scholarly journals Water-Soluble Photoinitiators in Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1073 ◽  
Author(s):  
Wiktoria Tomal ◽  
Joanna Ortyl
Keyword(s):  
Drug Delivery ◽  
Literature Review ◽  
Low Power ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Light Sources ◽  
High Water Solubility

Light-initiated polymerization processes are currently an important tool in various industrial fields. The advancement of technology has resulted in the use of photopolymerization in various biomedical applications, such as the production of 3D hydrogel structures, the encapsulation of cells, and in drug delivery systems. The use of photopolymerization processes requires an appropriate initiating system that, in biomedical applications, must meet additional criteria such as high water solubility, non-toxicity to cells, and compatibility with visible low-power light sources. This article is a literature review on those compounds that act as photoinitiators of photopolymerization processes in biomedical applications. The division of initiators according to the method of photoinitiation was described and the related mechanisms were discussed. Examples from each group of photoinitiators are presented, and their benefits, limitations, and applications are outlined.

scholarly journals Water-Soluble Photoinitiators in Biomedical Applications

2020 ◽  
Author(s):  
Wiktoria Tomal ◽  
Joanna Ortyl
Keyword(s):  
Drug Delivery ◽  
Literature Review ◽  
Low Power ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Light Sources ◽  
High Water Solubility

Light-initiated polymerization processes are currently an important tool in various industrial fields. The advancement of technology has resulted in the use of photopolymerization in various biomedical applications, such as the production of 3D hydrogel structures, the encapsulation of cells, and in drug delivery systems. The use of photopolymerization processes requires an appropriate initiating system which, in biomedical applications, must meet additional criteria: high water solubility, non-toxicity to cells, and compatibility with visible low-power light sources. This article is a literature review on those compounds that act as photoinitiators of photopolymerization processes in biomedical applications. The division of initiators according to the method of photoinitiation was described and the related mechanisms were discussed. Examples from each group of photoinitiators are presented, and their benefits, limitations and applications are outlined.

scholarly journals Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 495 ◽  
Author(s):  
Hakkarainen ◽  
Kõrkjas ◽  
Laidmäe ◽  
Lust ◽  
Semjonov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Fiber Diameter ◽  
Pulse Repetition Frequency ◽  
Reference Method ◽  
Delivery Systems ◽  
Water Soluble ◽  
Aqueous Acetic Acid ◽  
Promising Alternative

We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method. High-molecular polyethylene oxide (PEO) and chitosan were used as carrier polymers and theophylline anhydrate as a water-soluble model drug. The nanofibers were electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber diameter and morphology of the nanofibrous DDSs were modulated by varying ultrasonic parameters in the USES process (i.e., frequency, pulse repetition frequency and cycles per pulse). We found that the USES technology produced nanofibers with higher fiber diameter (402 ± 127 nm) than TES (77 ± 21 nm). An increase of a burst count in USES increased the fiber diameter (555 ± 265 nm) and the variation in fiber size. The slight-to-moderate changes in a solid state (crystallinity) were detected when compared the nanofibers generated by TES and USES. In conclusion, USES provides a promising alternative for aqueous-based fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications.

scholarly journals Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs

2013 ◽  
Vol 63 (4) ◽  
pp. 427-445 ◽  
Author(s):  
Katja Čerpnjak ◽  
Alenka Zvonar ◽  
Mirjana Gašperlin ◽  
Franc Vrečer
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Pharmaceutical Products ◽  
Delivery Systems ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

Abstract Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and drug formulations, and their compatibility with liquid, semi-solid, and solid dosage forms. Lipid formulations, such as self-emulsifying (SEDDS), self-microemulsifying SMEDDS) and self- -nanoemulsifying drug delivery systems (SNEDDS) were explored in many studies as an efficient approach for improving the bioavailability and dissolution rate of poorly water-soluble drugs. One of the greatest advantages of incorporating poorly soluble drugs into such formulations is their spontaneous emulsification and formation of an emulsion, microemulsion or nanoemulsion in aqueous media. This review article focuses on the following topics. First, it presents a classification overview of lipid-based drug delivery systems and mechanisms involved in improving the solubility and bioavailability of poorly water-soluble drugs. Second, the article reviews components of lipid-based drug delivery systems for oral use with their characteristics. Third, it brings a detailed description of SEDDS, SMEDDS and SNEDDS, which are very often misused in literature, with special emphasis on the comparison between microemulsions and nanoemulsions.

scholarly journals Synthesis of water-soluble chitosan for biomedical applications

2015 ◽  
Vol 18 (3) ◽  
pp. 170-180
Author(s):  
Anh Thi Tram Tu ◽  
Huy Thuc Ha
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Iron Oxide ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Wide Ph Range ◽  
Ft Ir ◽  
Ph Range

Highly deacetylated chitosan (CS) reacted with anhydride acetic (Ac2O) to produce chitosan with various degree of deacetylation (DDA) depending on the CS/Ac2O ratios. The structure of products was characterized by FT-IR, 1H NMR, 13C NMR, and the molecular weight was identified by GPC. The DDA of products decreases as the CS/Ac2O ratio increases. The products with less than 80 % DDA were soluble in water with a wide pH range. The water-soluble chitosan can be used in many biomedical applications such as manufacturing drug delivery systems or functionalized iron oxide nanoparticles.

scholarly journals Chitosan-grafted-poly(aniline-co-anthranilic acid) as a water soluble binder to form 3D structures for Si anodes

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7643-7653 ◽  
Author(s):  
Eunsoo Kim ◽  
Rajeev K. K. ◽  
Jaebin Nam ◽  
Junyoung Mun ◽  
Tae-Hyun Kim
Keyword(s):  
Anthranilic Acid ◽  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Polymeric Binder ◽  
3D Structures ◽  
Si Anodes ◽  
Poly Aniline ◽  
High Water Solubility

We develop a polymeric binder with outstanding cell properties, and high water solubility for Si anodes by grafting a conductive PAAA onto chitosan.

Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

2010 ◽  
Vol 88 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
High Water ◽  
Delivery Systems ◽  
High Water Content ◽  
Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

Water-soluble Au nanoclusters for multiplexed mass spectrometry imaging

2017 ◽  
Vol 53 (94) ◽  
pp. 12688-12691 ◽  
Author(s):  
Jinan Li ◽  
Jing Liu ◽  
Zheyi Liu ◽  
Yuan Tan ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Detection Sensitivity ◽  
Lateral Resolution ◽  
Au Nanoclusters ◽  
High Water Solubility

Homogeneous Au nanoclusters were utilized for enhancing the detection sensitivity and lateral resolution of multiplexed mass spectrometry imaging due to their high ultraviolet adsorption, high water solubility, and high biocompatibility.

scholarly journals New Approach for Administration of Doxazosin Mesylate: Comparative Study between Liquid and Solid Self-nanoemulsifying Drug Delivery Systems

2021 ◽  
Vol 12 (2) ◽  
pp. 1095-1101
Author(s):  
Al Zahraa G. Al Ashmawy ◽  
Noura G. Eissa ◽  
Gehan F. Balata ◽  
Hanan M. El Nahas
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Tween 80 ◽  
Delivery Systems ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Surfactant Mixture ◽  
Doxazosin Mesylate

Self-nanoemulsifying drug delivery systems (SNEDDS) in both liquid and solid forms were suggested to improve water solubility of Doxazosin mesylate (DOX) a poorly water- soluble antihypertensive drug. Oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (Ethanol and PEG 400) (1:1, 2:1, 3:1 and 4:1) were chosen to prepare a liquid and solid forms of SNEDDS according to their solubility. TEM images revealed change in the  crystalline nature of DOX into uniform particles with smooth surface. Characterization studies revealed droplet size ranges from  79.80±14.39 to 273.10±4.17 nm, zeta potential ranges from -5.57±0.10 to -21.13±0.46 mV and dissolution enhancement of more than two folds with more favorable properties for the solid forms. FTIR demonstrated significant physical changes in DOX crystalline structure. In conclusion, the solid SNEDDS containing oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (3:1 w/w) and adsorbent mixture of Avicel 101 and Aerosil 200 (40:1 w/w) might be a promising formula for better management of hypertension with expected shelf stability.

scholarly journals Evans Blue Dye: A Revisit of Its Applications in Biomedicine

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Linpeng Yao ◽  
Xing Xue ◽  
Peipei Yu ◽  
Yicheng Ni ◽  
Feng Chen
Keyword(s):  
Evans Blue ◽  
Biomedical Applications ◽  
Animal Studies ◽  
Water Solubility ◽  
Tight Binding ◽  
High Water ◽  
Blue Dye ◽  
Diagnostic Agent ◽  
Made In ◽  
High Water Solubility

Evans blue (EB) dye has owned a long history as a biological dye and diagnostic agent since its first staining application by Herbert McLean Evans in 1914. Due to its high water solubility and slow excretion, as well as its tight binding to serum albumin, EB has been widely used in biomedicine, including its use in estimating blood volume and vascular permeability, detecting lymph nodes, and localizing the tumor lesions. Recently, a series of EB derivatives have been labeled with PET isotopes and can be used as theranostics with a broad potential due to their improved half-life in the blood and reduced release. Some of EB derivatives have even been used in translational applications in clinics. In addition, a novel necrosis-avid feature of EB has recently been reported in some preclinical animal studies. Given all these interesting and important advances in EB study, a comprehensive revisiting of EB has been made in its biomedical applications in the review.

scholarly journals Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays

1999 ◽  
Vol 6 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Eric de Souza Gil ◽  
Maria Inês de Almeida Gonçalves ◽  
Elizabeth Igne Ferreira ◽  
Szulin Ber Zyngier ◽  
Renato Najjar
Keyword(s):  
Water Solubility ◽  
High Water ◽  
Water Soluble ◽  
Biological Assays ◽  
Visible Spectra ◽  
Uv Visible ◽  
K 562 Cells ◽  
Sugar Derivatives ◽  
High Water Solubility

The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by C13 and H1 NMR , infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.

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