linkage group. A novel, fast, and reliable algorithm developed for the TSP and based on evolution-strategy discrete optimization was applied in this study for multilocus ordering on the basis of pairwise recombination frequencies. The quality of derived maps under various complications (dominant vs. codominant markers, marker misclassification, negative and positive interference, and missing data) was analyzed using simulated data with ∼50-400 markers. High performance of the employed algorithm allows systematic treatment of the problem of verification of the obtained multilocus orders on the basis of computing-intensive bootstrap and/or jackknife approaches for detecting and removing questionable marker scores, thereby stabilizing the resulting maps. Parallel calculation technology can easily be adopted for further acceleration of the proposed algorithm. Real data analysis (on maize chromosome 1 with 230 markers) is provided to illustrate the proposed methodology.

scholarly journals China’s Investments in Germany and the Impact of the COVID-19 Pandemic

2021 ◽  
Vol 56 (2) ◽  
pp. 113-119
Author(s):  
Xinming Xia ◽  
Wan-Hsin Liu
Keyword(s):  
Large Scale ◽  
Know How ◽  
Advanced Technologies ◽  
The Future ◽  
Potential Impact ◽  
Chinese State ◽  
The Impact ◽  
Gain Access ◽  
Over Time

AbstractThis paper analyses how China’s investments in Germany have developed over time and the potential impact of the COVID-19 pandemic in this regard, based on four different datasets, including our own survey in mid-2020. Our analysis shows that Germany is currently one of the most attractive investment destinations for Chinese investors. Chinese state-owned enterprises have played an important role as investors in Germany — particularly in large-scale projects. The COVID-19 pandemic has had some negative but rather temporary effects on Chinese investments in Germany. Germany is expected to stay attractive to Chinese investors who seek to gain access to advanced technologies and know-how in the future.

Global Reaction Model to Describe the Kinetics of Catalytic Pyrolysis of Coffee Grounds Waste

2017 ◽  
Vol 899 ◽  
pp. 173-178 ◽  
Author(s):  
Ronydes Batista Jr. ◽  
Bruna Sene Alves Araújo ◽  
Pedro Ivo Brandão e Melo Franco ◽  
Beatriz Cristina Silvério ◽  
Sandra Cristina Danta ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Large Scale ◽  
Catalytic Pyrolysis ◽  
Petroleum Products ◽  
Reaction Model ◽  
Heating Rates ◽  
Coffee Grounds ◽  
One Step ◽  
Global Reaction ◽  
The One

In view of the constant search for new sources of renewable energy, the particulate agro-industrial waste reuse emerges as an advantageous alternative. However, despite the advantages of using the biomass as an energy source, there is still strong resistance as the large-scale replacement of petroleum products due to the lack of scientifically proven efficient conversion technologies. In this context, the pyrolysis is presented as one of the most widely used thermal decomposition processes. The knowledge of aspects of chemical kinetics, thermodynamics these will, heat and mass transfer, are so important, since influence the quality of the product. This paper presents a kinetic study of slow pyrolysis of coffee grounds waste from dynamic thermogravimetric experiments (TG), using different powder catalysts. The primary thermal decomposition was described by the one-step reaction model, which considers a single global reaction. The kinetic parameters were estimated using nonlinear regression and the differential evolution method. The coffee ground waste was dried at 105°C for 24 hours. The sample in nature was analyzed at different heating rates, being 10, 15, 20, 30 and 50 K/min. In the catalytic pyrolysis, about 5% (w/w) of catalyst were added to the sample, at a heating rate of 30 K/min. The results show that the one-step model does not accurately represent the data of weight loss (TG) and its derivative (DTG), but can do an estimative of the activation energy reaction, and can show the differences caused by the catalysts. Although no one can say anything about the products formed with the addition of the catalyst, it would be necessary to micro-pyrolysis analysis, we can say the influence of the catalyst in the samples, based on the data obtained in thermogravimetric tests.

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