scholarly journals Electrospinning Nanofibers for Therapeutics Delivery

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 532 ◽  
Author(s):  
S. Shahriar ◽  
Jagannath Mondal ◽  
Mohammad Hasan ◽  
Vishnu Revuri ◽  
Dong Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Circulation ◽  
Biological Properties ◽  
Detailed Mechanism ◽  
Novel Therapeutics ◽  
Therapeutic Drugs ◽  
Different Types ◽  
Materials Used ◽  
Significant Attention ◽  
Selection Of

The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.

SOMES: A REVIEW ON COMPOSITION, FORMULATION METHODS AND EVALUATIONS OF DIFFERENT TYPES OF “SOMES” DRUG DELIVERY SYSTEM

2020 ◽  
pp. 7-18
Author(s):  
KUSUMA PRIYA M. D. ◽  
VINOD KUMAR ◽  
DAMINI V. K. ◽  
ESWAR K. ◽  
KADIRI RAJESH REDDY ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Surface Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Different Types ◽  
Potent Drug ◽  
Evaluation Parameters ◽  
Selection Of

Many drugs are available in the market for several diseases, disorder or even for a condition, but it is difficult to select a suitable carrier to attain maximum bioavailability and potential for a potent drug. Attaining a controlled and sustained release of a drug is purely focused on the selection of a carrier (natural, synthetic and hybrid) like nanosomes. Nanosomes have become a prominent tool in the field of pharmacy. Nanosomes are small uniform structures which deliver the drug to the specific targeted site, which mainly depends upon the presence of ligands, shape, size and surface chemistry. Nanosomes are available in various types which include Niosomes, Liposomes, Electrosomes, Aquasomes, Transfersomes, Phytosomes, Enzymosomes, Ethosomes, Invasome and Sphingosomes. In general, all these nanosomes are quite similar in nature with minute differences in their vesicular characteristics and composition. This review traces various ‘somes’ composition and their role in the formulation, applications, advantages, disadvantages, common formulation procedures and evaluation parameters.

scholarly journals Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1216
Author(s):  
Shrishti Singh ◽  
Jeffrey Moran
Keyword(s):  
Drug Delivery ◽  
Blood Circulation ◽  
Therapeutic Agents ◽  
Extracellular Matrices ◽  
Future Research ◽  
Use Of Self ◽  
Dense Network ◽  
Different Types ◽  
Delivery Efficiency

For effective treatment of diseases such as cancer or fibrosis, it is essential to deliver therapeutic agents such as drugs to the diseased tissue, but these diseased sites are surrounded by a dense network of fibers, cells, and proteins known as the extracellular matrix (ECM). The ECM forms a barrier between the diseased cells and blood circulation, the main route of administration of most drug delivery nanoparticles. Hence, a stiff ECM impedes drug delivery by limiting the transport of drugs to the diseased tissue. The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. Here, we provide a comprehensive look at the current ECM models in use to mimic the in vivo diseased states, the different types of SPPs that have been experimentally tested in these models, and suggest directions for future research toward clinical translation of SPPs in diverse biomedical settings.

scholarly journals BIOPROFILE OF MICROORGANISMS ISOLATED FROM URINE OF CATS WITH DISEASES OF URINARY SYSTEM

2020 ◽  
pp. 142-147
Author(s):  
N. V. Morozova ◽  
◽  
М. V. Sycheva ◽  
V. I. Sorokin ◽  
◽  
...  
Keyword(s):  
Biological Properties ◽  
Photometric Method ◽  
Urinary System ◽  
E Coli ◽  
Different Types ◽  
Bacteriological Method ◽  
Antilysozyme Activity ◽  
High Level ◽  
Adhesion Index ◽  
Selection Of

The research aim: to study the bioprophiles of microorganisms isolated from the urine of cats in the pathology of the urinary system (cystitis and urolithiasis). 46 strains of different types of bacteria were isolated from the urine of 34 sick animals by bacteriological method and identified using the biochemical test systems “Lachema” (“Erba Lachema s.r.o.”, European Union). The photometric method was used to determine the anti-lysozyme and anti-hemoglobin activity, the adhesion index, and the ability to form biofilms in isolates. It was established that microorganisms isolated from urolithiasis in cats were more often isolated in associations than microorganisms isolated from cystitis, among which monocultures prevailed. Biological properties of isolated microorganisms were studied, bioprofile were identified characterizing the strains. It is shown that cultures of S. aureus, E. coli, S. epidermidis from urine with urolithiasis was significantly higher values antigemoglobin activity; in E. coli – antilysozyme activity, in S. aureus – increased adhesion, in S. epidermidis – the ability to form biofilms than in urine strains with cystitis. P. aeruginosa strains isolated from urine with cystitis were characterized by a high level of adhesion compared to cultures of this species isolated from urine with urolithiasis. The results obtained can be used for differentiation of strains that can cause studied pathologies, as well as for selection of adequate therapy under the control of studied biological properties of microorganisms.

scholarly journals Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 402 ◽  
Author(s):  
Seunghee Lee ◽  
Shayan Fakhraei Lahiji ◽  
Jeesu Jang ◽  
Mingyu Jang ◽  
Hyungil Jung
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Irritation ◽  
Skin Penetration ◽  
Therapeutic Drugs ◽  
Dissolving Microneedles ◽  
Materials Used ◽  
Micro Pillars ◽  
Adhesive Materials

The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive materials used in patches may cause skin irritation, inflammation, and redness. Therefore, we developed a patchless, micro-pillar integrated DMN (P-DMN) that is simple to fabricate and enhances transdermal drug delivery compared with traditional DMN patches. The micro-pillars were made of polymethyl methacrylate at a height of 300 μm and a base diameter of 500 μm. To fabricate P-DMNs, we employed hyaluronic acid, which is a widely used derma filler and plays a role in tissue re-epithelialization. We demonstrate that utilizing P-DMNs significantly improves the delivery efficiency of an encapsulated drug surrogate (91.83% ± 7.75%) compared with traditional DMNs (64.86% ± 8.17%). Interestingly, P-DMNs remarkably increase the skin penetration accuracy rate of encapsulated drugs, up to 97.78% ± 2.22%, compared with 44.44% ± 7.85% in traditional DMNs. Our findings suggest that P-DMNs could serve as a highly accurate and efficient platform for transdermal delivery of various types of micro- and macro-biomolecules.

Different Types of Materials Used for Stone Column

2013 ◽  
Vol 405-408 ◽  
pp. 155-157
Author(s):  
Mohd Ashraf Mohamad Ismail ◽  
Lye Khong Ng ◽  
Hooi Min Yee
Keyword(s):  
Research Study ◽  
Soft Soil ◽  
Stone Column ◽  
Consolidation Process ◽  
Column Material ◽  
Different Types ◽  
Materials Used ◽  
Selection Of

The degree of improvement of a soft soil by stone column is due to the inclusion of a stiffer column material and the densification of the surrounding soft soil during the installation of the vibrocompacted stone column itself and the subsequent consolidation process occurring in the soft soil before the final loading of improved soil. Research study on different materials for stone column has not attracted much attention. A systematic verification of the effectiveness of different materials for stone column need to be carried out. It is an important output to be presented as a general guidelines for the selection of proper stone column material which can be used effectively and economically.

Electrospun Nanofibers for Drug Delivery Applications

2022 ◽  
pp. 33-51
Author(s):  
Bishweshwar Pant ◽  
Mira Park
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Electrospun Nanofibers ◽  
Biological Properties ◽  
Electrospinning Process ◽  
Energy Storage Materials ◽  
Indirect Methods ◽  
Textile Industries ◽  
Selection Of

Nanofiber systems with various composition and biological properties have been extensively studied for various biomedical applications. The electrospinning process has been regarded as one of the versatile techniques to prepare nano to microfibers. The electrospun nanofibers are being used especially in textile industries, sensors, filters, protective clothing, energy storage materials, and biomedical applications. In the last decade, electrospun nanofibers have been highly investigated for drug delivery systems to achieve a therapeutic effect in specifically targeted sites. Various drugs or biomolecules can be easily loaded into the electrospun nanofibers by direct or indirect methods. The proper selection of polymers (or blends of various polymers), drugs, solvents to prepare the composite nanofibers with desired morphology are the tools in enhancing the bioavailability, stability, and bioactivity of drugs.

scholarly journals Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 79
Author(s):  
Irina N. Savina ◽  
Mohamed Zoughaib ◽  
Abdulla A. Yergeshov
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Gelation Process ◽  
Biological Environment ◽  
Advanced Biomaterials ◽  
The Relationship ◽  
Interconnected Pores ◽  
Selection Of

Cryogels obtained by the cryotropic gelation process are macroporous hydrogels with a well-developed system of interconnected pores and shape memory. There have been significant recent advancements in our understanding of the cryotropic gelation process, and in the relationship between components, their structure and the application of the cryogels obtained. As cryogels are one of the most promising hydrogel-based biomaterials, and this field has been advancing rapidly, this review focuses on the design of biodegradable cryogels as advanced biomaterials for drug delivery and tissue engineering. The selection of a biodegradable polymer is key to the development of modern biomaterials that mimic the biological environment and the properties of artificial tissue, and are at the same time capable of being safely degraded/metabolized without any side effects. The range of biodegradable polymers utilized for cryogel formation is overviewed, including biopolymers, synthetic polymers, polymer blends, and composites. The paper discusses a cryotropic gelation method as a tool for synthesis of hydrogel materials with large, interconnected pores and mechanical, physical, chemical and biological properties, adapted for targeted biomedical applications. The effect of the composition, cross-linker, freezing conditions, and the nature of the polymer on the morphology, mechanical properties and biodegradation of cryogels is discussed. The biodegradation of cryogels and its dependence on their production and composition is overviewed. Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing.

NMR Assisted Antimicrobial Peptide Designing: Structure Based Modifications and Functional Correlation of a Designed Peptide VG16KRKP

2020 ◽  
Vol 27 (9) ◽  
pp. 1387-1404 ◽  
Author(s):  
Karishma Biswas ◽  
Humaira Ilyas ◽  
Aritreyee Datta ◽  
Anirban Bhunia
Keyword(s):  
Antimicrobial Agents ◽  
Biological Properties ◽  
Structure Characterization ◽  
Drug Resistant ◽  
Functional Correlation ◽  
Naturally Occurring ◽  
High Resolution Nmr ◽  
Different Types ◽  
Reduced Activity ◽  
Poor Stability

Antimicrobial Peptides (AMPs), within their realm incorporate a diverse group of structurally and functionally varied peptides, playing crucial roles in innate immunity. Over the last few decades, the field of AMP has seen a huge upsurge, mainly owing to the generation of the so-called drug resistant ‘superbugs’ as well as limitations associated with the existing antimicrobial agents. Due to their resilient biological properties, AMPs can very well form the sustainable alternative for nextgeneration therapeutic agents. Certain drawbacks associated with existing AMPs are, however, issues of major concern, circumventing which are imperative. These limitations mainly include proteolytic cleavage and hence poor stability inside the biological systems, reduced activity due to inadequate interaction with the microbial membrane, and ineffectiveness because of inappropriate delivery among others. In this context, the application of naturally occurring AMPs as an efficient prototype for generating various synthetic and designed counterparts has evolved as a new avenue in peptide-based therapy. Such designing approaches help to overcome the drawbacks of the parent AMPs while retaining the inherent activity. In this review, we summarize some of the basic NMR structure based approaches and techniques which aid in improving the activity of AMPs, using the example of a 16-residue dengue virus fusion protein derived peptide, VG16KRKP. Using first principle based designing technique and high resolution NMR-based structure characterization we validate different types of modifications of VG16KRKP, highlighting key motifs, which optimize its activity. The approaches and designing techniques presented can support our peers in their drug development work.

Inorganic Gold and Polymeric Poly(Lactide-co-glycolide) Nanoparticles as Novel Strategies to Ameliorate the Biological Properties of Antimicrobial Peptides

2020 ◽  
Vol 21 (4) ◽  
pp. 429-438 ◽  
Author(s):  
Bruno Casciaro ◽  
Francesca Ghirga ◽  
Deborah Quaglio ◽  
Maria Luisa Mangoni
Keyword(s):  
Antimicrobial Peptides ◽  
Biological Properties ◽  
Biological Profile ◽  
Innovative Strategy ◽  
Different Types ◽  
New Antibiotics ◽  
Interesting Class ◽  
Alternative Antimicrobials ◽  
Nanoparticulate Systems ◽  
Infective Activity

Cationic antimicrobial peptides (AMPs) are an interesting class of gene-encoded molecules endowed with a broad-spectrum of anti-infective activity and immunomodulatory properties. They represent promising candidates for the development of new antibiotics, mainly due to their membraneperturbing mechanism of action that very rarely induces microbial resistance. However, bringing AMPs into the clinical field is hampered by some intrinsic limitations, encompassing low peptide bioavailability at the target site and high peptide susceptibility to proteolytic degradation. In this regard, nanotechnologies represent an innovative strategy to circumvent these issues. According to the literature, a large variety of nanoparticulate systems have been employed for drug-delivery, bioimaging, biosensors or nanoantibiotics. The possibility of conjugating different types of molecules, including AMPs, to these systems, allows the production of nanoformulations able to enhance the biological profile of the compound while reducing its cytotoxicity and prolonging its residence time. In this minireview, inorganic gold nanoparticles (NPs) and biodegradable polymeric NPs made of poly(lactide-coglycolide) are described with particular emphasis on examples of the conjugation of AMPs to them, to highlight the great potential of such nanoformulations as alternative antimicrobials.

Chitosan in Biomedical Engineering: A Critical Review

2019 ◽  
Vol 14 (2) ◽  
pp. 93-116 ◽  
Author(s):  
Shabnam Mohebbi ◽  
Mojtaba Nasiri Nezhad ◽  
Payam Zarrintaj ◽  
Seyed Hassan Jafari ◽  
Saman Seyed Gholizadeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Biomedical Engineering ◽  
Biological Properties ◽  
Advanced Materials ◽  
Comprehensive Overview ◽  
Chemical Structures ◽  
Bio Imaging ◽  
Significant Attention ◽  
Unique Chemical

Biomedical engineering seeks to enhance the quality of life by developing advanced materials and technologies. Chitosan-based biomaterials have attracted significant attention because of having unique chemical structures with desired biocompatibility and biodegradability, which play different roles in membranes, sponges and scaffolds, along with promising biological properties such as biocompatibility, biodegradability and non-toxicity. Therefore, chitosan derivatives have been widely used in a vast variety of uses, chiefly pharmaceuticals and biomedical engineering. It is attempted here to draw a comprehensive overview of chitosan emerging applications in medicine, tissue engineering, drug delivery, gene therapy, cancer therapy, ophthalmology, dentistry, bio-imaging, bio-sensing and diagnosis. The use of Stem Cells (SCs) has given an interesting feature to the use of chitosan so that regenerative medicine and therapeutic methods have benefited from chitosan-based platforms. Plenty of the most recent discussions with stimulating ideas in this field are covered that could hopefully serve as hints for more developed works in biomedical engineering.

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