scholarly journals Meta-Analysis of Carbohydrate Solution Intake during Prolonged Exercise in Adults: From the Last 45+ Years’ Perspective

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4223
Author(s):  
Dimitrios I. Bourdas ◽  
Athanasios Souglis ◽  
Emmanouil D. Zacharakis ◽  
Nickos D. Geladas ◽  
Antonios K. Travlos
Keyword(s):  
Prolonged Exercise ◽  
Meta Analysis ◽  
Age Groups ◽  
Acute Effect ◽  
Superior Performance ◽  
Control Group ◽  
Eligibility Criteria ◽  
Gender And Age ◽  
Solution Intake ◽  
Administration Timing

Carbohydrate (CHO) supplementation during prolonged exercise postpones fatigue. However, the optimum administration timing, dosage, type of CHO intake, and possible interaction of the ergogenic effect with athletes’ cardiorespiratory fitness (CRF) are not clear. Ninety-six studies (from relevant databases based on predefined eligibility criteria) were selected for meta-analysis to investigate the acute effect of ≤20% CHO solutions on prolonged exercise performance. The between-subject standardized mean difference [SMD = ([mean post-value treatment group–mean post-value control group]/pooled variance)] was assessed. Overall, SMD [95% CI] of 0.43 [0.35, 0.51] was significant (p < 0.001). Subgroup analysis showed that SMD was reduced as the subjects’ CRF level increased, with a 6–8% CHO solution composed of GL:FRU improving performance (exercise: 1–4 h); administration during the event led to a superior performance compared to administration before the exercise, with a 6–8% single-source CHO solution increasing performance in intermittent and ‘stop and start’ sports and an ~6% CHO solution appearing beneficial for 45–60 min exercises, but there were no significant differences between subjects’ gender and age groups, varied CHO concentrations, doses, or types in the effect measurement. The evidence found was sound enough to support the hypothesis that CHO solutions, when ingested during endurance exercise, have ergogenic action and a possible crossover interaction with the subject’s CRF.

scholarly journals Tolerability of statin-based management of patients with a history of statin-associated muscle symptoms: protocol for a systematic review

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e052341
Author(s):  
Fanny Villoz ◽  
Christina Lyko ◽  
Cinzia Del Giovane ◽  
Nicolas Rodondi ◽  
Manuel R Blum
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Mean Difference ◽  
Control Group ◽  
Cochrane Central Register ◽  
Eligibility Criteria ◽  
Clinical Issue ◽  
Standard Data ◽  
Evaluation Approach ◽  
History Of

IntroductionStatin-associated muscle symptoms (SAMSs) are a major clinical issue in the primary and secondary prevention of cardiovascular events. Current guidelines advise various approaches mainly based on expert opinion. We will lead a systematic review and meta-analysis to explore the tolerability and acceptability and effectiveness of statin-based therapy management of patients with a history of SAMS. We aim to provide evidence on the tolerability and different strategies of statin-based management of patients with a history of SAMS.Methods and analysisWe will conduct a systematic review of randomised controlled trials (RCTs) and non-randomised studies with a control group. We will search in Data sources MEDLINE, EMBASE, Cochrane Central Register of Controlled Clinical Trials, Scopus, Clinicaltrials.gov and Proquest from inception until April 2021. Two independent reviewers will carry out the study selection based on eligibility criteria. We will extract data following a standard data collection form. The reviewers will use the Cochrane Collaboration’s tools and Newcastle-Ottawa Scale to appraise the study risk of bias. Our primary outcome will be tolerability and our secondary outcomes will be acceptability and effectiveness. We will conduct a qualitative analysis of all included studies. In addition, if sufficient and homogeneous data are available, we will conduct quantitative analysis. We will synthesise dichotomous data using OR with 95% CI and continuous outcomes by using mean difference or standardised mean difference (with 95% CI). We will determine heterogeneity visually with forest plots and quantitatively with I2 and Q-test. We will summarise the confidence in the quantitative estimate by using Grading of Recommendations Assessment, Development and Evaluation approach.Ethics and disseminationAs a systematic review of literature without collection of new clinical data, there will be no requirement for ethical approval. We will disseminate findings through peer-reviewed publications.PROSPERO registration numberCRD42020202619.

Association between circulating leptin levels and multiple sclerosis: a systematic review and meta-analysis

2018 ◽  
Vol 94 (1111) ◽  
pp. 278-283 ◽  
Author(s):  
Xue-Feng Xie ◽  
Xiao-Hui Huang ◽  
Ai-Zong Shen ◽  
Jun Li ◽  
Ye-Huan Sun
Keyword(s):  
Multiple Sclerosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Control Group ◽  
Sample Type ◽  
Healthy Controls ◽  
Eligibility Criteria ◽  
Effect Model ◽  
Healthy Control

AimLeptin, synthesised by adipocytes, has been identified as a hormone that can influence inflammatory activity. Several studies have investigated leptin levels in patients with multiple sclerosis (MS), but the results are not consistent. This study aims to derive a more precise evaluation on the relationship between circulating leptin levels and MS.DesignA comprehensive literature searched up to July 2017 was conducted to evaluate the association of circulating leptin levels and MS. The random-effect model was applied to calculate pooled standardised mean difference (SMD) and its 95% CI.Main outcome measuresCirculating leptin levels of patients with MS and healthy controls.ResultsOf 2155 studies identified, 33 met eligibility criteria and 9 studies with 645 patients with MS and 586 controls were finally included in the meta-analysis. Meta-analysis revealed that, compared with the healthy control group, the MS group had significantly higher plasma/serum leptin levels, with the SMD of 0.70% and 95% CI (0.24 to 1.15). Subgroup analyses suggested that the leptin levels of patients with MS were associated with region, age, study sample size, measurement type, gender and blood sample type.ConclusionOverall, our study suggests that patients with MS have a significantly higher leptin level than in healthy controls. Further mechanism studies and longitudinal large cohort studies are still needed to further reveal the role of leptin in the pathogenesis of MS.

Corticosteroid as an Adjunct in the Treatment of Endobronchial Tuberculosis: A Systematic Review & Meta-analysis

2020 ◽  
Vol 16 (1) ◽  
pp. 53-60
Author(s):  
Nihar R. Mishra ◽  
Manoj K. Panigrahi ◽  
Girish C. Bhatt ◽  
Rashmi R. Das
Keyword(s):  
Adverse Events ◽  
Meta Analysis ◽  
Intervention Group ◽  
Oral Prednisolone ◽  
Oral Steroid ◽  
Control Group ◽  
Eligibility Criteria ◽  
Steroid Group ◽  
Significant Difference ◽  
Endobronchial Tuberculosis

Background: Corticosteroid exerts anti-inflammatory action and can prevent tissue damage resulting from various causes. Studies have shown that corticosteroids may prevent the damaging effect of tuberculosis (TB) in various organs, but there is no published meta-analysis specifically looking for the effect of corticosteroid in endobronchial TB. Objective: To synthesize the evidence regarding the usefulness of corticosteroid in endo-bronchial TB. Methods: A comprehensive search was performed of the major electronic databases till 30th November 2018. Randomized trials comparing treatment with corticosteroid as an adjunct to antitubercular drugs (ATT) versus placebo/no treatment in endobronchial TB were included. Three authors independently applied eligibility criteria, assessed the studies for methodological quality, and extracted data. The review is registered at PROSPERO database [CRD42016047063]. Results: Out of 525 search results, 4 trials including 205 patients (151 children) were eligible for inclusion. Oral prednisolone was used in various dose schedules. Rifampicin containing ATT regimen was used in 3 trials. The bronchoscopy findings showed no significant improvement at 1 month (effect size could not be calculated due to 0 event in the intervention group, p = 0.05), 2 months (RR 1.26, 95% CI 0.89 to 1.8), and at completion of ATT (RR 0.63, 95% CI 0.1 to 4.14) in steroid-treated group compared to the control group. The need for repeat bronchoscopy was significantly decreased in the steroid group (RR 0.13, 95% CI 0.02 to 0.9). Among the adverse events, the infection rate was significantly lesser in the steroid group (RR 0.53, 95% CI 0.29 to 0.97); but other adverse events (mortality, hypertension, and abdominal distension) showed no significant difference between the two groups. The GRADE evidence generated was of very low quality. Conclusions: The present meta-analysis showed that oral steroid does not help patients with endobronchial tuberculosis. However, the quality of evidence was very low. Future trials with robust design and a larger sample size would be required to provide any firm recommendation regarding the use of oral prednisolone in endobronchial tuberculosis.

scholarly journals The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Bo Dong ◽  
Zeqin Chen ◽  
Xuan Yin ◽  
Danting Li ◽  
Jie Ma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Western Medicine ◽  
Acupuncture Treatment ◽  
Meta Analysis ◽  
Alternative Therapy ◽  
Control Group ◽  
Eligibility Criteria ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Hamd Score

Objective.To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia.Data Source.Seven databases were searched starting from 1946 to March 30, 2016.Study Eligibility Criteria.Randomized-controlled trials of adult subjects (18–75 y) who had depression-related insomnia and had received acupuncture.Results.18 randomized-controlled clinical trials (RCTs) were introduced in this meta-analysis. The findings determined that the acupuncture treatment made significant improvements in PSQI score (MD = −2.37, 95% CI −3.52 to −1.21) compared with Western medicine. Acupuncture combined with Western medicine had a better effect on improving sleep quality (MD = −2.63, 95% CI −4.40 to −0.86) compared with the treatment of Western medicine alone. There was no statistical difference (MD = −2.76, 95% CI −7.65 to 2.12) between acupuncture treatment and Western medicine towards improving the HAMD score. Acupuncture combined with Western medicine (MD = −5.46, CI −8.55 to −2.38) had more effect on improving depression degree compared with the Western medicine alone.Conclusion. This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia.

Interventions Supporting Children’s Mathematics School Success

2013 ◽  
Vol 18 (2) ◽  
pp. 89-113 ◽  
Author(s):  
Ursula Fischer ◽  
Korbinian Moeller ◽  
Ulrike Cress ◽  
Hans-Christoph Nuerk
Keyword(s):  
Meta Analysis ◽  
Age Groups ◽  
Evaluation Criteria ◽  
Effect Sizes ◽  
Evaluation Procedure ◽  
Control Group ◽  
Mathematical Learning ◽  
Group Iii ◽  
Alternative Intervention ◽  
Actual Target

In today’s society, mathematics is one of the most important competencies imparted in school. To improve children’s mathematical skills, existing interventions and trainings in mathematical learning address different proficiency levels and age groups, take place in different settings, can focus on a single task or a set of different tasks, be applied for different durations, and address different types of numerical content. However, when such trainings are evaluated, this often happens only insufficiently. In this review, we derive and apply four evaluation criteria in a meta-analysis of mathematical intervention literature: (i) evaluation with the actual target group, (ii) evaluation in comparison to a performance-matched control group, (iii) evaluation in comparison to a comparable alternative intervention, and (iv) separate evaluation of subcomponents in the case of multi-componential approaches. Based on these criteria, we review current intervention approaches, paying particular attention to how they were evaluated. A meta-analysis on 39 effect sizes extracted from 37 studies revealed a reliable impact of three of the above-proposed evaluation criteria on the reported efficacy of an intervention. In contrast, sample and methodological characteristics like grade level of participants or training duration were not associated with effect sizes. These data indicate that the reported efficacy of an intervention in mathematical learning may depend not only on the type of intervention conducted, but also on the thoroughness of the evaluation procedure.

scholarly journals Psychological and psychosocial interventions offered to forensic mental health inpatients: a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024351 ◽  
Author(s):  
Douglas MacInnes ◽  
Serena Masino
Keyword(s):  
Mental Health ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Feasibility Studies ◽  
Psychosocial Interventions ◽  
Well Being ◽  
Control Group ◽  
Violence Risk ◽  
Forensic Mental Health ◽  
Eligibility Criteria

ObjectiveTo examine the evidence for the use of psychological and psychosocial interventions offered to forensic mental health inpatients.DesignCINAHL, MEDLINE, PsycINFO, ScienceDirect and Web of Science databases were searched for research published in English between 1 January 1990 and 31 May 2018.Outcome measuresDisturbance, mental well-being, quality of life, recovery, violence/risk, satisfaction, seclusion, symptoms, therapeutic relationship and ward environment. There were no limits on the length of follow-up.Eligibility criteriaWe included randomised controlled trial (RCT) studies of any psychological or psychosocial intervention in an inpatient forensic setting. Pilot or feasibility studies were included if an RCT design was used.We restricted our search criteria to inpatients in low, medium and high secure units aged over 18. We focused on interventions considered applicable to most patients residing in forensic mental health settings.Data extraction and synthesisTwo independent reviewers extracted data and assessed risk of bias.Results17 232 citations were identified with 195 full manuscripts examined in detail. Nine papers were included in the review. The heterogeneity of the identified studies meant that meta-analysis was inappropriate. The results were presented in table form together with a narrative synthesis. Only 7 out of 91 comparisons revealed statistically significant results with no consistent significant findings. The most frequently reported outcomes were violence/risk and symptoms. 61% of the violence/risk comparisons and 79% of the symptom comparisons reported improvements in the intervention groups compared with the control groups.ConclusionsCurrent practice is based on limited evidence with no consistent significant findings. This review suggests psychoeducational and psychosocial interventions did not reduce violence/risk, but there is tentative support they may improve symptoms. More RCTs are required with: larger sample sizes, representative populations, standardised outcomes and control group interventions similar in treatment intensity to the intervention.PROSPERO registration numberCRD42017067099.

scholarly journals Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

2019 ◽  
Vol 11 ◽  
pp. 1759720X1985851 ◽  
Author(s):  
Railson de Oliveira Ferreira ◽  
Raíra de Brito Silva ◽  
Marcela Baraúna Magno ◽  
Anna Paula Costa Ponte Sousa Carvalho Almeida ◽  
Nathália Carolina Fernandes Fagundes ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Risk Factor ◽  
Quantitative Analysis ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Control Group ◽  
Case Group ◽  
Eligibility Criteria ◽  
Inflammatory Profile

Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis ( n = 1177) than controls ( n = 254) (OR 1.97; CI 1.68–2.31; p < 0.00001). However, considerable heterogeneity among studies was verified (I2 = 96%, p < 0.00001). Periodontitis may represent a risk factor for RA by heredity, bacterial infection, and the pro-inflammatory profile shared between both diseases. Although most of the elective studies report an association between periodontitis and RA, the quantitative analysis showed a high heterogeneity, leading to the need for further studies.

scholarly journals Including the Nordic hamstring exercise in injury prevention programmes halves the rate of hamstring injuries: a systematic review and meta-analysis of 8459 athletes

2019 ◽  
Vol 53 (21) ◽  
pp. 1362-1370 ◽  
Author(s):  
Nicol van Dyk ◽  
Fearghal P Behan ◽  
Rod Whiteley
Keyword(s):  
Systematic Review ◽  
Injury Prevention ◽  
Risk Ratio ◽  
Injury Risk ◽  
Meta Analysis ◽  
Research Question ◽  
Age Groups ◽  
Eligibility Criteria ◽  
Hamstring Injuries ◽  
Prevention Programmes

Research questionDoes the Nordic hamstring exercise (NHE) prevent hamstring injuries when included as part of an injury prevention intervention?DesignSystematic review and meta-analysis.Eligibility criteria for selecting studiesWe considered the population to be any athletes participating in any sporting activity, the intervention to be the NHE, the comparison to be usual training or other prevention programmes, which did not include the NHE, and the outcome to be the incidence or rate of hamstring injuries.AnalysisThe effect of including the NHE in injury prevention programmes compared with controls on hamstring injuries was assessed in 15 studies that reported the incidence across different sports and age groups in both women and men.Data sourcesMEDLINE via PubMed, CINAHL via Ebsco, and OpenGrey.ResultsThere is a reduction in the overall injury risk ratio of 0.49 (95% CI 0.32 to 0.74, p=0.0008) in favour of programmes including the NHE. Secondary analyses when pooling the eight randomised control studies demonstrated a small increase in the overall injury risk ratio 0.52 (95% CI 0.32 to 0.85, p=0.0008), still in favour of the NHE. Additionally, when studies with a high risk of bias were removed (n=8), there is an increase of 0.06 in the risk ratio to 0.55 (95% CI 0.34 to 0.89, p=0.006).ConclusionsProgrammes that include the NHE reduce hamstring injuries by up to 51%. The NHE essentially halves the rate of hamstring injuries across multiple sports in different athletes.Trial registration numberPROSPERO CRD42018106150.

Evaluating the Lower Anterior Facial Height in Patients Treated with Extraction Versus Non-extraction Fixed Mechanotherapy: “A Systematic Review and Meta-analysis”

2021 ◽  
pp. 030157422110116
Author(s):  
Atam Dev Jain ◽  
Manish Goyal ◽  
Mukesh Kumar ◽  
Shruti Premsagar ◽  
Shalini Mishra ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Statistical Tests ◽  
Data Extraction ◽  
Meta Analysis ◽  
Control Group ◽  
Eligibility Criteria ◽  
Facial Height ◽  
Anterior Nasal Spine ◽  
Chi Squared ◽  
Secondary Outcomes

Objective: The objective of this study was to evaluate the effects of the four first premolars extraction compared with a non-extraction treated control group on the lower anterior facial height. Methods: Electronic search was conducted on PubMed, Cochrane, Scopus, Lilacs, Scielo, clinical trials, and opengrey.eu databases; only article published in English were included. The eligibility criteria were extraction of four first premolars compared with a non-extraction control group treated with fixed mechanotherapy. Anterior Nasal Spine to Menton (ANS-Me) (mm) was taken as the primary outcome; Frankfurt mandibular plane angle (FMA) and Nasion to Menton (N-Me) were selected as secondary outcomes. Non-randomized Studies-of Intervention (ROBINS-I) tool was used for the quality assessment and risk of bias. Heterogeneity was analyzed using statistical tests, including chi-squared-based Q-statistic, tau-square, and I-squared statistics. Review Manager was used for quantitative assessment and meta-analysis. Results: Five retrospective studies were included for quantitative assessment and three were included in the meta-analysis due to certain missing data. Extraction of four first premolars did not affect both primary and secondary outcomes with P = .65, P = .93, and P = .91, respectively, for ANS-Me, FMA, and N-Me. Conclusion: This review and meta-analysis concluded that there was no statistically significant effect of extraction of four first premolars on lower anterior facial height.

scholarly journals Anti-basal ganglia antibodies in primary obsessive–compulsive disorder: systematic review and meta-analysis

2014 ◽  
Vol 205 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Daniel M. Pearlman ◽  
Haily S. Vora ◽  
Brian G. Marquis ◽  
Souhel Najjar ◽  
Lauren A. Dudley
Keyword(s):  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Neuropsychiatric Disorders ◽  
Control Group ◽  
Pool Data ◽  
Obsessive Compulsive ◽  
Eligibility Criteria ◽  
Compulsive Disorder

BackgroundAutoimmune-mediated basal ganglia dysfunction is implicated in the pathophysiology of neuropsychiatric disorders commonly manifesting with obsessive–compulsive features (e.g. Sydenham chorea). The relationship between autoimmunity and primary obsessive–compulsive disorder (OCD), however, is less clear.AimsTo pool data on serum and cerebrospinal fluid (CSF) anti-basal ganglia antibody (ABGA) positivity in primary OCD (without neurological or autoimmune comorbidity) relative to controls or neuropsychiatric disorders previously associated with increased odds of ABGA positivity.MethodWe performed electronic database and hand-searches for studies meeting pre-specified eligibility criteria from which we extracted data using a standardised form. We calculated pooled estimates of ABGA positivity using a random-effects model.ResultsSeven case–control studies totalling 844 participants met the eligibility criteria. Meta-analysis showed that a significantly greater proportion of those with primary OCD were ABGA seropositive compared with various controls (odds ratio (OR) = 4.97, 95% CI 2.88–8.55, P<0.00001). This effect was not associated with heterogeneity or publication bias, and remained significant after stratifying the analysis by age, gender, disease severity, illness duration, immunostaining methodology, study quality, publication type, kind of control group, and sample size. There were no significant differences in ABGA seropositivity for comparisons between primary OCD and Tourette syndrome, attention-deficit hyperactivity disorder or paediatric acute-onset neuropsychiatric syndrome. Results of one study testing CSF samples showed that a significantly greater proportion of participants with primary OCD were ABGA CSF-positive compared with healthy controls (OR = 5.60, 95% CI 1.04–30.20, P = 0.045).ConclusionsOdds of ABGA seropositivity are increased fivefold in primary OCD compared with controls, but are comparable to those associated with disorders previously associated with ABGA, providing circumstantial evidence of autoimmunity in a subset of those with primary OCD. Further experimental studies are needed to ascertain whether this relationship is causal.

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