scholarly journals On the Equivalence of the Biological Effect Induced by Irradiation of Clusters of Heavy Atom Nanoparticles and Homogeneous Heavy Atom-Water Mixtures

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2034
Author(s):  
Balder Villagomez-Bernabe ◽  
José Ramos-Méndez ◽  
Frederick J. Currell

A multiscale local effect model (LEM)-based framework was implemented to study the cell damage caused by the irradiation of clusters of gold nanoparticles (GNPs) under clinically relevant conditions. The results were compared with those obtained by a homogeneous mixture of water and gold (MixNP) irradiated under similar conditions. To that end, Monte Carlo simulations were performed for the irradiation of GNP clusters of different sizes and MixNPs with a 6 MV Linac spectrum to calculate the dose enhancement factor in water. The capabilities of our framework for the prediction of cell damage trends are examined and discussed. We found that the difference of the main parameter driving the cell damage between a cluster of GNPs and the MixNP was less than 1.6% for all cluster sizes. Our results demonstrate for the first time a simple route to intuit the radiobiological effects of clusters of nanoparticles through the consideration of an equivalent homogenous gold/water mixture. Furthermore, the negligible difference on cell damage between a cluster of GNPs and MixNP simplifies the modelling for the complex geometries of nanoparticle aggregations and saves computational resources.

2019 ◽  
Vol 20 (11) ◽  
pp. 1046-1051 ◽  
Author(s):  
Przemysław Gajda-Morszewski ◽  
Klaudyna Śpiewak-Wojtyła ◽  
Maria Oszajca ◽  
Małgorzata Brindell

Lactoferrin was isolated and purified for the first time over 50-years ago. Since then, extensive studies on the structure and function of this protein have been performed and the research is still being continued. In this mini-review we focus on presenting recent scientific efforts towards the elucidation of the role and therapeutic potential of lactoferrin saturated with iron(III) or manganese(III) ions. The difference in biological activity of metal-saturated lactoferrin vs. the unmetalated one is emphasized. The strategies for oral delivery of lactoferrin, are also reviewed, with particular attention to the metalated protein.


Author(s):  
Adi Ophir ◽  
Ishay Rosen-Zvi

This chapter traces the developments of various terms denoting “others” in biblical literature. In much of the biblical corpus, Israel is still one goy among many, and the difference between it and its Others is neither binary nor stable. After a brief analysis of the dynamics of familial and ethnwic separations in Genesis and Exodus, this chapter concentrates on the priestly and Deuteronomistic modes of separating peoples, examines the novelty and limitedness of the Deuteronomistic legislation, where the nokhri (stranger) is systematically contrasted for the first time with the Israelite (referred to as “your brother”), and follows the various modes of separations and their rationales.


1982 ◽  
Vol 72 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Tan Keng-Hong ◽  
Lee Soo-Lam

AbstractDacus dorsalis Hend. infested eleven, D. cucurbitae Coq. five and D. umbrosus F. two of the eighteen common fruits and vegetables grown in Penang, West Malaysia. D. tau (Wlk.) infested bacang (Mangifera foetida), D. caudatus F. chilli (Capsicum annuum) and D. frauenfeldi Schin. water guava (Eugenia javanica), together with D. dorsalis. Pomelo (Citrus grandis) was found infested for the first time by D. cucurbitae. No flies were trapped using Capilure and trimedlure as baits. Cue-lure attracted D. caudatus, D. cucurbitae, D. frauenfeldi, D. occipitalis (Bez.) and D. tau. Methyl eugenol attracted D. dorsalis and D. umbrosus. Dorsalure was less attractive to D. caudatus and D. dorsalis than cue-lure and methyl eugenol, respectively, but it was equally attractive to D. frauenfeldi as cue-lure. Using traps baited with cue-lure or methyl eugenol in five ecosystems, the highest numbers of males of D. dorsalis, D. umbrosus, D. frauenfeldi and D. caudatus trapped were from a village, on a vegetable farm for D. cucurbitae, and D. occipitalis was only caught in a forest. Analysis showed that for each species of Dacus the difference between ecosystems was highly significant. The few examples caught in grassland were probably migrants.


2004 ◽  
Vol 19 (12) ◽  
pp. 3607-3613 ◽  
Author(s):  
H. Iikawa ◽  
M. Nakao ◽  
K. Izumi

Separation by implemented oxygen (SIMOX)(111) substrates have been formed by oxygen-ion (16O+) implantation into Si(111), showing that a so-called “dose-window” at 16O+-implantation into Si differs from Si(100) to Si(111). In SIMOX(100), an oxygen dose of 4 × 1017/cm2 into Si(100) is widely recognized as the dose-window when the acceleration energy is 180 keV. For the first time, our work shows that an oxygen dose of 5 × 1017/cm2 into Si(111) is the dose-window for the formation of SIMOX(111) substrates when the acceleration energy is 180 keV. The difference between dose-windows is caused by anisotropy of the crystal orientation during growth of the faceted buried SiO2. We also numerically analyzed the data at different oxidation velocities for each facet of the polyhedral SiO2 islands. Numerical analysis results show good agreement with the experimental data.


2001 ◽  
Vol 15 (17n19) ◽  
pp. 683-687
Author(s):  
A. SILVA-CASTILLO ◽  
F. PEREZ-RODRIGUEZ

We have applied the 45° reflectometry for the first time to study exciton-polaritons in quantum wells. The 45° reflectometry is a new polarization-modulation technique, which is based on the measurement of the difference [Formula: see text] between the p-polarization reflectivity (Rp) and the squared s-polarization reflectivity [Formula: see text] at an angle of incidence of 45°. We show that [Formula: see text] spectra may provide qualitatively new information on the exciton-polariton modes in a quantum well. These optical spectra turn out to be very sensitive to the zeros of the dielectric function along the quantum-well growth direction and, therefore, allow to identify the resonances associated with the Z exciton-polariton mode. We demonstrate that 45° reflectometry could be a powerful tool for studying Z exciton-polariton modes in near-surface quantum wells, which are difficult to observe in simple spectra of reflectivity Rp


2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Wei Xu ◽  
Yu-Lin Chen ◽  
Ying Zhao ◽  
Li-Jie Wang ◽  
Jiu-Jun Li ◽  
...  

Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000 mg (800–5,000). Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents. 35.29% experienced an obvious sense of euphoria. All patients had nervous system symptoms, 6 (35.29%) cases developed coma (GCS < 8), and 5 (29.41%) cases experienced convulsion. Four cases were treated with hemodialysis. The incidence rate in young patients with repeat carbamazepine use and without the supervision of parents was higher than that in first-time users (5/7 versus 4/10), but the difference was not significant. The toxic dose of repeat users was 3428 ± 1035 mg, significantly higher than that of 1470 ± 646 mg in first-time users (P=0.001). Carbamazepine can produce a sense of euphoria, which is more likely to lead to its abuse and overdose in adolescents. To prevent carbamazepine abuse and overdose will be critical in educating at-risk adolescents and preventing associated morbidities in the future.


Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2440
Author(s):  
Francesco Spagnolo ◽  
Bruna Dalmasso ◽  
Enrica Tanda ◽  
Miriam Potrony ◽  
Susana Puig ◽  
...  

Inherited pathogenic variants (PVs) in the CDKN2A tumor suppressor gene are among the strongest risk factors for cutaneous melanoma. Dysregulation of the p16/RB1 pathway may intrinsically limit the activity of MAPK-directed therapy due to the interplay between the two pathways. In our study, we assessed, for the first time, whether patients with germline CDKN2A PVs achieve suboptimal results with BRAF inhibitors (BRAFi)+/−MEK inhibitors (MEKi). We compared the response rate of nineteen CDKN2A PVs carriers who received first-line treatment with BRAFi+/−MEKi with an expected rate derived from phase III trials and “real-world” studies. We observed partial response in 16/19 patients (84%), and no complete responses. The overall response rate was higher than that expected from phase III trials (66%), although not statistically significant (p-value = 0.143; 95% CI = 0.60–0.97); the difference was statistically significant (p-value = 0.019; 95% CI = 0.62–0.97) in the comparison with real-world studies (57%). The clinical activity of BRAFi+/−MEKi in patients with germline CDKN2A PV was not inferior to that of clinical trials and real-world studies, which is of primary importance for clinical management and genetic counseling of this subgroup of patients.


1892 ◽  
Vol s2-33 (130) ◽  
pp. 313-324
Author(s):  
ASAJIRO OKA ◽  
ARTHUR WILLEY

Sarcodidemnoides misakiense, Oka and Willey. Generic Characters.--Colony (or cormus) forming very thick lobose masses, laterally compressed; sessile, but not encrusting. Excurrent orifices placed on the tips of the knoll-like prominences. Ascidiozooids very numerous, not arranged in systems; branchial sac with four rows of stigmata; canal system complicated, differentiated into peripheral and central portions. Specific Characters.--Atrial apertures of Ascidiozooids simple pores without teeth or languet; spicules fairly abundant, extremely delicate, confined to a thin layer near surface of test. Test gelatinous, containing numerous bladder-cells, crystals, fusiform cells, and pigment concretions. Stomach of Ascidiozooids vertically placed; surface of attachment of colony narrower than the free portion. Colour, brilliant red. Habitat.--Moroiso, Japan, between the tide-marks. N.B.--Since the above was written I have seen for the first time the exhaustive work of Fernand Lahille, entitled ‘Recherches sur les Tuniciers des côtes de France,' Toulouse, 1890. Lahille devotes considerable attention to what have been spoken of above as tentacle-like processes of the larva, figures them in many larvæ, and gives an excellent figure of the metamorphosing larva of Styela glomerata. He gives an opinion as to their significance which I cannot entirely endorse in the light of my own researches on the "Postembryonic development of Styela," commenced last August at Plymouth. However, I hope to return to this question on a future occasion. Lahille raises an objection to von Drasche's genus Didemnoides on the ground that the thickness of the cormus is not an anatomical character, and that the distinction between thick and thin colonies is a purely subjective one. There is no doubt some truth in this; but the difference between a compound Ascidian which possesses, say, a very few spicules, and one which possesses none at all, would appear to be no more fundamental than that between a colony whose mode of growth resulted in the production of a fleshy mass and one which grew in the form of a thin leathery crust. As stated above, von Drasche intends by Didemnoides a fleshy form of Leptoclinum, the test containing spicules, and the Ascidiozooids having four rows of stigmata in the branchial sac. Lahille, on the contrary,applies the name Didemnoides to those Didemnidse which are characterised by the absence of spicules, and the possession of three rows of stigmata in the branchial sac. The compound Ascidian which we have described above has spicules in the test, and four rows of stigmata in the branchial sac. But as it would be too absurd to call the new form "Sarcoleptoclinum," we shall persist in regarding the genus Didemnoides from the point of view of von Drasche.--A. W.


2021 ◽  
Vol 11 (19) ◽  
pp. 8880
Author(s):  
Bowen Guan ◽  
Cunbo Fan ◽  
Ning An ◽  
Ricardo Cesar Podesta ◽  
Dra Ana Pacheco ◽  
...  

As one of the major error sources, satellite signature effect should be reduced or even erased from the distribution of the post-fit residuals to improve the ranging precision. A simulation of satellite signature effect removal process for normal point algorithm is conducted based on a revised model of satellite response, which fully considers the structural and distribution characteristics of retroreflectors. In order to eliminate both long-term and short-term satellite signature effect, a clipping method for SLR data processing is proposed by defining the clipping location as 5.6 mm away from the mean value of the long-term fit residuals to select effective returns for normal points. The results indicate that, compared to normal points algorithm, the RMS per NP of LAGEOS-1 observation data processed by the clipping method is reduced from 62.90 ± 9.9 mm to 56.07 ± 4.69 mm, and the stability of RMS is improved 53%. This study improves the satellite signature effect model and simulates the fluctuation of normal points caused by satellite signature effect for the first time. The new method based on the simulation of satellite signature effect has stronger robustness and applicability, which can further minimize the influence of satellite signature effect on the SLR production and significantly improve the data property.


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