scholarly journals Peri-Surgical Inflammatory Profile Associated with Mini-Invasive or Standard Open Lumbar Interbody Fusion Approaches

2021 ◽  
Vol 10 (14) ◽  
pp. 3128
Author(s):  
Giovanni Lombardi ◽  
Pedro Berjano ◽  
Riccardo Cecchinato ◽  
Francesco Langella ◽  
Silvia Perego ◽  
...  
Keyword(s):  
Interbody Fusion ◽  
Venous Blood ◽  
Innate Immune ◽  
Surgical Approaches ◽  
Lumbar Interbody Fusion ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hematological Markers ◽  
Inflammatory Profile ◽  
Definition Of

Background: Different surgical approaches are available for lumbar interbody fusion (LIF) to treat disc degeneration. However, a quantification of their invasiveness is lacking, and the definition of minimally invasive surgery (MIS) has not been biochemically detailed. We aimed at characterizing the inflammatory, hematological, and clinical peri-surgical responses to different LIF techniques. Methods: 68 healthy subjects affected by single-level discopathy (L3 to S1) were addressed to MIS, anterior (ALIF, n = 21) or lateral (LLIF, n = 23), and conventional approaches, transforaminal (TLIF, n = 24), based on the preoperative clinical assessment. Venous blood samples were taken 24 h before the surgery and 24 and 72 h after surgery to assess a wide panel of inflammatory and hematological markers. Results: martial (serum iron and transferrin) and pro-angiogenic profiles (MMP-2, TWEAK) were improved in ALIF and LLIF compared to TLIF, while the acute phase response (C-reactive protein, sCD163) was enhanced in LLIF. Conclusions: MIS procedures (ALIF and LLIF) associated with a reduced incidence of post-operative anemic status, faster recovery, and enhanced pro-angiogenic stimuli compared with TLIF. LLIF associated with an earlier activation of innate immune mechanisms than ALIF and TLIF. The trend of the inflammation markers confirms that the theoretically defined mini-invasive procedures behave as such.

scholarly journals Innate Immune Cells and C-Reactive Protein in Acute First-Episode Psychosis and Schizophrenia: Relationship to Psychopathology and Treatment

2019 ◽  
Author(s):  
Johann Steiner ◽  
Thomas Frodl ◽  
Kolja Schiltz ◽  
Henrik Dobrowolny ◽  
Roland Jacobs ◽  
...  
Keyword(s):  
Innate Immunity ◽  
First Episode Psychosis ◽  
Innate Immune ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
C Reactive Protein ◽  
Activation Markers ◽  
Reactive Protein ◽  
Immune System Activation ◽  
Episode Psychosis

Abstract Innate immunity has been linked to initiation of Alzheimer’s disease and multiple sclerosis. Moreover, risk of first-episode psychosis (FEP) and schizophrenia (Sz) is increased after various infections in predisposed individuals. Thus, we hypothesized an analogous role of innate immunity with increased C-reactive protein (CRP) in non-affective psychosis. Differential blood count, CRP, neutrophil and monocyte–macrophage activation markers, cortisol and psychotic symptoms (Positive and Negative Syndrome Scale [PANSS]) were assessed in controls (n = 294) and acutely ill unmedicated FEP (n = 129) and Sz (n = 124) patients at baseline and after 6 weeks treatment. Neutrophils, monocytes, and CRP were increased in patients vs controls at baseline (P < .001), and neutrophil and monocyte counts correlated positively with activation markers. Eosinophils were lower at baseline in FEP (P < .001) and Sz (P = .021) vs controls. Differences in neutrophils (P = .023), eosinophils (P < .001), and CRP (P < .001) were also present when controlling for smoking and cortisol, and partially remitted after antipsychotic treatment. FEP patients with high neutrophils (P = .048) or monocytes (P = .021) had higher PANSS-P scores at baseline but similar disease course. CRP correlated with PANSS-P at baseline (ρ = 0.204, P = .012). Improvement of positive symptoms after treatment correlated with declining neutrophils (ρ = 0.186, P = .015) or CRP (ρ = 0.237, P = .002) and rising eosinophils (ρ = −0.161, P = .036). In FEP, normalization of neutrophils (ρ = −0.231, P = .029) and eosinophils (ρ = 0.209, P = .048) correlated with drug dosage. In conclusion, innate immune system activation correlated with PANSS-P, supporting the immune hypothesis of psychosis. Neutrophil and monocyte counts and CRP levels may be useful markers of disease acuity, severity, and treatment response.

scholarly journals Diagnostic, Surgical, and Technical Considerations for Lumbar Interbody Fusion in Patients with Osteopenia and Osteoporosis: A Systematic Review

2021 ◽  
Vol 11 (2) ◽  
pp. 241
Author(s):  
Sauson Soldozy ◽  
Samuel R. Montgomery ◽  
Danyas Sarathy ◽  
Steven Young ◽  
Anthony Skaff ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cortical Bone ◽  
Interbody Fusion ◽  
Surgical Approaches ◽  
Ageing Population ◽  
Lumbar Interbody Fusion ◽  
Mineral Density ◽  
Hounsfield Units ◽  
Spine Surgeon ◽  
Technical Considerations

Objective: Osteoporosis is increasing in incidence as the ageing population continues to grow. Decreased bone mineral density poses a challenge for the spine surgeon. In patients requiring lumbar interbody fusion, differences in diagnostics and surgical approaches may be warranted. In this systematic review, the authors examine studies performing lumbar interbody fusion in patients with osteopenia or osteoporosis and suggest avenues for future study. Methods: A systematic literature review of the PubMed and MEDLINE databases was performed for studies published between 1986 and 2020. Studies evaluating diagnostics, surgical approaches, and other technical considerations were included. Results: A total of 13 articles were ultimately selected for qualitative analysis. This includes studies demonstrating the utility of Hounsfield units in diagnosis, a survey of surgical approaches, as well as exploring the use of vertebral augmentation and cortical bone screw trajectory. Conclusions: This systematic review provides a summary of preliminary findings with respect to the use of Hounsfield units as a diagnostic tool, the benefit or lack thereof with respect to minimally invasive approaches, and the question of whether or not cement augmentation or cortical bone trajectory confers benefit in osteoporotic patients undergoing lumbar interbody fusion. While the findings of these studies are promising, the current state of the literature is limited in scope and, for this reason, definitive conclusions cannot be drawn from these data. The authors highlight gaps in the literature and the need for further exploration and study of lumbar interbody fusion in the osteoporotic spine.

Acute Effects of Accumulating Exercise on Postprandial Lipemia and C-Reactive Protein Concentrations in Young Men

2009 ◽  
Vol 19 (6) ◽  
pp. 569-582 ◽  
Author(s):  
Masashi Miyashita ◽  
Stephen F. Burns ◽  
David J. Stensel
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Venous Blood ◽  
Postprandial Lipemia ◽  
Area Under The Curve ◽  
Acute Effects ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Crp ◽  
Postprandial Triacylglycerol

The current study investigated the acute effects of accumulating short bouts of running on circulating concentrations of postprandial triacylglycerol (TAG) and C-reactive protein (CRP). Ten men, age 21–32 yr, completed two 1-d trials. On 1 occasion participants ran at 70% of maximum oxygen uptake in six 5-min bouts (i.e., 8:30, 10, and 11:30 a.m. and 1, 2:30, and 4 p.m.) with 85 min rest between runs. On another occasion participants rested throughout the day. In both trials, participants consumed test meals at 9 a.m. and 12 p.m. In each trial, venous blood samples were collected at 8:30, 10, and 11:30 a.m. and 1, 2:30, 4, and 5:30 p.m. for plasma TAG measurement and at 8:30 a.m. and 5:30 p.m. for serum CRP measurement. Total area under the curve for plasma TAG concentration versus time was 10% lower on the exercise trial than the control trial (M ± SEM: 13.5 ± 1.8 vs. 15.0 ± 1.9 mmol · 9 hr−1 · L−1; p = .004). Serum CRP concentrations did not differ between trials or over time. This study demonstrates that accumulating short bouts of running reduces postprandial plasma TAG concentrations (a marker for cardiovascular disease risk) but does not alter serum CRP concentrations.

Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity

1990 ◽  
Vol 79 (2) ◽  
pp. 161-165 ◽  
Author(s):  
A. M. Cruickshank ◽  
W. D. Fraser ◽  
H. J. G. Burns ◽  
J. Van Damme ◽  
A. Shenkin
Keyword(s):  
Interleukin 6 ◽  
Elective Surgery ◽  
Venous Blood ◽  
Surgical Trauma ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Duration Of Surgery ◽  
Minor Surgery ◽  
Protein Response ◽  
Major Vascular Surgery

1. Recent studies have suggested that interleukin-6 is a major mediator of the acute-phase protein response in man. The aim of the present study was to investigate the relationships between the response of serum interleukin-6 to surgery, the type of surgical procedure performed and the response of serum C-reactive protein. 2. Timed venous blood samples were taken from 26 patients in five broad surgical categories (minor surgery, cholecystectomy, hip replacement, colorectal surgery and major vascular surgery). C-reactive protein and interleukin-6 were measured in each sample. 3. Serum interleukin-6 rose within 2–4 h of incision in all patients and the magnitude of the response differed among the various surgical groups. The response of interleukin-6 correlated (r = 0.80, P < 0.001) with the duration of surgery. In contrast, serum C-reactive protein was not detectable after minor surgery (< 10 mg/l) and the response of C-reactive protein did not differ among the more major surgical groups. The response of interleukin-6 showed a weak, but significant, correlation with the response of C-reactive protein (r = 0.67, P < 0.001). 4. We conclude that serum interleukin-6 is a sensitive, early marker of tissue damage. In general, the greater the surgical trauma, the greater the response of serum interleukin-6 and the greater the peak serum concentration of interleukin-6. Our results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis.

scholarly journals Capella's gastroplasty: metabolites and early phase proteins changes in midline and bilateral arciform approaches

2004 ◽  
Vol 41 (4) ◽  
pp. 215-219 ◽  
Author(s):  
Luiz Gonzaga de Moura Jr. ◽  
Sérgio Botelho Guimarães ◽  
Heládio Feitosa de Castro-Filho ◽  
Heine Ferreira Machado ◽  
Francisca das Chagas Feijó ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Surgical Procedure ◽  
Metabolic Response ◽  
Ketone Bodies ◽  
Abdominal Cavity ◽  
Operating Time ◽  
Surgical Approaches ◽  
C Reactive Protein ◽  
Synthesis Time ◽  
Reactive Protein

BACKGROUND: Obesity has adverse health effects. Dietary reeducation does not seem to offer sustained weight loss. For appropriately selected patients, surgery may be beneficial. AIM: To evaluate early postoperative metabolic response to surgery in patients submitted to Capella's gastroplasty using two different surgical approaches to the abdominal cavity. PATIENTS/METHOD: Twenty patients (9 males and 11 females, aged 21 to 53 years) were randomized prior to submission to either one of the surgical access incisions (bilateral arciform or supra-umbilical midline incisions). Blood samples were collected at the beginning and end of the operation, 12 (T-12 h) and 24 hours (T-24 h) postoperatively. Dieresis and synthesis time, blood loss, planimetry of operative field, operative time, hospital stay, hemoglobin, hematocrit, lymphocytes, potassium, albumin, erythrocyte sedimentation rate, C-reactive protein, glucose, pyruvate, lactate and ketone bodies were analyzed. RESULTS: Dieresis time was significantly decreased when median approach was used. Total operating time, hospital stay, hematocrit, hemoglobin, lymphocyte count, potassium and albumin concentrations were similar in both groups. C-reactive protein (T-12 h), glucose and pyruvate concentrations (T-24 h) increased significantly after completion of surgical procedure. Ketone bodies concentrations were significantly decreased 24 hour following completion of surgical procedure. CONCLUSION: Capella's gastroplasty induces metabolic and inflammatory changes in blood parameters. There is no evidence of technical superiority of arciform over midline incisions in this study.

scholarly journals The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

2019 ◽  
Vol 69 (12) ◽  
pp. 3659-3663 ◽  
Author(s):  
Corina Eugenia Budin ◽  
Corina Marginean ◽  
Ioana Roxana Bordea ◽  
Liviu Sorin Enache ◽  
Elena Luminita Enache ◽  
...  
Keyword(s):  
Foster Care ◽  
Interleukin 6 ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Addictive Behaviors ◽  
C Reactive Protein ◽  
Entire Study ◽  
Daily Number ◽  
Reactive Protein ◽  
Inflammatory Profile

Foster care young people have an increased overall risk for the development of chronic health conditions.Smoking is a major risk factor for many conditions with inflammatory component. We performed a cross-sectional pilot study to assess the correlation between tobacco consumption status and inflammatory profile among adolescents living with foster parents in the central region of Romania. A number of 35 teenagers aged 10-18 were enrolled. Blood samples were collected by venipuncture for complete blood count (CBC), fibrinogen, Interleukin-6 (IL 6), C reactive protein (CRP). Exhaled CO was measured and urine samples were collected in the same session for cotinine assessment. Of the 123 teenagers initially enrolled, 35 completed the entire study protocol. Urinary cotinine accurately reflected smoker status. Smoking did not affect hemoglobin levels or other hematological parameters in foster care teenagers. The value of C-reactive protein was higher in smokers. Plasma fibrinogen correlated with the daily number of cigarettes. Interleukin-6 did not correlate with the smoker status or the daily number of cigarettes consumed. Our study highlights the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors.

scholarly journals The inflammatory profile of chronic kidney disease patients

2021 ◽  
Vol 5 (3) ◽  
pp. 107-111
Author(s):  
Chaker Hanen ◽  
Jarraya Faiçal ◽  
Toumi Salma ◽  
Kammoun Khawla ◽  
Mahfoudh Hichem ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Kidney Disease ◽  
Sedimentation Rate ◽  
Biological Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Inflammatory Profile

Background: Chronic kidney disease is a worldwide public health issue which is associated with an increased risk of end-stage renal failure and cardiovascular disease. Systemic inflammation exists during chronic renal failure. Recent researches have highlighted the pivotal role of inflammation between renal and cardiovascular disease. The aim of our study is to determine the inflammatory profile of the patient suffering from chronic kidney disease and the influence of hemodialysis on this profile. Methods: We carried out a cross sectional study on 93 patients in the Nephrology Department at Hedi Chaker University Hospital, Sfax, South of Tunisia. Among those patients, 72 patients underwent hemodialysis and 21 patients had chronic kidney disease at stage 3. Clinical data and antecedents were collected. Biological samples were taken after informing the patients and taking their consent. Biological data consisted in lipid profile, albumin rate, hemoglobin rate, uric acid concentration and the usual markers of inflammation noting sedimentation rate, C - reactive protein and orosomucoid. Results: Hemodialysis group of the 72 patients had mean hemodialysis vintage of 54.6 ± 43 months. The inflammatory profile was worse in hemodialysis patients compared to chronic kidney disease patients. Both sedimentation rate, C - reactive protein and orosomucoid were higher in hemodialysis group than in chronic kidney disease group with 71 ± 35.3 mm vs. 42.1 ± 15.5 mm (p < 0.05); 14.6 ± 28.7 mg/l vs. 6.7 ± 8 mg/l (p = 0.02); 1.3 ± 0.7g/l vs. 0.9 ± 0.4 g/l (p = 0.01), respectively. Conclusion: Inflammation increases in dialysis patient. It deserves the nephrologist’s consideration in order to minimize its harmful effects. The monitoring of inflammation markers must be integrated into the nephrologist’s medical practice.

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