scholarly journals Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation

2021 ◽  
Vol 22 (15) ◽  
pp. 8115
Author(s):  
Hisham Kashif ◽  
Dilan Shah ◽  
Sangeetha Sukumari-Ramesh
Keyword(s):  
Intracerebral Hemorrhage ◽  
Public Health Problem ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Brain Response ◽  
Rna Molecules ◽  
Critical Knowledge ◽  
Non Coding Rna ◽  
Injury And Repair ◽  
First Time

Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH. Neuroinflammation, a pathological hallmark of ICH, contributes to both brain injury and repair and hence, it is regarded as a potential target for therapeutic intervention. Recent studies document that microRNAs, small non-coding RNA molecules, can regulate inflammatory brain response after ICH and are viable molecular targets to alter brain function. Therefore, there is an escalating interest in studying the role of microRNAs in the pathophysiology of ICH. Herein, we provide, for the first time, an overview of the microRNAs that play roles in ICH-induced neuroinflammation and identify the critical knowledge gap in the field, as it would help design future studies.

scholarly journals Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study

2021 ◽  
Vol 10 (5) ◽  
pp. 1082
Author(s):  
Maria-José Montoya-García ◽  
Mercè Giner ◽  
Rodrigo Marcos ◽  
David García-Romero ◽  
Francisco-Jesús Olmo-Montes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Incidence Rate ◽  
Public Health Problem ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
Population Based ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Skeletal Site ◽  
Mortality Incidence

Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment.

scholarly journals CECT in Pulmonary Thrombolism

2021 ◽  
pp. 284-293
Author(s):  
Shaha Pramod ◽  
Ragi Skanda ◽  
Bhoite Amol ◽  
Tamboli Asif ◽  
Gautama Amol
Keyword(s):  
Pulmonary Embolism ◽  
Public Health Problem ◽  
Pulmonary Angiography ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Medical Sciences ◽  
Non Invasive ◽  
Highly Sensitive ◽  
Associated Conditions

Introduction: Pulmonary embolism (PE) is the third most common acute heart disease after myocardial infarction and stroke and is a major public health problem. PE is a disease that has high morbidity and mortality, yet it is challenging to obtain a diagnosis. Objective: The study aims to assess the role of MDCT-PA in the diagnosis of pulmonary embolism, and it's associated conditions in suspected cases of pulmonary embolism. Materials and Methods: The study was conducted in the department of radiology in KRISHNA INSTITUTE OF MEDICAL SCIENCES DEEMED TO BE UNIVERSITY situated in KARAD equipped with a 16 slice MDCT scanner (EMOTION) manufactured by Siemens. Results: Through the study period of one and half year and have met the inclusion criteria, a total of 90 consecutive patients who presented with suspicion of PE were referred for MDCT-PA in the department of radio-diagnosis, Krishna Hospital, Karad. A review of all the cases was done, and the results were presented in the form of tables. Conclusion: Multidetector computed tomography pulmonary angiography can be used to confidently diagnose pulmonary embolism in which it is not contraindicated. MDCT-PA is the investigation of choice because it is a rapid, non-invasive study, highly sensitive and specific.

scholarly journals Opportunistic Infections and Associated Factors among HIV/AIDS Patients taking Ante-Retroviral Therapy at Selected Hospitals in Sidama Zone, Southern Ethiopia: A facility-based cross-sectional study

2019 ◽  
Author(s):  
Demelash Wachamo ◽  
Fisseha Bonja
Keyword(s):  
Associated Factors ◽  
Opportunistic Infections ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Aids Patients ◽  
Cross Sectional ◽  
Hiv Aids

Abstract Background Opportunistic infections are late complications of HIV infection is the depletion of the immune system. It is a major public health problem and high morbidity AIDS patients die of AIDS-related infections in developing countries like Ethiopia. Identification of opportunistic infections (OIs) is important to develop a specific intervention. Therefore, this study aimed to assess the burden and associated factors of opportunistic infections.Method A facility-based cross-sectional study was conducted on 420 randomly selected HIV/AIDS patients taking anti-retroviral therapy. Data was collected from selected hospitals in Sidama Zone based on population proportion to size. Data was collected by a pre-tested questionnaire and a pre-tested checklist from the medical records of patients. Data entry and analyzed for descriptive and logistic regression models by SPSS v.23. The result declared as statistically significant at p < 0.05.Result The magnitude of opportunistic infections was 39.6%. Major identified OIs was oral candidacies 23.2%, recurrent bacterial pneumonia 21.5%, Herpes zoster 6.3%, and Pulmonary Tuberculosis 6.0%.The magnitude of opportunistic associated with; older age [AOR=2.69, 95% CI: 1.33-5.43], No formal education [AOR=3.12, 95% CI: 1.06-9.25], Low monthly income [AOR=2.27, 95%CI:1.35-3.83], initial CD4 count less than 200 cells/mm3 [AOR=1.91, 95% CI:1.05-3.46), WHO clinical stage II [AOR=2.43, 95% CI:1.34-4.42] and stage III and IV [AOR=4.27, 95% CI: 2.12-8.59], had no extra medicine additional to ART (prophylaxis) had [AOR= 5.91, 95% CI: 3.31-10.56], who interrupt ART medicines [AOR=2.03, 95% CI: 1.09- 3.80] and Khat chewing [AOR=5.48, 95% CI: 2.32-12.96] when compared to their counterparts.Conclusions The overall magnitude of opportunistic infections was high when compared with other studies. Health officials and clinicians need to give attention on the strengthening of the provision if ART with prophylaxis on early-stage and adhrerence, implementation of the TB/HIV collaboration activity, and early initiation of ART to reduce opportunistic infections.

scholarly journals Current Status of Insecticide Susceptibility in the Principal Malaria Vector, Anopheles gambiae in Three Northern States of Nigeria

2021 ◽  
Author(s):  
Mustapha Ahmed Yusuf ◽  
Mohammad Ali Oshaghi ◽  
Hassan Vatandoost ◽  
Ahmad Ali Hanafi-Bojd ◽  
Ahmadali Enayati ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
Adult Stage ◽  
Public Health Problem ◽  
Current Status ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Study Zone ◽  
Susceptibility Tests ◽  
Insight Into ◽  
Current Resistance

Background: Malaria is a major public health problem in Nigeria with 97% of its population with high morbidity and mortality. Mosquitoes play an important role in the transmission of malaria parasites. This study was conducted to eval­uate the current resistance status of Anopheles gambiae to insecticides.  Methods: Larvae of An. gambiae was collected from three zones; A, B and C differentiated on the basis of variation in agricultural ecosystems between August and November, 2018 in the northeast and northwestern parts of Nigeria. They were carefully reared to adult stage and insecticidal susceptibility tests were conducted. Results: The mosquitoes tested showed high levels of resistance to all the insecticides used with the exception of mala­thion. Study zone A, recorded 74% mortality after 24h to deltamethrin compared to 81% from zone B and 82% from zone C, respectively. Mosquitoes from zone B exposed to DDT had the highest level of resistance at 37% compared to 40% and 53% from zones A and C, respec­tively. Resistant to bendiocarb was also observed, with zone A having the lowest mortality of 44% com­pared to 48% from zone C and 55% from Zone B, respectively. According to the results of knockdown tests, mosquitoes from Zone A exposed to deltamethrin recorded the lowest knockdown across the study locations while zone B recorded the lowest knockdown for DDT. Conclusion: The results of the study provide an insight into the current status of An. gambiae to four major insecticides in northern Nigeria as guideline for mosquitocontrol.

scholarly journals Intracerebral Hemorrhage: Blood Components and Neurotoxicity

2019 ◽  
Vol 9 (11) ◽  
pp. 316 ◽  
Author(s):  
Neha Madangarli ◽  
Frederick Bonsack ◽  
Rajaneekar Dasari ◽  
Sangeetha Sukumari–Ramesh
Keyword(s):  
Intracerebral Hemorrhage ◽  
Public Health Problem ◽  
Brain Parenchyma ◽  
Neurological Deficits ◽  
Blood Component ◽  
Major Public Health Problem ◽  
Blood Components ◽  
Secondary Brain Damage ◽  
Mortality And Morbidity ◽  
The Brain

Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.

State of the art in managing nontraumatic intracerebral hemorrhage

2011 ◽  
Vol 30 (6) ◽  
pp. E22 ◽  
Author(s):  
Julie Dubourg ◽  
Mahmoud Messerer
Keyword(s):  
Public Health ◽  
Decision Making ◽  
Intracerebral Hemorrhage ◽  
Health Problem ◽  
State Of The Art ◽  
Public Health Problem ◽  
High Rate ◽  
Management Decision ◽  
Major Public Health Problem ◽  
Management Decision Making

Nontraumatic intracerebral hemorrhage constitutes a major public health problem worldwide. Intracerebral hemorrhage leads to a high rate of morbidity and mortality. To date, no medical or surgical trials have clearly attested to the benefit of a particular therapy. The aim of this review was to summarize the best evidence for management decision-making in intracerebral hemorrhage.

Non-suicidal self-injury in adolescents: A diagnostic and psychopathological approach. A case presentation

2017 ◽  
Vol 41 (S1) ◽  
pp. S450-S450
Author(s):  
M.D. Ortega Garcia ◽  
V. Marti Garnica ◽  
S. Garcia Marin ◽  
C. Martinez Martinez ◽  
R. Gomez Martinez ◽  
...  
Keyword(s):  
Mental Health Center ◽  
Public Health Problem ◽  
Personal Characteristic ◽  
Family Characteristics ◽  
Major Public Health Problem ◽  
Case Presentation ◽  
Self Injury ◽  
Self Harm ◽  
Competing Interest ◽  
First Time

Self-injurious behavior is a major public health problem. An increase in the number of self-injuring adolescents has been observed since the mid-1960s.Description of clinical caseC. is a 14 teenager who comes to a mental health center for the first time a year ago for having numerous self-injuries in the forearm. She says that she cannot avoid doing so in moments of anxiety and that, in addition, when she is hurt she calms down. Throughout the interviews, C. relates that after the death of her best friend in a traffic accident she is alone and with episodes of anxiety.Exploration and complementary testsIt is important to analyze the risk factors of self-injurious behaviors in adolescence such as:– personal characteristic;– psychiatric disorders;– family characteristics;– mass media.DiagnosisDepressive episode (F32).Differential diagnosisIn general, self-injury is considered as a symptom or characteristic of a specific psychiatric disorder. Stereotyped self-injury is characteristic of processes of cognitive deficit of the level of severe and profound mental retardation. Compulsive self-harm involves symptomatic habits such as severe scratching of the skin or already differentiated psychiatric entities, such as trichotillomania, onicofagia or delusional parasitosis… Important psychotic disorder.ConclusionsFollowing the Task Force's criteria, in relation to probably effective therapies, it can be concluded that the therapy based on mentation for adolescents (MBT-A) is the first effective treatment for the treatment of self-harm in adolescents.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland

2022 ◽  
Vol 204 (2) ◽  
Author(s):  
Szymon Walter de Walthoffen
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Beta Lactamase ◽  
Beta Lactam ◽  
Gene Encoding ◽  
Beta Lactamases ◽  
Lactamase Gene ◽  
Chromosomal Mutations ◽  
First Time

Abstract Purpose Neisseria gonorrhoeae is an etiological agent of gonorrhea which remains a major public health problem the mechanisms that determine resistance to drugs of the beta-lactam class, which are recommended for the treatment of gonorrhea, are currently the most important problem in its treatment. Chromosomal mutations are responsible for resistance to ceftriaxone and cefepime. The possibility of mutations in the gene encoding beta-lactamase (blaTEM) in the penicillinase plasmid may also turn out to be a serious threat. Methods The occurrence of resistance encoded on penicillinase plasmid has been investigated. For this purpose, the susceptibility of bacteria was determined and the gene for resistance to beta-lactams as well as the plasmids themselves was typed. Results Of the 333 strains tested, 21 (6.3%) had the beta-lactamase gene and produced penicillinase. Two of the beta-lactamase: TEM-1 and TEM-135 occurred among the tested strains of N. gonorrhoeae. Most of the known penicillinase plasmid types of N. gonorrhoeae were demonstrated: the Asian, the African, the Toronto/Rio plasmids and Australian variants. Conclusions In the first 3 years, TEM-1 beta-lactamases dominated in N. gonorrhoeae, which were replaced by TEM-135 in the following years of the study. Not all molecular methods are capable of varying the types of penicillinase plasmids. A particularly noteworthy observation is the fact that the Australia-type of penicillinase plasmid (3270 bp) was identified for the first time in Europe, and the second time in the world.

scholarly journals Suicide by Homemade Hydrogen Sulfide in Turkey a Case Report

2016 ◽  
Vol 21 (3) ◽  
pp. 189-192
Author(s):  
Uğur Koçak ◽  
Ahmet Hamdi Alpaslan ◽  
Murat Yağan ◽  
Erdal Özer
Keyword(s):  
Public Health ◽  
Hydrogen Sulfide ◽  
Case Report ◽  
Public Health Problem ◽  
University Student ◽  
Major Public Health Problem ◽  
Industrial Workers ◽  
Related Literature ◽  
Chemical Products ◽  
First Time

Suicide is a major public health problem and globally the second leading cause of death among young adults. Most of deaths due to H2S were seen among sewage or industrial workers because of acute exposure to this gas. Suicide by inhalation of homemade H2S has been reported for the first time in Japan, in 2007. In this study, for the first time, a 24-years-old male university student (from Turkey) preparing homemade H2S by using commercially available chemical products that were bought online in order to suicide was reported. The case is discussed in the light of related literature.

scholarly journals Patterns and characteristics of injuries encountered in road traffic accidents and effect of pre-hospital care on their outcome: a tertiary-hospital study in Lahore, Pakistan

2019 ◽  
Vol 6 (7) ◽  
pp. 2755
Author(s):  
Maryam Ikram ◽  
Rida Fatima ◽  
Anam Ikram ◽  
Farheen Shahid ◽  
Maham Rafiq ◽  
...  
Keyword(s):  
Hospital Care ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Early Recognition ◽  
Public Health Problem ◽  
Road User ◽  
Published Data ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Road Traffic Accidents

Background: Road traffic accidents are the eighth leading cause of death worldwide, contributing significantly to the global disease burden. As there is a paucity of published data on RTAs in Lahore, this study was carried out to highlight injuries encountered in RTA victims and provide baseline data for the establishment of prevention strategies in our locality.Methods: This is a descriptive cross-sectional study of RTA victims admitted in Mayo Hospital, Lahore to determine factors associated with RTAs, characteristics, and outcomes of injuries sustained and effect of Pre-hospital care in determining the outcome.Results: Out of total 100 subjects recruited, 89 were males and 11 females. Ages of patients ranged from 5 to 70 years with the most injured age group ranging between 11-30 years (59%). Motorcyclists were found as the most vulnerable road user group (61%). Most of the accidents occurred because of a collision with another vehicle (45%). 65 victims received pre-hospital care en route to Mayo Hospital, which was found effective in preventing major disabilities in 81% of cases (53 out of 65). Incidence of Musculoskeletal injuries was highest (55%). Most patients (86%) were discharged without permanent disabilities. No patient died during our study.Conclusions: This study shows road traffic accident is a major public health problem in our setting and contribute markedly to high morbidity. Urgent preventive measures should be established to reduce the risk of their occurrence. Early recognition and prompt treatment are important for the survival of the victims.

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