scholarly journals Arching from Function to Form—Important Design Elements of Simulation Exercises (SimEx) in Emergency Response and Disaster Risk Management

2021 ◽  
Vol 11 (11) ◽  
pp. 718
Author(s):  
Andra Iustina Covaciu ◽  
Marcus Abrahamsson ◽  
Albrecht Beck ◽  
Shivani Rai ◽  
Niroj Sapkota ◽  
...  

With Rasmussen’s abstraction hierarchy as starting point, the present article focuses on understanding some of the aspects guiding the development of a simulation exercise (SimEx) from a multi-faceted perspective, based on interviews and post-exercise evaluations conducted with both exercise designers and participants. The results show that, in order to achieve its overarching objective, an exercise must fulfill a wide range of “functions”, which in turn can take various kinds of “forms” or actual representations in the physical world. The paper discusses a number of identified required functions of a SimEx, sometimes labeled as design elements, and furthermore elaborates on differences and specific requirements at form level, e.g., virtual vs. physical exercises.

Author(s):  
О. Г. Гребеніков

The development of unmanned aerial vehicles is of great interest to both the largest aircraft companies and design enthusiasts, and among the total volume of developments, the volume of multicopter unmanned aerial vehicles occupies one of the leading positions. In this regard, the analysis of existing developments and the definition of future research in this direction is relevant. Multi-helicopter drones have a wide range of functions in both military and civilian use.The paper collects and analyzes statistical data of micro-unmanned aerial vehicles of the multicopter type to determine the achievements in the field of design of micro-unmanned aerial vehicles (UAVs). The current classification of UAVs is considered; as a result of the analysis of statistical data its expansion is offered. The take-off and mass characteristics of the micro UAV are described. The tables showing the existing UAVs are given. In addition, the flight characteristics, aerodynamic schemes and type of engine that are most rationally suited for micro-unmanned aerial vehicles according to their purpose and class are determined.Based on the obtained data, a prototype model of a micro-UAV with improved characteristics was built. The model successfully completed all tasks. This indicates that the new UAV "Fear-1" is a successful project and it has the ability to remotely control by phone or any other equipment designed for this purpose. In addition, the designed device can additionally hang in the specified coordinates."Fear-1" confidently performs tasks in automatic mode, as well as independently decides to return to the starting point of takeoff, if: there is a loss of communication, the battery level has reached a certain level, the UAV has completed its task or used more miles -amperes than specified by the output parameters. The drone has the ability to fly in "Follow me" mode on the selected GPS transmitter. The quadcopter was tested in difficult weather conditions, when the wind force reached 8 points (about 22 m / s). Noise immunity tests were also performed in the industrial frequency range (from 2.4 GHz to 5.8 GHz).


Author(s):  
Okolie S.O. ◽  
Kuyoro S.O. ◽  
Ohwo O. B

Cyber-Physical Systems (CPS) will revolutionize how humans relate with the physical world around us. Many grand challenges await the economically vital domains of transportation, health-care, manufacturing, agriculture, energy, defence, aerospace and buildings. Exploration of these potentialities around space and time would create applications which would affect societal and economic benefit. This paper looks into the concept of emerging Cyber-Physical system, applications and security issues in sustaining development in various economic sectors; outlining a set of strategic Research and Development opportunities that should be accosted, so as to allow upgraded CPS to attain their potential and provide a wide range of societal advantages in the future.


Trictrac ◽  
2016 ◽  
Vol 9 ◽  
Author(s):  
Liliana Danciu ◽  
Petru Adrian Danciu

The axes of the creation and birth of the imaginary as a mythical language. Our research follows the relationships of the concepts that are taking into account creation on the double axis of verticality and horizontality. We highlight those symbolic elements which would later constitute the mythical language about the sacred space-temporality. Inside this space-temporality a rich spectrum of mythical images develops; images capable of explaining the relationships of the creation plans. Without a religious perception of the temporality, the conceptualization of the axis would remain a philosophical approach. Through our point of view, the two are born simultaneously. Thanks to them, creation can be imagined. The first “frozen” formula of the mystical human spirit can be thought, brought to a palpable reality, expressed in an oral and then a written form. Studied together, temporality (sacred or not) and space are permanently imagined together. For example, a loss of mundane temporality in the secret ecstasy that offers to the soul an ascending direction does not mean getting out of universal temporality, but of its mundane section. In the sacred space the soul relates to time. Even the gods are submitted by the sacred, Aeon sometimes being synonymous to destiny. The universal creator seems to evade every touch, but not consistently, only when he avoids the descent into its created worlds. In sacredness, time and space seem or become confused, both expressing the same reality, by the immediate swing from thinking to deed. The mythical imagery conceives the displacement in the primary space-temporality by the spoken word. So, for something to appear and live, the spoken word is required. Even the divine dream appears as a pre-word of a creator’s thought. The thought follows the spoken word, the spoken word follows the gestures which finally indicate the meanings of the creative act, controlling the rhythm of the creation days. These three will later be adapted through imitation in rite. We are now situated at the limit of the physical world, a real challenge for the mythical imagery. The general feature of the mythical expression on the creation of the material world is the state of the divinity’s exhaustion, most often conceptualized by sacrifice or divine fatigue. The world geography identifies with the anatomy of a self-gutted god. Practically, material creation is most likely the complete revelation of God’s body autopsy. As each body decomposes, everything in it is an illusion. An axial approach of the phenomenon exists in all religious systems. The created element’s origin is exterior, with or without a pre-existing matter, by a god’s sacrifice or only because it has to be that way. This is the starting point of the discussion on the symbolism of axiality as a reason for the constitution of the language of creation, capable of retelling the imaginary construction of myth in an oral and then written form.


2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>


2018 ◽  
Vol 17 (5) ◽  
pp. 325-337 ◽  
Author(s):  
Hojjat Borna ◽  
Kasim Assadoulahei ◽  
Gholamhossein Riazi ◽  
Asghar Beigi Harchegani ◽  
Alireza Shahriary

Background & Objective: Neurodegenrative diseases are among the most widespread lifethreatening disorders around the world in elderly ages. The common feature of a group of neurodegenerative disorders, called tauopathies, is an accumulation of microtubule associated protein tau inside the neurons. The exact mechanism underlying tauopathies is not well-understood but several factors such as traumatic brain injuries and genetics are considered as potential risk factors. Although tau protein is well-known for its key role in stabilizing and organization of axonal microtubule network, it bears a broad range of functions including DNA protection and participation in signaling pathways. Moreover, the flexible unfolded structure of tau facilitates modification of tau by a wide range of intracellular enzymes which in turn broadens tau function and interaction spectrum. The distinctive properties of tau protein concomitant with the crucial role of tau interaction partners in the progression of neurodegeneration suggest tau and its binding partners as potential drug targets for the treatment of neurodegenerative diseases. Conclusion: This review aims to give a detailed description of structure, functions and interactions of tau protein in order to provide insight into potential therapeutic targets for treatment of tauopathies.


2021 ◽  
Vol 13 (3) ◽  
pp. 1589
Author(s):  
Juan Sánchez-Fernández ◽  
Luis-Alberto Casado-Aranda ◽  
Ana-Belén Bastidas-Manzano

The limitations of self-report techniques (i.e., questionnaires or surveys) in measuring consumer response to advertising stimuli have necessitated more objective and accurate tools from the fields of neuroscience and psychology for the study of consumer behavior, resulting in the creation of consumer neuroscience. This recent marketing sub-field stems from a wide range of disciplines and applies multiple types of techniques to diverse advertising subdomains (e.g., advertising constructs, media elements, or prediction strategies). Due to its complex nature and continuous growth, this area of research calls for a clear understanding of its evolution, current scope, and potential domains in the field of advertising. Thus, this current research is among the first to apply a bibliometric approach to clarify the main research streams analyzing advertising persuasion using neuroimaging. Particularly, this paper combines a comprehensive review with performance analysis tools of 203 papers published between 1986 and 2019 in outlets indexed by the ISI Web of Science database. Our findings describe the research tools, journals, and themes that are worth considering in future research. The current study also provides an agenda for future research and therefore constitutes a starting point for advertising academics and professionals intending to use neuroimaging techniques.


2021 ◽  
Vol 22 (5) ◽  
pp. 2754
Author(s):  
Naila Qayyum ◽  
Muhammad Haseeb ◽  
Moon Suk Kim ◽  
Sangdun Choi

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. Recent studies indicate an evolving role of TXNIP in the pathogenesis of complex diseases such as metabolic disorders, neurological disorders, and inflammatory illnesses. In addition, TXNIP has gained significant attention due to its wide range of functions in energy metabolism, insulin sensitivity, improved insulin secretion, and also in the regulation of glucose and tumor suppressor activities in various cancers. This review aims to highlight the roles of TXNIP in the field of diabetology, neurodegenerative diseases, and inflammation. TXNIP is found to be a promising novel therapeutic target in the current review, not only in the aforementioned diseases but also in prolonged microvascular and macrovascular diseases. Therefore, TXNIP inhibitors hold promise for preventing the growing incidence of complications in relevant diseases.


2019 ◽  
Vol 35 (8) ◽  
pp. 879-915 ◽  
Author(s):  
Bona Lu ◽  
Yan Niu ◽  
Feiguo Chen ◽  
Nouman Ahmad ◽  
Wei Wang ◽  
...  

Abstract Gas-solid fluidization is intrinsically dynamic and manifests mesoscale structures spanning a wide range of length and timescales. When involved with reactions, more complex phenomena emerge and thus pose bigger challenges for modeling. As the mesoscale is critical to understand multiphase reactive flows, which the conventional two-fluid model without mesoscale modeling may be inadequate to resolve even using extremely fine grids, this review attempts to demonstrate that the energy-minimization multiscale (EMMS) model could be a starting point to develop such mesoscale modeling. Then, the EMMS-based mesoscale modeling with emphasis on formulation of drag coefficients for different fluidization regimes, modification of mass transfer coefficient, and other extensions are discussed in an attempt to resolve the emerging challenges. Its applications with examples of development of novel fluid catalytic cracking and methanol-to-olefins processes prove that the mesoscale modeling plays a remarkable role in improving the predictions in hydrodynamic behaviors and overall reaction rate. However, the product content primarily depends on the chemical kinetic model itself, suggesting the necessity of an effective coupling between chemical kinetics and flow characteristics. The mesoscale modeling can be believed to accelerate the traditional experimental-based scale-up process with much lower cost in the future.


2002 ◽  
Vol 11 (3) ◽  
pp. 096369350201100
Author(s):  
E.M. Gravel ◽  
T.D. Papathanasiou

Dual porosity fibrous media are important in a number of applications, ranging from bioreactor design and transport in living systems to composites manufacturing. In the present study we are concerned with the development of predictive models for the hydraulic permeability ( Kp) of various arrays of fibre bundles. For this we carry out extensive computations for viscous flow through arrays of fibre bundles using the Boundary Element Method (BEM) implemented on a multi-processor computer. Up to 350 individual filaments, arranged in square or hexagonal packing within bundles, which are also arranged in square of hexagonal packing, are included in each simulation. These are simple but not trivial models for fibrous preforms used in composites manufacturing – dual porosity systems characterised by different inter- and intra-tow porosities. The way these porosities affect the hydraulic permeability of such media is currently unknown and is elucidated through our simulations. Following numerical solution of the governing equations, ( Kp) is calculated from the computed flowrate through Darcy's law and is expressed as function of the inter- and intra-tow porosities (φ, φt) and of the filament radius ( Rf). Numerical results are also compared to analytical models. The latter form the starting point in the development of a dimensionless correlation for the permeability of such dual porosity media. It is found that the numerically computed permeabilities follow that correlation for a wide range of φ i, φt and Rf.


2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Daisuke Kase ◽  
Keiji Imoto

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels were first reported in heart cells and are recently known to be involved in a variety of neural functions in healthy and diseased brains. HCN channels generate inward currents when the membrane potential is hyperpolarized. Voltage dependence of HCN channels is regulated by intracellular signaling cascades, which contain cyclic AMP, PIP2, and TRIP8b. In addition, voltage-gated potassium channels have a strong influence on HCN channel activity. Because of these funny features, HCN channel currents, previously called funny currents, can have a wide range of functions that are determined by a delicate balance of modulatory factors. These multifaceted features also make it difficult to predict and elucidate the functional role of HCN channels in actual neurons. In this paper, we focus on the impacts of HCN channels on neural activity. The functions of HCN channels reported previously will be summarized, and their mechanisms will be explained by using numerical simulation of simplified model neurons.


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