Assessment of the Soft-Tissue Seal at the Interface between the Base of the Fixed Denture Pontic and the Oral Mucosa

Fixed dentures (bridges) are often selected as a treatment option for a defective prosthesis. In this study, we assess the contact condition between the base of the pontic and oral mucosa, and examine the effect of prosthetic preparation and material biocompatibility. The molars were removed and replaced with experimental implants with a free-end type bridge superstructure after one week. In Experiment 1, we assessed different types of prosthetic pre-treatment: (1) the untreated control group (Con: mucosa recovering from the tooth extraction); (2) the laser irradiation group (Las: mucosa recovering after the damage caused by a CO2 laser); and (3) the tooth extraction group (Ext: mucosa recovering immediately after the teeth extraction). In Experiment 2, five materials (titanium, zirconia, porcelain, gold-platinum alloy, and self-curing resin) were placed at the base of the bridge pontic. Four weeks after the placement of the bridge, the mucosa adjacent to the pontic base was histologically analyzed. In Experiment 1, the Con and Las groups exhibited no formation of an epithelial sealing structure on the pontic base. In the Ext group, adherent epithelium was observed. In Experiment 2, the sealing properties at the pontic interface were superior for titanium and the zirconia compared with those made of porcelain or gold-platinum alloy. In the resin group, a clear delay in epithelial healing was observed.

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Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502006000300009 ◽

2006 ◽

Vol 21 (3) ◽

pp. 168-176 ◽

Cited By ~ 6

Author(s):

Míriam Elias Cavallini ◽

Nelson Adami Andreollo ◽

Konradin Metze ◽

Marina Raquel Araújo

Keyword(s):

Gastric Mucosa ◽

Microscopic Analysis ◽

Control Group ◽

Average Weight ◽

Gastric Cytoprotection ◽

Microscopic Studies ◽

Group A ◽

Ad Libitum ◽

Pre Treatment ◽

Group B

PURPOSE: To evaluate and to compare macro and microscopically the intense injuries of the gastric mucosa of rats which were caused by NSAIDS celecoxib and indomethacin and the gastric cytoprotection with omeprazole and misoprostol. METHODS: The sample is formed by one hundred and fifty Wistar rats with average weight 200 g, distributed in four groups, such as: Group A, subdivided in groups A1 and A2 - pre-treatment with omeprazole (20 mg/rat) during seven days and on the 8th day - use of NSAIDS, concerning A1 (20 rats) were given celecoxib (1mg/rat) and A2 (20 rats) were given indomethacin. The Group B, subdivided in group B1 and B2 - pre-treatment with misoprostol (20mg/rat) during seven days and on the 8th day use of NSAIDS, concerning B1 (20 rats) were given celecoxib (1 mg/ rat) and B2 (20 rats) were given indomethacin (12.5 mg/rat). The Group C: were not given cytoprotection during seven days, from the 7th to the 8th day - fast of food and water ad libitum, on the 8th day of NSAIDS use, concerning C1 (20 rats) were given celecoxib, C2 (20 rats) were given indomethacin (12.5 mg/ rat), C3 (20 rats) were given celecoxib (200mg/rato), and Group D - control group, concerning 10 rats were observed during seven days ingesting food and water ad libitum. On the 9th day, the stomachs were taken out and were macro and microscopically evaluated for the identification of the gastric injuries. RESULTS: On the macroscopic studies, the groups A2, B2 and C2 presented a remarkable high number of injuries for cm² /animal, respectively 18.55 injuries for cm² /animal, 16.25 injuries for cm² /animal and 13.55 injuries for cm²/animal. On the microscopic studies, the percentage of the injured mucosa, presented expressive difference among the groups A1, B1, C1 when compared to the groups A2, B2, C2 (p<0.0001). The average of the length/injury and the average of the depth of the injuries did not present expressive statistics differences among the groups A2, B2 and C2. The average of the edema presented expressive statistics difference among the groups A2 and D; B2 and C2 and between C2 and D (p < 0.05). CONCLUSIONS: The indomethacin on the applied concentration causes a great number of macroscopic and microscopic injuries to gastric mucosa of rats when compared to celecoxib which does not cause lesions. Omeprazole and misoprostol on the applied concentrations do not present macroscopic and microscopic effectiveness on the gastric cytoprotection when applying indomethacin. Considering the microscopic analysis of the average of the edema, the group of animals, which was given misoprostol as cytoprotection, presented a lower average compared to the group which was given omeprazole.

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Alleviation of doxorubicin-induced nephrotoxicity by Clerodendrum volubile leaf extract in Wistar rats: A preliminary study

Journal of Herbmed Pharmacology ◽

10.34172/jhp.2020.18 ◽

2020 ◽

Vol 9 (2) ◽

pp. 138-144 ◽

Cited By ~ 1

Author(s):

Olorunfemi Raphael Molehin

Keyword(s):

Leaf Extract ◽

Renal Damage ◽

Renal Toxicity ◽

Methanolic Extract ◽

Male Rats ◽

Control Group ◽

Antioxidant Parameters ◽

Group A ◽

Preliminary Study ◽

Pre Treatment

Introduction: Doxorubicin (DOX), a well-known chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal toxicity. This preliminary study was designed to investigate the ameliorative effects of methanolic leaf extract of Clerodendrum volubile (MECV) against DOX-induced nephrotoxicity in rats. Methods: Thirty male rats were divided into five groups; (a) Control group: rats were given 0.9% NaCl as vehicle, (b) DOX group: a single dose of DOX (25 mg/kg; i.p.) was administered and the rats were sacrificed 4 days after DOX injection, (c-e) Methanolic extract of C. volubile (MECV)-treated DOX groups: rats were given MECV (at the doses of 125, 250 and 500 mg/kg/d), respectively for 12 consecutive days, 8 days before and 4 days after the DOX administration. Results: DOX injection caused a significant increase (P<0.05) in serum creatinine and urea levels. The levels of renal antioxidant parameters: glutathione peroxidase, superoxide dismutase (SOD), catalase (CAT) and reduced glutathione were significantly (P<0.05) decreased in DOX-intoxicated rats with concomitant elevation of malondialdehyde level. Pretreatment with MECV restored antioxidant status, attenuated oxidative stress and improved kidney function markers. Pre-treatment with MECVprotected renal tissues against DOX-induced nephrotoxicity. Conclusion: The ameliorative effects of C. volubile leaves on these renal biochemical parameters may be via its antioxidant action and may serve as a novel combination agent with DOX to limit its renal damage.

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A Comparison of Acupuncture with Advice and Exercises on the Symptomatic Treatment of Osteoarthritis of the Hip – a Randomised Controlled Trial

Acupuncture in Medicine ◽

10.1136/aim.19.1.19 ◽

2001 ◽

Vol 19 (1) ◽

pp. 19-26 ◽

Cited By ~ 35

Author(s):

Roisin Haslam

Keyword(s):

Controlled Trial ◽

Randomised Trial ◽

Symptomatic Treatment ◽

Post Treatment ◽

Control Group ◽

Group A ◽

Pre Treatment ◽

Group B ◽

Randomised Controlled

Acupuncture is becoming a common technique within the physiotherapy profession as a treatment modality for pain relief; however, few randomised controlled trials have been undertaken to assess the effectiveness of acupuncture, particularly in the treatment of osteoarthritis (OA) of the hip. Therefore, a randomised trial to compare the effectiveness of acupuncture with advice and exercises on the symptomatic treatment of OA of the hip was carried out. Thirty-two patients awaiting a total hip arthroplasty were randomly allocated to either the experimental group, (A), to have six sessions of acupuncture each lasting up to 25 minutes, or the control group, (B), to be given advice and exercises for their hip over a six week period. Group A consisted of three men and 13 women, and group B consisted of four men and eight women. The average age in group A was 66 years and in group B it was 68 years. Patients were assessed for pain and functional ability, using a modified version of the WOMAC questionnaire, pre-treatment, immediately post-treatment and at eight weeks post-treatment. The pre-treatment WOMAC scores in the two groups were similar (p=0.85). There was a significant improvement in group A (decrease in WOMAC score) immediately post-treatment (p=0.002) and this was maintained at the eight-week follow-up (p=0.03). There were no significant changes in group B. When the changes in WOMAC scores were compared between groups, a significantly greater improvement was found between pre-treatment and immediately post-treatment in group A, compared with group B (p=0.02). The changes between pre-treatment and the eight-week follow-up also showed a significant improvement in group A compared with group B (p=0.03). In conclusion, this trial supports the hypothesis that acupuncture is more effective than advice and exercises in the symptomatic treatment of OA of the hip.

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The use of a probiotic in captive cheetahs (Acinonyx jubatus)

Journal of the South African Veterinary Association ◽

10.4102/jsava.v77i3.359 ◽

2006 ◽

Vol 77 (3) ◽

Cited By ~ 7

Author(s):

K.N. Koeppel ◽

H. Bertschinger ◽

M. Van Vuuren ◽

J. Picard ◽

J. Steiner ◽

...

Keyword(s):

Treatment Period ◽

Bacterial Infections ◽

Healthy Adult ◽

Control Group ◽

Acinonyx Jubatus ◽

Probiotic Group ◽

Group A ◽

Pre Treatment ◽

Group 2 ◽

Species Specific

Juvenile captive cheetahs (Acinonyx jubatus) often present with diarrhoea that is commonly associated with bacterial infections. A species-specific probiotic containing Lactobacillus Group 2 and Enterococcus faecium was prepared from healthy adult cheetahs. Juvenile cheetahs (n = 27) between 8 and 13 months of age were included in the probiotic trial. The animals were observed prior to and after feeding of the probiotic which was made available for 28 days. Feeding of the probiotic resulted in a significantly increased body weight in the treatment group (P = 0.026), while there was no increase in the control group. A relative improvement in the faecal quality in the probiotic group during the treatment period compared with the pre-treatment (P = 0.0363) and post-treatment (P = 0.004) period was observed. This was accompanied by an absence of blood and mucus in the faeces during the treatment period in the probiotic group.

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New Materials for Orthodontic Interceptive Treatment in Primary to Late Mixed Dentition. A Retrospective Study Using Elastodontic Devices

Materials ◽

10.3390/ma14071695 ◽

2021 ◽

Vol 14 (7) ◽

pp. 1695 ◽

Cited By ~ 1

Author(s):

Grazia Fichera ◽

Stefano Martina ◽

Giuseppe Palazzo ◽

Rosaria Musumeci ◽

Rosalia Leonardi ◽

...

Keyword(s):

Treated Group ◽

Mixed Dentition ◽

Control Group ◽

Clinical Perspective ◽

New Materials ◽

Digital Impressions ◽

Lateral Cephalograms ◽

Group A ◽

Pre Treatment ◽

Dental Crowding

The aim of this study was to assess the skeletal and dentoalveolar changes obtained after 1 year of treatment with elastodontic appliances (EA) in a retrospective cohort of children reporting early signs of malocclusion. Also, a detailed description of the tested EAs was reported. The study sample included 20 subjects, 8 males and 12 females, with a mean age of 8.4 ± 0.6 years, and a control group consisting of 20 subjects, 9 males and 11 females, with a mean age of 8.1 ± 0.8 years. All subjects in the treated group received the AMCOP second class (SC) (Ortho Protec, Bari, Italy) device. Digital impressions were taken along with a digital bite registration in centric relation before treatment (T0) and after 1 year (T1). Lateral cephalograms were also taken at T0 and T1 and cephalometric analysis was performed to assess the skeletal sagittal changes of the maxilla and the mandible (sella, nasion, A point angle, SNA^; sella, nasion, B point angle, SNB^; and A point–nasion–B point angle, ANB^) as well as the changes of the inter-incisors angle (IIA^). In the treated group, the distribution of subjects according to the presence of crowding and the pattern of malocclusion changed at T1. In the same group, there was an increase of subjects showing no signs of crowding and a class I occlusal relationship, while in the control group, there was a small increase of subjects developing dental crowding and featuring a worse sagittal relationship (class II) compared to pre-treatment condition. A statistically significant reduction of the overjet and overbite was recorded in the treated group between T0 and T1 (p < 0.05); in the control group, a slight increase in the overjet and overbite was detected at T1, being this increment significanct only for the latter parameter. In the tested group, no significant differences were found between SNA^ values detected at T0 and T1 (p > 0.05), instead the SNB^, ANB^, and IIA^ showed a significant increase after 1 year of treatment (p < 0.05). From a clinical perspective, all clinical goals were reached since patients showed remarkable improvements in overjet, overbite, crowding, and the sagittal molar relationship. Within the limitations of the present study, EAs could be effectively used for the interceptive orthodontic in growing patients.

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The effects of feeding graded levels of whole cottonseed on semen characteristics and testicular profiles of Red Sokoto Bucks

Acta Scientiarum Animal Sciences ◽

10.4025/actascianimsci.v43i1.50990 ◽

2020 ◽

Vol 43 ◽

pp. e50990

Author(s):

Joy Iyojo Itodo ◽

Rekwot Peter Ibrahim ◽

Joseph Sankey Rwuaan ◽

Tanga Aluwong ◽

Bugau John Shiradiyi ◽

...

Keyword(s):

Control Diet ◽

Control Group ◽

Total Gossypol ◽

Semen Characteristics ◽

Group A ◽

The Mean ◽

Pre Treatment ◽

Whole Cottonseed ◽

C 30 ◽

Group D

The present work evaluated the effects of feeding graded levels of whole cottonseed on reproductive parameters of Red Sokoto bucks. Twenty Red Sokoto bucks were used for the experiment. After a 14-day pre-treatment period, bucks were assigned for 90 days to one of four isonitrogeneous treatments: control (diet A); 0 mg kg-1 of total gossypol, (diet B); 15% mg kg-1 of total gossypol, (diet C); 30% mg kg-1 of total gossypol and (diet D); 45% mg kg-1 of total gossypol. The mean percentage sperm gross motility was significantly (p < 0.05) lower in group D (45% WCS) compared to groups C (30% WCS) and A (control) at days 60, 75 and 90. The mean semen pH and reaction time were not significantly (p > 0.05) different among treatment groups. Semen colour of the bucks in the control group was majorly creamy, in group C (30% WCS) and B (15% WCS) creamy to milky and group D (45% WCS) colourless. The mean semen volume was significantly (p < 0.05) higher in groups C and A compared to group D (45% WCS) at days 60, 75 and 90. The mean semen concentration was significantly (p < 0.05) lower in group D (45% WCS) when compared to group A (control) at days 30, 45, 60, 75 and 90. Group A (control) bucks had significantly (p < 0.05) higher percentage live sperm compared to those in group D (45% WCS) at days 45, 60, 75 and 90. Mean Sperm morphological abnormalities including detached head, free tail curved tail and midpiece droplets were significantly (p < 0.05) higher in group D (45%) than in group A (Control) at day 15 (for free tails) and day 90 (for all). Testicular and epididymal sperm reserves were higher in animals supplemented with up to 30% whole cottonseed. In conclusion, feeding bucks above 30% WCS resulted in more deleterious effects on the semen characteristics and testicular profile.

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Effectivity of ozone water application on the socket after posterior tteeth extraction to accelerate clotting time phase

Majalah Kedokteran Gigi Indonesia ◽

10.22146/majkedgiind.42461 ◽

2021 ◽

Vol 6 (2) ◽

pp. 89

Author(s):

Isnandar Isnandar ◽

Rahmi Syaflida ◽

Abdullah Oes ◽

Yuni Nurul Fairuz

Keyword(s):

Tooth Extraction ◽

Control Group ◽

Water Application ◽

Clotting Time ◽

Chi Square ◽

Control Group Design ◽

Posterior Teeth ◽

Significant Difference ◽

Chi Square Test ◽

Teeth Extraction

After tooth extraction, dentists always place sterile tampons on the extracted socket to stop bleeding, to prevent infection and to reduce patients’ discomfort. Ozone is a biocompatible, bactericidal gas that can accelerate the healing of wounded soft tissue. In addition, it comes up with hemostasis effect to stop bleeding and may accelerate the clotting time and wound healing. Another advantage of ozone therapy is that it can be treated without making any trauma. The purpose of this research is to evaluate the effectivity of ozone water application in the socket to accelerate clotting time phase after posterior teeth extraction in 3 minutes, 6 minutes, and 10 minutes. This research was clinical experimental research with post-test only control group design. The research sampling was done through non-probability sampling. Then, sample was divided into two groups, each of which consisted of 15 patients treated with ozone tampons and 15 patients treated with sterile tampons after tooth extraction. Data were analyzed using chi-square test, and results showed a significant difference between the two groups. Ozone tampons show better result in accelerating clotting time after posterior teeth extraction than sterile tampons.

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The Effect of Ethanol Extract Of Sarang Semut Plant (Hypnophytum Formicarum) to Granulation Tissue for Wound Healing After Teeth Extraction Experimental Research on Marmot (Cavia cobaya)

UI Proceedings on Health and Medicine ◽

10.7454/uiphm.v1i0.28 ◽

2017 ◽

Vol 1 ◽

Author(s):

Efa Ismardianita ◽

Fitri Ellanda ◽

Suci Amalia Agus ◽

Sartika Amelia Putri

Keyword(s):

Wound Healing ◽

Granulation Tissue ◽

Tooth Extraction ◽

Ethanol Extract ◽

Control Group ◽

Tissue Formation ◽

Control Group Design ◽

Granulation Tissue Formation ◽

Group I ◽

Teeth Extraction

Tooth extraction is a common thing, more often after extraction patients have any complication, to prevent it, physician provide some drugs from chemicals that often give adverse effects, so that required for a safe substitute medicine, which derived from herbs. One of the herbs are often used by people in the Mentawai Islands is a sarang semut's root species of Hypnophytum formicarum jack. This study aimed to determine the effect of sarang semut’s extract orally for granulation tissue formation in wound healing after tooth extraction. This research is experimental with posttest only control group design. Subjects were 48-animal guinea pigs, were divided into 4 groups: group I (control 0.5% CMC, treatment group II, III, IV with 4,65mg, and 9.3 mg 6,2 mg dose tuber ethanol extract dissolved anthill in CMC 0.5%), were given 3 ml orally, 3 times a day until the day of decapitation. Early research conducted identification and phytochemical screening, this plant belongs to the species Hypnophytum formicarum jack, contain flavonoids, phenols, triterpenoids and tannins. The data was analyzed with non-parametric Kruskal-Wallis, to see the significance between doses used Mann-Whitney. The results showed that the extract of sarang semut effect (<em>p</em> < 0.05) on the formation of granulation system in wound healing after tooth extraction. The most effective concentration was 4.65 mg

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Influence of sheep breed and application site on the efficacy of a flumethrin pour-on formulation against ticks

Journal of the South African Veterinary Association ◽

10.4102/jsava.v72i3.637 ◽

2001 ◽

Vol 72 (3) ◽

Cited By ~ 1

Author(s):

L.J. Fourie ◽

D.J. Kok ◽

R.J. Peter

Keyword(s):

Sheep Breed ◽

Application Site ◽

Control Group ◽

Merino Sheep ◽

Anogenital Region ◽

Group A ◽

Rhipicephalus Evertsi Evertsi ◽

Dorper Sheep ◽

Pre Treatment ◽

Extensive Farming

The objectives of this study were to determine the influence of application site and sheep breed on the efficacy of a flumethrin (1 % m/v) solution for the control of 'bont'-legged (Hyalomma spp.) and red-legged ticks (Rhipicephalus evertsi evertsi). This study was conducted from November 1996 to February 1997 on 3 farms in the southwestern Free State Province. Two trials were conducted on Dorper sheep and 2 on Merino sheep. For each specific application 30 sheep were selected and allocated to 3 groups of 10 animals each using randomisation through minimisation, with pre-treatment total tick count as only criterion. Groups consisted of an untreated control group, a group treated with 3 m of a flumethrin (1 % m/v) solution applied only to the anogenital region, and a group treated at a dose rate of 1 m flumethrin (1% m/v)/5 kg host body mass. The total dose volume for animals in the last group was divided into 3 equal parts and applied to the brisket/axillae, groin and anogenital regions respectively. Animals grazed under extensive farming conditions and were infested by ticks that occurred naturally in the environment. Ticks were counted and removed weekly over a 6-week period. In all 4 trials, Rhipicephalus e. evertsi was the dominant tick species, followed, in 3 of the trials, by Hyalomma spp. Efficacy (%) of control against ticks for Dorper sheep, treated only on the anogenital region, was variable, ranging between 29.5 and 97 %. In Merino sheep the efficacy values ranged between 23.1 and 90 %. The site-spcific (anogenital region) efficacy of control against ticks infesting Merino sheep was in general 100 % or almost 100 %. In Dorper sheep the efficacy values were >80 % for 3-5 weeks. The efficacy (%) of control against ticks for sheep treated on the brisket/axillae, groin and anogenital regions was always higher compared to sheep treated only on the anogenital region. In Dorper sheep, efficacy of control was >80 % for up to 4 weeks and in Merino sheep >80 % for 6 weeks.

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TRISMUS

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.02.447 ◽

2018 ◽

Vol 25 (02) ◽

pp. 226-231

Author(s):

Alvina Ali Shaikh ◽

Salman Shafique ◽

Hassan Shahid

Keyword(s):

Tooth Extraction ◽

Oral Surgery ◽

Third Molar ◽

Third Molar Surgery ◽

Surgical Removal ◽

Exclusion Criteria ◽

Impacted Third Molar ◽

Group A ◽

Mandibular Teeth ◽

Teeth Extraction

Objectives: To compare trismus in surgical removal of impacted mandibularthird molar using comma incision and standard Wards incision. Study Design: Cross sectionalstudy. Setting: Dental OPD of Isra Dental College, Isra University. Period: 1st January to 30thJune 2016. Materials and Methods: A sample of 50 patients of impacted third molar wasselected by non-probability purposive sampling for tooth extraction either by conventionaltechnique or by coma shaped incision at the Department of Oral surgery, Isra Dental CollegeHospital. Patients were selected according to inclusion and exclusion criteria. Post-operativemeasurement of trismus was measured on 1st, 3rd and 7th day respectively. Results: Mean ±SD age in group A and B was noted as 28.5 ± 4.32 and 27.2 ± 4.39 years respectively. Maleand female in groups A and B were noted as 16 (64%) and 9 (36%), & 14 (56%) and 11 (44%)respectively. Right and left lower mandibular teeth extraction in groups A and B were noted 11and 14, & 10 and 15 respectively. Trismus was measured preoperatively and subsequently atday 1, day 3 and day 7. Conclusion: In conclusion, the Coma incision was preferable over theconventional method- the standard Ward`s incision because of lesser degree of trismus seen.Further research with newer flap designs and the comma design should be preferred by theclinicians for the extraction of impacted third molar surgery.

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