scholarly journals Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1710 ◽  
Author(s):  
Kadour Cheraif ◽  
Boulanouar Bakchiche ◽  
Abdelaziz Gherib ◽  
Sanaa K. Bardaweel ◽  
Melek Çol Ayvaz ◽  
...  
Keyword(s):  
Essential Oils ◽  
Cytotoxic Effect ◽  
Food Preservation ◽  
Major Constituent ◽  
Cytotoxic Activities ◽  
Mentha Pulegium ◽  
Antioxidant Power ◽  
Ic50 Values ◽  
Lavandula Officinalis ◽  
Main Component

In this study, the essential oils (EOs) of six Algerian plants (Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L. and Lavandula officinalis Chaix) were obtained by hydrodistillation, and their compositions determined by GC-MS and GC-FID. The antioxidant activity of the EOS was evaluated via 2,2′-diphenyl-1-picrylhydrazyl (DPPH), ferric-reducing/antioxidant power (FRAP) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assays. Moreover, their cytotoxic effect was evaluated—as well as their tyrosinase, acetyl- and butyryl-cholinesterase (AChE and BuChE) inhibitory activities. The chemical analyses detected 44, 45, 51, 53, 26 and 40 compounds in EOs of A. campestris, A. herba-alba, J. phoenicea, J. oxycedrus, M. pulegium and L. officinalis, respectively. A. campestris EO was mainly composed of β-pinene (20.7%), while A. herba-alba EO contained davanone D (49.5%) as the main component. α-Pinene (41.8%) was detected as the major constituent in both J. phoenicea (41.8%) and J. oxycedrus (37.8%) EOs. M. pulegium EO was characterized by pulegone as the most abundant (76.9%) compound, while linalool (35.8%) was detected as a major constituent in L. officinalis EO. The antioxidant power evaluation revealed IC50 values ranging from 2.61 to 91.25 mg/mL for DPPH scavenging activity, while the FRAP values ranged from 0.97–8.17 µmol Trolox equivalents (TX)/g sample. In the ABTS assay, the values ranged from 7.01 to 2.40 µmol TX/g sample. In the presence of 1 mg/mL of the samples, tyrosinase inhibition rates ranged from 11.35% to 39.65%, AChE inhibition rates ranged from 40.57% to 73.60% and BuChE inhibition rates ranged from 6.47% to 72.03%. A significant cytotoxic effect was found for A. herba-alba EO. The obtained results support some of the traditional uses of these species in food preservation and for protection against several diseases.

scholarly journals Chemical Composition of Essential Oils from Different Parts of Zingiber kerrii Craib and Their Antibacterial, Antioxidant, and Tyrosinase Inhibitory Activities

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 228 ◽  
Author(s):  
Aknarin Pintatum ◽  
Surat Laphookhieo ◽  
Emilie Logie ◽  
Wim Vanden Berghe ◽  
Wisanu Maneerat
Keyword(s):  
Essential Oils ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Total Phenolic ◽  
Frap Assay ◽  
Antioxidant Power ◽  
Diammonium Salt ◽  
Ic50 Values ◽  
Weak Antibacterial Activity ◽  
Hacat Cell Lines

The essential oils of the fresh rhizomes; flowers; and leaves of Zingiber kerrii Craib were investigated using different extraction techniques; including solid-phase microextraction (SPME), hydrodistillation (HD), and organic solvent (OS), and characterized by gas chromatography–mass spectrometry (GC–MS). A total of 37 SPME; 19 HD; and 36 OS compounds were identified from the rhizome extract of Z. kerrii; with the major components being α-pinene; β-pinene; and terpinen-4-ol; respectively. From the flower extract; 16 SPME; 2 HD; and 10 OS compounds were identified; (E)-caryophyllene was found as a major compound by these techniques. The leaf extract exhibited 20 SPME; 13 HD; and 14 OS compounds; with α-pinene; (E)-caryophyllene; and n-hexadecanoic acid being the major compounds; respectively. The rhizome extract showed tyrosinase inhibitory activity of 71.60% and a total phenolic content of 22.4 mg gallic acid/g. The IC50 values of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays were 25.2 µg/mL and 153.6 µg/mL; respectively; and the ferric ion reducing antioxidant power (FRAP) assay value was 318.5 µM ascorbic acid equivalent (AAE)/g extract. The rhizome extract showed weak antibacterial activity. This extract showed no adverse toxicity in human keratinocyte (HaCaT) cell lines at concentrations below 200 µg/mL.

scholarly journals Activité Acaricide Des Huiles Essentielles Du Mentha Pulegium, Origanum Compactum Et Thymus Capitatus Sur L’acarien Phytophage Tetranychus Urticae Koch (Acari : Tetranychidae)

2018 ◽  
Vol 14 (3) ◽  
pp. 118 ◽  
Author(s):  
Asmae Bakkali Aissaoui ◽  
Amal El Amrani ◽  
Said Zantar ◽  
Larbi Toukour
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Tetranychus Urticae ◽  
Contact Toxicity ◽  
Mentha Pulegium ◽  
Plant Essential Oils ◽  
Thymus Capitatus ◽  
Origanum Compactum ◽  
Main Component ◽  
Tetranychus Urticae Koch

The use of botanical acaricides extracted from plants as an alternative to replace the chemical acaricides is an interesting and efficient option to control pests and ameliorate their toxic effects to humans and the environment. The aim of this work was to evaluate the contact toxicity of Pennyroyal mint (Mentha pulegium), oregano (Origanum compactum) and thyme (Thymus capitatus) essential oils against adults, larvae and eggs of two-spotted spider mite Tetranychus urticae Koch (Tetranychidae). The chemical composition of these three plant essential oils was also characterized. Laboratory tests were conducted to determine the acaricidal effect of plant essential oils at several doses in geometric progression. The consequences of treatments on mortality were measured in relationships with concentrations of essential oils. On the other hand, the major constituents of the three essential oils were identified by gas chromatography-mass spectrometer (GC-MS) techniques. GCMS analyses proved that the major compound present in the essential oils of thyme and oregano is carvacrol (55.59 and 55.28% respectively) while the main component of pennyroyal mint essential oil is pulegone (67,63%). Laboratory bioassay results indicated that essential oils of thyme and pennyroyal mint caused the most important acaricidal effects in comparison with the essential oil of oregano. At a concentration of 1%, thyme and pennyroyal eradicate all adults of the mite while oregano causes a mortality of 84.99%. On larvae, the mortality rate of thyme, pennyroyal and oregano is 97.7; 89.47 and 57.89% respectively. The results of the present study concluded that plant essential oils could be useful in promoting research aiming at the development of new agent for pest control from the plants with medicinal values.

scholarly journals Chemical characterization of essential oils and antioxidant activity of Dictyota dichotoma and Dictyopteris membranacea

2019 ◽  
pp. 33-42
Author(s):  
Redhouane Benfares ◽  
Affaf Kord ◽  
Khaled Boudjema ◽  
Manel Bouarab ◽  
Soumia Benrabah ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Steam Distillation ◽  
Chemical Characterization ◽  
Dictyota Dichotoma ◽  
Chemical Screening ◽  
Similar Chemical ◽  
Ic50 Values ◽  
Chemical Profiles ◽  
Main Component

The work focuses on the study of two brown algae Dictyota dichotoma and Dictyopteris membranacea. Extracts obtained by different organic solvents (dichloromethane, hexane, acetone, methanol, chloroform) were screened for their DPPH antiradical activity, whereas essential oils obtained by steam distillation were chemically characterized by GC-MS. Steam distillation yielded 0.07 and 0.095% of the essential oils for Dictyota dichotoma and Dictyopteris membranacea, respectively. The chemical screening of the essential oils of Dictyopteris membranacea and Dictyota dichotoma showed similar chemical profiles. Namely, trans-anethole showed to be the main component in both studied oils, yielding 12.28% and 10.70% for Dictyopteris membranacea and Dictyota dichotoma, respectively. Antioxidant activity of extracts was expressed by IC50 values and was in the range 0.375-1.72 mg/ml.

scholarly journals In vitro evaluation of anticaries, antimycobacterial, antileishmanial and cytotoxic activities of essential oils from Eremanthus erythropappus and of α-bisabolol, their major sesquiterpene

2020 ◽  
pp. 236-243
Author(s):  
Cassia Cristina Fernandes ◽  
Priscila Mileide de Andrade ◽  
Tainá Caroline Lucena dos Santos ◽  
Mariana Brentini Santiago ◽  
Antônio Eduardo Miller Crotti ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oils ◽  
Peritoneal Macrophages ◽  
Culture Collection ◽  
Cytotoxic Activities ◽  
Therapeutic Effects ◽  
Herbaceous Plant ◽  
Microdilution Method ◽  
Ic50 Values

Interest in researches into medicinal plants and therapeutic effects of essential oils (EOs) on humans has increased over the last few years. Eremanthus erythropappus, known as candeia, is a Brazilian aromatic herbaceous plant whose α-bisabolol-rich oil has been used in several cosmetic preparations. This paper reports in vitro anticaries, antimycobacterial, antileishmanial and cytotoxic activities of EOs from E. erythropappus leaves (EL-EO) and stalks (ES-EO), besides α-bisabolol, their main sesquiterpene. EL-EO and ES-EO were extracted by hydrodistillation and analyzed by GC-FID and GC-MS. α-Bisabolol, cis-α-bisabolene and β-bisabolene were identified as their major constituents. Antibacterial activity of EOs was evaluated against eight standard strains of pathogens from the American Type Culture Collection (ATCC) by determining minimum inhibitory concentrations (MICs) with the use of the microdilution method. Antibacterial activity was evaluated against Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus, S. salivarius, Mycobacterium tuberculosis, M. avium and M. kansasii. EL-EO, ES-EO and α-bisabolol exhibited high leishmanicidal activity against promastigote forms of Leishmania amazonensis; IC50 values were 9.22 µg/mL, 6.00 µg/mL and 3.12 µg/mL, respectively. The 50% cytotoxic concentrations (CC50) of EL-EO, ES-EO and α-bisabolol against mouse peritoneal macrophages were 24.65 µg/mL, 8.87 µg/mL and 1021.00 µg/mL, respectively. These results suggest that EOs from E. erythropappus seem to be very promising for the development of new bactericidal and leishmanicidal agents.

scholarly journals Antimicrobial Activity of Three Lamiaceae Essential Oils Against Common Oral Pathogens

2016 ◽  
Vol 20 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Miloš Nikolić ◽  
Tatjana Marković ◽  
Dejan Marković ◽  
Jasmina Glamočlija ◽  
Ana Ćirić ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Alternative Therapy ◽  
Major Constituent ◽  
Cytotoxic Activities ◽  
Oral Diseases ◽  
Candida Spp ◽  
Plant Parts ◽  
Natural Agents ◽  
Microdilution Method

Summary Chemical composition, antimicrobial and cytotoxic activities of commercial essential oils’ samples from the aerial plant parts of H. officinalis, R. officinalis and S. officinalis were investigated. Analyses by GC-FID and GC-MS confirmed 52 oil components. The major constituent of the H. officinalis oil was cis-pinocamphone (34.4%), followed by transpinocamphone (23.3%), and β-pinene (11.3%). Analysis of R. officinalis oil revealed 1.8-cineol as a major constituent (43.8%), as well as transpinocamphone (12.5%), α-pinene (11.5%) and β-pinene (8.2%). The most dominant constituent of S. officinalis oil was cis-thujone (32.7%), in addition to camphor (17.2%), 1.8-cineol (10.1%), α-pinene (8.6%), transthujone (7.7%) and camphene (7.3%). The essential oil antimicrobial activity assay was performed by the use of microdilution method against oral Candida spp. and bacteria, the major causative agents of a number of human oral disorders; all of them were susceptible to tested concentrations of H. officinalis, R. officinalis and S. officinalis essential oils, although the oil of S. officinalis exhibited the lowest antimicrobial potential. The results obtained in this study encourage use of investigated essential oils from Lamiaceae family in development of safe natural agents for prevention and/ or alternative therapy of human oral diseases. However, a special care during development of an effective natural preparation is required.

scholarly journals Chemical Composition and Cytotoxic Effect of Prangos turcica A. Duran, M. Sagiroglu & H. Duman

2021 ◽  
Vol 15 (6) ◽  
pp. 503-512
Author(s):  
Secil Yazici-tütüniş ◽  
Fatma Memnune Eruçar ◽  
Ezgi Öztaş ◽  
Emine Akalin ◽  
Gül Özhan ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cytotoxic Effect ◽  
Cytotoxic Activities ◽  
Lead Compound ◽  
Drug Substances ◽  
Ic50 Values ◽  
Treat Prostate Cancer ◽  
Meranzin Hydrate ◽  
Treatment Of Wounds ◽  
First Time

In addition to the antiflatulent, emollient, antifungal, antihemorrhoidal, antioxidant, anthelmintic effects, Prangos species have been used to stop bleeding and for the treatment of wounds and scars in central Asia and Turkey. In the present study, the compounds were isolated using chromatographic methods, and their structures were identified by 1H NMR and direct comparison with the reference compounds where available. Fifteen known coumarins were isolated from the dichloromethane extract as osthol, murraol, auraptenol, peroxyauraptenol, 4'-senecioiloxyosthol, meranzin hydrate, scopoletin, umbelliferone, isoimperatorin, oxypeucedanin, oxypeucedanin hydrate, oxypeucedanin methanolate, gosferol, psoralen, and marmesin. The cytotoxic activities of all isolated compounds from dichloromethane extract of P. turcica roots were evaluated using MTT assay on human adenocarcinoma (prostate PC-3) cells. 4'-senecioiloxyosthol, oxypeucedanin methanolate, gosferol, psoralen, peroxyauraptenol and marmesin were tested for the first time on the PC-3 cell line. Osthol and peroxyauraptenol showed the highest cytotoxic activity with IC50 values of 65 and 72 µg/mL, respectively. Additionally, auraptenol, scopoletin, gosferol, psoralen, 4'-senecioiloxyosthol and dichloromethane extract of root part (Pt/R/DCM) demonstrated moderate to low cytotoxic activity. Consequently, the most potent compounds, osthol and peroxyauraptenol, may be used as a lead compound to develop effective drug substances to treat prostate cancer.

scholarly journals Antifungal Activity and Composition of Essential Oils ofConyza canadensisHerbs and Roots

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Katalin Veres ◽  
Boglárka Csupor-Löffler ◽  
Andrea Lázár ◽  
Judit Hohmann
Keyword(s):  
Essential Oils ◽  
Antimicrobial Activities ◽  
Major Constituent ◽  
Chemical Compositions ◽  
Bacterial Strains ◽  
Strong Activity ◽  
Fungal Strains ◽  
Aerial Parts ◽  
Agar Disc ◽  
Main Component

Essential oils from herbs and roots ofConyza canadensis(horseweed), collected in Hungary, were obtained by hydrodistillation. The chemical compositions of the oils were analysed by combination of GC and GC/MS. The major constituent of the oil obtained from the aerial parts of horseweed was limonene (78%), while the main component of root oil was 2Z,8Z-matricaria ester. The antimicrobial activities of the oils were tested on Gram-positive (Enterococcus faecalis,Staphylococcus aureus, andStreptococcus pyogenes), Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, reference fungal strains, and fungal strains isolated from patients (Candida,Cryptococcus,Trichophyton,Rhodotorula, andAspergillus) by agar disc diffusion and broth dilution methods. None of the oils showed any activity against the tested bacterial strains, but exhibited moderate-to-strong activity against all fungi with the only exception ofA. fumigatus. The highest zone of inhibition was observed in case ofCryptococcus neoformansandTrichophyton interdigitalis

scholarly journals Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp. pisidica (Lamiceae)

2014 ◽  
Vol 9 (4) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Tatjana Kundaković ◽  
Tatjana Stanojković ◽  
Branka Kolundžija ◽  
Stevan Marković ◽  
Branka Šukilović ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Antimicrobial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Cytotoxic Effect ◽  
Cytotoxic Activities ◽  
Minimal Inhibitory Concentrations ◽  
Oxygenated Monoterpene ◽  
Very High ◽  
Satureja Montana

The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galičica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and β-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 μg/mL against S. epidermidis to 50 μg/mL against P. aeruginosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRC5 cells. The essential oil from Korab demonstrated significantly better results than the oil from Galičica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 μg/mL, while the oil from Galičica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 μg/mL).

scholarly journals Syzygium aromaticum L. (Clove): A vital herbal drug used in periodontal disease

2017 ◽  
Vol 5 (02) ◽  
pp. 45-51 ◽  
Author(s):  
Deepanjeet Kaur ◽  
Kaushal K. Chandrul
Keyword(s):  
Essential Oil ◽  
Periodontal Disease ◽  
Essential Oils ◽  
Geographic Origin ◽  
Major Constituent ◽  
Lower Amount ◽  
Syzygium Aromaticum ◽  
Great Opportunity ◽  
Eugenyl Acetate ◽  
Main Component

Cloves are widely used in dental care, and are effective against a large number of bacteria. The main component of clove oil is eugenol, with β-caryophyllene and eugenyl acetate. The review of published results reveals a great opportunity to treat periodontal disease. The purpose of this study is to compare the bud, leaf and stem essential oil compositions from S. aromaticum and then to evaluate the correlation of the results with anatomic and geographical origins of the essential oil. Many commercial essential oils isolated from bud, leaf and stem were used in this work. The oils were analyzed by GC and then constituents were identified from the whole. The major constituent in oils was eugenol, with increasing percentages from bud (72.08 - 82.36%) to leaf (75.04 - 83.58%) and stem (87.52 - 96.65%). In the clove bud essential oil eugenyl acetate is the second major component (8.6 - 21.3%) while detected in considerably lower amount in the leaf (0 - 1.45%) and stem (0.07 - 2.53%). In leaf essential oil, the second main compounds were β-caryophyllene (11.65 - 19.53%) and α-humulene (1.38 - 2.17%), less represented in bud essential oils (2.76 - 8.64% and 0.34 - 1.04% respectively) and in stem essential oils (1.66 - 9.7% and 0.22 - 1.31% respectively). For each plant material, variation in the percentage of the main constituents was observed according to the sample geographic origin.

Ethnopharmacological Survey of Medicinal Plants Used in the Traditional Treatment of Female Infertility in Fez Region, Morocco

2019 ◽  
Vol 18 (5) ◽  
pp. 321-339 ◽  
Author(s):  
M. Slighoua ◽  
I. Mahdi ◽  
F. Ez-zahra Amrati ◽  
S. Boukhira ◽  
A. EL Hamsas EL Youbi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Medicinal Plants ◽  
Plant Species ◽  
Rosmarinus Officinalis ◽  
Female Infertility ◽  
Mentha Pulegium ◽  
Traditional Treatment ◽  
Lavandula Officinalis

An ethnopharmacological survey was carried out among 224 informants to collect the information on medicinal plants used for the traditional treatment of female infertility in the Fes, Meknes and Boulemane region. In total, 63 plant species belonging to 29 families were used against female infertility. The most frequently cited plants were Lavandula officinalis (26.33%), Mentha pulegium (13.83%), Mentha suaveolens (11.16%), Rosmarinus officinalis (10.71%) and Petroselinum sativum (8.03%). Furthermore, the present study represents a useful documentation for the preservation of this knowledge about medicinal plants and for the amelioration of women reproductive health.

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