scholarly journals Characteristics of the Urinary Proteome in Women with Overactive Bladder Syndrome: A Case-Control Study

2021 ◽  
Vol 10 (11) ◽  
pp. 2446
Author(s):  
Marianne Koch ◽  
Pavel Lyatoshinsky ◽  
Goran Mitulovic ◽  
Barbara Bodner-Adler ◽  
Sören Lange ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Cellular Response ◽  
Control Group ◽  
Spectrometric Analysis ◽  
Case Group ◽  
Pathway Enrichment Analysis ◽  
Data Allocation ◽  
Overactive Bladder Syndrome ◽  
Tissue Elasticity ◽  
Response To Stress

Despite an estimated prevalence of 13% in women, the exact etiology of non-neurogenic overactive bladder syndrome is unclear. The aim of our study was to gain a better understanding of the pathophysiology of female overactive bladder syndrome by mapping the urinary proteomic profile. We collected urine samples of 20 patients with overactive bladder syndrome and of 20 controls. We used mass spectrometric analysis for label-free quantitation, Swissprot human database for data search, Scaffold for data allocation and the Reactome Knowledgebase for final pathway enrichment analysis. We identified 1897 proteins at a false discovery rate of 1% and significance level p < 0.001. Thirty-seven significant proteins of the case group and 53 of the control group met the criteria for further pathway analysis (p < 0.0003 and Log2 (fold change) >2). Significant proteins of the overactive bladder group were, according to the 25 most relevant pathways, mainly involved in cellular response to stress and apoptosis. In the control group, significant pathways mainly concerned immunological, microbial-protective processes and tissue- elasticity processes. These findings may suggest a loss of protective factors as well as increased cellular response to stress and apoptosis in overactive bladder syndrome.

scholarly journals Relationship between Obsessive-compulsive Disorder and Overactive Bladder Syndrome

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzad Allameh ◽  
Mahtab Motamed ◽  
Morteza Fallah-Karkan ◽  
Mohammad Poury ◽  
Saba Faraji ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Obsessive Compulsive Disorder ◽  
Depressive Disorders ◽  
Age Of Onset ◽  
Screen Test ◽  
Control Group ◽  
Case Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Significant Difference

Background: Overactive bladder (OAB) syndrome correlates with mental disorders, especially depressive disorders and anxiety disorders, and less frequently obsessive-compulsive symptoms, and occurs mostly in older people. Obsessive-compulsive disorder (OCD) is more frequent in OAB patients. Most OCD people are diagnosed at the age of about 19, typically with an earlier age of onset in boys than in girls, but the onset after age 35 does occur less frequently. Objectives: This study aimed to evaluate the relationship between OCD and OAB. Methods: In this case-control study, 1,160 cases who were over 18 years old who were referred to the urodynamic clinic of Shohada-e-Tajrish center from June 2013 to February 2018 in Tehran, Iran, enrolled of whom 580 were considered the control group who were non-OAB patients, and 580 subjects were considered the case group who were OAB patients. The diagnosis of OAB was confirmed by a single urologist. All cases had detrusor overactivity (DO) in urodynamic study (UDS). The OAB-validated 8-questionnaire screen test (OAB-V8) was conducted, and the diagnosis of OCD was confirmed by a single psychiatrist according to DSM-5 criteria. Moreover, the Yale-Brown questionnaire was completed for each patient to rate the severity of OCD symptoms. Results: About the Yale-Brown Obsessive-compulsive Scale (Y-BOCS) total score, there is a significant difference between patients with obsessive traits and the control group (P < 0.001). OCD scores were significantly higher in the OAB group compared to the control group (P < 0.001). Logistic regression analysis showed that the population of the studied patients with OAB was more probable to have OCD than non-OAB control subjects in aged classified groups (OR: 6.23; P < 0.001). Conclusions: The findings of this study showed that OAB patients reported higher obsessive-compulsive scores (Y-BOCS) compared to the controls. There is an independent correlation between OCD and OAB. However, the linkage between OCD and OAB justifies the need for more research.

scholarly journals Metabolic profiling of serum for osteoarthritis biomarkers

2021 ◽  
Author(s):  
Ziqian Xiao ◽  
Zhenyang Zhang ◽  
Shanbin Huang ◽  
Jerome Rumdon Lon ◽  
Shuilin Xie
Keyword(s):  
Enrichment Analysis ◽  
Normal Serum ◽  
Rabbit Serum ◽  
Control Group ◽  
Case Group ◽  
Pathway Enrichment Analysis ◽  
Serum Samples ◽  
Major Health Problem ◽  
The World ◽  
Potential Biomarkers

AbstractOsteoarthritis is a prevalent aging disease in the world, and in recent years it has shown a trend toward younger age, which is becoming a major health problem in the world and seriously endangers the health of the elderly. However, the etiology and pathogenesis of osteoarthritis are still unclear, causing great trouble for treatment. To screen out potential biomarkers that could be used as identification of osteoarthritis and explore the pathogenesis of osteoarthritis, we performed untargeted metabolomics analysis of nine New Zealand rabbit serum samples by LC-MS / MS, including three normal serum samples (control group) and six osteoarthritis serum samples (case group). Finally 44 differential metabolites were identified, and the ROC analysis results indicated that a total of 36 differential metabolites could be used as potential biomarkers. Further metabolic pathway enrichment analysis was performed on these differential metabolites, and we found that a total of 17 metabolic pathways were affected, which may provide directions for the study of osteoarthritis mechanisms.

scholarly journals Factors associated with overactive bladder syndrome in the elderly community: a cross-sectional study

2017 ◽  
Vol 20 (4) ◽  
pp. 474-483
Author(s):  
Albênica Paulino dos Santos Bontempo ◽  
Aline Teixeira Alves ◽  
Gabriela de Sousa Martins ◽  
Raquel Henriques Jácomo ◽  
Danieli Coeli Malschik ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Overactive Bladder ◽  
Cross Sectional Study ◽  
Sexual Life ◽  
Case Group ◽  
Overactive Bladder Syndrome ◽  
Depression And Anxiety ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated

Abstract Objective: to identify risk factors related to overactive bladder syndrome. Method: a cross-sectional study was performed with elderly women (>60 years) from the community of Ceilândia, in the Distrito Federal, Brazil, with or without symptoms of OBS, who were evaluated through interviews and questionnaires. The clinical and sociodemographic variables analyzed were: age; body mass index (BMI); parity, schooling, previous abdominal and urogynecologic surgeries, physical activity, smoking, constipation, systemic arterial hypertension (SAH), diabetes mellitus; depression and anxiety. The questionnaires applied were the Overactive Bladder Awareness Tool (OAB-V8), the Geriatric Depression Scale and the Beck Anxiety Scale. Data were analyzed descriptively. Binary logistic regression was used to evaluate the significant associations between the independent variables and the outcome of interest. Risk ratios were calculated for each independent variable with 95% confidence intervals. Result: A total of 372 volunteers were recruited, 292 of whom were eligible. Of these, 172 were allocated to the case group (58.9%) and 120 (41.1%) were control subjects. The two groups were homogeneous between one another. There was a high prevalence of OBS in the study population and significant differences for the variables presence of SAH, abdominal surgery and pelvic surgery, with the case group presenting a higher frequency of these events. In multivariate analysis, it was observed that an active sexual life reduces the chance of having OBS by 70.8%, while urogynecologic surgeries increase this risk 3.098 times. Conclusion: In univariate logistic regression analysis, BMI, SAH, a previous history of abdominal and urogynecologic surgery, number of abortions and the presence of symptoms of depression and anxiety, were found to be factors associated with OBS.

scholarly journals Effects of biofeedback-based sleep improvement program on urinary symptoms and sleep patterns of elderly Korean women with overactive bladder syndrome

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jooyeon Park ◽  
Choal Hee Park ◽  
Sang-Eun Jun ◽  
Eun-Ju Lee ◽  
Seung Wan Kang ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Sleep Onset ◽  
Intervention Group ◽  
Wilcoxon Test ◽  
Urinary Symptoms ◽  
Control Group ◽  
Overactive Bladder Syndrome ◽  
Korean Women ◽  
Sleep Patterns ◽  
Significant Difference

Abstract Background The prevalence of overactive bladder syndrome (OAB) increases with age. Sleep disturbances in elderly individuals with OAB is a common problem. The purpose of this study was to examine the effects of a biofeedback-based sleep improvement (BBSI) program on urinary symptoms and sleep patterns in elderly Korean women with OAB. Methods A non-equivalent control group pre−/post-test design was used. Elderly women with OAB were assigned to an intervention group (n = 20) or a control group (n = 18). The BBSI program was implemented in the intervention group for 12 weeks, while two educational sessions of general sleep hygiene and lifestyle modification were provided to the control group. Using SPSS 23.0, the data were analyzed by descriptive analysis using the chi-square test, Fisher’s exact test, Mann-Whitney test, and Wilcoxon test. Results After the 12-week BBSI program, significant improvements were found in the intervention group’s the square root of the mean squared differences of successive R-R intervals (p = 0.025), low frequency/high frequency ratio (p = 0.006), and epinephrine (p = 0.039). We also observed a significant difference in urinary symptoms, sleep efficiency, wake after sleep onset, number of awakenings, and number of awakenings within 3 h after sleep onset (p < 0.001, p = 0.004, p = 0.001, p = 0.001, and p = 0.048, respectively). However, no significant changes were found in these variables in the control group. Conclusions The BBSI program effectively improved urinary symptoms and sleep patterns of elderly Korean women with OAB. Further longitudinal research is required to investigate the sustainability and effects of the BBSI program. Trial registration KCT0003882. Date of registration: 02/05/2019. Retrospectively registered.

scholarly journals Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Bingsi Gao ◽  
Xingping Zhao ◽  
Xinyi Liu ◽  
Xuan Yang ◽  
Aiqian Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Pregnant Women ◽  
Preliminary Investigation ◽  
Intestinal Flora ◽  
Enrichment Analysis ◽  
First Trimester ◽  
Hunan Province ◽  
Control Group ◽  
Case Group ◽  
Pathway Enrichment Analysis

Objective. To conduct a preliminary investigation that shows the possible correlation between the change of gut microbiota and missed abortions (MAs), which further provides a new potential insight for the prevention and therapy of MAs. Method. One hundred women, including 50 patients with MAs (case group) and 50 normal pregnant women (control group), were enrolled in the study. Fecal specimens were collected in the first trimester. Bacterial DNA was extracted, hybridized with primers of specific genes, and then detected by bacterial chip. The composition and the relative abundance of the gut microbiota were compared and analyzed. Furthermore, Kyoto Encyclopedia of Genes and Genomes enrichment analysis was used to explore the relative pathways. Results. (1) The α -diversity and β -diversity of the gut microbiota in patients with MAs were significantly lower than that those in normal pregnant women ( P < 0.05 ). At the phylum level, Firmicutes, Proteobacteria, Actinomycetes, and Bacteroidetes accounted for the main proportion of intestinal flora in the 2 groups. Only Actinobacteria was high in the case group. Significant differences were found between the two groups at the phylum level ( P < 0.05 ). Prevotella, Lactobacillus, and Paracoccus were significantly more abundant in the control group than in the case group at the genus level ( P < 0.05 ). (2) KEGG pathway enrichment analysis found significant differences in 27 signaling pathways and metabolic pathways between the two groups of differentially expressed genes (all adjusted P < 0.05 ). (3) The positive rate of M. hominins (MH) detection in the control group was significantly higher in the MA group ( χ 2 = 7.853 , P = 0.004 ). Conclusion. The high abundance of Actinobacteria in the MA group was the first time found and reported in the study. The dysbiosis of the gut microbiota correlates with MAs. This study provided insights into the potential change of gut microbiota of MAs and the potential underlying mechanisms through certain impaired lipid metabolism and aroused inflammation pathways. Comprehensive insights regarding gut microbiota may facilitate improved understanding and the development of novel therapeutic and preventive strategies for MAs.

Treatment options for the overactive bladder syndrome

Therapy ◽  
2005 ◽  
Vol 2 (6) ◽  
pp. 921-936
Author(s):  
Hashim Hashim ◽  
Paul Abrams
Keyword(s):  
Overactive Bladder ◽  
Treatment Options ◽  
Overactive Bladder Syndrome

HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Sri Evi New Yearsi Pangadongan ◽  
Agustina Rahyu ◽  
Selvy Pasulu
Keyword(s):  
Cigarette Smoke ◽  
Bronchial Asthma ◽  
Sampling Technique ◽  
Total Sample ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Weather Changes ◽  
And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke  and history of family sickness with bronchial asthma incident to child 5 – 10  years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

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