scholarly journals Dienogest and the Risk of Reoperation in Endometriosis

2021 ◽  
Vol 11 (9) ◽  
pp. 924
Author(s):  
Yong-Soo Seo ◽  
Jin-Sung Yuk ◽  
Yong-Kyoon Cho ◽  
Ji-Yeon Shin
Keyword(s):  
Survival Analysis ◽  
Gnrh Agonist ◽  
Reoperation Rate ◽  
Control Group ◽  
Gynecological Surgery ◽  
Diagnosis Code ◽  
Control Groups ◽  
Group A ◽  
And Control ◽  
Reoperation Rates

Background: This retrospective cohort study aimed to determine whether there is a difference in reoperation rates between patients who used dienogest (DNG) and patients who did not use DNG. Methods: Using Health Insurance Review and Assessment Service (HIRA) data generated between 1 January 2010 and 30 June 2018, we identified women with an endometriosis diagnosis code who used GnRH agonists after gynecological surgery. Among them, women prescribed DNG were selected as the DNG group, and those who did not receive DNG were selected as the control group. A survival analysis of the reoperation between the two groups was performed. Results: DNG and control groups were extracted from 9735 people each. The reoperation rates were 0.4% and 0.6% in the DNG and control groups, respectively, without adjusting. In the Cox proportional risk analysis, DNG use increased the reoperation rate {hazard ratio (HR), 1.599; 95% confidence interval (CI), 1.005–2.545}. The site of endometriosis and the number of GnRH agonist injections were not associated with reoperation (HR, 1.008; 95% CI, 0.739–1.374; HR, 1.062; 95% CI, 0.690–1.635). In the subgroup survival analysis, according to the period between the last GnRH agonist injection and the first DNG dose, DNG did not increase the reoperation rates up to 9 months (~3 months: HR, 0.968; 95% CI, 0.551–1.699; 4~6 months: HR, 1.094; 95% CI, 0.58–2.063; 7~9 months: HR, 2.419; 95% CI, 0.735–7.962), but DNG increased the reoperation rate from 10 months onwards (10~12 months: HR, 3.826; 95% CI, 1.164–12.579 and ~13 months: HR, 8.436; 95% CI, 4.722–15.072). Conclusions: Women who used DNG had a higher endometriosis reoperation rate than women who did not use DNG. However, the initiation of DNG treatment within nine months after the last GnRH agonist injection did not affect the endometriosis reoperation rate.

scholarly journals Predicted Versus Non-Predicted Opioid Administration Using Preoperative Pain Sensitivity in Patients Undergoing Gynecological Surgery: A Randomized-Controlled Trial

2021 ◽  
Vol 10 (4) ◽  
pp. 585
Author(s):  
Sun-Kyung Park ◽  
Hansol Kim ◽  
Seokha Yoo ◽  
Won Ho Kim ◽  
Young-Jin Lim ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Sensitivity ◽  
Control Group ◽  
Gynecological Surgery ◽  
Control Groups ◽  
Preoperative Pain ◽  
Pain Scores ◽  
Pressure Pain Thresholds ◽  
Opioid Administration ◽  
And Control

Individualized administration of opioids based on preoperative pain sensitivity may improve postoperative pain profiles. This study aimed to examine whether a predicted administration of opioids could reduce opioid-related adverse effects after gynecological surgery. Patients were randomized to the predicted group or control group. Participants received a preoperative sensory test to measure pressure pain thresholds. Patients were treated with a higher or lower (15 or 10 μg/mL) dose of fentanyl via intravenous patient-controlled analgesia. The opioid dose was determined according to pain sensitivity in the predicted group, while it was determined regardless of pain sensitivity in the control group. The primary outcome was the incidence of nausea over the first 48 h postoperative period. Secondary outcomes included postoperative pain scores and opioid requirements. There was no difference in the incidence of nausea (40.0% vs. 52.5% in predicted and control groups, respectively; p = 0.191) and postoperative pain scores (3.3 vs. 3.5 in predicted and control groups, respectively; p = 0.691). However, opioid consumptions were lower in the predicted group compared to the control group (median 406.0 vs. 526.5 μg; p = 0.042). This study showed that offering a predicted dose of opioids according to pain sensitivity did not affect the incidence of nausea and pain scores.

scholarly journals The Application of Story Telling in Pre – School Children Towards Language Ability

2020 ◽  
Vol 9 (1) ◽  
pp. 183-189
Author(s):  
Mamik Ratnawati ◽  
Monika Sawitri Prihatini ◽  
Heni Maryati ◽  
Ririn Probowati ◽  
Fitri Firranda Nurmalisyah ◽  
...  
Keyword(s):  
School Children ◽  
Negative Impact ◽  
Language Skills ◽  
Control Group ◽  
Test Design ◽  
Story Telling ◽  
Control Groups ◽  
Post Test ◽  
Group A ◽  
And Control

The development of children under five is very important part. Various forms of disease, malnutrition, lack of and love stimulation at this age will lead a negative impact that persists until adulthood even to old age. The purpose of this study is to determine the differences in language skills of children with the treatment of story telling methods without story telling. The method this study used quasy experiment with pre test – post test design of treatment and control group. A sample of 50 children in the Nusantara and Kasih Bunda play ground in Sudimoro Village, Megaluh, Jombang. Sampling was carried out using a simple ramdom sampling. The results of study found that treatment group had an influence of story telling on language skills in pre-school children, whereas there were no differences in story telling of language skills in the treatment and control groups.  

scholarly journals Effect of Administration of Single Dose GnRH Agonist in Luteal Phase on Implantation Rate of Fresh ICSI Cycles

2021 ◽  
Vol 10 (2) ◽  
pp. 1-14
Author(s):  
Sally Alaa ◽  
Nadia Al-Hilli ◽  
Mufeda Jwad
Keyword(s):  
Gnrh Agonist ◽  
Luteal Phase ◽  
Implantation Rate ◽  
Control Group ◽  
Blood Levels ◽  
Control Groups ◽  
Cleavage Rate ◽  
And Control ◽  
Implantation And Pregnancy Rates ◽  
Metaphase Ii Oocytes

The luteal phase (LP) in the fresh ICSI cycle is insufficient, adequate LP support is one of the approved treatments for improving implantation and pregnancy rates. It is generally known that the LP is inadequate after ovarian stimulation due to negative from supra-physiological blood levels of steroids released by numerous corporal luteal, LH concentrations are low during the luteal phase. In this study, patients were divided into two groups: (40) patients as study group; those who received GnRHa (Decapeptil 0.1 mg), three days after embryo transfer, in addition to conventional luteal phase support (LPS) in the LP to increase the implantation and pregnancy rate in IVF; and their control group (40) received standard LPS only. On the second day of stimulation, blood samples for FSH, LH, TSH, E2, and prolactin were taken. On the day of ovulation induction, measure E2, progesterone, and LH; and on the day of embryo transfers, measure progesterone and LH. The overall characteristics of the patients in both groups were not significantly different. There was also no significant change in the number of total oocytes, mean of metaphase II oocytes percent, cleavage rate, grade I embryo percent, or serum hormones level between the study and control groups (p > 0.05). GnRH agonist treatment in the luteal phase improves clinical pregnancy and implantation rate in fresh ICSI cycles but is not statistically significant.

scholarly journals A High Protein Model Alters the Endometrial Transcriptome of Mares

Genes ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 576 ◽  
Author(s):  
Boakari ◽  
Ali ◽  
Dini ◽  
Loux ◽  
Fernandes ◽  
...  
Keyword(s):  
Ion Homeostasis ◽  
Control Group ◽  
P Value ◽  
Epithelial Tissue ◽  
Control Groups ◽  
Urea Treatment ◽  
Protein Model ◽  
Group A ◽  
Urea Group ◽  
And Control

High blood urea nitrogen (BUN) decreases fertility of several mammals; however, the mechanisms have not been investigated in mares. We developed an experimental model to elevate BUN, with urea and control treatments (7 mares/treatment), in a crossover design. Urea-treatment consisted of a loading dose of urea (0.03 g/kg of body weight (BW)) and urea injections over 6 hours (0.03 g/kg of BW/h). Control mares received the same volume of saline solution. Blood samples were collected to measure BUN. Uterine and vaginal pH were evaluated after the last intravenous infusion, then endometrial biopsies were collected for RNA-sequencing with a HiSeq 4000. Cuffdiff (2.2.1) was used to identify the differentially expressed genes (DEG) between urea and control groups (false discovery rate-adjusted p-value < 0.1). There was a significant increase in BUN and a decrease of uterine pH in the urea group compared to the control group. A total of 193 genes were DEG between the urea and control groups, with five genes identified as upstream regulators (ETV4, EGF, EHF, IRS2, and SGK1). The DEG were predicted to be related to cell pH, ion homeostasis, changes in epithelial tissue, and solute carriers. Changes in gene expression reveal alterations in endometrial function that could be associated with adverse effects on fertility of mares.

scholarly journals The Effects of Some Drugs Used to Treat Honeybee (Apis mellifera L.) Diseases and Pests on Lifespan of Honeybees

2017 ◽  
Vol 5 (7) ◽  
pp. 720
Author(s):  
Duran Özkök ◽  
Ethem Akyol
Keyword(s):  
Statistical Analysis ◽  
Apis Mellifera ◽  
Variance Analysis ◽  
Control Group ◽  
Analysis Method ◽  
Control Groups ◽  
Average Lifespan ◽  
Group A ◽  
Observation Hive ◽  
And Control

This study was conducted to determine the effects of Bayvarol®, Fumidil-B®, Neo-Terramycin® on adult honeybee lifespan. Total twenty honeybee colonies were used and randomly divided into four groups (each group consisted of five colonies). Experimental groups: Bayvarol ®, Fumidil-B® and Neo-Terramycin® were treated to first, second and third groups, respectively. No treatment was done to forth group taken as control group. A hundred one day old worker bees were taken from each group and marked with different colors and numbered on the thorax. After the marked, all worker bees were given into the observation hive. Marked worker bees were controlled and counted daily. Statistical analysis of data was done by variance analysis method and between groups comparisons were done with Duncan's multiple range tests. Average lifespans of the first, second, third and control groups were 44.97±4.90, 46.86±6.56, 45.38±6.12 and 47.72±6.06 days, respectively. There were found statistically significant differences among average lifespan of first, second, third and control groups (P

scholarly journals IMPROVEMENT OF WRITING SKILLS USING ACTIVITY BASED METHOD OF LEARNING AT GRADE-VI

2018 ◽  
Vol 57 (1) ◽  
pp. 17-27
Author(s):  
Zahoor Ul-Haq ◽  
Bushra Ahmed Khurram
Keyword(s):  
Writing Skills ◽  
Teaching Writing ◽  
Elementary Level ◽  
Control Group ◽  
Control Groups ◽  
Government School ◽  
Post Test ◽  
Group A ◽  
And Control ◽  
Experimental Group

This study was undertaken to investigate the outcome of using the activity based learning method on the development of writing skills of students of grade 6. The study used pretest post-test equivalent group design. 50 students were randomly selected from a government school as sample for this study. They were divided into experimental and control groups based on the scores they achieved in pre-test. Students in the experimentalgroup received instruction through activity based method of learning. In contrast, the traditional method of teaching writing was used for teaching the control group. A comparison of pre- and post-test scores on writing measure evidenced that the experimental group performed better that the control group on writing post-test. It was concluded that activities helped enhance the writing skills of the experimental group. This finding suggests that students of elementary level should be engaged in activity based learning to enhance their writing skills.

scholarly journals “Breakfast Time” Model to Improve Knowledge, Nutritional Status, Nutrient Consumption, BMI, and Hb Level of Female Students Suffering from Anemia at SMAN 7 Mataram

2018 ◽  
Vol 2 (11) ◽  
Author(s):  
Yuli Laraeni ◽  
Irianto Irianto ◽  
Abdul Salam
Keyword(s):  
Folic Acid ◽  
Female Students ◽  
Control Group ◽  
Control Groups ◽  
Time Model ◽  
Nutrient Consumption ◽  
Quasi Experimental ◽  
Group A ◽  
Randomized Control ◽  
And Control

Intruduction: SMAN 7 Mataram was ranked first as the school with the highest number of female students suffering from anemia (68.4%). This research aimed to observe “breakfast time” model to improve knowledge, nutrient consumption, and Hb level of female students at SMAN 7 Mataram. Methods: It was quasi experimental research using randomized control group a pretest-posttest design. There were 20 samples (saturation sampling) grouped into two: experimental and control groups (ten students in each group). Results: Based on the result of univariate and bivariate analyses on variables studied i.e. knowledge, Hb level, and nutrient consumption consisting of energy, protein, fat, carbohydrate, Vitamin A, Vitamin C, folic acid, and Zink; after breakfast time model was implemented, there were significant effects on the student Hb level. Its average 11.2 gr% increased to 12.7 gr% (p

scholarly journals The Effects of Topical Olive Oil on the Pain Intensity among Patients with Knee Osteoarthritis

2021 ◽  
pp. 33-38
Author(s):  
Abas Ghaysouri ◽  
Golbahar Iri ◽  
Amirhosein Meisami ◽  
Milad Borji ◽  
Behrouz Soltany
Keyword(s):  
Knee Osteoarthritis ◽  
Pain Intensity ◽  
Olive Oil ◽  
Control Group ◽  
Control Groups ◽  
Group A ◽  
The Mean ◽  
And Control ◽  
Experimental Group ◽  
Scale Data

Given the importance of relieving pain and disability experienced by the patients, the present study aimed to study the Effects of topical olive oil on the pain intensity among patients with knee osteoarthritis. The patients were randomly assigned into the experimental (28 patients) and control groups (27 patients). Firstly, in tropical olive oil (TOO) group, a high-quality olive oil, branded as Famila was used and in the control group, Diclofenac gel was applied. In experimental groups, 5 drops of herbal oils were applied to the knee thrice a day at morning, noon and evening and the knees were covered with a nylon sheet for more absorption. The patients were followed up for 4 weeks and their capability and pain intensities were evaluated prior the study, during the first week, the second week and the fourth week with Visual Analogue Scale. Data were analyzed using descriptive and analytical tests by SPSS V. 16 software. According to the findings, also the Mean (SD) pre-intervention Pain score in experimental group A was 8.10(0.91), which decreased to 1.78(0.78) after the intervention and in the control group from 8.55(0.69) to 3.85(0.98). Due to the greater effect of olive oil compared to Diclofenac gel on reducing pain of patients with KOA, it is recommended that patients use olive oil. Further studies are also recommended.

scholarly journals Evaluation of Gamavit effectiveness for correction of renal anemia in cats with chronic kidney disease: a controlled randomized study

2020 ◽  
Vol 2020 (5) ◽  
pp. 8-20
Author(s):  
Roman Leonard ◽  
Tat'yana Zaripova ◽  
Aleksandr Balahonov ◽  
Natal'ya Vdovina ◽  
Aleksandr Narovlyanskiy ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Renal Anemia ◽  
Control Group ◽  
Control Groups ◽  
Ckd Stage ◽  
Group A ◽  
And Control ◽  
Experimental Group ◽  
Stimulation Of

Renal anemia is one of the most common complications of chronic kidney disease (CKD) in cats, which significantly reduces their life quality. Most often, the mechanism of renal anemia development is associated with insufficiency of endogenous erythropoietin (EPO), or with a reduction in the life of red blood cells caused by uremic intoxication. Since anemia increases the severity of renal hypertension and other CKD symptoms, the search for effective drugs that can stimulate erythropoiesis in CKD and do not have nephrotoxic properties is particularly relevant. The aim of the work was to study the effectiveness of Gamavit in the treatment regimen for cats with CKD compared with the standard treatment protocol. Active ingredients of Gamavit are sodium nucleinate and denaturated placenta extract. The study included 20 cats of different breeds aged from 5 to 16 years with CKD stage III-IV according to the IRIS classification, accompanied by anemia and a decrease in hematocrit in the range from 25 to 16%. Patients were randomly divided into 2 equal groups - control (n=10) and experimental (n=10) using the block randomization method. In the control group a standard nephroprotective therapy regimen was used. In the experimental group Gamavit was added to the standard regimen. Gamavit was administered at a dose of 0.5 ml/kg 1 time per day, at the same time, during 14 consecutive days (7 days i/v and 7 days s/c). The conditions for feeding and keeping animals of the experimental and control groups were identical. For feeding, we used a standardized serial diet ― Purina CatChow Adult with chicken/turkey/salmon. Access to drinking water ― ad libitum. The initial number of red blood cells, as well as the hematocrit index and hemoglobin level in the experimental and control groups were at the lower limit of the norm or below the reference values. During the study, in the experimental group of the patients, these indicators returned to normal after 2 weeks, while in the control group there were no significant changes. The statistically significant difference between the experimental and control groups remained until the end of the observation (p=0.001). Levels of creatinine and urea in the blood serum of the patients of both groups consistently high throughout the study, but in the experimental group a significant decrease in these indicators was found. The initial level of EPO in both groups was significantly lower than in healthy cats. During the experiment, it was not possible to reach the lower limit of the normal value, which allows us to conclude that the stimulation of erythropoiesis indicators in the experimental group, observed under the influence of Gamavit, is not associated with the stimulation of endogenous EPO production. Thus, the study revealed that Gamavit stimulates erythropoiesis in cats with CKD stage III-IV, significantly increasing the number of red blood cells, and the levels of hematocrit and hemoglobin. This effect, combined with a decrease in uremic intoxication values (creatinine and urea levels), lead to an improvement in the general condition of patients and regression in a number of important clinical manifestations. Since no nephrotoxic effects and undesirable interactions with drugs of standard nephroprotective therapy were detected in the process of this study, Gamavit can be recommended for widespread use in cats as one of the pathogenetic, symptomatic, and therapeutic and prophylactic drugs in the complex therapy of CKD at the preclinical and clinical stages of the disease.

scholarly journals Efficacy of preoperative testosterone therapy in hypospadias: a systematic review and meta-analysis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Gozali Sembiring ◽  
Yacobda Sigumonrong
Keyword(s):  
Meta Analysis ◽  
Reoperation Rate ◽  
Cochrane Library ◽  
Control Group ◽  
Control Groups ◽  
Testosterone Treatment ◽  
Meatal Stenosis ◽  
Significant Difference ◽  
And Control ◽  
The Impact

Abstract Background Bleeding, hematoma, edema, wound infection, and scar formation are the common problems linked with hypospadias reconstruction. Hormone treatment is recommended before surgical treatment to improve intraoperative circumstances. However, no meta-analysis has explored the effectiveness and side effects of testosterone treatment before surgery in hypospadias. Main body of the abstract The purpose of this paperwork is to evaluate the impact of preoperative testosterone treatment in hypospadias based on clinical data from published trials. This study searched MEDLINE, Science Direct, and the Cochrane Library without regard to year. However, only English journals were included, with a manual search using the Preferred Reporting Items for Systematic Reviews and Meta-analysis of Observational Studies in Epidemiology Guidelines supplementing the search. In this meta-analysis, five papers were considered. Two of these investigations were multicenter randomized clinical trials. Two of the studies were prospective, with a median follow-up of varying lengths. A retrospective investigation was conducted. There were 585 patients in all that took part in this trial. After surgery, the complication rate was measured in both the intervention and control groups, including meatal stenosis, fistula, glans dehiscence, scarring, reoperation rate, urethral diverticulum, fine pubic hair, and sexual precocity. The only significant difference between the intervention and control groups was that the intervention group had a decreased frequency of glans dehiscence following surgery (OR 0.40 with the 95% CI of 0.17 until 0.97). Conclusions This study discovered that a patient who got testosterone before surgery had a considerably decreased complication risk for glandular dehiscence. Reoperation rate, urethral-cutaneous fistula, meatal stenosis, and penile scarring in children with hypospadias, on the other hand, revealed no significant difference in the testosterone-treated group against the control group.

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