scholarly journals Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1754
Author(s):  
Salar Hafez Ghoran ◽  
Mohamed El-Shazly ◽  
Nazim Sekeroglu ◽  
Anake Kijjoa
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Viral Infections ◽  
Therapeutic Agents ◽  
Published Data ◽  
Human Coronavirus ◽  
Scientific Communities ◽  
The World ◽  
Herbal Formulae ◽  
Therapeutic Leads

Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace. This pandemic has caused not only hundreds of thousands of mortalities but also a huge economic setback throughout the world. Therefore, the scientific communities around the world have focused on finding antiviral therapeutic agents to either fight or halt the spread of SARS-CoV-2. Since certain medicinal plants and herbal formulae have proved to be effective in treatment of similar viral infections such as those caused by SARS and Ebola, scientists have paid more attention to natural products for effective treatment of this devastating pandemic. This review summarizes studies and ethnobotanical information on plants and their constituents used for treatment of infections caused by viruses related to the coronavirus family. Herein, we provide a critical analysis of previous reports and how to exploit published data for the discovery of novel therapeutic leads to fight against COVID-19.

Clinical Management Updates for Novel Corona Virus (COVID-19)

2021 ◽  
Vol 14 (3) ◽  
pp. 5449-5456
Author(s):  
Yogesh Chand Yadav ◽  
Ramakant Yadav ◽  
Sushant Kumar
Keyword(s):  
Clinical Management ◽  
Respiratory Illness ◽  
Symptomatic Treatment ◽  
Structural Features ◽  
Therapeutic Agents ◽  
Human Coronavirus ◽  
Transmission Potential ◽  
The World ◽  
Severe Respiratory Illness ◽  
Droplet Transmission

The SARS-CoV-2 virus was first detected in Wuhan, China in December 2019 and was known to produce acute severe respiratory illness in humans which rapidly spread almost throughout the world within a few months. This human coronavirus has seven strains and they commonly produce illness in the nervous system, respiratory system and hepato- intestinal systems. This present review is an attempt to illustrate recent reports pertaining to the management of SARS-CoV-2. Further, it also highlights the diagnosis and clinical management of COVID-19. Various search engines like Scopus, Pubmed and WHO databases were accessed and literature on current advances about COVID-19 including structural features, replication, possible pathogenic, symptoms, diagnosis, prognosis, methods of prevention and possible therapeutic agents used for treatment of patients was reviewed. Current studies indicate that COVID-19 is very infectious with droplet transmission potential. The key modalities to prevent the infection is by keeping social distancing, respiratory/hand hygiene, detection of infection and subsequent quarantine of the infected persons. Presently, either no vaccine for prevention or specific treatments available, however, COVID-19 patients may be managed by using some repositioned drugs and symptomatic treatment.

scholarly journals Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review

2020 ◽  
pp. 1-11
Author(s):  
Xi-jun Wang ◽  
Shi Qiu ◽  
Aihua Zhang ◽  
Jian-hua Miao ◽  
Hui Sun ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurological Disorders ◽  
Chemical Biology ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Neuroprotective Effects ◽  
Alternative Medicines ◽  
Pharmacological Targets ◽  
The World

The incidence of neurological disorders is growing in the world together with an increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathology, which make necessary to search for new therapeutic agents. Natural products, most of them used in phytochemicals from herbal medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Numerous herbs have been applied to neurodegenerative disease treatments as complementary and alternative medicines. In the 21st century, omics-coupled functional pharmacology was developed for neurodegenerative drug discovery from natural products. In this article, we firstly provide the latest understanding of neurological disorders on risk factors, category, diagnosis and treatment, and then specially present an overview of natural products in neuroprotective effects research from chemical biology to pharmacological targets, and also discuss the natural products application and future challenge.

scholarly journals Alzheimer‘s disease: exploring nature’s ‘medicinal chest’ for new therapeutic agents

2020 ◽  
Vol 11 (1) ◽  
pp. 201-208
Author(s):  
Anthony Tsarbopoulos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Therapeutic Agents ◽  
Lead Compounds ◽  
Age Related ◽  
Aging Properties ◽  
Disease Modifying ◽  
Disease Modifying Agents

AbstractNatural products have served humanity as a valuable source for the discovery and development of therapeutic agents. In addition, these phytochemicals can function as lead compounds for the development of synthetic analogs aimed at treating human diseases. In our aging society, Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a significant and progressive loss of memory and other cognitive functions. As society demographics change, the predominance of AD and other age-related dementias is increasing, with concurrent financial and societal costs.AD represents one of the most remarkable scientific challenges for drug discovery as the search for effective disease-modifying agents has been unsuccessful. Medicinal plants have been used for their “anti-aging” properties, and cognitive enhancing properties. In the past decades, natural products have been studied for their anti-AD properties, and their potential for developing therapeutic agents against several molecular targets has been evaluated. This insight evaluates the prospects of medicinal plants for providing disease-modifying, as well as disease-preventing, agents for AD.

scholarly journals Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants

Scientifica ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-25
Author(s):  
Franklyn Nonso Iheagwam ◽  
Solomon Oladapo Rotimi
Keyword(s):  
Molecular Docking ◽  
Medicinal Plants ◽  
Therapeutic Targets ◽  
Zinc Database ◽  
Computer Aided Analysis ◽  
The World ◽  
Computer Aided ◽  
Repurposed Drugs ◽  
Therapeutic Leads ◽  
Better Than

The COVID-19 pandemic, which started in Wuhan, China, has spread rapidly over the world with no known antiviral therapy or vaccine. Interestingly, traditional Chinese medicine helped in flattening the pandemic curve in China. In this study, molecules from African medicinal plants were analysed as potential candidates against multiple SARS-CoV-2 therapeutic targets. Sixty-five molecules from the ZINC database subset (AfroDb Natural Products) were virtually screened with some reported repurposed therapeutics against six SARS-CoV-2 and two human targets. Molecular docking, druglikeness, absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the best hits were further simulated. Of the 65 compounds, only three, namely, 3-galloylcatechin, proanthocyanidin B1, and luteolin 7-galactoside found in almond (Terminalia catappa), grape (Vitis vinifera), and common verbena (Verbena officinalis), were able to bind to all eight targets better than the reported repurposed drugs. The findings suggest these molecules may play a role as therapeutic leads in tackling this pandemic due to their multitarget activity.

scholarly journals REVIEW ON POTENT ANTI-DIABETIC PLANTS OR HERBS FROM TRADITIONAL MEDICINE

2018 ◽  
Vol 8 (5) ◽  
pp. 92-98 ◽  
Author(s):  
Shilpa S. Kolhe ◽  
Punit R. Rachh
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Chemical Diversity ◽  
Tinospora Cordifolia ◽  
Ocimum Sanctum ◽  
Screening Programs ◽  
The World ◽  
Pure Compounds ◽  
Increasing Demand

This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. diabetes is one of the major causes of death and disability in the world. Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Due to an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest particularly in edible plants has grown throughout the world. Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. Phytochemicals identified from medicinal plants present an exciting opportunity for the development of new types of therapeutics for diabetes mellitus. Most prevalent among phytochemical groups are the alkaloids, glycosides, polysaccharides, and phenolics such as flavonoids, terpenoids and steroids. These include, Allium sativum, Eugenia jambolana, Momordica charantia Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium, Tinospora cordifolia, Trigonella foenum graecum and Withania somnifera. Keywords: Phytochemicals, diabetes, standardized extracts, bioactive compounds.

scholarly journals Natural Products From Madagascar, Socio-Cultural Usage, and Potential Applications in Advanced Biomedicine: A Concise Review

2021 ◽  
Author(s):  
Camillo La Mesa ◽  
Oliarinony Ranalison ◽  
Lovasoa N. Randriantseheno ◽  
Gianfranco Risuleo
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Primary Source ◽  
Therapeutic Agents ◽  
Botanical Origin ◽  
Disadvantaged Area ◽  
Concise Review ◽  
The World ◽  
Potential Applications ◽  
Natural Means

Natural products endowed of biological activity represent a primary source of commodities ranging from nutrition to therapeutic agents, as well as cosmetic tools, and recreational principles. These natural means have been used by mankind since centuries if not millennia. They are commonly used all over the world and socio-economical contexts but are particularly attractive in disadvantaged area or economically emerging situations all over the world. This is very likely due to the relatively easy recovery of these bioactive principles from the environment, to the low if any cost as well as ease of administration and to the general popular compliance concerning their consumption/ingestion. In this concise review, we focus on some popular bioactive principles of botanical origin which find a wide use in the Madagascan populations. But, due to space limitations only some most common and largely diffused principles in this country are considered. Finally, a possible nanotechnological administration is discussed in the case where a potential therapeutic usage is envisaged.

scholarly journals Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 607
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Emadelden Fouad ◽  
Ngeh Toyang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antiviral Activity ◽  
Influenza A ◽  
Viral Infections ◽  
Skin Diseases ◽  
Hepatitis Virus ◽  
World Health ◽  
World Population ◽  
Oral Diseases ◽  
The World

Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microbial infections, multiple types of cancers, reproductive disorders among a myriad of other ailments. The World Health Organization (WHO) estimates that over 65% of the world population solely utilize botanical preparations as medicine. Due to the abundance of plants, plant-derived medicines are more readily accessible, affordable, convenient, and have safer side-effect profiles than synthetic drugs. Plant-based decoctions have been a significant part of Jamaican traditional folklore medicine. Jamaica is of particular interest because it has approximately 52% of the established medicinal plants that exist on earth. This makes the island particularly welcoming for rigorous scientific research on the medicinal value of plants and the development of phytomedicine thereof. Viral infections caused by the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), hepatitis virus B and C, influenza A virus, and the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) present a significant global burden. This is a review of some important Jamaican medicinal plants, with particular reference to their antiviral activity.

Anti-Ulcer Activities of Medicinal Plants and Natural Products

2020 ◽  
pp. 114-127
Author(s):  
Madhu Rani ◽  
Rubina Chongtham ◽  
Ajeet Singh
Keyword(s):  
Natural Products ◽  
Peptic Ulcer ◽  
Medicinal Plants ◽  
Plant Species ◽  
Health Problem ◽  
Peptic Ulcers ◽  
Mucosal Defense ◽  
The World ◽  
Prevention And Treatment

The peptic ulcer is a widespread and common health problem around the world. The major causes include generation of free radicles, decrease in mucosal defense factor, or increase in mucosal injurious factors. Various plants and their products have been known to prevent or reduce peptic ulcers. Natural products from plants are a rich resource used for centuries to cure different ailments. The use of phyto-constituents as drugs has proved to be clinically effective and less toxic than existing drugs. An attempt has been made to review some plant species and their products as phytomedicines showing promising results in prevention and treatment of peptic ulcers.

scholarly journals Review Importance of Herbal Plants in the Management of Urolithiasis

2019 ◽  
Vol 62 (1) ◽  
pp. 61-66
Author(s):  
Muhammad Mansoor ◽  
Muhammad Jamil ◽  
Noman Latif ◽  
Sher Muhammad ◽  
Jaweria Gull ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Kidney Stone ◽  
Gall Stone ◽  
Urinary Calculi ◽  
Therapeutic Agents ◽  
Stone Disease ◽  
Cassia Fistula ◽  
Synthetic Drugs ◽  
The World ◽  
Herbal Plants

Medicinal plants have been known for millennia and are highly esteemed across the world as an abundant source of therapeutic agents for prevention of various ailments. Today large number of population is suffering from urinary calculi, kidney stone and gall stone. Stone disease has gained increasing relevance as a consequence to changes in living conditions, due to malnutrition and industrialization. Changes in incidence and prevalence, the occurrence of stone types and stone location, and the way in which stone removal are explained. Therapeutic plants (Armoracia lopathifolia, Cassia fistula, Diospyros melaoxylon etc.) are being used from centuries because of its safety, efficacy, ethnical acceptability and less side effects when compared with synthetic drugs. The present review deals with options to be followed for the potential of medicinal plants in stone dissolving activity.

scholarly journals Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines

2021 ◽  
Vol 11 ◽  
Author(s):  
Marzieh Omrani ◽  
Mohsen Keshavarz ◽  
Samad Nejad Ebrahimi ◽  
Meysam Mehrabi ◽  
Lyndy J. McGaw ◽  
...  
Keyword(s):  
Natural Products ◽  
Perceived Risk ◽  
Influenza A ◽  
Viral Infections ◽  
Respiratory Viruses ◽  
World Health ◽  
Screening Programs ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

The emergence of viral pneumonia caused by a novel coronavirus (CoV), known as the 2019 novel coronavirus (2019-nCoV), resulted in a contagious acute respiratory infectious disease in December 2019 in Wuhan, Hubei Province, China. Its alarmingly quick transmission to many countries across the world and a considerable percentage of morbidity and mortality made the World Health Organization recognize it as a pandemic on March 11, 2020. The perceived risk of infection has led many research groups to study COVID-19 from different aspects. In this literature review, the phylogenetics and taxonomy of COVID-19 coronavirus, epidemiology, and respiratory viruses similar to COVID-19 and their mode of action are documented in an approach to understand the behavior of the current virus. Moreover, we suggest targeting the receptors of SARS-CoV and SARS-CoV-2 such as ACE2 and other proteins including 3CLpro and PLpro for improving antiviral activity and immune response against COVID-19 disease. Additionally, since phytochemicals play an essential role in complementary therapies for viral infections, we summarized different bioactive natural products against the mentioned respiratory viruses with a focus on influenza A, SARS-CoV, MERS, and COVID-19.Based on current literature, 130 compounds have antiviral potential, and of these, 94 metabolites demonstrated bioactivity against coronaviruses. Interestingly, these are classified in different groups of natural products, including alkaloids, flavonoids, terpenoids, and others. Most of these compounds comprise flavonoid skeletons. Based on our survey, xanthoangelol E (88), isolated from Angelica keiskei (Miq.) Koidz showed inhibitory activity against SARS-CoV PLpro with the best IC50 value of 1.2 μM. Additionally, hispidulin (3), quercetin (6), rutin (8), saikosaponin D (36), glycyrrhizin (47), and hesperetin (55) had remarkable antiviral potential against different viral infections. Among these compounds, quercetin (6) exhibited antiviral activities against influenza A, SARS-CoV, and COVID-19 and this seems to be a highly promising compound. In addition, our report discusses the obstacles and future perspectives to highlight the importance of developing screening programs to investigate potential natural medicines against COVID-19.

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