scholarly journals Deciphering Genomic Heterogeneity and the Internal Composition of Tumour Activities through a Hierarchical Factorisation Model

Mathematics ◽  
2021 ◽  
Vol 9 (21) ◽  
pp. 2833
Author(s):  
José Carbonell-Caballero ◽  
Antonio López-Quílez ◽  
David Conesa ◽  
Joaquín Dopazo
Keyword(s):  
Point Of View ◽  
Biological Processes ◽  
Breast Cancer Patients ◽  
Hallmarks Of Cancer ◽  
Medical Treatments ◽  
Distinctive Features ◽  
Factorisation Model ◽  
High Degree ◽  
Cancer Diseases ◽  
Matrix Factorisation

Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a variable landscape of genomic configurations. In this context, matrix factorisation techniques represent a suitable approach for modelling such complex patterns of variability. In this work, we present a hierarchical factorisation model conceived from a systems biology point of view. The model integrates the topology of molecular pathways, allowing to simultaneously factorise genes and pathways activity matrices. The protocol was evaluated by using simulations, showing a high degree of accuracy. Furthermore, the analysis with a real cohort of breast cancer patients depicted the internal composition of some of the most relevant altered biological processes in the disease, describing gene and pathway level strategies and their observed combinations in the population of patients. We envision that this kind of approaches will be essential to better understand the hallmarks of cancer.

Resistance to Outflow of Cerebrospinal Fluid Determined by Bolus Injection Technique and Constant Rate Steady State Infusion in Humans

Neurosurgery ◽  
1985 ◽  
Vol 16 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Michael Kosteljanetz
Keyword(s):  
Cerebrospinal Fluid ◽  
Steady State ◽  
Bolus Injection ◽  
Point Of View ◽  
Injection Technique ◽  
Communicating Hydrocephalus ◽  
Constant Rate ◽  
High Degree ◽  
Infusion Technique

Abstract Two methods for the determination of resistance to the outflow of cerebrospinal fluid, the bolus injection technique and the constant rate steady state infusion technique, were compared. Thirty-two patients with a variety of intracranial diseases (usually communicating hydrocephalus) were studied. There was a high degree of correlation between the resistance values obtained with the two methods, but values based on the bolus injection technique were systematically and statistically significantly lower than those obtained with the constant rate infusion test. From a practical point of view. both methods were found to be applicable in a clinical setting.

The Degree Of Applying The Thinking Skills In Teaching Physical Education In Public Schools In Palestine From The Perspectives Of Teachers Of Physical Education Themselves

2020 ◽  
Vol 8 (3) ◽  
pp. 61-73
Author(s):  
Islam Abbas ◽  
Farah Naseer
Keyword(s):  
Public Schools ◽  
Physical Education ◽  
Reflective Thinking ◽  
Training Programs ◽  
Thinking Skills ◽  
Point Of View ◽  
High Degree

This study aimed to identify the degree of applying the thinking skills in teaching physical education in public schools in Palestine from the perspectives of teachers of physical education themselves. The study found that the degree of applying the thinking skills in the field of thinking during the event received the highest degree of approval from the point of view of the teachers of physical education, followed by the field of thinking of the event in the second place. The field of reflective thinking in general received a high degree of approval, with a percentage of 73.3%. The study also focused on the preparation of teachers with a high awareness in the use of reflective thinking skills, and the need to prepare training programs for students in the field of reflective thinking to help them solve their problems No compound skills.

Leadership Styles of Public Schools Principals in the City of Hail in the Kingdom of Saudi Arabia: أنماط القيادة لدى مدراء مدارس التعليم العام في مدينة حائل في المملكة العربية السعودية

2021 ◽  
Vol 5 (41) ◽  
pp. 161-138
Author(s):  
Fahad Husain Alshammari Fahad Husain Alshammari
Keyword(s):  
Public Schools ◽  
Leadership Style ◽  
School Principals ◽  
Statistical Significance ◽  
Point Of View ◽  
Years Of Experience ◽  
Public School Principals ◽  
Low Degree ◽  
Study Population ◽  
High Degree

    This study aimed to: Identify the leadership style prevailing among public school principals in Hail from the teachers ’point of view, and to reveal the statistical significance of the differences in the estimates of the study sample individuals of the leadership style prevailing among school principals, which may due to variables of (educational stage, number of years of experience, and specialization). The researcher used the descriptive method, and prepared a questionnaire consisting of (24) statements distributed to (3) dimensions, which are: Democratic style, authoritarian style and chaotic style. The current study population included all the teachers of public education schools in Hail, who numbered (9390) teachers. The questionnaire was applied to a random sample of (296) teachers. The study found a set of results, the most important of which are: The prevailing leadership style among school principals is the democratic style, followed by the authoritarian style, and then the chaotic style. Where the democratic style obtained a mean (4.18) and a high degree of approval from the study sample, while the domineering style obtained a mean (1.83) and a low degree of approval from the study sample, and the chaotic style obtained an average (1.73) and a low degree of approval. Very members of the study sample. The results also showed that there are statistically significant differences in the degree of the study sample’s estimates of the leadership style prevailing among school principals due to the variable of years of experience, while there are no statistically significant differences in the degree of the study sample’s estimates of the leadership style prevailing among school principals due to the variables of the educational stage or specialization. In light of these results, the researcher recommended organizing training courses for school principals to enlighten them about the modern trends in educational leadership, and urged school principals to follow the democratic style of administration.

scholarly journals The structure of the sedimentary complex of the Middle and South Caspian depressions (Azerbaijan sector)

2021 ◽  
Vol 43 (4) ◽  
pp. 199-216
Author(s):  
N.P. Yusubov ◽  
I.S. Guliyev
Keyword(s):  
Seismic Data ◽  
Oil And Gas ◽  
Sedimentary Cover ◽  
Clay Content ◽  
Geological Structure ◽  
Point Of View ◽  
South Caspian Basin ◽  
Origin And Evolution ◽  
Geological Interpretation ◽  
High Degree

The high degree of knowledge of the upper horizons of the sedimentary cover of the Middle and South Caspian depressions, given an insufficient increase in hydrocarbon reserves, leads to the need for a detailed approach to the search for oil and gas deposits in deep-seated sediments (over 6 km). During the geological interpretation of new highly informative seismic data, as well as data of deep drilling and petrological core studies, there were revealed obvious shortcomings in the concepts of the origin and evolution of the Middle and South Caspian depressions. These ideas misinterpret evolution, especially the South Caspian Basin, which is characterized by a number of unique features: very thick sedimentary cover (up to 22 km), extremely high sedimentation rate, low heat flow and reservoir temperatures, abnormally high pore and reservoir pressures, high clay content of the section, etc. The main purpose of the study was to elucidate the regional structure and features of the dissection of the sedimentary cover of the Middle and South Caspian depressions, the conditions of occurrence and distribution of facies and thicknesses of individual complexes of deposits. The paper analyzes the results of some previous studies of the geological structure of the Middle and South Caspian depressions based on the data of deep seismic sounding, seismological and gravimetric observations. We consider the main conclusions of these studies, about the geological structure of the sedimentary complex of the region’s, very outdated and subject to revision. The results of seismic stratigraphic analysis of seismic data allowed the authors to identify new data about the tectonic structure and express a completely different point of view regarding the structure of the sedimentary cover in the region. The work also touches on the issue associated with the tectonics of the region and the alleged subduction zone here.

scholarly journals The reality of Educational accountability and its mechanisms among school leaders in public education schools in Sharourah governorate/ Najran

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Mohammed Qasim Almqablah
Keyword(s):  
Public Education ◽  
School Leaders ◽  
Point Of View ◽  
School Level ◽  
First Semester ◽  
Female Teachers ◽  
General Average ◽  
And Performance ◽  
High Degree ◽  
Academic Year

The study aimed to identify the reality of practicing accountability among school leaders in public education schools in Sharourah Governorate / Najran and the degree of accountability in the administrative and technical domains. To achieve this goal, the researcher used the analytical survey approach. The study was applied to a sample of )177 ( teachers, including (101) male teachers and (76) female teachers, in the first semester of the academic year 2018- 2019. The results of the study found that, the practice of accountability among the leaders of public education schools in Sharourah governorate / Najran from teachers point of view has got a general average (4.02), high rating, and according to the domains level, practicing accountability in administrative domain has got an average; (3.93), with a high rating, also, practicing accountability in the technical domain has got an average of (3.90) with a high degree. There were no statistically significant differences at the level of (0.05 = α) between the arithmetical averages of the total score for the degree of accountability in administrative and technical domains due to the differences in the variables of the study (years of experience and the scientific qualification). There were statistically significant differences in the degree of accountability in administrative and technical domains due to gender in favor of males; and in the variable of a school level in favor of high school. The study recommended the need to spread the culture of accountability, And to clarify the nature, methods, objectives and mechanisms for teachers, and the need to provide standards and performance indicators used in accountability process.

scholarly journals Evaluation of learning resource rooms in public schools in Ajloun governorate according to teachers point of view: تقييم غرف مصادر التعلم في المدارس الحكومية في محافظة عجلون من وجهة نظر معلميها

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Dr. AHMAD ALI AL- JABALI
Keyword(s):  
Public Schools ◽  
Local Community ◽  
Point Of View ◽  
Average Score ◽  
Learning Resources ◽  
Resource Room ◽  
Arithmetic Average ◽  
Significant Difference ◽  
Evaluation Of Learning ◽  
High Degree

This study aims at identifying the evaluation of learning resources rooms in public schools in Ajloun governorate from the point of view of their teachers. The study was based on the descriptive analytical method. The study population consisted of (107) male and female teachers. random. The study reached a set of results, The most important: The arithmetic averages of the responses of the study sample to evaluate the room of learning resources as a whole came with a high degree, with an average of (3.63) and the field of parents with a high degree, and an arithmetic average (3.92), followed by the teacher field, with an average (3.66). ), Then the student field, with an average (3.64), while the resource room field, the lowest average score, with an average (3.40), The results also showed that there is no statistically significant difference according to sex and educational qualification, and that there are statistically significant difference for the job experience variable for (11 years and above). To disseminate the experience of forming a support committee to all departments, institutions and programs working with people with special needs in the local community.

scholarly journals The Degree of Effectiveness of The Management of Women in Administrative Empowerment and Its Obstacles at The Branches of Hail University from The Point of View of Faculty Members: درجة فاعلية الإدارة النسائية في التمكين الإداري ومعوقاتها لدى فروع جامعة حائل من وجهة نظر عضوات هيئة التدريس

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Maysaa hasan muflih BaniHani
Keyword(s):  
Point Of View ◽  
Faculty Members ◽  
Work Team ◽  
First Semester ◽  
Delegation Of Authority ◽  
The Social ◽  
Study Results ◽  
General Average ◽  
High Degree ◽  
The Impact

The purpose of this study was to investigate effectiveness of female administration in the Administrative Empowerment at Hail University branches and its impediments, from the point of view of the faculty members. The researcher used the descriptive analytical approach. The questionnaire was the tool of study and the study sample consisted of (53) of female faculty members at Hail University branches during the first semester 2018- 2019. The results of this study found that the overall degree of administrative empowerment was obtained at a general average (3.93) i.e. high degree and at the dimensional level. Indeed, the work team term was in the first rank with an average of 4.09, and then it comes the delegation of authority with an average of (3.89). The communication term comes at the third level with an average of (3.88) and in the last rank, it comes the motivation of the staff with an average of (3.86) and all of them with a rating of (high). As regard the obstacles in the women administration, the administrative impediments obtained the first rank with an average of (3.87) followed by the personal constraints with an average of (3.76), and then the political impediments with an average of (3.47), and finally the social obstacles with an average of (2.61). For instance, the study showed that there were no significant differences due to the impact of experience years and the impact of scientific qualification. There were some recommendations according to the study results, which were to increase the effectiveness of faculty members and remove obstacles facing them.

scholarly journals “Postface to a Catalogue on Bronze and Stone Inscriptions” by Li Qingzhao

2014 ◽  
Vol 26 (31) ◽  
pp. 68-86
Author(s):  
Anna Dashchenko
Keyword(s):  
Russian Translation ◽  
Chinese Literature ◽  
Background Knowledge ◽  
Point Of View ◽  
High Rank ◽  
Distinctive Features ◽  
History Of ◽  
Chinese And English

This article presents the first Russian translation of Postface to a Catalogue on Bronze and Stone Inscriptions (In Chinese: 金石录后序) with detailed comments. This postface was written in about 1135 by the outstanding Chinese poetess and the founder of Yi-an style Li Qingzhao (1084–1155). Her work is not just a supplement written to a fundamental catalogue compiled by her husband Zhao Mingcheng – a famous epigraphist, collector of ancient objects of art and high-rank official. Postface is a unique work because it introduces two genres: an epitaph in commemoration of her husband and an autobiographical essay. Moreover, it is the first female autobiography in the history of Chinese literature. The number of hieroglyphs in this text varies from 1866 to 1877 in different editions. We have revealed the distinctive features in Chinese and English traditions of commenting and studying the Postface. Chinese works are characterized by dominance of impressionist evaluations, lack of well-defined analytical categories and background knowledge. In addition, English works are characterized by using different approaches to translation of the dates and the reign periods, and by attention to the certain stories and personalities mentioned in the text for better understanding the biography of Li Qingzhao. Different opinions as to when this Postface was written have been analyzed and we have also presented our point of view to this matter.

scholarly journals SCURTĂ INCURSIUNE ÎN LUMEA LITERARĂ A SCRIITORILOR CONTEMPORANI ROMÂNI DE EXPRESIE SPANIOLĂ

2021 ◽  
pp. 238-255
Author(s):  
Ioana CECOVNIUC ◽  
Keyword(s):  
Point Of View ◽  
Distinctive Features ◽  
Starting Point ◽  
Definition Of ◽  
Significant Factors

The aim of this paper is to briefly review the work of three contemporary Romanian poets from an ectopic point of view. Consequently, the starting point will be from Tomás Albaladejo Mayordomo’s definition of “ectopic literature” (2011), seen as the literature that is produced by an author who changes his usual topos (physical, socio-cultural and linguistic background) for an initially odd or peculiar one. Distinctive features of “ectopic literature” as well as significant factors - such as autobiographical data and main themes - are earmarked to be applied to the work for subsequent analysis.

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