Cardiorespiratory Fitness, Blood Pressure and Ethnicity Are Related to Salivary Cortisol Responses after an Exercise Test in Children: The ExAMIN Youth SA Study

Background: Childhood elevated circulatory stress mediators such as cortisol seem to play an important role in the development of hypertension and metabolic disorders later in life. Little is known about the association of body composition, cardiorespiratory fitness (CRF), blood pressure (BP) and ethnicity with cortisol reactivity in young children. Methods: In this cross-sectional study, 324 black and 227 white school children (aged 7.4 ± 1.0 years) were screened for salivary cortisol reactivity, body mass index, BP and CRF (shuttle run) by standardised assessments for children. Results: Children in the lower cortisol reactivity percentile (<25th) had a higher heart rate (87.0 ± 12.9 bpm) and a lower CRF (3.1 ± 1.3 stages) compared to children in the upper (>25th) percentile (86.2 ± 11.5 bpm and 3.5 ± 1.7 stages, respectively). At baseline, children of black ethnicity had a higher cortisol level (p < 0.001). Immediately before the exercise test, no associations of obesity, BP, CRF and ethnicity with cortisol levels were found. In analysis of covariance (ANCOVA) we found that low CRF, high BP and black ethnicity were independently associated with lower cortisol reactivity by performing the shuttle run test (p < 0.01). Conclusion: Low CRF and high BP were associated with lower cortisol reactivity after a cardiorespiratory exercise test. Black children showed a lower cortisol reactivity which may contribute to the earlier onset of hypertension reported in black compared to white populations. Primary prevention programs need to focus on improving physical fitness to reduce the growing prevalence of cardiometabolic disorders during childhood.

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Abstract P334: The Relationship Between Urinary Sodium-to-Potassium Ratio And High Blood Pressure: TMM CommCohort Study

Circulation ◽

10.1161/circ.141.suppl_1.p334 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Mana Kogure ◽

Tomohiro Nakamura ◽

Naho Tsuchiya ◽

Takumi Hirata ◽

Akira Narita ◽

...

Keyword(s):

Blood Pressure ◽

Alcohol Intake ◽

Positive Association ◽

Cross Sectional Study ◽

Analysis Of Covariance ◽

Cross Sectional ◽

High K ◽

Prevention Of Hypertension ◽

The Relationship ◽

Low K

Introduction: Recently, the balance between sodium and potassium intake, i.e. sodium-to-potassium (Na/K) ratio, has received significant attention for prevention of hypertension. Previous studies reported the positive association between urinary Na/K (uNa/K) ratio and hypertension. However, even the same uNa/K ratio value, there might be high Na/ high K ratio or low Na/ low K ratio. Hypothesis: We assessed the hypothesis that blood pressure (BP) is higher in high Na/ high K group than that in low Na/ low K group even at the same uNa/K ratio in general population in cross-sectional study. Methods: The subjects were 20 to 74 years old who participated in The Tohoku Medical Megabank Project Community-based Cohort Study. Of these participants, we targeted 54,011 subjects (men: 20,505 women: 33,506 mean age: 59.9 years) who had information of BP, urinary Na and K. We estimated 24-h urinary excretion of Na and K using Tanaka formula. Urinary Na and K were each classified into quartiles (Na; Q1~Q4, K; Q1~Q4), and set all 16 groups of uNa/K ratio by combining Na and K respectively. To assess the relationship between casual uNa/K ratio and BP, we performed an analysis of covariance to calculate the adjusted mean systolic BP (SBP). We included covariate factors as age, sex, BMI and alcohol intake. We also assessed the relationship between uNa/K ratio and SBP using multiple regression analyses adjusted for covariate factors. We stratified the participants into two groups: ‘under treatment for hypertension’ (n=17,091) and ‘without treatment for hypertension (n=36,920)’. Results: The mean of uNa/K ratio for each group of Na (Q1)/K(Q1), Na (Q2)/K(Q2), Na (Q3)/K(Q3) and Na (Q4)/K(Q4) was all 4.0. As previous report showed, higher uNa/K ratio group showed higher SBP and lower uNa/K group showed lower BP. When we compared adjusted mean SBP of Na (Q1)/K(Q1) and Na (Q4)/K(Q4) the value were comparable, but the value were significantly higher in Na (Q4)/K(Q4) group (The adjusted mean SBP of Na (Q1)/K(Q1), Na (Q2)/K(Q2), Na (Q3)/K(Q3) and Na (Q4)/K(Q4) was 123.6, 124.9, 124.7 and 125.5 mmHg, respectively). The uNa/K was significantly positively associated with SBP independently of age, sex, BMI, and alcohol intake. The finding was unchanged the results in under treatment group. Conclusions: BP was significantly higher in high Na/ high K group than in low Na/ low K group even at the same uNa/K ratio. We suggested that not only increasing K intake but also reducing salt is important for preventing hypertension.

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Blunted Diurnal Cortisol Pattern Is Associated With Frailty: A Cross-Sectional Study of 745 Participants Aged 65 to 90 Years

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-3079 ◽

2014 ◽

Vol 99 (3) ◽

pp. E464-E468 ◽

Cited By ~ 40

Author(s):

Hamimatunnisa Johar ◽

Rebecca T. Emeny ◽

Martin Bidlingmaier ◽

Martin Reincke ◽

Barbara Thorand ◽

...

Keyword(s):

Salivary Cortisol ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Cortisol Reactivity ◽

Diurnal Cortisol ◽

Frailty Status ◽

Increased Risk ◽

Cortisol Levels ◽

Study Participants

Background: The role of neuroendocrine alterations in the etiology of frailty syndrome is still poorly understood. Hypothalamic-pituitary-adrenal axis dysregulation is a plausible candidate pathway contributing to frailty. Thus, we sought to examine the associations of diurnal cortisol secretion with frailty in older adults. Methods: A cross-sectional analysis was conducted among 745 study participants (age 65–90 years, mean age 75.1 years) of the population-based KORA Age study. Associations between salivary cortisol measures at awakening (morning 1 [M1]), 30 minutes after awakening (M2), and evening (E) and frailty criteria were determined. Results: Lower cortisol levels in the first morning sample (M1) (P = .18) and M2 (P = .14) and increased E levels (P = .004) were observed in prefrail (35.17%, n = 262) and frail (3.36%, n = 25) individuals, in a dose-response manner. Frailty was strongly associated with smaller ratios of morning to evening levels; M1 to E ratio (P = .02) and M2 to E ratio (P = .003). Higher evening cortisol levels were associated with a 24% increased risk of a prefrail state (odds ratio, 1.22; 95% confidence interval, 1.03–1.44). A smaller morning to evening ratio was associated with an increased risk of low grip strength (1.42, 1.09–1.86) and gait speed (1.31, 1.02–1.68). Conclusion: Frailty status is associated with blunted cortisol reactivity as demonstrated by lower morning and higher evening salivary cortisol levels.

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Cardiometabolic risk in children and adolescents: mediation analysis of crosssectional study. [Riesgo cardiometabólico en niños y adolescentes: análisis de mediación de un estudio transversal].

RICYDE Revista Internacional de Ciencias del Deporte ◽

10.5232/ricyde2021.06501 ◽

2021 ◽

Vol 17 (65) ◽

pp. 204-220

Author(s):

Noelia González-Gálvez ◽

◽

Jose Carlos Ribeiro ◽

Jorge Mota ◽

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Children And Adolescents ◽

Cardiorespiratory Fitness ◽

Cardiometabolic Risk ◽

Cross Sectional Study ◽

Mean Blood Pressure ◽

Sectional Study ◽

Cross Sectional ◽

Fitness Level

The aims of this study were a) to assess whether obesity acts as a mediator between i) cardiorespiratory fitness (CRF) and mean blood pressure; and ii) between between physical activity (PA) and mean blodd pressure in children and adolescents. A cross-sectional study was conducted with a 632 children and adolescents. It was measured mean blood pressure, body mass index, fat mass and waist circumference. CRF and PA was assessing with Course Navette test and ActiGraph. The analysis of the mediation was performed using Process macro for SPSS. The results indicate that obesity acts as a partial mediation in the association between CRF and mean blood pressure in 10-12 years old children (z=from -5.81 to -5.40; all p˂0.000). These results indicate that obesity acts as a complete mediator in the association between PA and mean blood pressure in 10-12 years old children (z=from -4.49 to -1.94; all p˂0.000). Our result reinforces the relevance of prevent weight increse and improve cardiorespiratory fitness level since erly age in children and adolescents to prevent high mean blood pressure. Increasing the level of physical activity can influence on obesity and cardiorespiratory fitness.

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Associations of mode and distance of commuting to school with cardiorespiratory fitness in Slovenian schoolchildren: a nationwide cross-sectional study

BMC Public Health ◽

10.1186/s12889-021-10326-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Gregor Jurak ◽

Maroje Soric ◽

Vedrana Sember ◽

Sasa Djuric ◽

Gregor Starc ◽

...

Keyword(s):

Cardiorespiratory Fitness ◽

Linear Models ◽

Cross Sectional Study ◽

Active Commuting ◽

Sectional Study ◽

Cross Sectional ◽

Main Effect ◽

Commuting Mode ◽

Run Test ◽

Shuttle Run

Abstract Background It is unclear whether active commuting has the potential to improve children’s health. This study examined the association of commuting mode and distance with children’s cardiorespiratory fitness (CRF). Methods We conducted a cross-sectional study, including 713 Slovenian schoolchildren aged 12 to 15 years. Commuting modes were self-reported, and four commuting groups were constructed, while CRF was determined with a 20-m shuttle run test. The distance from home to school was calculated using the Geographic Information System. Effects of commuting mode and distance, controlling for age, gender and amount of total physical activity, were evaluated using general two linear models (one for each direction of commuting to/from school). Results The main effect of commuting group on CRF and its interaction with distance were significant in the direction from school to home (P = 0.013 and P = 0.028, respectively), but not in the opposite direction. Predicted differences in CRF between commuting groups were moderate and generally higher in males than in females. When comparing commuting group median distance from home to school, males driven by car had around 4 ml/min/kg lower predicted CRF than those who walked (P = 0.01) or used wheels commuting (e.g., bicycle, skateboard). Conclusions The distance of commuting had a small effect on CRF, except in the Car group where children who live close to school had significantly lower CRF than those living further away. Children driven by car who live within wheels or walk distance from school should be targeted by interventions promoting active transport.

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Effects of occupational cobalt exposure on the heart in the production of cobalt and cobalt compounds: a 6-year follow-up

International Archives of Occupational and Environmental Health ◽

10.1007/s00420-019-01488-3 ◽

2019 ◽

Vol 93 (3) ◽

pp. 365-374

Author(s):

A. Linna ◽

J. Uitti ◽

P. Oksa ◽

P. Toivio ◽

V. Virtanen ◽

...

Keyword(s):

Blood Pressure ◽

Tissue Doppler ◽

Cross Sectional Study ◽

Analysis Of Covariance ◽

Cumulative Exposure ◽

Exposure Level ◽

Production Plant ◽

Cross Sectional ◽

Cobalt Exposure

Abstract Objective It has been suspected that cobalt is toxic to the heart. It can cause cardiotoxicity in heavily exposed humans and in experimental systems. The issue of interest for this study is whether cobalt also affects the myocardium at occupational exposure levels. Methods To study the effect of occupational cobalt exposure on the heart, we conducted a follow-up of workers at a cobalt production plant. The workers’ hearts had been examined by echocardiography in 1999–2000. Altogether 93 exposed and 49 non-exposed workers examined in 1999–2000 were re-examined in 2006. Occupational history and health data were collected with a questionnaire. Blood pressure was measured, and electrocardiography (ECG), laboratory tests, Holter registration, and echocardiography were conducted for all participants. Analysis of covariance (ANCOVA) was used to analyse the data. Results No differences were found between the exposed and unexposed groups for any of the echocardiographic parameters in 2006. There were no differences in the laboratory values, the ECG parameters, or the results of the Holter registration of the exposed and unexposed workers. Conclusions Although the previous results in 2000 suggested an association between cumulative exposure to cobalt and echocardiographic findings, the results of this new cross-sectional study with a tissue Doppler 6 years later did not confirm the association in the present cohort. If cobalt exposure affects heart muscle functions at this exposure level, the effects are smaller than those caused by physiological changes due to ageing, medication, and traditional cardiovascular risk factors, such as elevated blood pressure.

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Prevalence of Hypertension and Adiposity Indicators Among Children and Adolescents of Meghwal Community: A Cross-sectional Study from Udaipur, Rajasthan (India)

The Oriental Anthropologist: A Bi-annual International Journal of the Science of Man ◽

10.1177/0972558x20975252 ◽

2020 ◽

pp. 0972558X2097525

Author(s):

Sweta Prasad ◽

Imnameren Longkumer ◽

Kallur Nava Saraswathy

Keyword(s):

Blood Pressure ◽

Children And Adolescents ◽

Systolic Hypertension ◽

Statistical Significance ◽

Cross Sectional Study ◽

Adult Health ◽

Sectional Study ◽

Cross Sectional ◽

Increased Risk ◽

Cardiometabolic Disorders

Background: Early-age cardiometabolic disorders have a profound impact on adult health status. Studies indicated elevated blood pressure and increased adiposity among children and adolescents to be significantly correlated with adult cardiovascular diseases (CVDs). Aim: The study aims to estimate the prevalence of hypertension and adiposity indicators and their association among children and adolescents of Meghwal community, Rajasthan. Methods: This cross-sectional study recruited 150 boys and girls of 10–18 years. Anthropometric and physiologic variables were collected and categorized into adiposity indicators and blood pressure traits. Results: Prevalence of adiposity indicators in terms of both body mass index (BMI) and waist to height ratio (WHtR) was 2.67%, while almost half of the study participants had underweight BMI (46%). The study observed 16% and 8.67% prevalence of systolic hypertension stages I and II, respectively. Prevalence of diastolic hypertension stages I and II were 26.67% and 6.67%, respectively. The study indicated a range from 22% to 27% of high blood pressure traits attributable to increase in BMI. Further, overweight/obese BMI posed increased risk for systolic hypertension and diastolic pre-hypertension, albeit with no statistical significance. Conclusion: Findings from the present study throw light on the need for routine blood pressure measurements among children and adolescents for early detection and to prevent the risk of CVDs in adults.

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Development of Cardiorespiratory Fitness Standards for Working Memory Using Receiver Operating Curves In 15-Year-Old Adolescents

10.21203/rs.3.rs-88014/v1 ◽

2020 ◽

Author(s):

Vinicius Muller Reis Weber ◽

Daniel Zanardini Fernandes ◽

Leonardo Alex Volpato ◽

Maria Raquel Oliveira Bueno ◽

Marcelo Romanzini ◽

...

Keyword(s):

Working Memory ◽

Cardiorespiratory Fitness ◽

Memory Performance ◽

Cross Sectional Study ◽

Roc Curve Analysis ◽

Cross Sectional ◽

Run Test ◽

Normal Performance ◽

Shuttle Run ◽

Receiver Operating

Abstract Working memory performance is associated with better academic achievements in children and adolescents, and it is positively related to CRF. However, what level of cardiorespiratory fitness (CRF) discriminates higher working memory performance is not known. The purpose of this study was to identify thresholds of CRF linked to working memory in adolescents. Data of 141 adolescents (53.2% girls) were collected (14.9 years) from a cross-sectional study during the year 2019. CRF was assessed by the 20-m shuttle run test, and maximal oxygen uptake were calculated by Mahar´s equation. Working memory was evaluated by the Corsi blocks test and the performance was classified by percentiles. Receiver operating characteristic (ROC) curve analysis was used to identify CRF thresholds. The results of ROC analysis indicated that CRF could be used to discriminate working memory in adolescents. CRF thresholds of ³45.03 ml.kg-1.min-1for boys and ³36.63 ml.kg-1.min-1for girls were found to be indicative of “normal” performance in working memory. ConclusionCRF could discriminate low and normal working memory performance in 14-16 years old adolescents. These thresholds could allow for earlier identification and intervention of low working memory performance by the CRF.

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Higher cardiorespiratory fitness is strongly associated with lower cardiovascular risk factors in firefighters: a cross-sectional study in a German fire brigade

Scientific Reports ◽

10.1038/s41598-021-81921-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Markus Strauss ◽

Peter Foshag ◽

Ulrich Jehn ◽

Anna Brzęk ◽

Henning Littwitz ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Cardiorespiratory Fitness ◽

Cardiovascular Complications ◽

Cross Sectional Study ◽

Cardiovascular Risks ◽

Cross Sectional ◽

Resting Blood Pressure

AbstractPrevious studies have shown significant cardiovascular risks in firefighters and that they suffer from cardiovascular events, especially on duty. Otherwise, adequate cardiorespiratory fitness is considered to have a protective effect in reducing cardiovascular complications. Therefore, the study aimed to evaluate the association between cardiorespiratory fitness and cardiovascular risks factors in firefighters. We enrolled ninety-seven male German firefighters in this cross-sectional study of cardiorespiratory fitness and cardiovascular risk factors. We used spiroergometry testing to estimate oxygen consumption to determine cardiorespiratory fitness and to calculate metabolic equivalents. We evaluated cardiovascular risk factors included nicotine consumption, lipid profiles, body composition, resting blood pressure, and heart rate. We evaluated cardiovascular risk factors included nicotine consumption, lipid profiles, body composition, resting blood pressure and heart rate. The comparison of association between cardiorespiratory fitness and cardiovascular risk factors was performed by using χ2-test, analysis of variance, general linear regression with/without adjustment for age and body mass index (BMI). This study demonstrated a strong association between lower cardiovascular risk factors and higher cardiorespiratory fitness. There were significantly lower values for BMI, waist circumference, body fat percentage and resting systolic blood pressure, triglycerides, and total cholesterol (all p < 0.0443, age-adjusted) with increased cardiorespiratory fitness. Only 19.6% (n = 19) of the examined firefighters were classified as “fit and not obese”, 48.4% (n = 47) were “low fit and not obese” and 30.9% (n = 30) were “low fit and obese”. The results clarify that increasing cardiorespiratory fitness is a fundamental point for the reduction and prevention of cardiovascular complications in firefighters. It could be demonstrated, especially for central risk factors, particularly BMI, waist circumference, sytolic resting blood pressure and triglyceride values. Therefore, firefighters should be motivated to increase their cardiorespiratory fitness for the beneficial effect of decreasing cardiovascular risk profile.

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Intensity of Physical Activity, Cardiorespiratory Fitness, and Body Mass Index in Youth

Journal of Physical Activity and Health ◽

10.1123/jpah.7.1.54 ◽

2010 ◽

Vol 7 (1) ◽

pp. 54-59 ◽

Cited By ~ 65

Author(s):

Luisa Aires ◽

Pedro Silva ◽

Gustavo Silva ◽

Maria Paula Santos ◽

José Carlos Ribeiro ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Mass ◽

Cardiorespiratory Fitness ◽

Multinomial Logistic Regression ◽

Cross Sectional Study ◽

Normal Weight ◽

Intensity Level ◽

Cross Sectional ◽

Shuttle Run

Background:The purpose of this study was to analyze the relation between body mass index (BMI), Cardiorespiratory Fitness (CRF), and levels of physical activity (PA) from sedentary to very vigorous intensities, measured by accelerometry, in students from a middle and high school.Methods:This cross-sectional study included 111 children and adolescents, age 11 to 18 years. PA was assessed with an accelerometer for 7 consecutive days (1 minute epoch) using specific cut-points. PA components were derived using special written software (MAHUffe). CRF was assessed by maximal multistage 20m shuttle run. T-test was used to test differences between BMI groups, Pearson’s correlation, to analyze correlations between all variables and multinomial logistic regression, and to predict the value of BMI categories.Results:This paper provides evidence that BMI was inversely and significantly correlated with CRF. Only CRF was correlated with Vigorous and Very Vigorous PA levels and total amount of PA. Children with Overweight/Obesity were less likely to perform more laps than normal weight counterparts. The total amount or intensity level of PA did not show any influence on BMI level.Conclusions:Low CRF is strongly associated with obesity, which highlights the importance of increasing CRF for a protective effect even in youth. No associations were found for PA and BMI.

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Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis

American Journal of Nephrology ◽

10.1159/000485259 ◽

2017 ◽

Vol 46 (6) ◽

pp. 481-487 ◽

Cited By ~ 2

Author(s):

Jan M. Hughes-Austin ◽

Ryan W. Gan ◽

Kevin D. Deane ◽

Michael H. Weisman ◽

M. Kristen Demoruelle ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Blood Pressure ◽

High Sensitivity ◽

Cross Sectional Study ◽

Analysis Of Covariance ◽

Protein Antigens ◽

Cross Sectional ◽

Reactive Protein ◽

First Degree Relatives ◽

Citrullinated Protein

Background: Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications. We hypothesized that a greater number of detectable ACPA would be associated with high SBP and DBP, independent of other risk factors in these first-degree relatives. Methods: We evaluated associations between ACPA and SBP and DBP in a cross-sectional study of 72 first-degree relatives (defined as parent, child, or sibling) of RA patients. Fifteen ACPA were measured using a Bio-Plex bead-based assay; each was dichotomized as positive/negative based on pre-specified cut-points. Analysis of covariance was used to evaluate associations between ACPA positivity and SBP and DBP, adjusting for age, sex, race, body mass index (BMI), pack-years of smoking, high sensitivity C-reactive protein (hsCRP), and current use of anti-hypertensive medications. Results: Average age was 51 and 69% were women. Mean SBP was 119 ± 18 and DBP was 74 ± 9 mm Hg. Thirty-three (46%) first-degree relatives were positive for ≥1 ACPA; and were younger, had lower BMI, more pack-years of smoking, and higher hsCRP concentrations compared to ACPA negative first-degree relatives. For each additional positive ACPA, SBP was 0.98 ± 0.5 mm Hg (p = 0.05) higher, and DBP was 0.66 ± 0.3 mm Hg (p = 0.04) higher. Anti-cit-fibrinogen A (211–230) positive and anti-cit-filaggrin positive first-degree relatives had 11.5 and 13.9 mm Hg higher SBP (p = 0.02) respectively. Anti-cit-clusterin, cit-filaggrin, and cit-vimentin positive first-degree relatives had 7–8 mm Hg higher DBP (p = 0.03, 0.05, 0.05 respectively), compared to being negative for these individual ACPA. Consistent with associations between ACPA, SBP, and DBP, anti-cyclic citrullinated peptides (anti-CCP2) positive first-degree relatives had 16.4± (p = 0.03) higher SBP and 12.1± mm Hg (p = 0.01) higher DBP than anti-CCP2 negative first-degree relatives. Conclusion: In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.

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