scholarly journals Characterization and Applications of Colloidal Systems as Versatile Drug Delivery Carriers for Parenteral Formulations

2021 ◽  
Vol 14 (2) ◽  
pp. 108
Author(s):  
Lakshmi Kolluru ◽  
Prachi Atre ◽  
Syed Rizvi
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Water Soluble ◽  
Cell Membrane Permeability ◽  
Low Permeability ◽  
Colloidal Systems ◽  
Drug Candidates ◽  
Nano Emulsion ◽  
Stability Issues ◽  
Low Solubility

Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available to enhance water solubility, but this alone does not entail successful formulation. Making a micro/nano emulsion with a suitable surfactant not only increases the drug solubility but also the cell membrane permeability. Thus, not only biopharmaceutic classification system (BCS)-II (low solubility compounds) but also BCS-III (low permeability) and BCS-IV drugs (low solubility and low permeability) can be further exploited. Those drug candidates otherwise will not move further in NCE evaluation or clinical trials. This succinct review article delves into various aspects of biphasic micro/nano emulsion systems for parenteral drug delivery including the structure of the biphasic colloidal systems, characterization parameters, stability issues, regulatory considerations, and applications in life sciences.

scholarly journals A Literature Review on Self Nanoemulsifying Drug Delivery System (SNEDDS)

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Saikumar D ◽  
Leela Prasanna J
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Solubility ◽  
Solvent Molecule ◽  
Water Soluble ◽  
Statistical Experimental Design ◽  
Characterization Methods ◽  
Nano Emulsion ◽  
Pharmacologically Active

The Lipid-based drug delivery system is extensively reported within the literature for the enhancing drug solubility, permeability, and bioavailability. A considerable majority of novel pharmacologically active constituents produced in recent drug discovery programs are lipophilic and poorly soluble, posing a significant problem for pharmaceutical researchers enhancing the oral bioavailability of such drug molecules. Self-nano emulsifying drug delivery systems (SNEDDS), are the viable oil-based approaches for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, researchers have been focusing on the challenges of BCS Class II and Class IV Drugs for enhancing water Solubility of poorly water-soluble drugs. SNEDDS is a Validate method for enhancing the solubility and bioavailability of lipophilic compounds. It’s the isotropic mixture of oil, surfactant, co-surfactant molecules and it also containing co-solvent molecule. which spontaneously form oil-in-water nano emulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring. It’s Drug delivery system Which possess thermodynamically and kinetically stability. The physicochemical properties, drug solubilization capacity considerably regulates the selection of the SNEDDS components. The compositions of the SNEDDS are often optimized with the assistance of phase diagrams. Further to optimize SNEDDS can be done with the help of statistical experimental design. It’s a Novel drug delivery system which is applicable for the parenteral, Ophthalmic, intranasal and cosmetic drug delivery system. And therefore, the present review describes Preparation, components, mechanism of self-Nano emulsification, biopharmaceutical aspects, characterization methods and applications of Selfnanoemulsifying drug delivery system (SNEDDS).

scholarly journals RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW

2019 ◽  
pp. 28-32
Author(s):  
SUJIT NAYEK ◽  
ABHIRAMI VENKATACHALAM ◽  
SANGEETA CHOUDHURY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Divalent Cation ◽  
Technology Use ◽  
Oral Bioavailability ◽  
Anticancer Agent ◽  
Low Permeability ◽  
Delivery Mechanism ◽  
Low Solubility

Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mechanism, choice of prevalent components (Phospholipids and Cations), various ways of producing nanocochleates and nanocochleate stability. Nanocochleates have far fewer constraints than other traditional carriers. To characterize nanocochleates, the suitable analytical methods are required. Therefore, in the therapy of cancer, nanocochleate becomes commonly applied and more prospective drug delivery system.

scholarly journals Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs

2013 ◽  
Vol 63 (4) ◽  
pp. 427-445 ◽  
Author(s):  
Katja Čerpnjak ◽  
Alenka Zvonar ◽  
Mirjana Gašperlin ◽  
Franc Vrečer
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Pharmaceutical Products ◽  
Delivery Systems ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

Abstract Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and drug formulations, and their compatibility with liquid, semi-solid, and solid dosage forms. Lipid formulations, such as self-emulsifying (SEDDS), self-microemulsifying SMEDDS) and self- -nanoemulsifying drug delivery systems (SNEDDS) were explored in many studies as an efficient approach for improving the bioavailability and dissolution rate of poorly water-soluble drugs. One of the greatest advantages of incorporating poorly soluble drugs into such formulations is their spontaneous emulsification and formation of an emulsion, microemulsion or nanoemulsion in aqueous media. This review article focuses on the following topics. First, it presents a classification overview of lipid-based drug delivery systems and mechanisms involved in improving the solubility and bioavailability of poorly water-soluble drugs. Second, the article reviews components of lipid-based drug delivery systems for oral use with their characteristics. Third, it brings a detailed description of SEDDS, SMEDDS and SNEDDS, which are very often misused in literature, with special emphasis on the comparison between microemulsions and nanoemulsions.

scholarly journals FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM

2018 ◽  
Vol 1 (3) ◽  
pp. 14-18
Author(s):  
Ankita Raturi ◽  
Ganesh Bhatt ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Dissolution Rate ◽  
Water Solubility ◽  
Water Soluble ◽  
Biologically Active ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Lauryl Sulfate ◽  
Delivery Technique ◽  
Rosuvastatin Calcium

Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of sodium lauryl sulfate as surfactant and PVPK-30 as stabilizer. Prepared Nanosuspension was evaluated for its particle size study, in vitro dissolution study and characterized by Screening Electron microscopy (SEM). Different concentrations of sodium lauryl sulphate (SLS) and PVPK-30 were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.

Eggshell MembraneBased Turmeric Extract Loaded Orally Disintegrating Films

2021 ◽  
Vol 18 ◽  
Author(s):  
Merve Deniz Köse ◽  
Nazlı Ungun ◽  
Oguz Bayraktar
Keyword(s):  
Drug Delivery ◽  
Sem Analysis ◽  
Eggshell Membrane ◽  
Casting Method ◽  
Drug Candidates ◽  
Turmeric Extract ◽  
Novel Drug ◽  
First Time ◽  
Low Solubility

Background: The increasing interest in using natural bioactive compounds as new drug candidates and their low solubility led to designing and developing novel drug delivery systems. Out of those, orally disintegrating films (ODFs) are a very eminent drug delivery system among pediatrics and geriatrics. Objective: In our study, the solvent casting method was used to prepare eggshell membrane-based and turmeric extract loaded orally disintegrating films. Method: Characterization of the prepared films was done with FTIR, AFM, and SEM analysis. The release profile of the turmeric extract was determined and fitted to the mathematical models. Results: AFM results showed that the best interaction between components was achieved in Film-2. The highest cumulative release percentage was obtained for the film with 7.5 % (w/w) turmeric extract (Film-2) as 41.98% based on the HPLC measurements. The Higuchi model was the best-fitted model for Film-2. Conclusion: In this study, SEP and CMCH were used for the first time as biopolymers to prepare the orally disintegrating film. Turmeric extract was successfully integrated into films prepared from SEP and CMCH.

Nanocrystals: A Strategic Approach for Development of Futuristic Nano-formulations and their Patenting Applicability

2021 ◽  
Vol 17 ◽  
Author(s):  
Surya Goel ◽  
Vijay Agarwal ◽  
Monika Sachdeva
Keyword(s):  
Drug Delivery ◽  
Research Work ◽  
Health Sector ◽  
Water Soluble ◽  
The Novel ◽  
Health Issues ◽  
Preparation Methods ◽  
Drug Candidates ◽  
Drug Delivery Carrier ◽  
Strategic Approach

Background: Nanocrystals have been found as potent, beneficial and advantageous nanocarrier systems for ameliorating the solubility, bioavailability and permeability of those drug candidates that are less water-soluble and permeable. Such an approach possesses many complications that require more research work. Objective: The main objective of the manuscript is to prepare a review on all the aspects of nanocrystals, including their advantages, recent advancements, preparation methods, recent patents, marketed products and some patents related to their characterization techniques. Methods: This manuscript has been accrued through the help of online and offline journals, books, and from some other accessible sources. This field involves new developments or inventions in the novel nanocarrier system. Results: Nanocrystals have been found to exhibit better potentiality sorting out different problems like poor drug absorption, drug-associated side effects, and targeted drug delivery. In the last decade, these nanocarriers have been opted for resolving the problem of production due to less soluble drugs. By conducting more researches, this field can be more beneficial to the health sector. Conclusion: Nanocrystals significantly to deliver several drugs via different routes like topical, oral ophthalmic, pulmonary and parenteral. This manuscript substantially shows the applicability and importance of nanocrystals as a drug delivery carrier to treat various health issues.

scholarly journals A REVIEW ON PRONIOSOMES: A PRO-COLLOIDAL PARTICULATE DRUG CARRIER

2020 ◽  
Vol 11 (6) ◽  
pp. 119-130
Author(s):  
P V Swamy ◽  
Ch Sucharitha ◽  
G Surendra Babu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Carrier ◽  
Clinical Applications ◽  
Water Soluble ◽  
Ionic Surfactant ◽  
Future Trends ◽  
Colloidal Systems ◽  
Evaluation Parameters ◽  
Carrier Systems

Colloidal particulate carrier systems are the systems which carry particulates in a nanometre size. These systems are substantially effective for transportation and distribution of variety of loaded drugs to desired site and increase efficacy and decrease toxicity, to provide therapeutic activity in a controlled manner for a prolonged period of time. One such new emerging colloidal systems is proniosomes which has capacity to improve the bioavailability and also permeation of drugs across the stratum corneum to provide a controlled release action and reduce toxic effects associated with drugs. These are the dry formulations of water-soluble non-ionic surfactant coated carrier systems which immediately on hydration form niosomes. They have the capacity to overcome the various problems associated with niosomes and liposomes, like instability, transportation, distribution, storage and dosing. They offer versatile drug delivery concept for both hydrophilic and hydrophobic drugs. They have the capacity to deliver drugs effectively through different routes at specific site to achieve controlled release action. This review concentrates on preparation, characterization, components, structure, types, evaluation parameters, proniosomes in drug delivery and targeting, toxicities associated with proniosomes, proniosomes versus niosomes, clinical applications, mechanism of vesicle formation in proniosomes and future trends associated with it. Also, drug delivery via different routes, such as oral, parenteral, topical and transdermal, ocular, vaginal, mucosal, pulmonary and intranasal were discussed.

scholarly journals The Water-Soluble Chitosan Derivative, N-Methylene Phosphonic Chitosan, Is an Effective Fungicide against the Phytopathogen Fusarium eumartii

2021 ◽  
Vol 37 (6) ◽  
pp. 533-542
Author(s):  
Florencia Anabel Mesas ◽  
María Cecilia Terrile ◽  
María Ximena Silveyra ◽  
Adriana Zuñiga ◽  
María Susana Rodriguez ◽  
...  
Keyword(s):  
Water Solubility ◽  
Water Soluble ◽  
Phytopathogenic Fungus ◽  
Oxygen Species ◽  
Chitosan Derivative ◽  
Solubility In Water ◽  
Environmental Friendly ◽  
Antifungal Effects ◽  
Species Production ◽  
Low Solubility

Chitosan has been considered an environmental-friendly polymer. However, its use in agriculture has not been extended yet due to its relatively low solubility in water. N-Methylene phosphonic chitosan (NMPC) is a water-soluble derivative prepared by adding a phosphonic group to chitosan. This study demonstrates that NMPC has a fungicidal effect on the phytopathogenic fungus Fusarium solani f. sp. eumartii (F. eumartii) judged by the inhibition of F. eumartti mycelial growth and spore germination. NMPC affected fungal membrane permeability, reactive oxygen species production, and cell death. Also, this chitosan-derivative exerted antifungal effects against two other phytopathogens, Botrytis cinerea, and Phytophthora infestans. NMPC did not affect tomato cell viability at the same doses applied to these phytopathogens to exert fungicide action. In addition to water solubility, the selective biological cytotoxicity of NMPC adds value in its application as an antimicrobial agent in agriculture.

Recent Advances in Ultrasound-assisted Synthesis of Nano-emulsions and their Industrial Applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Parag Thakur ◽  
Shriram Sonawane ◽  
Irina Potorokob ◽  
Shirish H Sonawane
Keyword(s):  
Drug Delivery ◽  
Ostwald Ripening ◽  
Chemical Properties ◽  
Industrial Applications ◽  
Synthesis Methods ◽  
Colloidal Systems ◽  
Simple Method ◽  
Recent Advances ◽  
Ultrasound Assisted ◽  
Nano Emulsion

Background: Colloidal systems are used in various industrial and medical applications. Nanoparticles have good physio-chemical properties that enhance the performance of the system. Nano-emulsions can be synthesized by the ultrasonication. Ultrasonication is the simplest method than other available methods. The purpose of this article is to review the recent advances in ultrasound-assisted nano-emulsion synthesis and challenges regarding the safety of the nano-emulsion. Methods: Application of the nano-emulsions in the various industrial and medical processes like drug delivery process, food industry, pesticide industry and cosmetics industry are also reviewed. Results: Ultrasound-assisted synthesis of nano-emulsions simple method than other synthesis methods of the nanoemulsions. Nano-emulsions have growing applications in the cosmetic, drug delivery, pesticides and industry. Conclusion: Fabrication of the nano-emulsions is different for each application and product. Physiochemical properties should be strictly monitored in the nano-emulsions as they influence the efficiency of the nano-emulsions greatly. Ostwald ripening is the main phenomenon for the nano-emulsions mechanism.

scholarly journals Water-Soluble Photoinitiators in Biomedical Applications

2020 ◽  
Author(s):  
Wiktoria Tomal ◽  
Joanna Ortyl
Keyword(s):  
Drug Delivery ◽  
Literature Review ◽  
Low Power ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Light Sources ◽  
High Water Solubility

Light-initiated polymerization processes are currently an important tool in various industrial fields. The advancement of technology has resulted in the use of photopolymerization in various biomedical applications, such as the production of 3D hydrogel structures, the encapsulation of cells, and in drug delivery systems. The use of photopolymerization processes requires an appropriate initiating system which, in biomedical applications, must meet additional criteria: high water solubility, non-toxicity to cells, and compatibility with visible low-power light sources. This article is a literature review on those compounds that act as photoinitiators of photopolymerization processes in biomedical applications. The division of initiators according to the method of photoinitiation was described and the related mechanisms were discussed. Examples from each group of photoinitiators are presented, and their benefits, limitations and applications are outlined.

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