scholarly journals Intracerebral Hemorrhage: Blood Components and Neurotoxicity

2019 ◽  
Vol 9 (11) ◽  
pp. 316 ◽  
Author(s):  
Neha Madangarli ◽  
Frederick Bonsack ◽  
Rajaneekar Dasari ◽  
Sangeetha Sukumari–Ramesh
Keyword(s):  
Intracerebral Hemorrhage ◽  
Public Health Problem ◽  
Brain Parenchyma ◽  
Neurological Deficits ◽  
Blood Component ◽  
Major Public Health Problem ◽  
Blood Components ◽  
Secondary Brain Damage ◽  
Mortality And Morbidity ◽  
The Brain

Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.

Abstract T P253: Clinical Application of Haptoglobin in Models of Supraphysiologic Extracellular Brain Hemoglobin Levels

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Jenna L Leclerc ◽  
Sean Robbins ◽  
Tina Esfandiary ◽  
Alex Dang ◽  
Sylvain Doré
Keyword(s):  
Brain Injury ◽  
Public Health Problem ◽  
Cresyl Violet ◽  
Control Group ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Lesion Volume ◽  
Blood Components ◽  
Autologous Whole Blood ◽  
The Brain

Hemorrhagic stroke can occur from traumatic or spontaneous causes, is associated with high morbidity and mortality, and represents a worldwide major public health problem. With breakdown of the blood-brain barrier, and entry of toxic blood components and metabolites within the brain, a highly oxidative environment ensues and leads to a toxic neuroinflammatory cascade. A major cause of the debilitation following brain hemorrhage is due to the direct toxicity of blood components, namely hemoglobin (Hb), the most upstream precipitating factor. The acute phase plasma protein haptoglobin (Hp) binds Hb and inhibits its cytotoxic, pro-oxidative, and pro-inflammatory properties. Therefore, we hypothesized that local and specific overexpression of Hp within the brain would aid in the safe detoxification and clearance of free Hb, thereby protecting the neuropil from Hb-mediated oxidative stress, ultimately leading to improved anatomical and functional recovery. Here, we overexpressed Hp within the brain using specifically designed adeno-associated viral vectors, and induced hemorrhagic brain injury using two models – intrastriatal autologous whole blood injection and collagenase-induced spontaneous bleeding, which is accompanied by intraventricular hemorrhage in most cases. At 72h post-hemorrhage, mice were sacrificed and brains collected for Cresyl Violet staining and lesion volume quantification. Functional outcomes were assessed by a 24-point neurological deficit score. In both models, Hp-overexpressing mice demonstrated reduced lesion volume (p<0.05) and improved neurologic status at 24h, 48h, and 72h post-hemorrhage (p<0.05), when compared to an identically treated control group (n=7-9/group). In conclusion, locally modulating Hp expression within the brain could represent an important clinically relevant strategy for the treatment of acute hemorrhagic brain injury by attenuating the toxicity of free Hb and improving its clearance from the brain.

scholarly journals CT Scan importance in the first eight hours of head injury

2018 ◽  
Vol 5 (4) ◽  
pp. 766
Author(s):  
Mohammed Alfageeh ◽  
Moneerah Bahran ◽  
Sultan Albargi ◽  
Ibrahim Althomali ◽  
Adnan Alzahrani ◽  
...  
Keyword(s):  
Public Health ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Public Health Problem ◽  
Neurological Deficits ◽  
Major Public Health Problem ◽  
Adults And Children ◽  
The Brain

Traumatic brain injury following head injury is a major public health problem that can result in significant long-term morbidity and mortality among adults and children worldwide. Emergency brain imaging is necessary for individuals subjected to traumatic brain injury to early detect treatable conditions. Prompt neurosurgical management of treatable conditions can prevent further damage and secondary neurological deficits. This will subsequently improve the outcome and reduce long-term disability. Computed Tomography (CT) of the brain is the investigation of choice for assessment of patients with head injury due to its availability, advantages, and sensitivity for multiple lesions following head trauma. This article will review and discuss the importance of CT imaging in evaluating patients with traumatic brain injury, its advantages, limitations, and prognostic values.

DHA/EPA SUPPLEMENTATION DECREASES ANXIETY-LIKE BEHAVIOUR, BUT IT DOES NOT AMELIORATE METABOLIC PROFILE IN OBESE MALE RATS

2021 ◽  
pp. 1-25
Author(s):  
João Neto ◽  
Jeferson Jantsch ◽  
Simone de Oliveira ◽  
Matheus Filipe Braga ◽  
Luís Felipe dos Santos de Castro ◽  
...  
Keyword(s):  
Public Health Problem ◽  
Male Rats ◽  
Major Public Health Problem ◽  
Omega 3 ◽  
Elevated Plus Maze Test ◽  
Tnf Α ◽  
Plus Maze ◽  
Neuropsychiatric Diseases ◽  
The Brain ◽  
Diet Model

Abstract Obesity is a major public health problem that predisposes to several diseases and higher mortality in patients with COVID-19. Obesity also generates neuroinflammation, which predisposes to the development of neuropsychiatric diseases. Since there is a lack of effective treatments for obesity, the search for new strategies to reverse its consequences is urgent. In this perspective, the anti-inflammatory properties of omega-3 polyunsaturated fatty acids such as DHA/EPA might reduce the harmful effects of obesity. Here, we used the cafeteria diet model to induce obesity in Wistar rats. Animals received ultra-processed food for 20 weeks, and DHA/EPA supplementation (500mg/Kg/day) was performed between the 16th and the 20th week. At the end of the experiment, it was evaluated: body weight, visceral fat deposition, plasma glucose, insulin and triglycerides, and it was also measured the levels of inflammatory cytokines TNF-α and IL-6 in plasma and liver, and TNF-α in the prefrontal cortex. The elevated plus-maze test was performed to analyze anxiety-like behaviour. Our results demonstrated that DHA/EPA could not reverse weight and fat gain and did not modify plasma dosages. However, there was a decrease in IL-6 in the liver (DHA/EPA effect: p = 0.023) and TNF-α in the brain (CAF compared to CAF+DHA/EPA, p < 0.05). Also, there was a decrease in the anxiety index in CAF+DHA/EPA compared to the CAF group (p < 0.01). Thus, DHA/EPA supplementation is helpful to reverse the consequences of obesity in the brain.

Abstract 178: Cholesterol Limits Macrophage Activation in Response to Intracerebral Hemorrhage-Relevant Signals

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Jonathan H DeLong ◽  
Sofia Velazquez ◽  
Margaret J Landreneau ◽  
Lauren H Sansing
Keyword(s):  
Intracerebral Hemorrhage ◽  
Macrophage Activation ◽  
Cholesterol Content ◽  
Brain Parenchyma ◽  
Activation Markers ◽  
Multiple Systems ◽  
Murine Bone Marrow ◽  
Inflammatory Phenotype ◽  
Injury Models ◽  
The Brain

Introduction: In response to intracerebral hemorrhage (ICH), monocytes are recruited to the brain parenchyma, where they differentiate into macrophages and contribute to a pathological inflammatory response. However, by day 3 after ICH, brain macrophages have adopted a more reparative phenotype and are important for clearance of apoptotic cells and recovery. The signals that control this inflammatory to reparative differentiation are incompletely understood, but cholesterol has been found to limit macrophage activation in multiple systems. The brain has the highest cholesterol content of any organ and we hypothesized that cholesterol uptake by macrophages limits inflammation and promotes the development of reparative macrophages following ICH. Methods and Results: Murine bone marrow-derived macrophages were stimulated with a cocktail of thrombin, S100A8, and IL-1b in order to mimic the Danger-Associated Molecular Patterns present in the brain after ICH (ICH-DAMP), LPS, or vehicle for 14-18 hours. Cytokine production was quantified by cytometric bead array and activation markers by flow cytometry. ICH-DAMP was found to upregulate CCL2, IL-6 and TNF, recapitulating the inflammatory phenotype seen in the first days after ICH. However, when cells were stimulated in the presence of cholesterol, production of CCL2, IL-6, and TNF were limited. Dectin-1 has inhibitory properties in some sterile injury models. ICH-DAMP was found to limit expression of dectin-1, and cholesterol reversed this inhibition. Exposure to exogenous cholesterol also upregulated the cholesterol transporter ABCA1, allowing cells to efflux excess cholesterol. The drug Valspodar was therefore used to block cholesterol efflux and was found to further limit ICH-DAMP-mediated upregulation of CCL2. Conclusion: These results suggest that the cholesterol in the brain may limit macrophage activation in response to the stimuli present during intracerebral hemorrhage.

scholarly journals Cerebral Cystic Echinococcosis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Abolghasem Siyadatpanah ◽  
Enrico Brunetti ◽  
Amir Emami Zeydi ◽  
Yousef Dadi Moghadam ◽  
Nelson Iván Agudelo Higuita
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Larval Stage ◽  
Cystic Echinococcosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cestode Species ◽  
Iranian Patient ◽  
The World ◽  
The Brain

Cystic echinococcosis (CE) is a neglected helminthic disease and major public health problem in several regions of the world. The zoonosis is caused by the larval stage of different cestode species belonging to the genus Echinococcus. CE can affect any organ with the liver and lungs being most commonly involved. The brain is involved in less than 2% of the cases. We report a case of a CE1 echinococcal cyst of the brain in an Iranian patient.

scholarly journals Ten year cardio-cerebro-vascular mortality and morbidity in a Southern Italy cohort: the VIP Project data

2015 ◽  
Vol 80 (1) ◽  
Author(s):  
Vincenzo Capuano ◽  
Norman Lamaida ◽  
Sergio Torre ◽  
Ernesto Capuano ◽  
Maria Immacolata Borrelli ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Events ◽  
Southern Italy ◽  
Geographical Area ◽  
Public Health Problem ◽  
Local Analysis ◽  
Mortality Data ◽  
Major Public Health Problem ◽  
Mortality And Morbidity ◽  
European Standard Population

Rationale: In Italy the mortality data were obtained almost exclusively from the data RENCAM (Name Causes of Death Register), while there are few prospective surveys. In order to assess whether there are particular epidemiological conditions in the geographical area of Mercato S. Severino, in Southern Italy, we have studied, and reassessed at ten years (1998/99 - 2008/09), a cohort of adult general population in a project of cardiovascular epidemiology and prevention. Materials and Methods: We calculated the rates of mortality and morbidity from cardiovascular events covering the period 1998/99 - 2008/09, in a cohort of 1200 persons (600 men and 600 women) aged 25 to 74 years. Data were standardized using the European standard population. Results: Mortality from cardiovascular causes was 46,5% in men and 48,7% in women; it was mainly concentrated in the age group 65-74 years where it occurred on 62,9% of deaths in men and 66,7% in women. Regarding morbidity, the incidence of events to ten years of non-fatal myocardial infarction was 2,2% in men and of 1,8% in women. PTCA interventions to ten year have been 3,3% in men and 3,4% in women, the interventions of aorto-coronary bypass have been 2,4% and 0,5% for men and women respectively. While all major cardiovascular events have been more frequent in men, in women there was a higher incidence of stroke (1,6% vs 0,9%). Conclusions: Although by comparison with other European countries Italy is among the countries considered at low-risk of coronary heart disease, in Campania cardiovascular diseases reach higher rates than the rest of the country. Our results are in line with the literature data and confirm that cardiovascular diseases are a major public health problem. Local analysis to propose means to provide useful information for planning prevention interventions targeted to their own territory.

scholarly journals Participatory Research for Preventing Pesticide-Related DSH and Suicide in Sundarban, India: A Brief Report

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Arabinda N. Chowdhury ◽  
Sohini Banerjee ◽  
Arabinda Brahma ◽  
Mrinal K. Biswas
Keyword(s):  
Participatory Research ◽  
Community Based Participatory Research ◽  
Public Health Problem ◽  
Local Context ◽  
Major Public Health Problem ◽  
Group Discussions ◽  
Mortality And Morbidity ◽  
Agricultural Community ◽  
Admission Data ◽  
And Training

Deliberate self-harm (DSH) is a major public health problem in the Sundarban region, India. This study is aimed to develop a DSH-suicide prevention programme based on the principles of community-based participatory research (CBPR). Perception and opinion of community about the problem of pesticide-related DSH and suicide were elicited in a series of facilitated focus group discussions in Namkhana block of Sundarban region. Based on their suggestion, a broad preventive programme was launched involving the development of information, education, and communication (IEC) and training modules and training of the stakeholders of the block. Most of the members of each target group found that the IEC materials were culture fair (message is acceptable, understandable, and meaningful in the local context) and very useful. Analysis of Dwariknagar BPHC, DSH admission data showed a definite reduction of DSH incidents after this CBPR approach to prevention was initiated. Similar model of DSH prevention in the other blocks of Sundarban region or in agricultural community may help to reduce the enormous mortality and morbidity from pesticide-related DSH and suicide.

scholarly journals Hypoxia-Inducible Factor-1α Accumulation in the Brain after Experimental Intracerebral Hemorrhage

2002 ◽  
Vol 22 (6) ◽  
pp. 689-696 ◽  
Author(s):  
Yajun Jiang ◽  
Jimin Wu ◽  
Richard F. Keep ◽  
Ya Hua ◽  
Julian T. Hoff ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Messenger Rna ◽  
Hypoxia Inducible Factor ◽  
Early Response ◽  
Brain Parenchyma ◽  
Thrombin Inhibitor ◽  
Sprague Dawley ◽  
Time Points ◽  
Autologous Whole Blood ◽  
The Brain

Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of HIF-1α and HIF-1β protein subunits, has been implicated in cellular protection and cell death in cerebral ischemia. The extent to which HIF-1 plays a role in brain pathology during intracerebral hemorrhage (ICH) is unknown. This study determined whether HIF-1α is upregulated at different time points in a rat model of ICH and the role of thrombin and red blood cell lysis in upregulation. Recently, thrombin has been implicated as a nonhypoxic regulator of HIF-1α in cultured smooth-muscle cells. Male Sprague-Dawley rats received intracerebral infusions of saline, autologous whole blood, blood plus hirudin, thrombin, thrombin plus hirudin, or lysed erythrocytes. Rats were killed at different time points for Western blot analysis, immunohistochemistry, immunofluorescent double staining, and reverse transcription polymerase chain reaction measurements of HIF-1α. HIF-1α protein levels increased without changing HIF-1α messenger RNA levels after intracerebral infusions of blood, thrombin, and lysed erythrocytes. HIF-1α positive cells, which proved to be neurons, were found in the brain after ICH. Hirudin, a specific thrombin inhibitor, reduced HIF-1α upregulation in response to both thrombin and blood. This study demonstrates that perihematomal HIF-1α protein is upregulated after ICH. This phenomenon is an early response of brain parenchyma to the clot. Thrombin and erythrocyte lysate are involved in HIF-1α upregulation through reducing HIF-1α degradation.

scholarly journals Metode Pengukuran Volume Perdarahan Pemeriksaan MSCT Kepala pada Kasus Intraserebral Hemmorhage

2021 ◽  
Vol 7 (1) ◽  
pp. 1-7
Author(s):  
Siti Masrochah ◽  
Rinda Yuliana Lestar ◽  
Luthfi Rusyadi
Keyword(s):  
Qualitative Research ◽  
Intracerebral Hemorrhage ◽  
Brain Parenchyma ◽  
Slice Thickness ◽  
Manual Method ◽  
Advantages And Disadvantages ◽  
Bleeding Volume ◽  
Irregular Bleeding ◽  
Volume Method ◽  
The Brain

Background: Intracerebral hemorrhage is bleeding in the brain parenchyma. An accurate measurement of bleeding volume to determine the appropriate medical action. This study to determine the method of measuring the volume of intracerebral hemorrhage in MSCT examination of the head and determine the advantages and disadvantages between the manual method (Broderick, ABC's, Ellipsoid) and the software method (automatic volume, otsu).Methods: This type of descriptive qualitative research with the Literature Review. Data obtained by identifying problems then searching for keywords, looking for several journals sourced from databases such as Google Scholar, Science Direct, Springer. Data analysis by studying theoretically the method of measuring the volume of bleeding methods manually (Broderick, ABC’s, ellipsoid) and using software methods (automatic volume, otsu).Results: The results of measuring the volume of bleeding in the same patient with the manual method (Broderick) produce more bleeding volume (overestimate) that is 8750 mm3 from the 7960 mm3 automatic volume method. The manual method (Broderick, ABC’s, Ellipsoid) uses the ABC / 2 formula and uses 5 mm slice thickness, the automatic volume software method uses 1 mm slice thickness segmentation and technique, while the otsu software method uses 2.5 mm segmentation and slice thickness techniques.Conclusion: The advantages of the manual method (Broderick, ABC’s, ellipsoid) take approximately 1 minute to determine the estimated outcome of the bleeding volume, the weakness is higher in irregular bleeding. The advantages of the software method (automatic volume, otsu) in the use of precise segmentation techniques for accurate volume results, weaknesses are too long in determining the estimated bleeding volume results.

scholarly journals Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Qi Qin ◽  
Yunsi Yin ◽  
Yi Xing ◽  
Xuan Wang ◽  
Yan Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Lipid Metabolism ◽  
Public Health Problem ◽  
Vascular Cognitive Impairment ◽  
Lipid Biomarkers ◽  
Systemic Review ◽  
Major Public Health Problem ◽  
Clinical Biomarkers ◽  
The Brain ◽  
Potential Biomarkers

Background: Vascular cognitive impairment (VCI) is a major public health problem. The current diagnosis of VCI is made based on the assessment of clinical symptoms and neuropsychological measurements, and is supported by neuroimaging. These methods are both time-consuming and expensive, which leads to needs for alternative biomarkers for VCI. Metabolomics is an emerging and powerful tool to discover of new biomarkers of disease, which can investigate variations in different metabolic processes such as lipid, since the brain is highly enriched in lipids and that lipid changes may lead to pathology in the brain. Vascular cognitive impairment is vulnerable to the disturbance of lipid metabolism. Furthermore, blood samples, which could be identified as reliable clinical biomarkers are relatively convenient to obtain and provide a non-invasive assessment. Therefore, our study aims to understand whether peripheral lipid biomarkers can be used as diagnostic biomarkers and monitor the progression of VCI.Methods: We systematically searched the PubMed, Embase, CNKI, and VIP databases to find VCI and lipid metabolism in reports from inception through February 2021. Studies meeting the following criteria were eligible: (1) original studies in humans; (2) lipid metabolites in blood; (3) reports of VCI.Results: Through our review, nine original articles were eligible. Blood-based metabolites that might be potential biomarkers were identified. Most of them including PC, PE, Cers, and ChEs were significantly lower, while elevation of FAs and DGs were associated with VCI. Most importantly, these blood-based metabolites might be proposed as potential biomarkers for VCI, which provides direction for further validation.Discussion and Conclusion: To the best of our knowledge, this is the first systemic review concerning the relationship of lipid metabolism and VCI. It identifies potential biomarkers and provides insights into the disease pathobiology. However, more advanced studies and researches on a lipidomic platform must be done to understand the exact pathology behind and identify potential lipid biomarkers, which might help achieve the goal of discovering novel therapeutics.

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