scholarly journals Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan Diets

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 779 ◽  
Author(s):  
Pietro Manuel Ferraro ◽  
Matteo Bargagli ◽  
Alberto Trinchieri ◽  
Giovanni Gambaro
Keyword(s):  
Risk Factors ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Dairy Products ◽  
Fruits And Vegetables ◽  
Medical Condition ◽  
Scientific Evidence ◽  
Scientific Work ◽  
Dietary Factors ◽  
Dietary Advice

Nephrolithiasis is a common medical condition influenced by multiple environmental factors, including diet. Since nutritional habits play a relevant role in the genesis and recurrence of kidney stones disease, dietary manipulation has become a fundamental tool for the medical management of nephrolithiasis. Dietary advice aims to reduce the majority of lithogenic risk factors, reducing the supersaturation of urine, mainly for calcium oxalate, calcium phosphate, and uric acid. For this purpose, current guidelines recommend increasing fluid intake, maintaining a balanced calcium intake, reducing dietary intake of sodium and animal proteins, and increasing intake of fruits and fibers. In this review, we analyzed the effects of each dietary factor on nephrolithiasis incidence and recurrence rate. Available scientific evidence agrees on the harmful effects of high meat/animal protein intake and low calcium diets, whereas high content of fruits and vegetables associated with a balanced intake of low-fat dairy products carries the lowest risk for incident kidney stones. Furthermore, a balanced vegetarian diet with dairy products seems to be the most protective diet for kidney stone patients. Since no study prospectively examined the effects of vegan diets on nephrolithiasis risk factors, more scientific work should be made to define the best diet for different kidney stone phenotypes.

scholarly journals P0175DETERMINANTS OF RENAL PAPILLARY APPEARANCE IN RENAL STONE FORMERS: AN IN-DEPTH EXAMINATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Matteo Bargagli ◽  
Rossella De Leonardis ◽  
Mauro Ragonese ◽  
Angelo Totaro ◽  
Francesco Pinto ◽  
...  
Keyword(s):  
Kidney Stones ◽  
Kidney Stone ◽  
Medical Condition ◽  
Stone Formation ◽  
Blood Parameters ◽  
Stone Disease ◽  
Stone Composition ◽  
Stone Recurrence ◽  
Stone Formers

Abstract Background and Aims Nephrolithiasis is a medical condition characterized by high prevalence among the general population both in Europe and in the U.S. and it is responsible for high costs reaching up to $10 billion per year. It is associated with specific comorbidities such as obesity, arterial hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Kidney stones development is believed to start either from Randall’s plaques or from stone plugs. Both these lesions can be seen on renal papillary surfaces, but what promotes the formation of plaques and plugs is not entirely understood. The aim of this study is to investigate the association between the urinary metabolic milieu and a published endoscopic papillary evaluation score (PPLA). We also evaluated the correlation of PPLA score with kidney stone recurrence during follow-up. Method We prospectively enrolled 31 stone forming patients who undergone retrograde intrarenal surgery procedures. Visual inspection of the accessible renal papillae was performed in order to calculate the PPLA score based on the appearance of ductal plugging, surface pitting, loss of papillary contour and Randall’s plaque extension. Demographic information, blood samples, 24h urine collections and kidney stone events during follow-up were collected. Stone composition was analyzed using infrared-spectroscopy. Relative urinary supersaturations (RSS) for calcium oxalate (CaOx), calcium phosphate (CaPi) and uric acid (UA) were calculated using the Equil2 software. PPLA score > 3 was defined as high. Results Median follow-up period was 11 (min/max 5, 34) months. PPLA score was inversely correlated with BMI (rho = −0.39, p = 0.035) and history of recurrent kidney stones (median PPLA 5.0 vs 2.5, p = 0.029), these results were confirmed when PPLA was considered as a categorical variable (median BMI 27 vs 24, recurrent stone disease 12 vs 62%, p= 0.006). Furthermore, high PPLA score was associated with lower odds of new kidney stone events during follow-up (OR 0.154, 95% confidence interval 0.024, 0.998, p = 0.05). No significant correlations were found between PPLA score, stone composition, blood parameters, 24h urine solute excretions and RSS for CaOx, CaPi and UA. Conclusion Different papillary abnormalities seem to be linked to specific mechanisms of stone formation. Although data regarding PPLA score are inconsistent, it may be a valid asset for both medical and surgical management of nephrolithiasis. Larger, long-term prospective clinical studies need to be conducted to assess the validity of PPLA score system in evaluating risk of stone recurrence.

scholarly journals Assessment of knowledge of risk factors and prevention of obesity among school children: a cross sectional study

2019 ◽  
Vol 7 (1) ◽  
pp. 111
Author(s):  
Praveena R. Gunagi ◽  
Shobha S. Karikatti ◽  
Sunanda B. Halki
Keyword(s):  
Risk Factors ◽  
School Children ◽  
Fruits And Vegetables ◽  
Preventive Measures ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Dietary Factors ◽  
Sectional Study ◽  
School Students ◽  
Cross Sectional

Background: Childhood obesity is a major contributor to the global burden of chronic diseases and is an important determinant of cardiovascular diseases, type II diabetes etc. This can largely be attributed to the transformation in the lifestyles of children. There is still lack of knowledge about obesity among high school children. Objective of this study was to assess the knowledge of risk factors of obesity among school children and to find out the knowledge of hazards and preventive measures of obesity among school children.Methods: A cross-sectional study was conducted among school students aged between 13-14 years from 9 randomly selected schools. The total sample included 480 students.Results: Out of 480 subjects 70.4% had heard about obesity, 62.3% were aware about the increasing prevalence of obesity among the youngsters, 26.7% thought unhealthy dietary factors and 29% thought mental stress were the main factors leading to obesity and non-communicable diseases. More than 75% students had correct knowledge of dietary factors associated with obesity like eating larger portion of food, eating fried foods, having junk foods. 51-75% of the students responded correctly for the factors i.e. using motorcycle for short distance.Conclusions: More than half of the students had knowledge of specific dietary and physical activity risk factors. Majority of the students identified high blood pressure, diabetes and heart problem as hazards of obesity. Only one third of the students knew preventive measures like adequate intake of fruits and vegetables, limiting unhealthy snacks and limiting screen time to prevent obesity.

scholarly journals Intake of Vitamins B6 and C and the Risk of Kidney Stones in Women

1999 ◽  
Vol 10 (4) ◽  
pp. 840-845
Author(s):  
GARY C. CURHAN ◽  
WALTER C. WILLETT ◽  
FRANK E. SPEIZER ◽  
MEIR J. STAMPFER
Keyword(s):  
Relative Risk ◽  
Vitamin C ◽  
Confidence Interval ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Vitamin B6 ◽  
Stone Formation ◽  
Dietary Factors ◽  
Incident Cases ◽  
Kidney Stone Formation

Abstract. Urinary oxalate is an important determinant of calcium oxalate kidney stone formation. High doses of vitamin B6 may decrease oxalate production, whereas vitamin C can be metabolized to oxalate. This study was conducted to examine the association between the intakes of vitamins B6 and C and risk of kidney stone formation in women. The relation between the intake of vitamins B6 and C and the risk of symptomatic kidney stones were prospectively studied in a cohort of 85,557 women with no history of kidney stones. Semiquantitative food-frequency questionnaires were used to assess vitamin consumption from both foods and supplements. A total of 1078 incident cases of kidney stones was documented during the 14-yr follow-up period. A high intake of vitamin B6 was inversely associated with risk of stone formation. After adjusting for other dietary factors, the relative risk of incident stone formation for women in the highest category of B6 intake (≥40 mg/d) compared with the lowest category (<3 mg/d) was 0.66 (95% confidence interval, 0.44 to 0.98). In contrast, vitamin C intake was not associated with risk. The multivariate relative risk for women in the highest category of vitamin C intake (≥1500 mg/d) compared with the lowest category (<250 mg/d) was 1.06 (95% confidence interval, 0.69 to 1.64). Large doses of vitamin B6 may reduce the risk of kidney stone formation in women. Routine restriction of vitamin C to prevent stone formation appears unwarranted.

Temporal Trends of Dietary Risk Factors after a Diagnosis of Kidney Stones

2021 ◽  
pp. CJN.09200721
Author(s):  
Pietro Manuel Ferraro ◽  
Tamara Cunha ◽  
Eric Taylor ◽  
Gary Curhan
Keyword(s):  
Kidney Stones ◽  
Kidney Stone ◽  
Stone Formation ◽  
Dietary Factors ◽  
Dash Score ◽  
Sweetened Beverages ◽  
Stone Formers ◽  
Supplemental Calcium ◽  
History Of

Diet is an important contributor to kidney stone formation, but there are limited data regarding long-term changes in dietary factors after a diagnosis of a kidney stone. We analyzed data from three longitudinal cohorts, the Health Professionals Follow-Up Study and the Nurses' Health Studies I and II, comparing changes in dietary factors in participants with and without a history of kidney stones during follow-up. The total daily intake of dietary calcium, supplemental calcium, animal protein, caffeine, fructose, potassium, sodium, oxalate, phytate, vitamin D, vitamin C, sugar-sweetened beverages, fluids, NEAP and DASH score were assessed by repeat FFQs and computed as absolute differences; a difference-in-differences (DID) approach was used to account for general temporal changes using data from participants without a history of kidney stones from the same calendar period. 184,398 participants with no history of kidney stones were included, 7,095 of whom became confirmed stone formers. Several intakes changed significantly over time in stone formers compared with non-formers, with some showing a relative increase up to 8 years later, including caffeine (DID 8.8 mg/day, 95% CI 3.4, 14.1), potassium (23.4 mg/day, 95% CI 4.6, 42.3), phytate (12.1 mg/day, 95% CI 2.5, 21.7), sodium (43.1 mg/day, 95% CI 19.8, 66.5) and fluid intake (47.1 mL/day, 95% CI 22.7, 71.5). Other dietary factors showed a significant decrease, such as oxalate (−7.3 mg/day, 95% CI −11.4, −3.2), vitamin C (−34.2 mg/day, 95% CI −48.8, −19.6), and vitamin D (−18.0 IU/day, 95% CI −27.9, −8.0). A significant reduction in sugar-sweetened beverages of −0.5 (95% CI −0.8, −0.3) and −1.4 (95% CI −1.8, −1.0) servings/week and supplemental calcium −105.1 (95% CI −135.4, −74.7) and −69.4 (95% CI −95.4, −43.4) mg/day for NHS I and NHS II, respectively intake was observed in women. Animal protein, dietary calcium, fructose intake, DASH score and NEAP did not change significantly over time. After the first episode of a kidney stone, mild and inconsistent changes were observed concerning dietary factors associated with kidney stone formation.

Sex Differences of Kidney Stone Urine Risk Factors after Roux-en-Y Gastric Bypass

2021 ◽  
Vol 52 (2) ◽  
pp. 173-176
Author(s):  
Megan Prochaska ◽  
John Asplin ◽  
Arlene Chapman ◽  
Elaine Worcester
Keyword(s):  
Risk Factors ◽  
Gastric Bypass ◽  
Sex Differences ◽  
Calcium Phosphate ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Men And Women ◽  
Before And After ◽  
Urine Composition ◽  
Bariatric Surgical Procedure

<b><i>Introduction:</i></b> Roux-en-Y gastric bypass (RYGB) is a bariatric surgical procedure that is associated with higher risk of kidney stones after surgery. We examined urine composition in 18 men and women before and after RYGB to examine differences in kidney stone risk. <b><i>Methods:</i></b> Three 24-h urine collections were performed before and 1 year after RYGB. We analyzed mean urinary values for pre- and post-RYGB collections and compared men and women. <b><i>Results:</i></b> Seven men and eleven women completed pre- and post-RYGB urine collections. Pre-RYGB, men had higher calcium oxalate supersaturation (CaOx SS) (7.0 vs. 5.0, <i>p</i> = 0.04) compared with women. Post-RYGB, women had higher urine CaOx SS (13.1 vs. 4.6, <i>p</i> = 0.002), calcium phosphate supersaturation (1.04 vs. 0.59, <i>p</i> = 0.05), and lower urine volumes (1.7 vs. 2.7L, <i>p</i> &#x3c; 0.001) compared with men. <b><i>Discussion/Conclusion:</i></b> There are important differences in urine composition by sex that may contribute to higher kidney stone risk in women after RYGB compared with men.

scholarly journals Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Parvin Khalili ◽  
Zahra Jamali ◽  
Tabandeh Sadeghi ◽  
Ali Esmaeili-nadimi ◽  
Maryam Mohamadi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care Providers ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Adult Population ◽  
Stone Disease ◽  
Care Providers ◽  
Baseline Phase ◽  
Kidney Stone Disease ◽  
History Of

Abstract Background The prevalence of kidney stones in the world is increasing and environmental factors seem to play a major role in this issue. The aim of the present study was to investigate the prevalence of risk factors of kidney stones in the adult population of Rafsanjan city based on the data of the Rafsanjan Cohort Study (RCS). Methods In the baseline phase of this study, 10,000 people aged 35 to 70 years are enrolled in the RCS, as one of the prospective epidemiological research studies in Iran. From this population, 9932 participants completed related demographic questionnaires as well as reported a history of diabetes mellitus, kidney stone, and hypertension diseases. The obtained data were analyzed using univariable and multivariable logistics regression. Results According to the obtained results, 46.54% of the studied population were male and 53.46% were female. The mean age of the participants was 49.94 ± 9.56 years. 2392 people accounting for 24.08% of the population had kidney stones. After adjustment of the variables, six variables of gender, WSI, no consumption of purified water, BMI, and history of hypertension and diabetes were found to be significant related factors of kidney stone disease. Conclusions Gender, hypertension, obesity, diabetes, and personal habits like alcohol consumption, opium use and, cigarette smoking are effective in the development of kidney stones. So, by identifying the susceptible patients and teaching them, the burden of the disease on society and the individual can be reduced. The results of this study are helpful to health care providers for preventive planning for kidney stone disease.

scholarly journals Association of kidney stone disease with dietary factors: a review

2020 ◽  
Vol 83 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Henry Konjengbam ◽  
Sanjenbam Yaiphaba Meitei
Keyword(s):  
Kidney Stones ◽  
Kidney Stone ◽  
Dietary Habits ◽  
Northeast India ◽  
Stone Disease ◽  
Climatic Conditions ◽  
Dietary Factors ◽  
Leafy Vegetables ◽  
Kidney Stone Disease ◽  
Green Leafy Vegetables

AbstractKidney stone disease is one of the most common urologic disorders worldwide. The incidence of kidney stones disease is increasing all over the world. It is a multifactorial disease accompanied by various factors. The dietary factor is one of the most important risk factors for the formation and recurrence of kidney stone disease. Formation and recurrence of kidney stone disease can be prevented by modifying our day to day dietary habits. Fewer intakes of animal protein, higher intake of fluid, higher intake of fruits, and higher intake of green leafy vegetables, which contain a low amount of oxalate, can prevent the formation of kidney stones and recurrence of kidney stones. From this review, it may be presumed that the higher prevalence rate of kidney stone disease in northeast India may be the dietary factors accompanied by environmental and climatic conditions of the region.

MO122SEX DIFFERENCES IN THE RISK OF KIDNEY STONES

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Pietro Manuel Ferraro ◽  
Eric N Taylor ◽  
Gary C Curhan
Keyword(s):  
Risk Factors ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Cox Proportional Hazards ◽  
Sodium Oxalate ◽  
Dietary Intakes ◽  
Calendar Time ◽  
Men And Women ◽  
History Of ◽  
Over Time

Abstract Background and Aims Kidney stone disease is a highly prevalent condition. Men are at higher risk of developing stones compared with women, however recent data suggest a changing epidemiology with women being relatively more affected than in the past. The reasons for such differences and changes over time are not clear. Method We analyzed the association between sex and the first symptomatic incident kidney stone using data from three large, longitudinal cohorts. Incidence rates for men and women overall and across categories of age and calendar time were computed and hazard ratios (HRs) and 95% confidence intervals (CIs) generated with age-adjusted Cox proportional hazards regression models. Mediation analysis was performed in order to estimate the amount of excess risk for men explained by established risk factors, including BMI, waist circumference, history of high blood pressure, history of diabetes, use of thiazides, dietary intakes of animal protein, caffeine, fructose, potassium, sodium, oxalate, phytate, dietary and supplemental intakes of calcium, vitamin C and vitamin D, sugar-sweetened beverages and total fluid intake. Results The analysis included data from 268,616 participants, contributing 5,876,205 person-years of follow-up, during which 10,303 incident stone events were confirmed. The overall incidence rate of kidney stones was 271 and 158 per 100,000 person-years for men and women, respectively. The age-adjusted HR for men compared with women was 2.32 (95% CI 2.20, 2.45). About 18% of the difference in rates was explained by the risk factors included in the analysis. The risk of stones was consistently higher across categories of age among men compared with women. With regard to calendar time, the risk remained higher among men, but tended to decrease over time while it increased among women, resulting in a relative risk reduction of 38% for after 2009 compared with before 1990. Conclusion The risk of kidney stones is higher among men compared with women. This difference is only partly explained by modifiable risk factors.

scholarly journals Dietary factors and the risks of oesophageal adenocarcinoma and Barrett's oesophagus

2010 ◽  
Vol 23 (2) ◽  
pp. 230-246 ◽  
Author(s):  
Ai Kubo ◽  
Douglas A. Corley ◽  
Christopher D. Jensen ◽  
Rubinder Kaur
Keyword(s):  
Risk Factors ◽  
Fruits And Vegetables ◽  
Epidemiological Studies ◽  
Incidence Rates ◽  
Dietary Factors ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Barrett's Oesophagus ◽  
Dark Green ◽  
Demographic Distribution

Incidence rates for oesophageal adenocarcinoma have increased by over 500 % during the past few decades without clear reasons. Gastro-oesophageal reflux disease, obesity and smoking have been identified as risk factors, although the demographic distribution of these risk factors is not consistent with the demographic distribution of oesophageal adenocarcinoma, which is substantially more common among whites and males than any other demographic groups. Numerous epidemiological studies have suggested associations between dietary factors and the risks of oesophageal adenocarcinoma and its precursor, Barrett's oesophagus, though a comprehensive review is lacking. The main aim of the present review is to consider the evidence linking dietary factors with the risks of oesophageal adenocarcinoma, Barrett's oesophagus, and the progression from Barrett's oesophagus to oesophageal adenocarcinoma. The existing epidemiological evidence is strongest for an inverse relationship between intake of vitamin C, β-carotene, fruits and vegetables, particularly raw fruits and vegetables and dark green, leafy and cruciferous vegetables, carbohydrates, fibre and Fe and the risk of oesophageal adenocarcinoma and Barrett's oesophagus. Patients at higher risk for Barrett's oesophagus and oesophageal adenocarcinoma may benefit from increasing their consumption of fruits and vegetables and reducing their intake of red meat and other processed food items. Further research is needed to evaluate the relationship between diet and the progression of Barrett's oesophagus to oesophageal adenocarcinoma. Evidence from cohort studies will help determine whether randomised chemoprevention trials are warranted for the primary prevention of Barrett's oesophagus or its progression to cancer.

Prostate Cancer

2018 ◽  
Author(s):  
Kathryn M. Wilson ◽  
Lorelei Mucci
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Family History ◽  
Prostate Specific Antigen ◽  
Advanced Prostate Cancer ◽  
Advanced Disease ◽  
African Ancestry ◽  
Specific Antigen ◽  
Dietary Factors ◽  
Increased Risk

Prostate cancer is among the most commonly diagnosed cancers among men, ranking second in cancer globally and first in Western countries. There are marked variations in incidence globally, and its incidence must be interpreted in the context of diagnostic intensity and screening. The uptake of prostate-specific antigen screening since the 1990s has led to dramatic increases in incidence in many countries, resulting in an increased proportion of indolent cancers that would never have come to light clinically in the absence of screening. Risk factors differ when studying prostate cancer overall versus advanced disease. Older age, African ancestry, and family history are established risk factors for prostate cancer. Obesity and smoking are not associated with risk overall, but are associated with increased risk of advanced prostate cancer. Several additional lifestyle factors, medications, and dietary factors are now emerging as risk factors for advanced disease.

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