scholarly journals Functionalized Poly(N-isopropylacrylamide)-Based Microgels in Tumor Targeting and Drug Delivery

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 203
Author(s):  
Simona Campora ◽  
Reham Mohsen ◽  
Daniel Passaro ◽  
Howida Samir ◽  
Hesham Ashraf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Scanning Calorimetry ◽  
The Past ◽  
Viability Assay ◽  
Specific Tumor ◽  
Breast Cells ◽  
Novel Design ◽  
Target Cancer

Over the past several decades, the development of engineered small particles as targeted and drug delivery systems (TDDS) has received great attention thanks to the possibility to overcome the limitations of classical cancer chemotherapy, including targeting incapability, nonspecific action and, consequently, systemic toxicity. Thus, this research aims at using a novel design of Poly(N-isopropylacrylamide) p(NIPAM)-based microgels to specifically target cancer cells and avoid the healthy ones, which is expected to decrease or eliminate the side effects of chemotherapeutic drugs. Smart NIPAM-based microgels were functionalized with acrylic acid and coupled to folic acid (FA), targeting the folate receptors overexpressed by cancer cells and to the chemotherapeutic drug doxorubicin (Dox). The successful conjugation of FA and Dox was demonstrated by dynamic light scattering (DLS), Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), UV-VIS analysis, and differential scanning calorimetry (DSC). Furthermore, viability assay performed on cancer and healthy breast cells, suggested the microgels’ biocompatibility and the cytotoxic effect of the conjugated drug. On the other hand, the specific tumor targeting of synthetized microgels was demonstrated by a co-cultured (healthy and cancer cells) assay monitored using confocal microscopy and flow cytometry. Results suggest successful targeting of cancer cells and drug release. These data support the use of pNIPAM-based microgels as good candidates as TDDS.

scholarly journals Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan

2014 ◽  
Vol 15 (5) ◽  
pp. 8216-8234 ◽  
Author(s):  
Alle Madhusudhan ◽  
Gangapuram Reddy ◽  
Maragoni Venkatesham ◽  
Guttena Veerabhadram ◽  
Dudde Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Carboxymethyl Chitosan ◽  
Ph Dependent ◽  
Target Cancer

A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance

2016 ◽  
Vol 4 (22) ◽  
pp. 3854-3858 ◽  
Author(s):  
Juan Liu ◽  
Xiaowei Ma ◽  
Chunni Lei ◽  
Xiangdong Xue ◽  
Tuo Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
The Self ◽  
Doxorubicin Resistance ◽  
Dna Nanostructure ◽  
Self Assembled ◽  
Target Cancer

The self-assembled DNA nanostructure was able to specifically target cancer cells and release the drug at pH 5.0.

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

scholarly journals A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells

2019 ◽  
Vol 7 (39) ◽  
pp. 5983-5991 ◽  
Author(s):  
Zihou Li ◽  
Xuehua Ma ◽  
Yuanzhi Xia ◽  
Kun Qian ◽  
Ozioma Udochukwu Akakuru ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Targeting ◽  
Folate Receptor ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Specific Uptake ◽  
Ph Sensitive Polymer ◽  
Cancerous Cells ◽  
Targeting Strategy ◽  
Target Cancer

A T2-weighted MRI contrast agent (SPION-AN-FA@mPEG) can precisely target cancer cells with folate receptor α (FRα) diminishing non-specific uptake by normal healthy cells.

scholarly journals Urotensin-II-Targeted Liposomes as a New Drug Delivery System towards Prostate and Colon Cancer Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Silvia Zappavigna ◽  
Marianna Abate ◽  
Alessia Maria Cossu ◽  
Sara Lusa ◽  
Virginia Campani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cell Uptake ◽  
Urotensin Ii ◽  
Cell Viability Assay ◽  
Epithelial Cancers ◽  
Viability Assay ◽  
Pc3 Cells

Urotensin-II (UT-II) and its receptor (UTR) are involved in the occurrence of different epithelial cancers. In particular, UTR was found overexpressed on colon, bladder, and prostate cancer cells. The conjugation of ligands, able to specifically bind receptors that are overexpressed on cancer cells, to liposome surface represents an efficient active targeting strategy to enhance selectivity and efficiency of drug delivery systems. The aim of this study was to develop liposomes conjugated with UT-II (LipoUT) for efficient targeting of cancer cells that overexpress UTR. The liposomes had a mean diameter between 150 nm and 160 nm with a narrow size distribution (PI≤0.1) and a doxo encapsulation efficiency of 96%. Moreover, the conjugation of UT-II to liposomes weakly reduced the zeta potential. We evaluated UTR expression on prostate (DU145, PC3, and LNCaP) and colon (WIDR and LoVo) cancer cells by FACS and western blotting analysis. UTR protein was expressed in all the tested cell lines; the level of expression was higher in WIDR, PC3, and LNCaP cells compared with LoVo and DU145. MTT cell viability assay showed that LipoUT-doxo was more active than Lipo-doxo on the growth inhibition of cells that overexpressed UTR (PC3, LNCaP, and WIDR) while in LoVo and DU145 cell lines, the activity was similar to or lower than that one of Lipo-doxo, respectively. Moreover, we found that cell uptake of Bodipy-labeled liposomes in PC3 and DU145 was higher for LipoUT than the not-armed counterparts but at higher extent in UTR overexpressing PC3 cells (about 2-fold higher), as evaluated by both confocal and FACS. In conclusion, the encapsulation of doxo in UT-II-targeted liposomes potentiated its delivery in UTR-overexpressing cells and could represent a new tool for the targeting of prostate and colon cancer.

Lumazine synthase protein cage nanoparticles as modular delivery platforms for targeted drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (89) ◽  
pp. 48596-48600 ◽  
Author(s):  
Junseon Min ◽  
Soohyun Kim ◽  
Jisu Lee ◽  
Sebyung Kang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Protein Cage ◽  
Lumazine Synthase ◽  
Targeted Drug ◽  
Target Cancer

Lumazine synthase protein cage nanoparticle is developed as a modular delivery nanoplatform that delivers drugs to their target cancer cells.

scholarly journals Veillonella parvula: a strictly anaerobic bacterium with high efficacy for safe and specific tumor targeting and colonization

2021 ◽  
Author(s):  
Amirhosein Kefayat ◽  
Fatemeh Ghahremani ◽  
Soodabeh Rostami
Keyword(s):  
Tumor Targeting ◽  
Anaerobic Bacterium ◽  
Genetic Manipulation ◽  
Treated Group ◽  
Strictly Anaerobic ◽  
The Past ◽  
Tumor Bearing ◽  
Infectious Origin ◽  
Specific Tumor ◽  
Significant Therapeutic Effect

Bacterial cancer therapy has gained lots of attention in the past decade and is now considering a reliable option for the future. However, some concerns have limited its application into clinic settings like insufficient colonization of tumors and infectious origin of the currently used bacteria. Veillonella parvula (V. parvula) as a strictly anaerobic bacterium which has rarely identified as a pathogen in human, was intravenously administrated into 4T1 breast tumor-bearing BALB/c mice. V. parvula exhibited significant tumor-targeting and colonization efficacy, 24 h after administration and formed clustered colonies at the tumors’ central region. The normal organs became completely clear from the bacteria after 72 h, and no side effects or death were observed at the animals after administration of V. parvula. Although mean tumor volumes in the V. parvula treated group was lower than the control (~ 25.4%), their difference wasn’t statistically significant (P > 0.05). Despite significant tumor colonization (5500000:1 in comparison with normal organs), V. parvula didn’t cause a significant therapeutic effect on the metastasis or survival time of tumor-bearing mice. Taking together, V. parvula is a completely safe and tumor-specific targeting agent per se, without any genetic manipulation.

Application of Nanotechnology in Biomedicine: A Major Focus on Cancer Therapy

2015 ◽  
Vol 35 ◽  
pp. 55-66 ◽  
Author(s):  
Hadi Zare-Zardini ◽  
Farzad Ferdowsian ◽  
Hossein Soltaninejad ◽  
Adel Ghorani Azam ◽  
Safoura Soleymani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Detection ◽  
Tumor Targeting ◽  
Medical Applications ◽  
Nano Materials ◽  
Major Focus ◽  
The Past ◽  
New Compounds ◽  
Cancer Diseases

Most of mortality worldwide occurs because of cancer diseases. Nanostructures are the new compounds that have become one of the most important technologies for using in different fields over the past two years especially in medicine. In between, nanotechnology has the potential to cancer detection and therapy. This study is a review of prospects in applications of nano-materials for cancer detection and treatment. We have summarized the nano-materials (metal nanospheres, nanorods, nanoshells and nanotubes) in medical applications targeting cancer. We also discuss advances in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization about tumor targeting, controlled release and drug delivery. This paper will discuss the therapeutic applications of different nano-materials with a major focus on their applications for the treatment of cancer. Briefly, the toxicity of conventional nanostructures was also mentioned in this paper.

scholarly journals Evaluation the Effect of Low Level Laser on Nanoparticles Containing Chemotherapy Drug Procedure in Prostate Cancer Cells in Vitro

2019 ◽  
Vol 4 (7) ◽  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Chemotherapy Drugs ◽  
The Past ◽  
Cell Counts ◽  
Level Laser ◽  
The Common ◽  
White Blood Cell Counts

Prostate cancer is the second most common cancer after lung cancer in men. Chemotherapy is one of the common methods of treating prostate cancer that results in the destruction of cancer cells. The side effects of chemotherapy include head and eyelash loss, white blood cell counts, weak immune defenses, infections, pain, dry mouth and osteoporosis. The presence of toxic effects of chemotherapy drugs is one of the problems of treatment because these drugs often act nonspecifically. Over the past two decades, new drug delivery systems have been developed that have somewhat been able to Liposomes can be used as a biocompatible drug delivery system for carrying out chemotherapy drugs.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

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