scholarly journals The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

2020 ◽  
Vol 17 (8) ◽  
pp. 2962 ◽  
Author(s):  
Katarzyna Kasprowicz ◽  
Wojciech Ratkowski ◽  
Wojciech Wołyniec ◽  
Mariusz Kaczmarczyk ◽  
Konrad Witek ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Venous Blood ◽  
Iron Concentration ◽  
Intervention Group ◽  
Marathon Runners ◽  
Post Exercise ◽  
Before And After ◽  
Vitamin D3 Supplementation ◽  
Serum Hepcidin ◽  
And Control

Deficiencies in iron and vitamin D are frequently observed in athletes. Therefore, we examined whether different baseline vitamin D3 levels have any impact on post-exercise serum hepcidin, IL-6 and iron responses in ultra-marathon runners. In this randomized control trial, the subjects (20 male, amateur runners, mean age 40.75 ± 7.15 years) were divided into two groups: experimental (VD) and control (CON). The VD group received vitamin D3 (10,000 UI/day) and the CON group received a placebo for two weeks before the run. Venous blood samples were collected on three occasions—before the run, after the 100 km ultra-marathon and 12 h after the run—to measure iron metabolism indicators, hepcidin, and IL-6 concentration. After two weeks of supplementation, the intervention group demonstrated a higher level of serum 25(OH)D than the CON group (27.82 ± 5.8 ng/mL vs. 20.41 ± 4.67 ng/mL; p < 0.05). There were no differences between the groups before and after the run in the circulating hepcidin and IL-6 levels. The decrease in iron concentration immediately after the 100-km ultra-marathon was smaller in the VD group than CON (p < 0.05). These data show that various vitamin D3 status can affect the post-exercise metabolism of serum iron.

scholarly journals Toe Clearance Rehabilitative Slippers for Older Adults With Fall Risk: A Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
pp. 215145932110291
Author(s):  
Atsuko Satoh ◽  
Yukoh Kudoh ◽  
Sangun Lee ◽  
Masumi Saitoh ◽  
Miwa Miura ◽  
...  
Keyword(s):  
Older Adults ◽  
Fall Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Berg Balance Scale ◽  
Control Group ◽  
Mobility Assessment ◽  
Before And After ◽  
Day Services ◽  
And Control

Introduction: To evaluate fall-prevention rehabilitative slippers for use by self-caring, independent older adults. Materials and Methods: This assessor-blinded, randomized, and controlled 1-year study included 59 self-caring, independent participants (49 women) who attended day services. The mean age of participants was 84.0 ± 5.3 years. Participants were randomly selected from 8 nursing homes. We tested slippers top-weighted with a lead bead (200, 300, or 400 g). Intervention group participants walked while wearing the slippers for 10-20 min, 1-3 days/week at the day service center. Fall risk was measured using the Berg Balance Scale and the Tinetti Performance-Oriented Mobility Assessment (POMA) before and at 3-month intervals after the intervention/control phase. Results: After 12 months, the intervention group demonstrated significant improvement. Berg Balance and POMA compared to the control group ( p < .05 p < .01, respectively). Mobility scores improved significantly for both measurements in the intervention group before and after ( p < .01), but the control group had significantly lower scores. Discussion: Overall, falls decreased in the intervention group from 10 to 7, and control group falls increased from 9 to 16 ( p = .02). No adverse events related to the intervention were reported. Conclusions: Rehabilitation training slippers may reduce falls in older adults.

The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Asieh Mehdipour ◽  
Parvin Abedi ◽  
Somayeh Ansari ◽  
Maryam Dastoorpoor
Keyword(s):  
Randomized Controlled Trial ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Moderate Depression ◽  
Before And After ◽  
The Mean ◽  
And Control

Abstract Objectives Postmenopausal women are at greater risk of depression. Depression may negatively affect the quality of life of women. An emotional freedom technique (EFT) is an evidence-based therapy combining cognitive and exposure components with acupressure. This study aimed to evaluate the effect of EFT on depression in postmenopausal women. Methods This was a randomized controlled trial in which 88 women with mild to moderate depression recruited from a menopausal clinic in Ahvaz, Iran, and randomly assigned into two groups of EFT (n=44) and control for sham therapy (n=44). Women in the EFT group received two sessions of training and asked to continue EFT for 8 weeks, one time per day. The Beck Depression Inventory (BDI2) completed by women before and after the intervention. The control group received training on sham acupressure points similar to the intervention group. Data collected using a demographic and BDI2. Women requested to complete the BDI2 before and after the intervention. The independent t-test, chi-square, and ANCOVA were used to analyze data. Results The mean depression score in the intervention group reduced from 20.93 ± 4.6 to 10.96 ± 4.38 in comparison to the control group that reduced from 19.18 ± 2.79 to 17.01 ± 6.05 after intervention (p=0.001). After the 8 week intervention, the frequency of moderate depression decreased from 56.8 to 9.35% in the intervention and from 50 to 29.5% in the control group. In total, 63.4 and 34.15% in the intervention and control groups were free of depression respectively after the intervention (p<0.001). Conclusions The results of this study showed that using EFT for 8 weeks could significantly reduce the mean score of depression in postmenopausal women. Using this method in public health centers for postmenopausal women is recommended.

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism

2021 ◽  
Vol 16 ◽  
Author(s):  
Reihaneh Rezaee ◽  
Masoud Mohebbi ◽  
Mozhgan Afkhamizadeh ◽  
Mohammad Ali Yaghoubi ◽  
Mona Najaf Najafi ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Intervention Group ◽  
Serum Levels ◽  
Overt Hypothyroidism ◽  
Serum Osteocalcin ◽  
Significant Difference ◽  
Before And After ◽  
Metabolic Conditions ◽  
And Control

Background and Objective: Subclinical hypothyroidism can potentially develop to overt hypothyroidism. Thyroid hormones have substantial roles in metabolism and glucose homeostasis and thus are closely related to determinant factors of metabolic syndromes, such as obesity and insulin resistance. Osteocalcin is considered a predictor of metabolic conditions in thyroid diseases. This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism. Methods: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric data, were measured at baseline and at the end of the study. SPSS was used to analyze the data and P<0.05 was considered significant. Results: Mean age in the intervention and control groups was 35.07 ± 9.94 and 31.30 ± 4.30, respectively (P=0.20). There was no significant difference between osteocalcin levels before and after the intervention in either of the groups (P=0.54). TSH level was significantly decreased in the levothyroxine group after the intervention (P<0.01). T4 level was significantly increased in the intervention group (P=0.02). Conclusion: Levothyroxine had no significant effect on increasing the levels of serum osteocalcin in patients with subclinical hypothyroidism. We have registered the trial in the Iranian registry of clinical trials (IRCT) with the registration code IRCT20171129037677N1.

scholarly journals A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

2021 ◽  
Author(s):  
Zahra Alizadeh ◽  
Nastaran Keyhanian ◽  
Sara Ghaderkhani ◽  
Simin Dashti-Khavidaki ◽  
Raheleh Shokouhi Shoormasti ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Intervention Group ◽  
Control Group ◽  
Low Light ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
To Receive ◽  
Chest Ct Scan

No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%).  The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.   

scholarly journals OPTIMALISASI POSISI JANIN MELALUI PRENATAL YOGA TERHADAP OUTPUT PERSALINAN DI PUSKESMAS WILAYAH KOTA CIREBON

2020 ◽  
Vol 8 (3) ◽  
pp. 396
Author(s):  
Nurasih Nurasih ◽  
Endang Nurrochmi
Keyword(s):  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Chi Square ◽  
Control Group Design ◽  
Before And After ◽  
Chi Square Test ◽  
And Control

In Indonesia, Yoga is currently one of the most popular sports, not only for the general public but also for pregnant women. Many benefits can be obtained from prenatal yoga including the mother feeling comfortable and relaxed throughout pregnancy and during childbirth, training the pelvic floor muscles and perineum, keeping the body's muscles relaxed, balanced during childbirth, reducing stress, increasing and improving oxygen circulation to the body and fetus. . This study aims to determine the effect of prenatal yoga on optimizing fetal position on third trimester Primigravida maternal delivery output at Puskesmas Cirebon City. This research is a quasi-experimental research pre post control group design and only post control group design with T test and Chi Square test. Paired T Test results of the intervention group (mean difference = 3.111, P value = 0.000, control group (mean difference = 0.833, P value = 0.318). Independent T Test results obtained (average difference = -1.944, P value = 0.024), Chi Square test obtained a value of P = 0.73. There is a difference in the average anxiety before and after the intervention in the intervention group, there is no difference in average anxiety before and after the intervention in the control group. There is a difference in the average anxiety between the intervention and control groups. There is a difference in mean Long I stage between the intervention and control groups There was no effect of prenatal yoga on the type of labor.

scholarly journals Effect of Stretching Exercises Plus Caflam on Flexibility of Female Athletes

2021 ◽  
pp. 9-15
Author(s):  
Sajjad Ali Gill ◽  
Samaviya Noor ◽  
Abida Naseer ◽  
Saeed Javed ◽  
Sumeria Rajab ◽  
...  
Keyword(s):  
Social Sciences ◽  
Female Athletes ◽  
Intervention Group ◽  
Control Group ◽  
Post Exercise ◽  
Post Evaluation ◽  
Proprioceptive Neuromuscular Facilitation ◽  
University Level ◽  
And Control ◽  
Stretching Exercises

The present study investigated how stretching exercises (Static, Dynamic and Proprioceptive neuromuscular facilitation (PNF)) along with Caflam (diclofenac potassium) affect the flexibility of female athletes at Punjab University Level. It is a controlled experiment with (n=40) female athletes, aged 18-24 years, divided into two groups intervention (N=30) and control group (N=10) randomly. Stretching exercises were conducted through 6 weeks divided into two sessions that consisted of both static and dynamic exercises in each session. Flexibility was measured with sit and reach test in pre and post evaluation sessions. The study purpose was to identify the effect of stretching exercises on flexibility of female athletes (N=40) by using different stretching exercises techniques (static and dynamic stretching exercises) on female athletes. Paired sample t-test used and found that it showed highly significant results using “Statistical Package for Social Sciences” (SPSS) V.22 utilized. The effect size was also calculated through Cohans’D which was 1.41. The subjects were followed for 4 months to check the recurrence rate of the control & intervention groups and found that 19% having injuries of lower extremity (control group) and 11% having after post-exercise evaluation (intervention group).  

scholarly journals Implementation of Coaching on Nursing Motivation and Workplace for Nurses to Reduce Burnout

2019 ◽  
Vol 2 (2) ◽  
pp. 84-93
Author(s):  
Florentina Dhiana Sri Setyohariyati ◽  
Emiliana Tarigan ◽  
Havids Aima
Keyword(s):  
Work Experience ◽  
Quantitative Methods ◽  
Intervention Group ◽  
Control Group ◽  
Before And After ◽  
Coaching Training ◽  
Quasi Experimental ◽  
Implementation Of Coaching ◽  
And Control ◽  
Conflict Of Value

Introduction. Burnout is a symptom that is often experienced by nurses, especially in the operating room, intensive unit and emergency room. Burnout is characterized by fatigue of heavy workloads, lack of control and appreciation, unfair treatment as employees, lack of social support at work, and conflict of value values that cause Emotional Exhausting, Depersonalization, Personal Accreditation. Coaching implementation by mentors to the implementing nurses is expected to reduce burnout. Methods. This study aims to analyze the description of the differences and influence of coaching implementation by mentor to the executor nurse burnout at Siloam Hospitals Group. Research uses quantitative methods with quasi experimental designs, pretest-posttest control group and causal research. The sample in the study was chosen by consecutve sampling in all respondents included in the inclusion criteria. The sample in this study amounted to 117 nurses, who were divided into 2 groups ie inetrvensi group with 88 respondents and control group with 29 respondents. Coaching implementation is given within 12 weeks with the frequency of meetings 3-4 times. Results. The results of this study showed that there was a decrease in burnout before and after intervention with paired t test in the intervention group and control group, with value (p = 0.002). Conclusion. The results of the intervention analysis on the implementation of coaching training simultaneously have an effect on motivation, workplace, age, gender, education and work experience simultaneously with a contribution of F 3,316 with a significance number of 0.005 <0.05. This study recommends the need for further research.

scholarly journals EDUKASI PENGGUNAAN SUPLEMEN KESEHATAN PADA IBU-IBU PKK DI MASA PANDEMI COVID-19 WILAYAH DESA PEMECUTAN KAJA, KECAMATAN DENPASAR UTARA, KOTA DENPASAR

2021 ◽  
Vol 5 (1) ◽  
pp. 636
Author(s):  
Dhiancinantyan Windydaca Brata Putri ◽  
Ni Putu Wintariani ◽  
Dewi Puspita Apsari ◽  
Ni Putu Aryati Suryaningsih
Keyword(s):  
Vitamin C ◽  
Community Service ◽  
Vitamin D3 ◽  
Central Government ◽  
Before And After ◽  
Good Score ◽  
Area North ◽  
Keywords Education ◽  
And Control ◽  
Health Supplements

ABSTRAKPemerintah pusat terus menggalakkan pencegahan dan pengendalian Covid-19, melalui Gugus Tugas COVID-19. Salah satu cara untuk menjaga daya tahan tubuh dari serangan virus corona adalah dengan mengkonsumsi vitamin atau suplemen. Informasi vitamin/suplemen yang akan disebarkan pada pengabdian masyarakat ini adalah vitamin C, Zink, dan Vitamin D3 di wilayah Desa Pemecutan Kaja, Kecamatan Denpasar Utara, Kota Denpasar dengan sasaran ibu-ibu PKK. Tujuan dari pengabdian masyarakat ini adalah memberikan edukasi terkait pentingnya mengkonsumsi suplemen kesehatan dimasa pandemi COVID-19 dan bagaimana mengkonsumsi suplemen/vitamin dimasa pandemi COVID-19. Metode kegiatan ini dengan memberikan edukasi berupa poster secara langsung dan e-booklet melalui whatsapp grup kepada ibu-ibu PKK dan pengukuran pengetahuan dilakukan sebelum dan setelah pemberian edukasi. Hasil yang didapatkan adalah terdapat peningkatan pengetahuan ibu PKK secara signifikan (p=0,000) yakni dari skor baik semula berjumlah 19% meningkat menjadi 98% partisipan. Data tersebut menunjukkan bahwa tujuan dari program kerja tercapai, yaitu peningkatan pengetahuan partisipan ibu-ibu PKK terhadap penggunaan suplemen kesehatan di masa pandemi covid-19. Kata kunci: edukasi; suplemen; covid-19. ABSTRACTThe central government continues to promote the prevention and control of Covid-19, through the COVID-19 task force.One way to maintain the immune system from the corona virus is to take vitamins or supplements. Information on vitamins/supplements that will be distributed in this community service is vitamin C, Zink, and Vitamin D3 in the Pemecutan Kaja Village area, North Denpasar District, Denpasar City with the target of PKK women. The purpose of this activity is to provide education regarding the importance of consuming health supplements during the COVID-19 pandemic and how to take supplements/vitamins during the COVID-19 pandemic. The method of this activity is to provide education in the form of direct posters and e-booklets via whatsapp groups to PKK women and knowledge measurements are carried out before and after providing education. The results obtained were that there was a significant increase in the knowledge of PKK women (p = 0.000), namely from the original good score of 19%, it increased to 98% of participants. The data shows that the goal of the work program was achieved, namely increasing the knowledge of PKK women on the use of health supplements during the COVID-19 pandemic. Keywords: education; supplements; covid-19. 

scholarly journals Pengaruh kompres hangat terhadap nyeri leher pada penderita hipertensi esensial di wilayah Puskesmas Depok I, Sleman Yogyakarta

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Siti Fadlilah
Keyword(s):  
Essential Hypertension ◽  
Neck Pain ◽  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Before And After ◽  
Post Test ◽  
Headache Pain ◽  
And Control

Hypertension is increased blood pressure in the artery. Signs and indication arise from this disease are a dizzy, headache, pain in the nape of the neck (neck pain), easily angered, and hard to breathe. This neck pain can offend essential hypertension in daily patient activities. One of the non-pharmacological actions to decrease or overcome the neck pain is by a warm compress. The warm compress is giving a sense of warm/heat in a certain area. This research is purposed to find out the influence of warm compress towards neck pain in essential hypertension patients. This research is carried out in Puskesmas Depok I area, Sleman, Yogyakarta. Type of this research is quasi-experiment with pre-test post-test with control group design. Several samples consist of 40 respondents and divided into two groups, which are 20 respondents of the intervention group and 20 respondents of the control group. Statistic test used in this research is Wilcoxon and Mann Whitney tests. Before applying pre-test, 12 respondents (60%) are having moderate pain, and after giving warm compress (post-test), 17 respondents (75%) are having minor pain. There is a significant scale of neck pain before and after the warm compress treatment (p-value = 0,003) as well as contrast scale of neck pain between intervention group and control group (p-value = 0,000). There is the influence of warm compress towards neck pain in essential hypertension patients in Puskesmas Depok I area, Sleman, Yogyakarta.

scholarly journals Effect of Classical Music on Physiological Characteristics and Observational and Behavioral Measures of Pain in Unconscious Patients Admitted to Intensive Care Units

2021 ◽  
Vol 10 (4) ◽  
pp. 368-379
Author(s):  
Abolfazl Rahgoi ◽  
◽  
Shahla Mohammadzadeh Zarankesh ◽  
Sedeigheh Sadat Kasaeizadeghan ◽  
Mehran Naghibeiranvand ◽  
...  
Keyword(s):  
Intensive Care ◽  
Classical Music ◽  
Intervention Group ◽  
Physiological Characteristics ◽  
Behavioral Measures ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Unconscious Patients ◽  
And Control

Objective: Assessment and management of pain in patients under artificial respiration and hospitalized in Intensive Care Units (ICUs) are difficult, and is less considered by physicians and nurses. This study aims to determine the effect of classical music on physiological characteristics, and observational and behavioral measures of pain in unconscious patients admitted to ICUs. Methods: This is a quasi-experimental study conducted in 2019 on 30 unconscious patients admitted to ICU of Shohadaye Haft-e-Tir Hospital in Tehran, Iran, who were selected using a convenience sampling method, and divided into two groups of intervention and control. After obtaining a written informed consent from patients to participate, they completed a demographic/physiological form, Critical Care Pain Observation Tool (COPT) and Behavioral Pain Scale (BPC). Collected data were analyzed in SPSS V. 22 software by using descriptive and inferential statistics. Results: The Mean±SD age of patients in the intervention and control groups was 40.33±14.01 and 46±15.70 years, respectively. Comparison of physiological characteristics before and after the intervention showed no statistically significant difference in any groups except in Glasgow Coma Scale score (P<0.05). The mean pretest and posttest COPT scores in the intervention group were 3.73±0.94 and 1.96±1.32, respectively, and their mean pretest and posttest BPC scores were 5.94±1.39 and 4.22±1.08, respectively. Comparing the mean COPT and BPC scores before and after music therapy showed a statistically significant difference in the intervention group (P<0.05). Conclusion: It seems that classical music can reduce observational and behavioral measures of pain in unconscious patients hospitalized in ICUs. More studies are recommended for examining the effect of classical music on physiological characteristics of these patients.

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