scholarly journals Rheology Impact of Various Hydrophilic-Hydrophobic Balance (HLB) Index Non-Ionic Surfactants on Cyclopentane Hydrates

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3725
Author(s):  
Khor Siak Foo ◽  
Cornelius Borecho Bavoh ◽  
Bhajan Lal ◽  
Azmi Mohd Shariff
Keyword(s):  
Hydrate Formation ◽  
Tween 80 ◽  
Tween 20 ◽  
Growth Time ◽  
Ionic Surfactants ◽  
Promoting Effect ◽  
Rheological Measurement ◽  
Viscosity Profile ◽  
Tween 40 ◽  
Solubility Characteristic

In this study, series of non-ionic surfactants from Span and Tween are evaluated for their ability to affect the viscosity profile of cyclopentane hydrate slurry. The surfactants; Span 20, Span 40, Span 80, Tween 20, Tween 40 and Tween 80 were selected and tested to provide different hydrophilic–hydrophobic balance values and allow evaluation their solubility impact on hydrate formation and growth time. The study was performed by using a HAAKE ViscotesterTM 500 at 2 °C and a surfactant concentration ranging from 0.1 wt%–1 wt%. The solubility characteristic of the non-ionic surfactants changed the hydrate slurry in different ways with surfactants type and varying concentration. The rheological measurement suggested that oil-soluble Span surfactants was generally inhibitive to hydrate formation by extending the hydrate induction time. However, an opposite effect was observed for the Tween surfactants. On the other hand, both Span and Tween demonstrated promoting effect to accelerate hydrate growth time of cyclopentane hydrate formation. The average hydrate crystallization growth time of the blank sample was reduced by 86% and 68% by Tween and Span surfactants at 1 wt%, respectively. The findings in this study are useful to understand the rheological behavior of surfactants in hydrate slurry.

Effect Of Surfactant Chain Length On Emulsification Dynamics Of Self Emulsifying Formulation Of Poorly Soluble Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Shailendra Chouhan ◽  
Lalit Singh Chauhan
Keyword(s):  
Chain Length ◽  
Tween 80 ◽  
Tween 20 ◽  
Almond Oil ◽  
Peg 400 ◽  
Globule Size ◽  
Poorly Soluble ◽  
Tween 40 ◽  
Poorly Soluble Drug ◽  
Tween 60

Aim: In this work the aim was to study the chain length of surfactant on the self emulsifying system of a poorly soluble drug, aceclofenac. The selection of almond oil as a lipid vehicle was done on basis of solubility and compatibility of the vehicle with the drug. Methods: The effect of varying chain length of different surfactants of Tween series namely Tween 20, Tween 40, Tween 60 and Tween 80 was evaluated on self emulsifying efficiency by constructing pseudoternary diagrams. PEG-400 was used as co-surfactant in a definite ratio with all the surfactants to minimize their concentration. The best self emulsifying ability was exhibited by Tween 80: PEG-400 combination followed by Tween 60: PEG-400, Tween 40: PEG-400, Tween 20: PEG-400. This observation indicates that as the chain length of Tweens increases their ability to form a good microemulsion increases if same co-surfactant is used. Results: However it has also been found that the presence of unsaturated bond in Tween 80 provides it an elasticity which supports good intermixing of oil and water and leading to formation of a fine microemulsion. Six different formulations were prepared using combination of almond oil, Tween 80, PEG-400 and the drug aceclofenac. Conclusion : The formulations were subjected to various evaluation parameters such as dispersibility, transmittance, pH, globule size, polydispersibility, zeta potential, viscosity, refractive index and in vitro dissolution. The best formulation was found to have globule size of less than 100 nm, zeta potential of -3.35 ± 0.60 mV which indicates formation of a microemulsion of aceclofenac with good stability.

Effect of some surfactants on the chemiluminescent reactions of bis(2,4,6-trichlorophenyl)oxalate and bis(2-nitrophenyl)oxalate with hydrogen peroxide

2012 ◽  
Vol 90 (6) ◽  
pp. 534-541 ◽  
Author(s):  
Patrícia Dantoni ◽  
Ana Clara B. Rodrigues ◽  
Margareth Mie N. Matsuda ◽  
Nina Coichev
Keyword(s):  
Hydrogen Peroxide ◽  
Tween 80 ◽  
Peak Height ◽  
Tris Buffer ◽  
Tween 20 ◽  
Ionic Surfactants ◽  
Maximum Peak ◽  
Buffer Solutions ◽  
Micellar Systems ◽  
Brij 35

The chemiluminescent reactions of bis(2,4,6-trichlorophenyl)oxalate (TCPO) and bis(2-nitrophenyl)oxalate (2-NPO) with hydrogen peroxide in acetonitrile/water micellar systems (anionic, cationic, and non-ionic) and γ-cyclodextrin were studied in the presence of fluoranthene or 9,10-diphenylanthracene, imidazole, and two buffer solutions, HTRIS+/TRIS and H2PO4–/HPO42–. The relative chemiluminenscence (CL) intensity is higher in the presence of the cationic (DDAB, CTAC, DODAC, and OTAC), anionic (SDS), and non-ionic (Tween 80) surfactants. In the presence of some non-ionic surfactants (Brij 35, Brij 76, and Tween 20), the CL intensity was partially quenched compared with the reaction with no surfactant. The sensitivity for hydrogen peroxide determination in the range 0.01 × 10−4 to 1.0 × 10−4 mol L–1, considering the slope of the calibration curves (maximum peak height of CL vs. concentration), improved with the introduction of DDAH, CTAB, and SDS in HTRIS+/TRIS buffer.

The Role of Non-Ionic Surfactants in Solubilization and Delivery of Sparingly Soluble Drug Naproxen Sodium (NS): A Case Study

2019 ◽  
Vol 233 (7) ◽  
pp. 933-947 ◽  
Author(s):  
Noor Saeed Khattak ◽  
Luqman Ali Shah ◽  
Muhammad Sohail ◽  
Safeer Ahmad ◽  
Muhammad Farooq ◽  
...  
Keyword(s):  
Naproxen Sodium ◽  
Tween 20 ◽  
Ionic Surfactants ◽  
High Concentration ◽  
Different Temperatures ◽  
Tween 40 ◽  
Tween 60 ◽  
Enthalpy Of Micellization ◽  
Free Energy Of Micellization

Abstract Nonsteroidal anti-inflammatory hydrophobic drugs (NSAIDs) are amongst the most commonly given categories of drugs worldwide in the treatment of pain, irritation and some of them even fever in many conditions. Critical micelle concentration of NSAIDs with Naproxen sodium (NS) and its mixture with non-ionic surfactants i.e. Tween 20, Tween 40 and Tween 60 was investigated at 293 K, 303 K, 313 K and 323 K at different concentrations using surface tension and dynamic laser light scattering (DLS) techniques. Due to amphiphilic behaviour in aqueous solution NS form aggregates at sufficiently high concentration. Thermodynamic/adsorption properties like free energy of micellization (ΔGmic), enthalpy of micellization (ΔHmic), entropy of micellization (ΔSmic), Γmic and area per molecule (A2) of NS in the presence of surfactants were also measured at different temperatures. The results showed that the presence of surfactants favoured the ΔGmic and become more enhanced with increase in temperature. Further the solubility of drug is more favourable with increase in polyethylene chain in basic surfactant molecules i.e. 20–60, which indicates that Tween-60 enhanced the solubility of NS more comparatively to Tween-40 and Tween-20 and may be applied as best additive for solubilisation of NS.

Orthogonal Test Design for Optimization of Emulsifying Effectiveness of Phytosterol Adding to Milk Using Tween as Emulsifiers

2013 ◽  
Vol 700 ◽  
pp. 280-283
Author(s):  
Guo Wei Shu ◽  
Ji Li Cao ◽  
He Chen ◽  
Yuan Tan ◽  
Ling Ma
Keyword(s):  
Orthogonal Experiment ◽  
Tween 80 ◽  
Orthogonal Test ◽  
Tween 20 ◽  
Test Design ◽  
Single Factor ◽  
Orthogonal Test Design ◽  
Tween 40 ◽  
Tween 60

Effect of four emulsifiers including Tween 20, Tween 40, Tween 60 and Tween 80 on emulsifying effectiveness of phytosterol adding to milk was studied by single factor and orthogonal experiment. The concentrations of four emulsifiers were all 0.2%, 0.3%, 0.4%, 0.5%, 0.6% and 0.7%. The optimal emulsified conditions showed as follows: the optimal concentrations of Tween 20, Tween 40, Tween 60 and Tween 80 were 0.40%, 0.40%, 0.20% and 0.30%, respectively, the emulsification R reached 1.043 under the conditions mentioned above.

scholarly journals Solubilization and thermodynamic properties of simvastatin in various micellar solutions of different non-ionic surfactants: Computational modeling and solubilization capacity

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249485
Author(s):  
Faiyaz Shakeel ◽  
Sultan Alshehri ◽  
Mohamed A. Ibrahim ◽  
Mohammad Altamimi ◽  
Nazrul Haq ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Tween 80 ◽  
Tween 20 ◽  
Ionic Surfactants ◽  
Micellar Solutions ◽  
Solubilization Capacity ◽  
Brij 35 ◽  
Brij 58 ◽  
Experimental Solubility Data ◽  
Experimental Solubility

The aim of this work was to solubilize simvastatin (SIM) using different micellar solutions of various non-ionic surfactants such as Tween-80 (T80), Tween-20 (T20), Myrj-52 (M52), Myrj-59 (M59), Brij-35 (B35) and Brij-58 (B58). The solubility of SIM in water (H2O) and different micellar concentrations of T80, T20, M52, M59, B35 and B58 was determined at temperatures T = 300.2 K to 320.2 K under atmospheric pressure p = 0.1 MPa using saturation shake flask method. The experimental solubility data of SIM was regressed using van’t Hoff and Apelblat models. The solubility of SIM (mole fraction) was recorded highest in M59 (1.54 x 10−2) followed by M52 (6.56 x 10−3), B58 (5.52 x 10−3), B35 (3.97 x 10−3), T80 (1.68 x 10−3), T20 (1.16 x 10−3) [the concentration of surfactants was 20 mM in H2O in all cases] and H2O (1.94 x 10−6) at T = 320.2 K. The same results were also recorded at each temperature and each micellar concentration of T80, T20, M52, M59, B35 and B58. “Apparent thermodynamic analysis” showed endothermic and entropy-driven dissolution/solubilization of SIM in H2O and various micellar solutions of T80, T20, M52, M59, B35 and B58.

scholarly journals Hot Compressed Water Pretreatment and Surfactant Effect on Enzymatic Hydrolysis Using Agave Bagasse

Energies ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4746
Author(s):  
Marcela Sofia Pino ◽  
Michele Michelin ◽  
Rosa M. Rodríguez-Jasso ◽  
Alfredo Oliva-Taravilla ◽  
José A. Teixeira ◽  
...  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Production Efficiency ◽  
Alcoholic Beverage ◽  
Enzymatic Saccharification ◽  
Raw Material ◽  
Tween 20 ◽  
Ionic Surfactants ◽  
Peg 400 ◽  
Water Pretreatment ◽  
Hot Compressed Water

Agave bagasse is a residual biomass in the production of the alcoholic beverage tequila, and therefore, it is a promising raw material in the development of biorefineries using hot compressed water pretreatment (hydrothermal processing). Surfactants application has been frequently reported as an alternative to enhance monomeric sugars production efficiency and as a possibility to reduce the enzyme loading required. Nevertheless, the surfactant’s action mechanisms in the enzymatic hydrolysis is still not elucidated. In this work, hot compressed water pretreatment was applied on agave bagasse for biomass fractionation at 194 °C in isothermal regime for 30 min, and the effect of non-ionic surfactants (Tween 20, Tween 80, Span 80, and Polyethylene glycol (PEG 400)) was studied as a potential enhancer of enzymatic saccharification of hydrothermally pretreated solids of agave bagasse (AGB). It was found that non-ionic surfactants show an improvement in the conversion yield of cellulose to glucose (100%) and production of glucose (79.76 g/L) at 15 FPU/g glucan, the highest enhancement obtained being 7% regarding the control (no surfactant addition), using PEG 400 as an additive. The use of surfactants allows improving the production of fermentable sugars for the development of second-generation biorefineries.

scholarly journals FORMULATION AND CHARACTERIZATION OF LAFUTIDINE NANOSUSPENSION FOR ORAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (2) ◽  
pp. 20 ◽  
Author(s):  
Noor Mohammed Dawood ◽  
Shaimaa Nazar Abdal-hammid ◽  
Ahmed Abbas Hussien
Keyword(s):  
Particle Size ◽  
Fourier Transforms ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Tween 80 ◽  
Precipitation Method ◽  
Oral Drug ◽  
Tween 20 ◽  
Dissolution Profile ◽  
Particle Size Reduction

Objective: The objective of this study was to prepare nanosuspension of a practical water insoluble antiulcer drug which is lafutidine to enhance the solubility, dissolution rate with studying the effect of different formulation variables to obtain the best formula with appropriate physical properties and higher dissolution rate.Methods: Nanosuspension of lafutidine was prepared using solvent anti-solvent precipitation method using Polyvinylpyrrolidone K-90(PVP K-90) as the stabilizer. Ten formulations were prepared to show the effect of different variables in which two formulations showed the effect of stabilizer type, three formulations showed the effect of stabilizer concentration, two formulations showed the effect of combination of polymer with surfactant such as tween 80, three formulations show the effect of stirring speed and three formulations prepare to show the effect of addition of co-surfactant such as tween 20. All these formulations are evaluated for their particle size and entrapment efficiency and in vitro release. The selected one was evaluated for zeta potential, scanning electron microscope, atomic force microscopy, Fourier transforms infrared spectroscopy, differential scanning calorimetry, saturation solubility and stability study.Results: The formulations (F3-F10) were in the nano size. The optimum concentration of the stabilizer was in the formulation when the drug: polymer: surfactant ratio 1:4:4 and the optimum stirring speed was 1500 rpm. Dramatic effect on the particle size reduction was found by the addition of co-surfactant (tween 20) in formulation F7 that has a particle size 15.89±1.8 nm. The selected formula F7 showed an enhanced dissolution profile (10 min) compared to the pure drug at all-time intervals.Conclusion: The results show that the formulation that contains drug: PVP-K90: tween 80: tween 20 in ratio 1:4:2:2 is the best one and can be utilized to formulate lafutidine nanosuspension. 

scholarly journals FORMULATION AND EVALUATION OF ATORVASTATIN CALCIUM NANOCRYSTALS CONTAINING P-GLYCOPROTEIN INHIBITORS FOR ENHANCING ORAL DELIVERY

2021 ◽  
pp. 19-23
Author(s):  
SARAH LABIB ◽  
MOHAMED NASR ◽  
MOHAMED NASR
Keyword(s):  
Polyethylene Glycol ◽  
Oral Drug Delivery ◽  
Tween 80 ◽  
Degree Of Crystallinity ◽  
Oral Drug ◽  
Tween 20 ◽  
Atorvastatin Calcium ◽  
Peg 400 ◽  
P Glycoprotein ◽  
Saturated Solubility

Objective: The main objective of this study was to develop atorvastatin calcium (ATR) as an oral drug delivery system for a P-glycoprotein (P-gp) substrate drug using different pharmaceutical excipients that inhibit P-glycoprotein and evaluate the influence of nanocrystals on the dissolution characteristics and bioavailability compared to the plain drug. Methods: A nanosuspension was prepared by Solvent-antisolvent precipitation method using a solvent containing stabilizer that act as a p-gp inhibitor dissolved in distilled water as polyethylene glycol 300, polyethylene glycol 400 (PEG 300, PEG 400), tween 20 and tween 80 while the solvent selected for atorvastatin calcium was methanol. The concentrations were as follows: PEG 300 and 400 = 0.25% w/v, tween 20 and 80 = 0.75% v/v. Nanocrystals were extracted from the suspension and characterized. Results: Particle size of the drug was 1307±127.79 nm while the formulas prepared ranged from 223±17.67 to 887±58.12 nm. Pure ATR had a saturated solubility of 0.059±0.005 mg/ml and the prepared nanocrystals ranged from 0.32±0.021 to 0.88±0.019 mg/ml. The Percentage of drug released of plain atorvastatin calcium reached 41.49% while the formula ranged from 44.32 to 61.5%. Both XRD and SEM discussed the degree of crystallinity as follows: F1<F2<F4<F3<ATR. Conclusion: 0.3% of PEG 300 and PEG 400 were not enough to formulate proper nanocrystals while 0.75% tween 20 and tween 80 achieved acceptable formulas. F4 which is prepared with tween 80 exhibited the highest enhancement in saturated solubility, dissolution rate and subsequently expected to have improved oral bioavailability.

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