scholarly journals Occurrence and Role of Selected RNA-Viruses as Potential Causative Agents of Watery Droppings in Pigeons

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1025
Author(s):  
Ewa Łukaszuk ◽  
Tomasz Stenzel
Keyword(s):  
Viral Infections ◽  
Rna Viruses ◽  
Clinical Signs ◽  
Health Problems ◽  
Review Article ◽  
Interspecies Transmission ◽  
Causative Agents ◽  
Enteropathogenic Viruses ◽  
Domestic Pigeons

The diseases with watery droppings (diarrhea and/or polyuria) can be considered some of the most severe health problems in domestic pigeons of various ages. Although they do not always lead to bird death, they can contribute to poor weight gains and hindered development of young pigeons and, potentially, to poor racing results in sports birds. The gastrointestinal tract disorders of pigeons may be of various etiology, but some of the causative agents are viral infections. This review article provides information collected from scientific reports on RNA-viruses belonging to the Astroviridae, Picornaviridae, and Coronaviridae families; the Avulavirinae subfamily; and the Rotavirus genus that might be implicated in such health problems. It presents a brief characterization, and possible interspecies transmission of these viruses. We believe that this review article will help clinical signs of infection, isolation methods, occurrence in pigeons and poultry, systemize and summarize knowledge on pigeon enteropathogenic viruses and raise awareness of the importance of disease control in pigeons.

The Role of microRNAs in the Viral Infections

2019 ◽  
Vol 24 (39) ◽  
pp. 4659-4667 ◽  
Author(s):  
Mona Fani ◽  
Milad Zandi ◽  
Majid Rezayi ◽  
Nastaran Khodadad ◽  
Hadis Langari ◽  
...  
Keyword(s):  
Viral Infections ◽  
Rna Viruses ◽  
Regulation Of Gene Expression ◽  
Molecular Structures ◽  
Main Function ◽  
Cellular Functions ◽  
Viral Genes ◽  
Non Coding Rnas ◽  
Post Transcriptional Regulation

MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. In fact, many of them act as an oncogene or tumor suppressor. These molecular structures participate in many physiological and pathological processes of the cell. The virus can also produce them for developing its pathogenic processes. It was initially thought that viruses without nuclear replication cycle such as Poxviridae and RNA viruses can not code miRNA, but recently, it has been proven that RNA viruses can also produce miRNA. The aim of this articles is to describe viral miRNAs biogenesis and their effects on cellular and viral genes.

scholarly journals Poult Enteritis and Mortality Syndrome in Turkey Poults: Causes, Diagnosis and Preventive Measures

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2063
Author(s):  
Awad A. Shehata ◽  
Shereen Basiouni ◽  
Reinhard Sting ◽  
Valerij Akimkin ◽  
Marc Hoferer ◽  
...  
Keyword(s):  
Preventive Measures ◽  
Clinical Signs ◽  
Accurate Diagnosis ◽  
Economic Losses ◽  
Turkey Poults ◽  
Causative Agents ◽  
Enteric Disorders ◽  
And Control ◽  
Enteropathogenic Viruses ◽  
Poult Enteritis

Poult enteritis and mortality syndrome (PEMS) is one of the most significant problem affecting turkeys and continues to cause severe economic losses worldwide. Although the specific causes of PEMS remains unknown, this syndrome might involve an interaction between several causative agents such as enteropathogenic viruses (coronaviruses, rotavirus, astroviruses and adenoviruses) and bacteria and protozoa. Non-infectious causes such as feed and management are also interconnected factors. However, it is difficult to determine the specific cause of enteric disorders under field conditions. Additionally, similarities of clinical signs and lesions hamper the accurate diagnosis. The purpose of the present review is to discuss in detail the main viral possible causative agents of PEMS and challenges in diagnosis and control.

scholarly journals BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection

2020 ◽  
pp. jcs.251835
Author(s):  
Azia S. Evans ◽  
Nicholas J. Lennemann ◽  
Carolyn B. Coyne
Keyword(s):  
Mass Spectrometry ◽  
Mammalian Cells ◽  
Viral Infections ◽  
Rna Viruses ◽  
Rna Virus ◽  
Negative Regulator ◽  
Host Factors ◽  
Important Negative Regulator ◽  
Cellular Components

Autophagy is a degradative cellular pathway that targets cytoplasmic contents and organelles for turnover by the lysosome. Various autophagy pathways play key roles in the clearance of viral infections, and many families of viruses have developed unique methods for avoiding degradation. Some positive stranded RNA viruses, such as enteroviruses and flaviviruses, usurp the autophagic pathway to promote their own replication. We previously identified the endoplasmic reticulum-localized protein BPIFB3 as an important negative regulator of non-canonical autophagy that uniquely impacts the replication of enteroviruses and flaviviruses. Here, we find that many components of the canonical autophagy machinery are not required for BPIFB3 depletion induced autophagy and identify the host factors that facilitate its role in the replication of enteroviruses and flaviviruses. Using proximity-dependent biotinylation (BioID) followed by mass spectrometry, we identify ARFGAP1 and TMED9 as two cellular components that interact with BPIFB3 to regulate autophagy and viral replication. Importantly, our data demonstrate that non-canonical autophagy in mammalian cells can be controlled outside of the traditional pathway regulators and define the role of two proteins in BPIFB3 depletion mediated non-canonical autophagy.

scholarly journals Successive Inoculations of Pigs with Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) and Swine H1N2 Influenza Virus Suggest a Mutual Interference between the Two Viral Infections

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2169
Author(s):  
Juliette Bougon ◽  
Céline Deblanc ◽  
Patricia Renson ◽  
Stéphane Quéguiner ◽  
Stéphane Gorin ◽  
...  
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Clinical Signs ◽  
Swine Influenza ◽  
Time Correlation ◽  
Respiratory Syndrome Virus ◽  
Cell Mediated Immune Response ◽  
Specific Pathogen ◽  
Porcine Respiratory

Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A virus (swIAV) are major pathogens of the porcine respiratory disease complex, but little is known on their interaction in super-infected pigs. In this study, we investigated clinical, virological and immunological outcomes of successive infections with PRRSV-1 and H1N2 swIAV. Twenty-four specific pathogen-free piglets were distributed into four groups and inoculated either with PRRSV at study day (SD) 0, or with swIAV at SD8, or with PRRSV and swIAV one week apart at SD0 and SD8, respectively, or mock-inoculated. In PRRSV/swIAV group, the clinical signs usually observed after swIAV infection were attenuated while higher levels of anti-swIAV antibodies were measured in lungs. Concurrently, PRRSV multiplication in lungs was significantly affected by swIAV infection, whereas the cell-mediated immune response specific to PRRSV was detected earlier in blood, as compared to PRRSV group. Moreover, levels of interferon (IFN)-α measured from SD9 in the blood of super-infected pigs were lower than those measured in the swIAV group, but higher than in the PRRSV group at the same time. Correlation analyses suggested an important role of IFN-α in the two-way interference highlighted between both viral infections.

Role of Dentist in Diagnosis and Management of Mucormycosis in Association with COVID-19

2021 ◽  
Vol 11 (7) ◽  
pp. 159-163
Author(s):  
Piyush Dongre ◽  
Tanya Bansal
Keyword(s):  
Early Diagnosis ◽  
Fungal Infections ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Review Article ◽  
The Novel ◽  
Diagnosis And Management ◽  
Global Pandemic ◽  
Clinical Signs And Symptoms

In surge of the novel corona virus, there is increase in the frequency of fungal infections. Mucormycosis is one of the deep fungal infections which are increasing rapidly in this global pandemic period. Thus the early diagnosis and management is of utmost importance to decline the rate of this fatal infection. The clinical signs and symptoms and the culture reports are strictly considered in the management of oral fungal infection. This review article focuses on the importance of early diagnosis, prevention and management of mucormycosis and the role of the dentist in doing so. Key words: Mucormycosis, diagnosis, management, dentist.

scholarly journals Hazardous and Extremely Hazardous Emergent Viral Infections of the Beginning of XXI Century: Rise, Spread, Hazard for Public Health

2018 ◽  
Vol 2 (2) ◽  
pp. 61-68 ◽  
Keyword(s):  
Viral Infections ◽  
Clinical Signs ◽  
Hemorrhagic Fever ◽  
Armed Forces ◽  
Human Beings ◽  
Potential Threat ◽  
Russian Territory ◽  
Causative Agents ◽  
The Russian Federation ◽  
Severe Fever

The article is dedicated to the review of some hazardous and extremely hazardous emergent viral infections of the beginning of the XXI century – severe acute respiratory syndrome (SARS), Middle-East respiratory syndrome (MERS), Lujo hemorrhagic fever (LHF) and severe fever with thrombocytopenia syndrome (SFTS). Special attention is paid to the time of reveal and identification of infectious agents, their taxonomic belonging, genome organization, possible ways of the appearance of strains, virulent for human beings, to endemic regions, probable ways of infection, reservoirs and transmitters of infection, morbidity and mortality. These infections should be of particular concern because of the severity of illnesses, caused by the above mentioned viruses, the absence of characteristic clinical signs that makes diagnostics more difficult, especially in non-endemic areas, the absence of means of specific prophylaxis and treatment and the difficulties in their identification. The analyze of this emergent viral infections reveals their potential threat for the Armed Forces and population of the Russian Federation in case of accidental or intentional delivery of causative agents of these diseases to the Russian territory

scholarly journals Pathogenetic aspects of rabbits’ experimental infection caused by bovine leukemia virus

2020 ◽  
Vol 22 (100) ◽  
pp. 16-22
Author(s):  
T. A. Romanishina ◽  
D. V. Feschenko ◽  
G. O. Rinyak ◽  
V. V. Honcharenko ◽  
A. A. Macibora ◽  
...  
Keyword(s):  
Blood Serum ◽  
Bovine Leukemia Virus ◽  
Viral Infections ◽  
Early Stage ◽  
Leukemia Virus ◽  
Clinical Signs ◽  
Development Stage ◽  
The Body ◽  
Interspecies Transmission ◽  
Economic Losses

Bovine leukemia virus (BLV) is an infectious disease of cattle, causing high economic losses worldwide, especially in the field of dairy farming. There is no common vision on the problem of interspecies transmission of BLV. Therefore, a detailed study of the etiologic relationship between leukemia in cattle and other animal species is relevant. Various laboratory animal models provide insight into the pathogenesis of viral infections. The article presents the research results of two series rabbits’ intravenous infection with bovine leukemia virus (BLV) using the culture antigen FLK-BLV and the blood of rabbits with clinical, hematological and immunological signs of viral tumor growth. Blood from all animals was taken from the ear vein after 14, 21, 30 days, and then monthly for six months: to study the morphological parameters of blood and to determine the titer of antibodies to BLV. Blood serum for the presence of antibodies to BLV was examined using a diagnostic kit for the indication of animals infected with the leukemia virus in an immunodiffusion reaction produced by LLC “SRE Veterinary Medicine”, Kharkiv. It was found that the stage of the BLV provirus in the blood leukogram of infected animals was characterized by pronounced lymphocytosis on the 21st day of the experiment. The highest concentration of antibodies to BLV in the blood serum was found on the 90th day after the administration of the virus-containing material, which disappeared from the blood on the 150–180th day after infection. In experimental rabbits, after five months for thirty days, in the absence of antibodies to leukemia in the blood serum, multiple tumors of a dense consistency began to develop throughout the body. Such clinical signs and changes in the of rabbits’ blood of the experimental group are characteristic of serologically positive cows on the hematological development stage of leukemic process and correlate with the results of domestic and foreign authors. The presence of a large number of lymphoblasts, as well as leukolysis cells, in the histological preparation of lymph nodes, lungs, heart and the accumulation of lymphocytes’ immature forms around the interlobular vessels of the liver, which were found in pathohistological studies of the experimental rabbits’ organs, may indicate the development of the leukemia process on early stage in them. The results obtained indicate the ability of BLV to overcome successfully the interspecies barrier upon parenteral ingestion of heterologous individuals from infected lymphocytes and in the form of a culture antigen.

Actinobacillus pleuropneumoniae: a review of an economically important pathogen

Livestock ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 308-314
Author(s):  
Christina Gale ◽  
Eduardo Velazquez
Keyword(s):  
Clinical Signs ◽  
Actinobacillus Pleuropneumoniae ◽  
Good Choice ◽  
Control Measures ◽  
Feed Conversion ◽  
Need For Treatment ◽  
Porcine Pleuropneumonia ◽  
Causative Agents ◽  
On Farm

Actinobacillus pleuropneumoniae is one of the causative agents of porcine pleuropneumonia, which is an economically important respiratory disease of pig production. Clinical signs vary based on the severity of disease and lung lesions present, but include fever and severe respiratory signs including coughing and laboured breathing. Numerous serotypes exist which vary in their virulence, and virulence of serotypes has also been shown to be vary between countries. It is important to establish which serotypes are present and active on a farm as well as carrying out seroprofiling to determine the correct time for implementation of control measures such as vaccination. Understanding of transmission routes is vital, including the role of carrier animals on the farm which are persistently infected and can shed the bacteria, therefore infecting other animals. Therefore, as with all infectious diseases, good standards of internal and external biosecurity are important in controlling the disease on farm. Vaccination has been shown to be effective on affected farms in preventing outbreaks, reducing clinical signs if they occur, and most important to the farmer, preventing losses in mortality, feed conversion ratio and growth. Therefore, vaccines are often a good choice for controlling pleuropneumonia on farm and reducing the need for treatment using antimicrobials.

scholarly journals Type III interferons disrupt the lung epithelial barrier upon viral recognition

Science ◽  
2020 ◽  
Vol 369 (6504) ◽  
pp. 706-712 ◽  
Author(s):  
Achille Broggi ◽  
Sreya Ghosh ◽  
Benedetta Sposito ◽  
Roberto Spreafico ◽  
Fabio Balzarini ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lower Respiratory Tract ◽  
Viral Infections ◽  
Rna Viruses ◽  
Epithelial Barrier ◽  
Upper Airways ◽  
Type Iii ◽  
Lung Epithelial ◽  
Pathophysiological Role

Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting evidence indicates that most severe cases are characterized by aberrant immune responses and do not depend on viral burden. In this study, we assessed how type III interferons (IFN-λ) contribute to the pathogenesis induced by RNA viruses. We report that IFN-λ is present in the lower, but not upper, airways of patients with coronavirus disease 2019 (COVID-19). In mice, we demonstrate that IFN-λ produced by lung dendritic cells in response to a synthetic viral RNA induces barrier damage, causing susceptibility to lethal bacterial superinfections. These findings provide a strong rationale for rethinking the pathophysiological role of IFN-λ and its possible use in clinical practice against endemic viruses, such as influenza virus as well as the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

scholarly journals Role of Internal Medicines in the Management of Infections w.s.r. to Viral and Fungal Diseases: A Review

2021 ◽  
pp. 10-13
Author(s):  
Neeraj Kanungo ◽  
Vijayata Kanungo ◽  
Ajit Kumar Ojha
Keyword(s):  
Infectious Diseases ◽  
General Health ◽  
Viral Infections ◽  
Fungal Infections ◽  
Modern Science ◽  
Health Problems ◽  
Fungal Diseases ◽  
Pathological Conditions ◽  
Microbial Toxins

Ayurveda works towards the prevention and management of various health problems, Ayurveda also suggests many natural ways to promote general health. Ayurveda in this regards provides several modalities for controlling infectious diseases which described as Sankramak Roga in Ayurveda. As per Ayurveda these Sankramak Roga mainly arises due to the vitiated state of Doshas and this vitiation arises by microbial toxins in case of infectious diseases. Therefore Doshas pacifying medicines recommended controlling infections. Ayurveda drugs like Kapura, Neema, Guduchi, Tulsi and Vacha, etc. helps to treat such pathological conditions. The present scenario of pandemic disaster requires an approach where Ayurveda and modern science can join hand together to combat against this situation. The consequences of viral infections also increases susceptibility towards other infections i.e.; fungal diseases. Considering these all facts this article explored Ayurveda as well as modern approaches for the management of various types of Sankramak Roga w.s.r. to viral and fungal infections.

Sign in / Sign up

Export Citation Format

Share Document