scholarly journals Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 656 ◽  
Author(s):  
Shi Su ◽  
Peter M. Kang
Keyword(s):  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Systemic Review ◽  
Advantages And Disadvantages ◽  
Literature Source ◽  
Target Sites ◽  
Different Types ◽  
Bio Imaging ◽  
Targeted Drug ◽  
Careful Design

Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

scholarly journals Formulation and Evaluation of Copper Nanoparticles Loaded Microsponges

2019 ◽  
Vol 11 (04) ◽  
Author(s):  
S. Kothai ◽  
R. Umamaheswari
Keyword(s):  
Copper Nanoparticles ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Hibiscus Rosa Sinensis ◽  
Novel Approach ◽  
Targeted Drug ◽  
Antimicrobial And Antioxidant Activity ◽  
Emulsion Solvent Diffusion Method

Microsponges become imperative in the field of targeted drug delivery and in other biomedical applications. There was a clamant need for designing microsponges incorporating with green synthesised metal nanoparticles rather than the chemical drug in order to reduce the side effects of the drug and thus increasing the effectiveness of nature of the whole material. It provokes us to design this novel approach of loading copper nanoparticles into the microsponges. Here in this work, microsponges based on ethyl cellulose and polyvinyl alcohol were synthesised by Quasi-Emulsion Solvent diffusion method in which copper nanoparticles procured from Hibiscus rosa-sinensis leaf extract was incorporated. The Loaded microsponges were characterised by High Resolution Scanning Electron Microscopy (HR-SEM) and Particle size distribution Analyzer (PSA). The Drug content and Entrapment Efficiency of the microsponges were found out. The antimicrobial and antioxidant activity of the loaded microsponges were evaluated.

scholarly journals Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Gels ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 6 ◽  
Author(s):  
Filippo Pinelli ◽  
Giuseppe Perale ◽  
Filippo Rossi
Keyword(s):  
Drug Delivery ◽  
Surface Functionalization ◽  
Targeted Drug Delivery ◽  
Delivery Systems ◽  
Research Field ◽  
Colloidal Systems ◽  
Advantages And Disadvantages ◽  
Targeted Drug ◽  
Final System ◽  
Targeted Drug Delivery Systems

Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

scholarly journals Alginate-Based Platforms for Cancer-Targeted Drug Delivery

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Lili He ◽  
Zhenghui Shang ◽  
Hongmei Liu ◽  
Zhi-xiang Yuan
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Innovative Strategies ◽  
General Chemical ◽  
Different Types ◽  
Targeted Drug ◽  
Potential Use

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

BIOMEDICAL APPLICATIONS OF MAGNETIC NANOPARTICLES

NANO ◽  
2010 ◽  
Vol 05 (05) ◽  
pp. 245-270 ◽  
Author(s):  
AIGUO WU ◽  
PING OU ◽  
LEYONG ZENG
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Therapeutic Agents ◽  
Short Description ◽  
Resonance Imaging ◽  
Drug Delivery Carrier ◽  
Targeted Drug ◽  
Magnetic Resonance Imaging Mri

In this review, the applications of magnetic nanoparticles in biomedicine are summarized and introduced in three parts. (1) A short description of magnetic nanoparticles is explained. (2) Applications of magnetic nanoparticles in biomedicine are summarized. In biology, new progress of the magnetic separation techniques based on magnetic nanoparticles is discussed. In medicine, the magnetic nanoparticles as therapeutic agents (particularly as a hyperthermia agent, a targeted drug delivery carrier, and a magnetofection agent) as well as contrast agents in magnetic resonance imaging (MRI) are explained in detail. (3) A discussion and remarking conclusion of magnetic nanoparticles in biomedical applications are described. Finally, a perspective of the magnetic nanoparticles in biomedicine in future is also described.

Image Guided Automated Non-Prehensile Magnetic Micromanipulation of Cells

2015 ◽  
Author(s):  
Akash Das ◽  
Ajay D. Thakur ◽  
Atul Thakur
Keyword(s):  
Target Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Cell Manipulation ◽  
Target Cells ◽  
Image Guided ◽  
Targeted Drug ◽  
And Control ◽  
Minimal Adverse Effect ◽  
Ferromagnetic Particles

Biomedical applications like cell manipulation and targeted drug delivery require automated micro-manipulation of biological material. Magnetic micro-manipulation has high actuation speed and minimal adverse effect on cell viability. Ferromagnetic particles, actuated via magnetic field, are used to push a target cell. The process is however cumbersome therefore require automation. This paper reports design, fabrication, and control of an image guided automated non-prehensile magnetic micromanipulation system. The developed system consists of ferromagnetic microspheres (henceforth referred to as microbots) which are actuated via independently controlling currents in four solenoids placed in a quadrupole configuration. We use image based localization for determining the microbot and target cell locations. We developed feedback planner which invokes either of the two maneuvers, namely, push or align to move microbot in order to push the cell towards the goal location. Instead of customize microtools we use simple spherical shaped microbots for pushing target cells.

Novel DNA Aptamers Against CCL21 Protein: Characterization and Biomedical Applications for Targeted Drug Delivery to T Cell-Rich Zones

2018 ◽  
Vol 28 (4) ◽  
pp. 242-251 ◽  
Author(s):  
Louis Chonco ◽  
Gerónimo Fernández ◽  
Rahul Kalhapure ◽  
María J. Hernáiz ◽  
Cecilia García-Oliva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
T Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Protein Characterization ◽  
Dna Aptamers ◽  
Targeted Drug

scholarly journals Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021 ◽  
Vol 8 (10) ◽  
pp. 134
Author(s):  
Abdulkader Baki ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Diagnostic Imaging ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Targeted Drug

Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

scholarly journals Versatile and Robust Method for Antibody Conjugation to Nanoparticles with High Targeting Efficiency

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2153
Author(s):  
Indra Van Zundert ◽  
Maria Bravo ◽  
Olivier Deschaume ◽  
Pierre Cybulski ◽  
Carmen Bartic ◽  
...  
Keyword(s):  
Targeted Drug Delivery ◽  
High Demand ◽  
Cell Specificity ◽  
Wide Range ◽  
Different Types ◽  
Coating Method ◽  
Antibody Conjugation ◽  
Targeted Drug ◽  
Chemotherapy Agents ◽  
Targeted Drug Delivery Systems

The application of antibodies in nanomedicine is now standard practice in research since it represents an innovative approach to deliver chemotherapy agents selectively to tumors. The variety of targets or markers that are overexpressed in different types of cancers results in a high demand for antibody conjugated-nanoparticles, which are versatile and easily customizable. Considering up-scaling, the synthesis of antibody-conjugated nanoparticles should be simple and highly reproducible. Here, we developed a facile coating strategy to produce antibody-conjugated nanoparticles using ‘click chemistry’ and further evaluated their selectivity towards cancer cells expressing different markers. Our approach was consistently repeated for the conjugation of antibodies against CD44 and EGFR, which are prominent cancer cell markers. The functionalized particles presented excellent cell specificity towards CD44 and EGFR overexpressing cells, respectively. Our results indicated that the developed coating method is reproducible, versatile, and non-toxic, and can be used for particle functionalization with different antibodies. This grafting strategy can be applied to a wide range of nanoparticles and will contribute to the development of future targeted drug delivery systems.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

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