scholarly journals Molecular Pathology of Human Papilloma Virus-Negative Cervical Cancers

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6351
Author(s):  
Hiroshi Yoshida ◽  
Kouya Shiraishi ◽  
Tomoyasu Kato
Keyword(s):  
Molecular Pathology ◽  
Clear Cell ◽  
Hpv Vaccination ◽  
False Negative ◽  
Small Subset ◽  
Papilloma Virus ◽  
Cervical Cancers ◽  
Clear Cell Type ◽  
Common Cancer ◽  
Genetic Profiles

Cervical cancer is the fourth most common cancer in women worldwide and is predominantly caused by infection with human papillomavirus (HPV). However, a small subset of cervical cancers tests negative for HPV, including true HPV-independent cancers and false-negative cases. True HPV-negative cancers appear to be more prevalent in certain pathological adenocarcinoma subtypes, such as gastric- and clear-cell-type adenocarcinomas. Moreover, HPV-negative cervical cancers have proven to be a biologically distinct tumor subset that follows a different pathogenetic pathway to HPV-associated cervical cancers. HPV-negative cervical cancers are often diagnosed at an advanced stage with a poor prognosis and are expected to persist in the post-HPV vaccination era; therefore, it is important to understand HPV-negative cancers. In this review, we provide a concise overview of the molecular pathology of HPV-negative cervical cancers, with a focus on their definitions, the potential causes of false-negative HPV tests, and the histology, genetic profiles, and pathogenesis of HPV-negative cancers.

scholarly journals Awareness of human papilloma virus infection and vaccination among the medical students of Davangere

2021 ◽  
Vol 8 (7) ◽  
pp. 3316
Author(s):  
Netra G. ◽  
Geethalakshmi R. G.
Keyword(s):  
Cervical Cancer ◽  
Medical Students ◽  
Human Papilloma Virus ◽  
Hpv Vaccination ◽  
Human Papilloma Virus Infection ◽  
Hpv Infection ◽  
Sources Of Information ◽  
Cross Sectional ◽  
Papilloma Virus ◽  
Common Cancer

Background: Cervical cancer is fifth most common cancer worldwide and second most common cancer in women in India, with an incidence of 1,22,844 cases and accounts for over 67,477 deaths annually (GLOBOCON 2012). Although vaccines are available to prevent the cervical cancer there is lack of awareness regarding the same. Hence the present study has been proposed. The objective was to study the awareness of human papilloma virus (HPV) vaccination among the medical students.Methods: A cross-sectional study was conducted between September 2017 to December 2017 among the medical students. All those who gave consent were included and a predesigned, pretested proforma consisting of variables about demographic characteristics, HPV, vaccination and the other necessary information required for the study was collected.Results: 72.4% of the participants were aware of the HPV infection, 70.5% about the HPV vaccination and 69.5% of the participants thought that only females should be vaccinated. 52.3% of the participants expressed interest for vaccination. Interns had 100% awareness about the infection and vaccination. Students who were not interested in vaccination, 18.9% of them said they are not sexually active, 8.5% thought there was no need of vaccine, 6.1% felt vaccine is too expensive and 1.3% worried about the safety of the vaccine. Sources of information was mainly through lectures/textbooks (64.8%) followed by doctors/healthcare facility (20.9%).Conclusions: Study revealed appreciable level of awareness among the participants. With this study, the participants are encouraged to get vaccinated as the age group of participants is appropriate for the vaccination.

Cervical Cancer

2018 ◽  
Author(s):  
Karin Sundström ◽  
Joakim Dillner ◽  
Hans-Olov Adami
Keyword(s):  
Cervical Cancer ◽  
Current Knowledge ◽  
Hpv Vaccination ◽  
Cervical Cancer Prevention ◽  
Prevention Strategies ◽  
Main Risk Factor ◽  
Additional Risk ◽  
Papilloma Virus ◽  
Sexually Transmitted ◽  
Common Cancer

Cervical cancer is the fourth most common cancer among women worldwide, with at least half a million women developing the disease each year. This chapter details the significance of infection with human papilloma virus (HPV) as the main risk factor, and summarizes current knowledge on additional risk factors of significance including tobacco use, oral contraceptives, parity, and other sexually transmitted infections such as HIV. For other factors such as diet, BMI, and physical activity, impact on risk appears limited. The chapter outlines both the importance of cervical cytological screening in reducing the incidence of this cancer form and the latest prevention opportunities for the disease that have emerged since the realization of its infectious cause, namely, HPV vaccination and HPV-based screening. It also describes that access to these cervical cancer prevention strategies is as yet unequally distributed across the world, especially in those regions that may be in largest need.

scholarly journals Assessment of knowledge and attitude of medical and nursing students towards screening for cervical carcinoma and HPV vaccination in a tertiary care teaching hospital

2017 ◽  
Vol 4 (11) ◽  
pp. 4186 ◽  
Author(s):  
Sunite A. Ganju ◽  
Neha Gautam ◽  
Vijay Barwal ◽  
Sohini Walia ◽  
Shriya Ganju
Keyword(s):  
Cervical Cancer ◽  
Nursing Students ◽  
Hpv Vaccination ◽  
Tertiary Care ◽  
Staff Nurses ◽  
Papilloma Virus ◽  
Common Cancer ◽  
Raising Awareness ◽  
Males And Females ◽  
Knowledge And Attitude

Background: Cervical cancer is the second most common cancer among women and infection with high risk human papilloma virus (HPV) is a pre-requisite for cervical cancer. The present study was undertaken to assess the knowledge regarding cervical cancer screening and HPV vaccination among medical and nursing staff.Methods: Four hundred participants; 200 MBBS students, 120 BSc nursing students and 80 staff nurses answered a standardized questionnaire which was analysed.Results: Majority of the MBBS students correctly believed that cervical cancer was not the most common cancer in females and 77.5% believed that HPV is identified in more than 50% cases. Around 80% of the respondents knew that HPV is transmitted sexually and could be transmitted during pregnancy and can affect both males and females. More than 80% of the staff nurses answered correctly that HPV could be transmitted by needle sharing and 76% believed that the infection could be symptomless. More than 80% of the participants were aware that a vaccine is available against HPV but only 5.5% were vaccinated. Though the knowledge was there but several gaps were noticed regarding HPV vaccination, the major concerns being safety, efficacy and availability of the vaccine.Conclusions: HPV is a vaccine preventable cancer and for accepting the vaccination the health professionals can play a pivotal role in raising awareness and controlling the disease.

scholarly journals HPV Vaccination in India: Critical Appraisal

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Aruna Nigam ◽  
Pikee Saxena ◽  
Anita S. Acharya ◽  
Archana Mishra ◽  
Swaraj Batra
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Critical Appraisal ◽  
Hpv Vaccination ◽  
Invasive Cervical Carcinoma ◽  
Papilloma Virus ◽  
Indian Context ◽  
Common Cancer ◽  
Cervical Cancer Vaccine

Cervical cancer is the third most common cancer in women worldwide. The role of human papilloma virus (HPV) in the genesis of cervical carcinoma is well documented. The HPV 16 and 18 are found to be most commonly associated with invasive cervical carcinoma. The advent of cervical carcinoma vaccine has advanced the hopes that eradication of cervical carcinoma might be possible in future. The scenario of prevention of cervical carcinoma is completely different in developed and developing countries. The implementation of the vaccination as a routine in India is still controversial. Here we have tried to critically analyse these issues in Indian context. However it is clear that cervical cancer vaccine is not an immediate panacea and cannot replace the cervical cancer screening which is mandatory in Indian context.

HPV VACCINE AND CERVICAL CANCER

2011 ◽  
pp. 108-115
Author(s):  
Vu Quoc Huy Nguyen
Keyword(s):  
Cervical Cancer ◽  
Relative Risk ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Preventive Strategy ◽  
Protective Effects ◽  
Papilloma Virus ◽  
Vaccine Trials ◽  
Close Relationship ◽  
The Relationship

Persistent infection with high-risk Human Papilloma Virus (HPV) has been identified as the causal factor of cervical cancer, with relative risk up to 300-400 folds. This very close relationship leads to the preventive strategy of vaccination against HPV infections and HPV-related lesions. The article describes molecular and immunologic characteristics of HPV, currently available HPV vaccines and its protective effects; the relationship between HPV vaccination and cervical cancer screening, and an introduction to therapeutic HPV vaccine trials.

scholarly journals Prostate cancer and the human papilloma virus: causative association, role of vaccines, and the impact of the COVID-19 pandemic

2021 ◽  
Author(s):  
Naomi Morka ◽  
Joseph M. Norris ◽  
Mark Emberton ◽  
Daniel Kelly
Keyword(s):  
Prostate Cancer ◽  
Human Papilloma Virus ◽  
Hpv Vaccination ◽  
Significant Proportion ◽  
Vaccine Uptake ◽  
Papilloma Virus ◽  
Vaccination Campaigns ◽  
The Impact ◽  
Hpv Vaccine Uptake

AbstractProstate cancer affects a significant proportion of men worldwide. Evidence from genetic and clinical studies suggests that there may be a causal association between prostate cancer and the human papilloma virus (HPV). As HPV is a vaccine-preventable pathogen, the possibility of a role in prostate cancer causation may reinforce the importance of effective HPV vaccination campaigns. This is of particular relevance in light of the COVID-19 pandemic, which may have considerable effects on HPV vaccine uptake and distribution.

Using The Health Belief Model to Explore Female's Perceptions of Male HPV Vaccination

2020 ◽  
Vol 30 (4) ◽  
Author(s):  
Rebecca Vidourek ◽  
Keith King ◽  
Brittany Rosen ◽  
Sara Fehr
Keyword(s):  
Hpv Vaccination ◽  
Health Belief ◽  
Transmitted Infection ◽  
Papilloma Virus ◽  
Sexually Transmitted ◽  
Vaccination Rates ◽  
Midwestern University ◽  
Belief Model ◽  
The Health Belief Model

Background: Human Papilloma Virus (HPV) is a common sexually transmitted infection. The HPV vaccination is an effective method of preventing cervical cancer and genital warts. The present study examined females’ perceptions of male HPV vaccination. Methods: Participants were females (N = 306) from one Midwestern university. Results: Results indicated significant differences in perceived benefits to male HPV vaccination students’ based on grade and knowing a male/female that had the vaccine. No significant differences in perceived barriers were found in the study. Conclusions: These findings should be considered when developing programs aimed at educating students on the male HPV vaccine. The role of females in increasing male HPV vaccination rates should be considered.

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